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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Design Property Network-Based Change Propagation Prediction Approach for Mechanical Product Development显示文摘Design changes are unavoidable during mechanical product development; whereas the avalanche propagation of design change imposes severely negative impacts on the design cycle. To improve the validity of the change propagation prediction, a mathematical programming model is presented to predict the change propagation impact quantitatively. As the foundation of change propagation prediction, a design change analysis model(DCAM)is built in the form of design property network. In DCAM,the connections of the design properties are identified as the design specification, which conform to the small-world network theory. To quantify the change propagation impact, change propagation intensity(CPI) is defined as a quantitative and much more objective assessment metric.According to the characteristics of DCAM, CPI is defined and indicated by four assessment factors: propagation likelihood, node degree, long-chain linkage, and design margin. Furthermore, the optimal change propagation path is searched with the evolutionary ant colony optimization(ACO) algorithm, which corresponds to the minimized maximum of accumulated CPI. In practice, the change impact of a gear box is successfully analyzed. The proposed change propagation prediction method is verified to be efficient and effective, which could provide different results according to various the initial changes. | songhua ma zhaoliang jiang wenping liu chuanzhen huang | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 8 |
| 3 | Characterization of flavor fingerprinting of red sufu during fermentation and the comparison of volatiles of typical products显示文摘Traditional Chinese red sufu is a popular condiment,and typical flavor is an important indicator of sensory qualities in commercial products.In this study,the volatile aroma analysis of Wangzhihe red sufu(WRS)from different fermentation stages and four typical red sufu products from different locations was carried out by gas chromatography-mass spectrometry(GC–MS),gas chromatography-mass spectrometry/olfactory(GC–MS/O),electronic nose(E-nose)and sensory evaluation.Results showed that 106 volatile compounds were identified in Wangzhihe red sufu during fermentation process,in which phenolics and alcohols were dominant at molded and salted phetze stages,while esters and alcohols became predominate at post-fermentation stage.The volatile aroma substances varied at each fermentation stage.Furthermore,86 volatiles,including 16 aroma-active compounds,were detected in four typical red sufu products.The multivariate analysis results showed the difference in samples from different fermentation stages and typical red sufu products according to GC–MS and E-nose analysis.Combined with flavor omics,discriminant model was established for effective discrimination of samples from different fermentation stages and locations,as well as references to sufu maturity extent.The study presented a new strategy for quality evaluation of red sufu,which could be the supplement to quality evaluation standards. | Peng Wang Xiaoran Ma Wenping Wang Dandan Xu Xin Zhang Jian Zhang Yong Sun | 2019 | Food Science and Human Wellness2019，8，4： | 7 |
| 4 | Multiobjective optimization using an immunodominance and clonal selection inspired algorithm显示文摘Based on the mechanisms of immunodominance and clonal selection theory,we propose a new multiobjective optimization algorithm,immune dominance clonal multiobjective algorithm(IDCMA).IDCMA is unique in that its fitness values of current dominated individuals are assigned as the values of a custom distance measure,termed as Ab-Ab affinity,between the dominated individuals and one of the nondominated individuals found so far.According to the values of Ab-Ab affin-ity,all dominated individuals(antibodies) are divided into two kinds,subdominant antibodies and cryptic antibodies.Moreover,local search only applies to the sub-dominant antibodies,while the cryptic antibodies are redundant and have no func-tion during local search,but they can become subdominant(active) antibodies during the subsequent evolution.Furthermore,a new immune operation,clonal proliferation is provided to enhance local search.Using the clonal proliferation operation,IDCMA reproduces individuals and selects their improved maturated progenies after local search,so single individuals can exploit their surrounding space effectively and the newcomers yield a broader exploration of the search space.The performance comparison of IDCMA with MISA,NSGA-Ⅱ,SPEA,PAES,NSGA,VEGA,NPGA,and HLGA in solving six well-known multiobjective function optimization problems and nine multiobjective 0/1 knapsack problems shows that IDCMA has a good performance in converging to approximate Pareto-optimal fronts with a good distribution. | GONG MaoGuo JIAO LiCheng MA WenPing DU HaiFeng | 2008 | Science in China(Series F)2008，51，8： | 6 |
