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| 1 | Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer’s Disease显示文摘Synaptic dysfunction and abnormal processing of amyloid precursor protein(APP) are early pathological features in Alzheimer’s disease(AD). Recently, noncoding RNAs such as micro RNAs(mi RNAs) and circular RNAs(circ RNAs) have been reported to contribute to the pathogenesis of AD. We found an age-dependent elevation of mi R-138 in APP/PS1(presenilin-1) mice. Mi R-138 inhibited the expression of ADAM10 [a disintegrin and metalloproteinase domain-containing protein 10], promoted amyloid beta(Ab) production, and induced synaptic and learning/memory deficits in APP/PS1 mice, while its suppression alleviated the AD-like phenotype in these mice. Overexpression of sirtuin 1(Sirt1), a target of mi R-138, ameliorated the mi R-138-induced inhibition of ADAM10 and elevation of Ab in vitro. The circ RNA HDAC9(circ HDAC9) was predicted to contain a mi R-138 binding site in several databases. Its expression was inversely correlated with mi R-138 in both Ab-oligomertreated N2 a cells and APP/PS1 mice, and it co-localized with mi R-138 in the cytoplasm of N2 a cells. Circ HDAC9 acted as a mi R-138 sponge, decreasing mi R-138 expression, and reversing the Sirt1 suppression and excessive Ab production induced by mi R-138 in vitro. Moreover,circ HDAC9 was decreased in the serum of both AD patients and individuals with mild cognitive impairment.These results suggest that the circ HDAC9/mi R-138/Sirt1 pathway mediates synaptic function and APP processing in AD, providing a potential therapeutic target for its treatment. | Yanjun Lu Lu Tan Xiong Wang | 2019 | Neuroscience Bulletin2019，35，5： | 20 |
| 2 | Performance enhancement of perovskite-sensitized mesoscopic solar cells using Nb-doped TiO2 compact layer显示文摘Perovskite 太阳能电池是常规光电的设备的最有希望的选择之一,并且广泛的研究集中于设备优化进一步改进他们的表演。TiO 2 的紧缩的层通常在 perovskite 太阳能电池被使用阻止到达做氟的符号的听氧化物电极接近洞。在这贡献,我们用做的 Nb 设计了 TiO 2 协议层,它与 10.26% 的力量变换效率(PCE ) 导致了太阳能电池,它比有一样的配置的设备的高,但是包含太古的 TiO 2 协议层(PCE =9.22%) 。设备表演改进被归因于减少的选择接触抵抗并且增加了源于做的 Nb 的费用再结合抵抗,它被阻抗光谱学大小揭示。发达策略为 perovskite 太阳能电池强调接口优化的重要性。 | Xiong Yin Yanjun Guo Zhaosheng Xue Peng Xu Meng He Bin Liu | 2015 | Nano Research2015，8，6： | 9 |
| 3 | The cotton WRKY transcription factor GhWRKY70 negatively regulates the defense response against Verticillium dahliae显示文摘WRKY transcription factors (TFs) play important roles in the regulation of biotic and abiotic stresses. However, the functions of most WRKY TFs in upland cotton (Gossypium hirsutum) are still unknown. In this study, we functionally identified a group Ⅲ WRKY transcription factor, GhWRKY70, in upland cotton. Reverse transcription-quantitative PCR analysis showed that GhWRKY70 expression was induced by Verticillium dahliae, salicylic acid (SA) and methyl jasmonate. Virus-induced gene silencing of GhWRKY70 increased the resistance of cotton to V. dahliae. Specifically, jasmonic acid (JA) response-associated genes were upregulated and SA-related genes were downregulated in GhWRKY70-silenced cotton plants. Overexpression of GhWRKY70 reduced tolerance to V. dahliae in Arabidopsis thaliana. Transgenic Arabidopsis plants showed increased expression of SA-associated genes and reduced expression of JA response-associated genes. These results suggest that GhWRKY70 negatively regulates tolerance to V. dahliae in at least two ways: (ⅰ) by upregulating the expression of SA-associated genes and (ⅱ) by reducing the expression of JA-associated genes. | Xianpeng Xiong Shichao Sun Yanjun Li Xinyu Zhang Jie Sun Fei Xue | 2019 | The Crop Journal2019，7，3： | 5 |
