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| 1 | Aberrant DNA methylation in 5′ regions of DNA methyltransferase genes in aborted bovine clones显示文摘High rate of abortion and developmental abnormalities is thought to be closely associated with inefficient epigenetic reprogramming of the transplanted nuclei during bovine cloning. It is known that one of the important mechanisms for epigenetic reprogramming is DNA methylation. DNA methylation is established and maintained by DNA methyltransferases (DNMTs), therefore, it is postulated that the inefficient epigenetic reprogramming of transplanted nuclei may be due to abnormal expression of DNMTs. Since DNA methylation can strongly inhibit gene expression, aberrant DNA methylation of DNMT genes may disturb gene expression. But presently, it is not clear whether the methylation abnormality of DNMT genes is related to developmental failure of somatic cell nuclear transfer embryos. In our study, we analyzed methylation patterns of the 5′ regions of four DNMT genes including Dnmt3a, Dnmt3b, Dnmt1 and Dnmt2 in four aborted bovine clones. Using bisulfite sequencing method, we found that 3 out of 4 aborted bovine clones (AF1, AF2 and AF3) showed either hypermethylation or hypomethylation in the 5′ regions of Dnmt3a and Dnmt3b, indicating that Dnmt3a and Dnmt3b genes are not properly reprogrammed. However, the individual AF4 exhibited similar methylation level and pattern to age-matched in vitro fertilized (IVF) fetuses. Besides, we found that the 5′ regions of Dnmt1 and Dnmt2 were nearly completely unmethylated in all normal adults, IVF fetuses, sperm and aborted clones. Together, our results suggest that the aberrant methylation of Dnmt3a and Dnmt3b 5′ regions is probably associated with the high abortion of bovine clones. | Jinghe Liu Xingwei Liang Jiaqiao Zhu Liang Wei Yi Hou Da-Yuan Chen Qing-Yuan Sun | 2008 | Journal of Genetics and Genomics2008，35，9： | 10 |
| 2 | A quantitative approach to monitoring new sand cay migration in Nansha Islands显示文摘Sand cay is a special kind of islet formed by coral detritus and bioclast, which is common in Nansha Islands of China. Some sand cays play an important role in ocean strategy and economy, but surprisingly we know little about them, especially those recently formed sand cays. In this research, we monitor migration of a new sand cay in Nanxun Jiao(Gaven Reef) using a series of Quick Bird and World View-2 satellite images between June 2006 and August 2013. We conduct a regression between migration distance and wind observational data to examine the migration patterns of the new sand cay. The migration distance is calculated based on the sand cay locations extracted based on Normalized Difference Water Index(NDWI). The wind observational data downloaded from NOAA are reformed into four wind direction vectors. Based on the results of regression, we concluded that the migration of the new sand cay on Nanxun Jiao was significantly associated with the east, west and north wind.East wind was the main influence factor of the migration; its impact strength was almost twice as the west and north wind. The south wind has little effect on the migration of the sand cay, which is partly blocked by the artificial structure in the south. | ZHU Haitian JIANG Xingwei MENG Xuelian FENG Qian CUI Songxue LIANG Chao | 2016 | Acta Oceanologica Sinica2016，35，3： | 9 |
| 3 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 4 | Meta-Analysis of Complications of Colonic Stenting Versus Emergency Surgery for Acute Left-sided Malignant Colonic Obstruction显示文摘 | Zhihua Liu Liang Kang Chao Li Meijin Huang Xingwei Zhang Jianping Wang | 2014 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2014，，： | 1 |
| 5 | Channel puncturing based low-complexity belief propagation detection for multi-user MIMO systems显示文摘A low complexity punctured belief propagation(BP)detection utilizing channel puncturing for multi-user multiple-input multiple-output(MU-MIMO)systems is proposed in this paper.This paper constructs a cycle-free fator graph by puncturing certain non-zero entries in a transformed channel matrix,and proposes an adjusted BP algorithm with a more exact a posteriori message updating equation.The proposed algorithm converges rapidly in several iterations due to the cycle-free structure in the factor graph.Nevertheless,puncturing brings distorted noise and thus leads to performance degradation.To tackle this issue,this article further designs a layered detection with the help of maximum likelihood detector(MLD).Simulations demonstrate that the proposed detection algorithm achieves the identical performance to MLD with much lower complexity. | Cai Xingwei Ji Wei Qiu Ling Liang Xiaowen | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，6： | 0 |
| 6 | Cattle Farming’s Impact on Climate Change显示文摘D URING the year 2021,the Earth has been battered and bruised by diverse extreme weather patterns,which have resulted in floods,storms,and extreme heat causing wildfires in multiple parts of the world.The Canadian province of British Columbia,once deemed to be one of the most livable regions in the world,saw its temperature hit a record high of 46.6 degrees Celsius last summer.These unusual weather phenomena have once again triggered the urgent action needed in dealing with climate change. | ZHANG ZIQIN LIANG XINGWEI | 2021 | China Today2021，70，11： | 0 |
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