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| 1 | Conversion of confined metal@ZIF-8 structures to intermetallic nanoparticles supported on nitrogen-doped carbon for electrocatalysis显示文摘 | Zhiyuan Qi Yuchen Pei Tian Wei Goh Zhaoyi Wang Xinle Li Mary Lowe Raghu V. Maligal-Ganesh Wenyu Huang | 2018 | Nano Research2018，11，6： | 6 |
| 2 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 3 | A D-optimal Multi-position Calibration Method for Dynamically Tuned Gyroscopes显示文摘This paper presents a novel experimental design to greatly improve the calibration accuracy of the acceleration-insensitive bias and the acceleration-sensitive bias of the dynamically tuned gyroscopes(DTGs).In order to reduce experimental cost,the D-optimal criteria with constraints are constructed.The turntable positions and the number of test points are chosen to build D-optimal experimental designs.The D-optimal experimental designs are tested by multi-position calibration experiment for tactical-grade DTGs.Test results show that,with the same cost,the fit uncertainty is reduced by about 50% by using the D-optimal 8-position experimental procedure,compared to using a defacto standard experimental procedure in ANSI/IEEE Std 813-1988.Furthermore,the new experimental procedure almost achieves optimal accuracy with only 12-position which is half the cost of the widely adopted 24-position experimental procedure for achieving optimal accuracy. | FU Li ZHU Yongquan WANG Lingling WANG Xinling | 2011 | Chinese Journal of Aeronautics2011，24，2： | 5 |
| 4 | Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates. | Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang | 2021 | Cell Research2021，31，1： | 5 |
| 5 | Characteristics of ultrafine particles emitted from a dimethyl ether (DME) engine显示文摘Measurements of exhaust particle number concentration and size distribution from a dimethyl ether (DME) engine at different engine loads and speeds were carried out by using a two-stage dilution sys- tem and an SMPS. The results of the DME engine were compared with those of the original diesel en- gine. The fuel composition had significant effects on the exhaust particle size distribution, the total exhaust particle number and mass concentrations. Compared with those of the DME engine, the parti- cle mass emissions of the diesel engine increased 5.7-17.7 times. At high engine speed (n=2200 r/min), compared with those of the DME engine, the total particle number emissions of the diesel engine in- creased 0.75-2.2 times, while the total particle number emissions of the diesel engine decreased by about 50%-80% for middle and high loads at middle engine speed (n=1400 r/min). Compared with those of the DME engine, the total exhaust particle number concentrations in the accumulation mode of the diesel engine increased 4.2-62.6 times and the exhaust particle geometric number mean diameters in the accumulation mode increased by about 10-30 nm. This correlated with higher oxygen level and lack of C-C bonds in DME. A lot of nucleation mode particles were emitted from the DME engine, this correlated with the processes of nucleation and condensation of the volatile and semi-volatile com- pounds in the exhaust gas. | LI XinLing HUANG Zhen WANG JiaSong WU JunHua | 2008 | Chinese Science Bulletin2008，53，2： | 4 |