| 4 | Effect of heat treatment on microstructures and properties of a novel Al-Zn-Mg-Cu alloy for oil drilling显示文摘In view of the special requirements for strength, heat resistance and corrosion resistance of Al-Zn-Mg-Cu alloy for oil drilling, the Al-6.2 Zn-2.5 Mg-1.6 Cu alloy was prepared by increasing Cu content on basis of Russian Series 1953 alloy. The effect of heat treatment on the microstructures and properties of the alloy was characterized by optical microscope(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM), and investigated by tensile test at room temperature, thermal exposure test and corrosion test. The results show that the strength after T6 aging treatment exhibit a decrease trend as an increase of the solution temperature from465 ℃ to 480 ℃. After the solution treated by the rate of 470 ℃/1 h, second phases dissolve into the matrix very well and the strength property reaches optimum. The alloy has better comprehensive properties treated by a solution treatment of 470 ℃/1 h and then followed by an aging treatment of 120 ℃/24 h + 170 ℃/1 h + 120 ℃/24 h. Under the aging state, the precipitated phases inside the grains are suitable in size, while on the grain boundary distribute discontinuously and the precipitate-free zone is obvious. Besides, the alloy still maintain high tensile properties. The yield strength, tensile strength and elongation are 650 MPa, 686 MPa,12.0%, respectively. The yield strength retention after heat exposure is 92%. The alloy has good corrosion resistance and the exfoliation corrosion degree. The average corrosion rate in the H2S and CO2 environment is 0.0024 mm/a, which is far less than the required 0.12 mm/a. It is insensitive to H2S and CO2 environments. | Yanjun Fu Xiwu Li Kai Wen Shuhui Huang Yang Dong Mao Rao Fubo Yang Yugang Wang Baiqing Xiong Zhihui Li | 2019 | Progress in Natural Science:Materials International2019，29，2： | 2 |
| 5 | Putative Phosphatase UvPsr1 Is Required for Mycelial Growth, Conidiation, Stress Response and Pathogenicity in Ustilaginonidea virens显示文摘Ustilaginoidea virens is the causal agent of rice false smut,which can be a highly destructive disease of rice.The plasma membrane phosphatase Psr1 proteins,which act as a regulator of the salinity stress response in yeast,are widely distributed across fungi,but their functional characterization is sketchy.In this study,we characterized the functions of Psr1 protein,UvPsr1,in U.virens.Analyses of the AUvpsr1 and its complementation strain showed that UvPsr1 is required for normal mycelial growth,conidiation and tolerance to oxidative,osmotic and cell wall stresses.When rice panicles were inoculated with the AUvpsr1 strains,no symptoms of false smut disease developed,showing that UvPSR1 also contributes to the pathogenicity of the fungus.The deletion mutant of UvPSR1 also appeared to produce a smaller titer of toxic compounds able to inhibit elongation of the germinated seeds.In conclusion,our results indicated that UvPsr1 is a new pathogenic factor of U.virens. | Xiong Meng Meng Shuai Qiu Jiehua Shi Huanbin Shen Xiangling Kou Yanjun | 2020 | Rice science2020，27，6： | 2 |
| 6 | Laser annealing of SiO2 film deposited by ICPECVD for fabrication of silicon based low loss waveguide显示文摘硅二氧化物退火的激光(诱导地联合的血浆形成的 SiO 2) 电影提高了化学蒸汽免职(ICPECVD ) 为低损失硅的制造被学习基于的波导。激光在扔 ICPECVD 的 SiO 2 电影上退火的影响被调查。表面粗糙,折射索引,并且蚀刻退火的样品的率与 2 电影由热氧化获得了的 SiO 的那些相比。扔 ICPECVD 的 SiO 2 电影的表演能被激光退火显著地改进,这被表明。艾尔 2 O 3/SiO2 波导与更低的 cladding 由 ICPECVD 和激光退火过程形成了的 SiO 2 在硅底层上被制作了,并且它的繁殖损失被发现与有热地氧化的更低的 cladding 的波导的可比较。 | Ya'nan WANG Yi LUO Changzheng SUN Bing XIONG Jian WANG Zhibiao HAO Yanjun HAN Lai WANG Hongtao LI | 2016 | Frontiers of Optoelectronics2016，9，2： | 1 |
| 7 | Detection of human novel influenza A (H1N1) viruses using multi-fluorescent realtime RT-PCR显示文摘 | Hui Donga Zhang Yanjun Hui Xiong | 2010 | Virus Research2010，147，1： | 1 |
