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| 1 | The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism显示文摘It has been well recognized that the development and use of artificial materials with high osteogenic ability is one of the most promising means to replace bone grafting that has exhibited various negative effects.The biomimetic features and unique physiochemical properties of nanomaterials play important roles in stimulating cellular functions and guiding tissue regeneration.But efficacy degree of some nanomaterials to promote specific tissue formation is still not clear.We hereby comparatively studied the osteogenic ability of our treated multiwalled carbon nanotubes(MCNTs)and the main inorganic mineral component of natural bone,nano-hydroxyapatite(nHA)in the same system,and tried to tell the related mechanism.In vitro culture of human adiposederived mesenchymal stem cells(HASCs)on the MCNTs and nHA demonstrated that although there was no significant difference in the cell adhesion amount between on the MCNTs and nHA,the cell attachment strength and proliferation on the MCNTs were better.Most importantly,the MCNTs could induce osteogenic differentiation of the HASCs better than the nHA,the possible mechanism of which was found to be that the MCNTs could activate Notch involved signaling pathways by concentrating more proteins,including specific bone-inducing ones.Moreover,the MCNTs could induce ectopic bone formation in vivo while the nHA could not,which might be because MCNTs could stimulate inducible cells in tissues to form inductive bone better than nHA by concentrating more proteins including specific bone-inducing ones secreted from M2 macrophages.Therefore,MCNTs might be more effective materials for accelerating bone formation even than nHA. | Zhipo Du Xinxing Feng Guangxiu Cao Zhending She Rongwei Tan Katerina E.Aifantis Ruihong Zhang Xiaoming Li | 2021 | Bioactive Materials2021，6，2： | 3 |
| 2 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 3 | Iron sites on defective BiOBr nanosheets:Tailoring the molecular oxygen activation for enhanced photocatalytic organic synthesis显示文摘Sunlight-driven activation of molecular oxygen(O_(2))for organic oxidation reactions offers an appealing strategy to cut down the reliance on fossil fuels in chemical industry,yet it remains a great challenge to simultaneously tailor the charge kinetics and promote reactant chemisorption on semiconductor catalysts for enhanced photocatalytic performance.Herein,we report iron sites immobilized on defective BiOBr nanosheets as an efficient and selective photocatalyst for activation of O_(2) to singlet oxygen(^(1)O_(2)).These Fe^(3+) species anchored by oxygen vacancies can not only facilitate the separation and migration of photogenerated charge carrier,but also serve as active sites for effective adsorption of 02.Moreover,low-temperature phosphorescence spectra combined with X-ray photoelectron spectroscopy(XPS)and electronic paramagnetic resonance(EPR)spectra under illumination reveal that the Fe species can boost the quantum yield of excited triplet state and accelerate the energy transfer from excited triplet state to adsorbed O2 via a chemical loop of Fe^(3+)/Fe^(2+),thereby achieving highly efficient and selective generation of ^(1)O_(2).As a result,the versatile iron sites on defective BiOBr nanosheets contributes to near-unity conversion rate and selectivity in both aerobic oxidative coupling of amines to imines and sulfoxidation of organic sulfides.This work highlights the significant role of metal sites anchored on semiconductors in regulating the charge/energy transfer during the heterogeneous photocatalytic process,and provides a new angle for designing high-performance photocatalysts. | Xinhui Ye Yu Li Peipei Luo Bingcai He Xinxing Cao Tongbu Lu | 2022 | Nano Research2022，15，2： | 1 |
| 4 | Probing surface structure on two-dimensional metal-organic layers to understand suppressed interlayer packing显示文摘Two-dimensional metal-organic layers(MOLs)from alternatively connected benzene-tribenzoate ligands and Zr6(μ3-O)_(4)(μ3-OH)_(4) or Hf6(μ3-O)_(4)(μ3-OH)_(4) secondary building units can be prepared in gram scale via solvothermal synthesis.However,the reason why the monolayers did not pack to form thick crystals is unknown.Here we investigated the surface structure of the MOLs by a combination of sum-frequency generation spectroscopy,nanoscale infrared microscopy,atomic force microscopy,aberration-corrected transmission electron microscopy,and compositional analysis.We found a partial coverage of the monolayer surface by dangling tricarboxylate ligands,which prevent packing of the monolayers.This finding illustrates low-density surface modification as a strategy to prepare new two-dimensional materials with a high percentage of exposed surface. | Peican Chen Yi Liu Xuefu Hu Xiaolin Liu En-Ming You Xudong Qian Jiawei Chen Liangping Xiao Lingyun Cao Xinxing Peng Zhongming Zeng Yibing Jiang Song-Yuan Ding Honggang Liao Zhaohui Wang Da Zhou Cheng Wang | 2020 | Nano Research2020，13，11： | 0 |
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