| 6 | The diagnostic value of tumor abnormal protein and high sensitivity C reactive protein in screening for endometrial cancer with endometrial thickness less than 8 mm显示文摘Objective This study aimed to combine tumor abnormal protein(TAP) and high-sensitivity C-reactive protein(hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less than 8 mm, and to provide a reference for clinical screening and diagnosis. Methods Clinical data from 19 cases of endometrial cancer, diagnosed on the basis of pathological findings, were collected from September 2014 to December 2015. The inclusion criteria were as follows: the patients were first diagnosed with endometrial thickness less than 8 mm and were all in menopause. Perimenopausal patients(n = 26) with uterine fibroids seen during the same period were selected as a control group. Serum TAP and hs-CRP levels of the patients in the two groups were simultaneously determined on admission. Results We found that both TAP and hs-CRP levels in the experimental group were higher than those in the control group [(182.95 ± 72.14) μm^2 vs.(133.19 ± 55.18) μm^2, P = 0.019;(7.52 ± 19.03) mg/L vs.(1.66 ± 2.31) mg/L, P = 0.136]. The sensitivity of TAP for the diagnosis of endometrial cancer was 73.68%, the specificity was 69.23%, and the Youden index was 0.4291. The diagnostic sensitivity and specificity of hs-CRP was 15.79% and 100%, respectively, and the Youden index was 0.1579. After plotting the receiver operating characteristics curves, the optimal cut-off value for TAP in diagnosing endometrial cancer was found to be 160.662 μm^2 and that for hs-CRP was 1.07 mg/L. Conclusion For patients suspected of having endometrial cancer with endometrial thickness less than 8 mm, combined detection of TAP and hs-CRP levels can be used as a screening tool and can provide new ideas regarding clinical diagnosis and treatment. | Yi Li Ruiqin Yue Dongrui Qin Yanqing Wang Xinling Zhou Xinyong Jing Chuanzhong Wu | 2016 | Oncology and Translational Medicine2016，2，4： | 3 |
| 7 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
| 8 | Exploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators显示文摘Allatostatins(ASTs), a family of insect neuropeptide, can inhibit juvenile hormone(JH) biosynthesis by the corpora allata(CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators(IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro(IC_(50): 0.09 mmol/L) in our previous studies. In the present work, two series of B1 analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with log P value over 2.0 exhibited good activity,which indicated the hydrophobicity is important to the bioactivity. Three dimension quantitative structure-activity relationship(3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog Ⅱ12(IC_(50): 0.08 mmol/L) exhibited similar inhibitory activity to the lead B1,but its synthetic route was simpler than B1. Therefore, Ⅱ12 could be used as a new lead compound for the discovery eco-friendly IGRs. | Meizi Wang Li Zhang Xianwei Wang Yun Ling Xiaoqing Wu Xinlu Li Yiduo Mi Xinling Yang | 2018 | Chinese Chemical Letters2018，29，9： | 2 |
| 9 | Modeling Study of Seasonal Variation of the Pelagic-Benthic Ecosystem Characteristics of the Bohai Sea显示文摘在 1998 和 1999 在 Bohai 海基于中国德语的全面调查的实验数据,一个简单联合 pelagic-benthic 生态系统多盒子模型被用来模仿生态系统季节变异。远洋的亚模型由七个州的变量组成:浮游植物,浮游动物,锡,尖端,文档,停靠港和溶解的氧() 。benthicsub 模型在沉积包括宏底生生物, meiobenthos,细菌,岩屑,听和尖端。除从海底部渗出的太阳辐射,水温和营养素的效果以外,以地为基地的输入被考虑。在盒子之间的移流术语的影响也被考虑。同时, micro-bial-loop 的效果与 simpleparameterization 被介绍。季节变异和生态系统的水平分布声明 Bohai 海的变量被模仿。与观察相比, themulti 盒子模型的结果是合理的。建模的结果证明大约 13% 光合作用初级生产量去主要食物环, 20% 转到 benthic 领域, 44% 被浮游植物的呼吸消费,并且剩余的去文档。模型结果也在 Bohai 海,和它对年度浮游动物生产的贡献的生态系统显示出微生物引起的食物环的重要性能是 60%-64% 。 | ZHANG Xinling WU Zengmao LI Jie YU Guangyao ZHANG Zhinan GAO Shanhong | 2006 | Journal of Ocean University of China2006，5，1： | 2 |
| 10 | Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with embryo quality显示文摘在小囊的液体的自由激进分子的活动与卵巢的应答有关,在 vitro 授精(IVF ) ,和胚胎转移成功评价。然而,学习与卵巢的症候群(PCOS ) 正在缺乏的 polycystic 分析在免费激进的清除能力和不肥沃的女人的胚胎质量之间的关系。这研究的目的是与 PCOS 和他们的胚胎评估在女人的免费激进的清除窗户之间的关系优秀的。从有 PCOS 的女人的小囊的液体的免费激进的清除能力被决定由一, a-diphenyl-b-picrylhydrazyl (DPPH ) , 2,2-azinobis (3-ethylbenzthiazoline-6-sulphonic 酸) 试金, superoxide 基,和反应的氧种类(ROS ) 试金。在 DPPH 和 ROS 试金,从等级的小囊的液体我和 II 胚胎是比从等级 III 和 IV 胚胎的小囊的液体显著地高级的。激进的清除能力和 ROS 的上面的控制限制铺平的 DPPH 的更低的控制限制分别地是 13.2% 和 109.0 每秒字符数。计算更低的控制限制和上面的控制限制进一步在所有等级的胚胎的小囊的液体被证实。小囊的液体的免费激进的清除活动的这些截止价值能在在经历 IVF 的 PCOS 病人选择胚胎的发展帮助胚胎学家。 | Bo Huang Zhou Li Xinling Ren Jihui Ai Lixia Zhu Lei Jin | 2017 | Frontiers of Medicine2017，11，2： | 2 |