| 8 | Investiga-tion on a Two-Stage Solar Liquid-Desiccant (LiBr) Dehu-midification System Assisted by CaCl2 Solution 显示文摘 | XIONG Zhenqin DAI Yanjun WANG Ruzhu | 2009 | Ap-plied Thermal Engineering2009，29，5： | 1 |
| 9 | Dischargecharacteristics of cohesive fine coal from aerated hopper显示文摘 | Huang Wanjie Gong Xin Guo Xiaolei Dai Zhenghua Liu Haifeng Zheng Lijiao Xiong Yanjun | 2009 | Powder Technology2009，194，12： | 1 |
| 10 | Liquid Level Sensor Based on CMFTIR Effect in Polymer Optical Fiber显示文摘挫败的弯曲宏的导致的光纤维 cladding 模式总计内部思考效果被用来与单个宏拐弯聚合物的简单结构认识到液体水平探查光纤维循环。测试结果证明扑灭比率到达 1.06 dB。第一洗澡现象不是明显的(大约 0.8%) 。传感器的坚韧性更好,并且反污染的能力与常规传感器相比是更强壮的。做这根察觉到的探针的过程是极其容易的,并且费用是很低的。 | Yulong HOU Wenyi LIU Huixin ZHANG Shan SU Jia LIU Yanjun ZHANG Jun LIU Jijun XIONG | 2016 | Photonic Sensors2016，6，4： | 0 |
| 11 | Synthesis and Biological Activities of Novel Methyl Xanthine Derivatives显示文摘 | CHEN Youwei WANG Baolei GUO Yanjun ZHOU Yunyun PAN Li XIONG Lixia YU Shujing LI Zhengming | 2014 | Chemical Research in Chinese Universities2014，30，1： | 0 |
| 12 | UvWhi2 Is Required for Stress Response and Pathogenicity in Ustilaginoidea virens显示文摘Some stress response-related genes have been identified in Ustilaginoidea virens,but it is not clear whether and how defects of stress responses affect the pathogenesis processes of U.virens.In this study,we identified a general stress response factor UvWHI2 as a homolog of Saccharomyces cerevisiae Whi2 in U.virens.The relative expression level of Uv Whi2 was significantly up-regulated during infection,suggesting that UvWHI2 may be involved in pathogenesis.Furthermore,knockout of Uv Whi2 showed decreased mycelial growth,increased conidiation in the potato sucrose medium and a defect in pathogenicity.In addition,the RNA-Seq and phenotypic analysis showed that UvWHI2 was involved in response to oxidative,hyperosmotic,cell wall stress and nutrient limitation.Further studies revealed that the defects of stress responses of the?Uvwhi2 mutant affected the formation of secondary spores on the nutrient limited surface and the rice surface,resulting in a significant reduction of pathogenicity of U.virens.Our results suggest that UvWHI2 is necessary for fungal growth,stress responses and the formation of secondary spores in U.virens.In addition,the defects of stress responses can affect the formation of secondary spores on the rice surface,and then compromise the pathogenicity of U.virens. | MENG Shuai QIU Jiehua XIONG Meng LIU Zhiquan Jane Sadhna JAGERNATH LIN Fucheng SHI Huanbin KOU Yanjun | 2022 | Rice science2022，29，1： | 0 |
| 13 | A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs显示文摘Beta-glucan has been shown to have a beneficial effect on gastrointestinal health.This experiment was conducted to investigate the effects ofβ-glucan isolated from Agrobacterium sp.ZX09 on growth performance and intestinal health of weaning pigs.A total of 108 weaned pigs(21 d of age;6.05±0.36 kg)were randomly divided into 3 groups(6 pens/group;6 pigs/pen),and the groups were each treated with the following diets:1)basal diet,2)basal diet supplemented with 20 mg/kg olaquindox,3)basal diet supplemented with 200 mg/kgβ-glucan,for 21 d.Compared with the control group,pigs fed with200 mg/kgβ-glucan had greaterBW,average daily gain and duodenal villus height to crypt depth ratio(P<0.05).Olaquindox increased the duodenal or jejunal villus height of pigs compared withβ-glucan.Compared with the control group,β-glucan tended to increase the occludin mRNA expression in the jejunum(0.05 | Yuliang Wu Xue Li Hongnan Liu Yanjun Du Jian Zhou Lijun Zou Xia Xiong Huilin Huang Zhiliang Tan Yulong Yin | 2021 | Animal Nutrition2021，，4： | 0 |