| 5 | Optimal stimulation parameters for Renzhong (DU 26) electro-acupuncture for improving motor function in a rat model of middle cerebral artery occlusion显示文摘The selection of electro-acupuncture parameters remains poorly unified between clinical studies.The present study observed the effects of electro-acupuncturing Renzhong (DU 26) with different stimulation parameters on motor function recovery following middle artery occlusion injury in rats.Results showed an optimal stimulation parameter for Renzhong electro-acupuncture that was low frequency and mild current (2 Hz,1 mA) significantly improved cortical excitability and conductive function,and promoted recovery in a rat model of motor function in middle artery occlusion.Frequency had a greater impact than current or interaction,and played a critical role in electro-acupuncture therapy. | Lin Han Shu Wang Jinquan Ma Wenping Yao Yan Shen Xuemin Shi | 2011 | Neural Regeneration Research2011，6，12： | 5 |
| 6 | Zinc Anode for Mild Aqueous Zinc-Ion Batteries: Challenges, Strategies, and Perspectives显示文摘The rapid advance of mild aqueous zinc-ion batteries(ZIBs)is driving the development of the energy storage system market.But the thorny issues of Zn anodes,mainly including dendrite growth,hydrogen evolution,and corrosion,severely reduce the performance of ZIBs.To commercialize ZIBs,researchers must overcome formidable challenges.Research about mild aqueous ZIBs is still developing.Various technical and scientific obstacles to designing Zn anodes with high stripping efficiency and long cycling life have not been resolved.Moreover,the performance of Zn anodes is a complex scientific issue determined by various parameters,most of which are often ignored,failing to achieve the maximum performance of the cell.This review proposes a comprehensive overview of existing Zn anode issues and the corresponding strategies,frontiers,and development trends to deeply comprehend the essence and inner connection of degradation mechanism and performance.First,the formation mechanism of dendrite growth,hydrogen evolution,corrosion,and their influence on the anode are analyzed.Furthermore,various strategies for constructing stable Zn anodes are summarized and discussed in detail from multiple perspectives.These strategies are mainly divided into interface modification,structural anode,alloying anode,intercalation anode,liquid electrolyte,non-liquid electrolyte,separator design,and other strategies.Finally,research directions and prospects are put forward for Zn anodes.This contribution highlights the latest developments and provides new insights into the advanced Zn anode for future research. | Jinzhang Yang Bosi Yin Ying Sun Hongge Pan Wenping Sun Baohua Jia Siwen Zhang Tianyi Ma | 2022 | Nano-Micro Letters2022，14，3： | 5 |
| 7 | CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2,and STAT3 pathway in colorectal cancer显示文摘CMTM4(CKLF-like MARVEL transmembrane domain containing 4),a potential tumor suppressor gene,is involved in several types of malignancies.It has been reported to be downregulated and exhibit anti-tumorigenic activities by regulating cell growth and cell cycle in clear cell renal cell carcinoma.It has also been identified as a tumor suppressor in hepatocellular carcinoma(HCC),and its negative expression is a risk factor for poor prognosis of HCC patients.In the present study,an integrated bioinformatics analysis based on The Cancer Genome Atlas(TCGA)database showed that CMTM4 was frequently reduced in colorectal cancer(CRC)and high expression of CMTM4 was associated with increased overall survival rates.Based on these findings,we adopted gain-of-function and lost-of-function strategies using SW480 and HT29 CRC cell lines which have relatively low and high endogenous CMTM4 levels,respectively.We observed impeded cell proliferation and migration upon overexpression of CMTM4 in SW480 cells,and the opposite effects were observed upon knockdown of CMTM4 in HT-29 cells.Cell signaling pathways essential for CRC progression were then examined,and the phosphorylation levels of AKT,ERK1/2,and STAT3 were found to be decreased by CMTM4 overexpression in SW480 cells and elevated by CMTM4 silencing in HT29 cells.Their inhibitors were used to validate that the three signaling pathways contributed to the inhibitory effects of CMTM4 on CRC cells.Taken together,our results suggest that CMTM4 plays a tumor suppressive role in CRC. | Hui Xue Ting Li Pingzhang Wang Xiaoning Mo Hejun Zhang Shigang Ding Dalong Ma Wenping Lv Jing Zhang Wenling Han | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 5 |