| 11 | A chromosome-scale genome assembly of Artemisia argyi reveals unbiased subgenome evolution and key contributions of gene duplication to volatile terpenoid diversity显示文摘Artemisia argyi Le´vl.et Vant.,a perennial Artemisia herb with an intense fragrance,is widely used in traditional medicine in China and many other Asian countries.Here,we present a chromosome-scale genome assembly of A.argyi comprising 3.89 Gb assembled into 17 pseudochromosomes.Phylogenetic and comparative genomic analyses revealed that A.argyi underwent a recent lineage-specificwhole-genomeduplication(WGD)event after divergence fromArtemisia annua,resulting in two subgenomes.Wedeciphered the diploid ancestral genome of A.argyi,and unbiased subgenome evolution was observed.The recent WGD led to a large number of duplicated genes in the A.argyi genome.Expansion of the terpene synthase(TPS)gene family through various types of gene duplication may have greatly contributed to the diversity of volatile terpenoids in A.argyi.In particular,we identified a typical germacrene D synthase gene cluster within the expanded TPS gene family.The entire biosynthetic pathways of germacrenes,(+)-borneol,and(+)-camphor were elucidated in A.argyi.In addition,partial deletion of the amorpha-4,11-diene synthase(ADS)gene and loss of function of ADS homologs may have resulted in the lack of artemisinin production in A.argyi.Our study provides newinsights into the genome evolution of Artemisia and lays a foundation for further improvement of the quality of this important medicinal plant. | Hongyu Chen Miaoxian Guo Shuting Dong Xinling Wu Guobin Zhang Liu He Yuannian Jiao Shilin Chen Li Li Hongmei Luo | 2023 | Plant Communications2023，4，3： | 2 |
| 12 | A Novel Training Sequence Applied to DCS-Based Channel Estimation显示文摘Studies have indicated that the distributed compressed sensing based(DCSbased) channel estimation can decrease the length of the reference signals effectively. In block transmission, a unique word(UW) can be used as a cyclic prefix and reference signal. However, the DCS-based channel estimation requires diversity sequences instead of UW. In this paper, we proposed a novel method that employs a training sequence(TS) whose duration time is slightly longer than the maximum delay spread time. Based on proposed TS, the DCS approach perform perfectly in multipath channel estimation. Meanwhile, a cyclic prefix construct could be formed, which reduces the complexity of the frequency domain equalization(FDE) directly. Simulation results demonstrate that, by using the method of simultaneous orthogonal matching pursuit(SOMP), the required channel overhead has been reduced thanks to the proposed TS. | Weizhang Xu Xinle Yu Yanfei Li Lu Si Zhanxin Yang | 2018 | China Communications2018，15，11： | 2 |
| 13 | Formation and transformation of volatile nanoparticles from a diesel engine during exhaust dilution显示文摘A classic H 2 SO 4-H 2 O binary homogeneous nucleation model coupled to an aerosol dynamics model,suitable for studying the formation and transformation of volatile nanoparticles (VNPs) during diesel engine exhaust dilution,has been developed.Using the H 2 SO 4-H 2 O binary homogeneous nucleation model,the nucleation ratio and molecular cluster size were calculated.The effect of aerosol dynamic processes on VNP number size distributions was studied.The effects of fuel sulfur content (FSC) and sampling conditions in the laboratory on VNP number size distributions were also calculated.Our simulations demonstrated that nucleation