| 14 | Size-dependent optical properties of InGaN quantum dots in GaN nanowires grown by MBE显示文摘在 nanowires (DINW ) 的量点为新奇 nanoscale 半导体 optoelectronic 设备被认为积木同样重要。在这份报纸,纯轴的异质接面 InGaN/GaN DINW 被使用帮助血浆的分子的横梁取向附生(PA-MBE ) 种系统。InGaN 量点(QD ) 是像磁盘的由扫描电子显微镜学(SEM ) 和传播电子显微镜学(TEM ) 观察了。QD 的直径能被 nanowires (NW ) 的生长条件控制,当 QD 的厚度能到 InGaN 的生长时间被控制时。温度依赖者光致发光(TDPL ) 大小证明有小、一致的尺寸的 DINW 的 PL 山峰与增加温度显示出一般红移动。然而,有不一致的尺寸的 DINW 的 PL 山峰与增加温度显示出反常蓝移动,它由于有不同尺寸的 DINW 的不同的内部量效率。 | Yanxiong E Zhibiao HAO Jiadong YU Chao WU Lai WANG Bing XIONG Jian WANG Yanjun HAN Changzheng SUN Yi LUO | 2016 | Frontiers of Optoelectronics2016，9，2： | 0 |
| 15 | Simple dynamic energy core equivalent rays method to design freeform surface for extended source显示文摘一个简单方法被建议设计形式自由的表面因为 Lambertian 扩大了来源。在这个方法,它能经由与一条动态地计算的相等的光线代替每条事件光线为点来源利用设计方法。为形式自由的表面上的每个方面,相等的光线为相应事件横梁从精力射出加权的 average-emitting-position,并且重定向进被印射的 source-to-target 决定的方向。设计例子的结果证明轻分布一致性能被这个方法改进,例如,甚至 59% 罐头的改进被完成。 | Kun WANG Yanjun HAN Hongtao LI Yi LUO Zhibiao HAO Lai WANG Changzheng SUN Bing XIONG Jian WANG | 2016 | Frontiers of Optoelectronics2016，9，2： | 0 |
| 16 | The Binarity of Early-type Stars from LAMOST medium-resolution Spectroscopic Survey显示文摘Massive binaries play significant roles in many fields.Identifying massive stars,particularly massive binaries,is of great importance.In this paper,by adopting the technique of measuring the equivalent widths of several spectral lines,we identified 9382 early-type stars from the LAMOST medium-resolution survey and divided the sample into four groups,T1(~O-B4),T2(~B5),T3(~B7)and T4(~B8-A).The relative radial velocities RVrelwere calculated using Maximum Likelihood Estimation.The stars with significant changes of RVreland at least larger than 15.57 km s-1 were identified as spectroscopic binaries.We found that the observed spectroscopic binary fractions for the four groups are 24.6%±0.5%,20.8%±0.6%,13.7%±0.3%and 7.4%±0.3%,respectively.Assuming that orbital period(P)and mass ratio(q)have intrinsic distributions as f(P)∝Pπ(1 | Yanjun Guo Jiao Li Jianping Xiong Jiangdan Li Luqian Wang Heran Xiong Feng Luo Yonghui Hou Chao Liu Zhanwen Han Xuefei Chen | 2022 | Research in Astronomy and Astrophysics2022，22，2： | 0 |
| 17 | Dual-bionic regenerative microenvironment for peripheral nerve repair显示文摘Autologous nerve grafting serves is considered the gold standard treatment for peripheral nerve defects;however,limited availability and donor area destruction restrict its widespread clinical application.Although the performance of allogeneic decellularized nerve implants has been explored,challenges such as insufficient human donors have been a major drawback to its clinical use.Tissue-engineered neural regeneration materials have been developed over the years,and researchers have explored strategies to mimic the peripheral neural microenvironment during the design of nerve catheter grafts,namely the extracellular matrix(ECM),which includes mechanical,physical,and biochemical signals that support nerve regeneration.In this study,polycaprolactone/silk fibroin(PCL/SF)-aligned electrospun material was modified with ECM derived from human umbilical cord mesenchymal stem cells(hUMSCs),and a dual-bionic nerve regeneration material was successfully fabricated.The results indicated that the developed biomimetic material had excellent biological properties,providing sufficient anchorage for Schwann cells and subsequent axon regeneration and angiogenesis processes.Moreover,the dual-bionic material exerted a similar effect to that of autologous nerve transplantation in bridging peripheral nerve defects in rats.In conclusion,this study provides a new concept for designing neural regeneration materials,and the