increased the cluster number concentration and that FSC,temperature and humidity significantly affected the nucleation ratio and molecular cluster size.Coagulation promoted the evolution of cluster-particle size distributions from monodisperse to polydisperse.Soot present in the exhaust can suppress the formation of VNPs.FSC and sampling conditions,like the primary dilution temperature,the primary dilution relative humidity,residence time and the primary dilution ratio have significant effects on VNP number size distributions. | LI XinLing HUANG Zhen | 2012 | Chinese Science Bulletin2012，57，8： | 2 |
| 14 | Altered Plasma Concentrations of Trace Elements in Ulcerative Colitis Patients Before and After Surgery显示文摘 | Xinling Ma Ke Zhao Li Wei Peng Song Gang Liu Hongqiu Han Chunmei Wang | 2013 | Biological Trace Element Research2013，，1： | 1 |
| 15 | Experimental study on impacts of fuel type on thermo-acoustic instability in a gas turbine model combustor显示文摘Effects of liquid fuel composition variations on characteristics of self-excited thermo-acoustic instabilities in a lean premixed,pre-vaporized gas turbine model combustor were experimentally studied.Test fuels included practical RP-3 jet fuel and its blending with iso-octane and n-dodecane,which were branched and linear alkanes respectively.Under the test conditions,dynamic pressure measurements indicated that the dominant instability frequency was highest for RP-3 flame,while RP-3/ndodecane flame exhibited the strongest instability strength.A further analysis showed that the instability frequency correlated well with the profiles of adiabatic flame temperature,and the strength of the instability highly depended on the ignition delay times of the fuels.Measurements of the flame structure and flow field with OH*chemiluminescence (CL) imaging and twodimensional particle image velocimetry (PIV) techniques indicated that changes in the fuel composition did not alter the unstable modes and general sequences of flame-flow structure oscillations.Further power spectra and proper orthogonal decomposition(POD) analysis suggested that axial oscillations along with precessing vortex core (PVC) induced helical motion predominated periodic flame structure and flow field oscillations. | RUAN Can CHEN FeiEr YU Tao CAI WeiWei HE ZhuoYao MAO YeBing LI XinLing LU XingCai | 2021 | Science China(Technological Sciences)2021，64，6： | 1 |
| 16 | Particle size distribution from a GTL engine 显示文摘 | Li Xinling Huang Zhen Wang Jiasong | 2007 | Science of the Total Environment2007，382，： | 1 |
| 17 | Can enrich and perfect the community maternal health services system显示文摘 | Zhao Xinling Li Bin | | 0，，09： | 1 |
| 18 | Application of Big Data in Agricultural Informationization in Shandong Province under the Background of 'Internet +'显示文摘This paper explains the basic concepts of ' Internet + ' and big data,analyzes the main problems in the application of big data technology in agricultural informationization of Shandong Province,summarizes corresponding solutions from the aspects of government guidance,financial input,open sharing of agricultural big data,big data storage and processing,data mining,etc.,and prospects the application trend of big data technology in agricultural informationization to achieve the connotative development of agriculture in Shandong Province. | Xinling GAN Yong LI | 2019 | Asian Agricultural Research2019，11，4： | 1 |
| 19 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘 | XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG | | 0，，08： | 1 |
| 20 | Automatic tracing and measuring crankpin surface for the initia orentation in non-circular grinding显示文摘 | SHEN Nanyan LI Jing WANG Xinling | 2012 | Advanced Materials Research2012，569，： | 1 |
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