prepared dual-bionic repair materials have excellent auxiliary regenerative ability and further preclinical testing is warranted to evaluate its clinical application potential. | Yanjun Guan Zhiqi Ren Boyao Yang Wenjing Xu Wenjun Wu Xiangling Li Tieyuan Zhang Dongdong Li Shengfeng Chen Jun Bai Xiangyu Song Zhibo Jia Xing Xiong Songlin He Chaochao Li Fanqi Meng Tong Wu Jian Zhang Xiuzhi Liu Haoye Meng Jiang Peng Yu Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 18 | High-speed optoelectronic devices显示文摘High-speed optoelectronic devices are key components of modern fiber communication systems,and the backbone of information technology.In this paper,we present our work on high-speed devices over the past decades,including high-performance semiconductor lasers and integrated light sources,wideband electrooptic modulators,high saturation power photodetectors,and their applications in both fiber communications and microwave photonics.Gain-coupled distributed feedback(DFB)lasers were fabricated with high singlemode yield.Electroabsorption modulated lasers(EMLs)were demonstrated based on identical epitaxial layer integration scheme,including single channel 40 Gb/s EMLs,and 4×25 and 4×56 Gb/s EML arrays.Both In P and thin-film lithium niobate based low half-wave voltage electro-optic modulators with modulation bandwidth over 40 GHz were demonstrated.Back-illuminated modified uni-traveling-carrier photodetectors(MUTC-PDs)with high saturation power and bandwidth exceeding 100 GHz were developed.Applications of high-speed optoelectronic devices in fiber-optic links and sub-THz wave generation are presented. | Yi LUO Changzheng SUN Bing XIONG Jian WANG Zhibiao HAO Yanjun HAN Hongtao LI Lai WANG | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
| 19 | Branched core-shell a-TiO_(2)@N-TiO_(2) nanospheres with gradient-doped N for highly efficient photocatalytic applications显示文摘A branched core-shell nanosphere composed of an anatase TiO_(2)(a-TiO_(2)) core and a TiO_(2)nanobranch shell with gradient-doped N(a-TiO_(2)@N-TiO_(2)) is synthesized by a simple in situ doping method, in which mixed crystal anatase-rutile TiO_(2)(ar-TiO_(2)) nanosphere is first prepared by oxidizing Ti using H_(2)O_(2), and then is etched by NH_(3)·H_(2)O to form(NH_(4))2TiO_(3)nanobranches, which is converted into a-TiO_(2)@N-TiO_(2)following an ambient annealing process. The diameter of a-TiO_(2)core is ~500 nm, and the thickness of NTiO_(2)branched shell is ~100 nm with gradually increased N concentration from the bottom to the edge.Ultra-thin amorphous coating layers on the branches are also observed. The morphology of the composites could be further tuned by the amount of NH_(3)·H_(2)O, and its effect on the photocatalytic performance is also investigated. The optimized a-TiO_(2)@N-TiO_(2)shows an outstanding hydrogen evolution rate of 308.1 μmol g^(-1)h^(-1)under air mass(AM) 1.5 illumination, and also exhibits highly active in photocatalytic degradation of various refractory organic pollutants, including organic dyes, phenols, antibiotics,and personal care products, with removal ratios higher than 96% after 2 h operation. This can be due to the gradient-doped N-TiO_(2)nanobranches, which not only provide bending band structure and defect level derived from the N impurities and O vacancies, resulting the formation of n-n+heterojunctions to improve the charge separation, but also enhance the charge transfer at the liquid-solid interface due to the numerous nanobranches and amorphous coating layers. | Qingsong Zhang Yang Xiao Liu Yang Yanjun Wen Zhu Xiong Lin Lei Lin Wang Qingyi Zeng | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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