| 8 | Intelligent multi-user detection using an artificial immune system显示文摘Artificial immune systems (AIS) are a kind of new computational intelligence methods which draw inspiration from the human immune system. In this study, we introduce an AIS-based optimization algorithm, called clonal selection algorithm, to solve the multi-user detection problem in code-division multipleaccess communications system based on the maximum-likelihood decision rule. Through proportional cloning, hypermutation, clonal selection and clonal death, the new method performs a greedy search which reproduces individuals and selects their improved maturated progenies after the affinity maturation process. Theoretical analysis indicates that the clonal selection algorithm is suitable for solving the multi-user detection problem. Computer simulations show that the proposed approach outperforms some other approaches including two genetic algorithm-based detectors and the matched filters detector, and has the ability to find the most likely combinations. | GONG MaoGuo, JIAO LiCheng, MA WenPing & MA JingJing Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China Institute of Intelligent Information Processing, Xidian University, Xi’an 710071, China | 2009 | Science in China(Series F)2009，52，12： | 5 |
| 9 | Characterization of NPR1 Genes from Norton and Cabernet Sauvignon Grapevine显示文摘Non-expressor of pathogenesis-related genes 1 (NPR1) plays a significant role in the defense responses of plants to pathogens by regulating the expression of defense-related genes. In the present study, we isolated two NPR1 genes from Vitis aestivalis cv. Norton and Vitis vinifera cv. Cabernet Sauvignon, which were referred to as VaNPR1.1 and VvNPR1. 1-CS, respectively. They encode a protein of 584 amino acids with a predicted molecular weight of 64.8 kDa and a theoretical isoelectric point (pI) of 5.74. The predicted amino acid sequences of VaNPR1.1 and VvNPR1.1-CS differ by only one amino acid. Over-expression of VaNPR1.1 gene in Arabidopsis npr1-1 mutant plants restores the transcriptional expression of AtPR-1 gene, though not to the full scale. This result demonstrated that a grapevine VaNPR1.1 possesses a similar function to the Arabidopsis NPR1 in the regulation of defense-related genes. Over-expression of VaNPR1.1 in transgenic Arabidopsis plant increased tolerance to salinity, but had no effect on the drought tolerance. We conclude that VaNPR1.1 is a functional ortholog of AtNPR1 and also involved in grapevine's response to the salt stress. | ZHANG Yi-ming NI Xi-lu MA Hui-qin Wenping Qiu | 2013 | Journal of Integrative Agriculture2013，12，7： | 4 |
| 10 | Immunodominance and clonal selection inspired multiobjective clustering显示文摘The biological immune system is a highly parallel and distributed adaptive system. The information processing abilities of the immune system provide important insights into the field of computation. Based on immunodominance in the biological immune system and the clonal selection mechanism, a novel data mining method, Immune Dominance Clonal Multiobjective Clustering algorithm (IDCMC), is presented. The algorithm divides an individual population into three sub-populations according to three different measurements, and adopts different evolution and selection strategies for each sub-population. The update of each sub-population, however, is not carried out in isolation. The periodic combination operation of the analysis of the three sub-populations represents considerable advantages in its global search ability. The clustering task is a multiobjective optimization problem, which is more robust with respect to the variety of cluster structures of different datasets than a single-objective clustering algorithm. In addition, the new algorithm can determine the number of clusters automatically, which should identify the most promising clustering solutions in the candidate set. The experimental results, using artificial datasets with different manifold structure and handwritten digit datasets, show that the IDCMC outperforms the PESA-Ⅱ-based clustering method, the genetic algorithm-based clustering technique and the original K-Means algorithm in solving most of the problems tested. | Wenping Ma , Licheng Jiao, Maoguo Gong Key Laboratory of Intelligent Perception and Image Understanding of the Ministry of Education of China, Institute of Intelligent Information Processing, Xidian University, Xi’an 710071, China | 2009 | Progress in Natural Science:Materials International2009，19，6： | 3 |
| 11 | On cross-correlation indicators of an S-box显示文摘替换盒子(S 盒子) 经常在许多对称的加密算法被用作最重要的非线性的部件。S 盒子的密码的性质直接影响整个零系统的安全。最近,概括了全球雪崩特征(GGAC ) 被介绍测量在二任意的布尔功能之间的关联。在这份报纸,更好评估 S 盒子的安全,我们在场为它的二跨关联的指示物。另外,由学习相关性质在二平衡布尔功能之间跨关联,我们为 S 盒子为二平衡功能并且也在与 GGAC 有关的 sum-of-squares 指示物上建议更低的界限。 | Sheng GAO Wenping MA Zepeng ZHUO Fenghe WANG | 2011 | Frontiers of Computer Science2011，5，4： | 2 |
| 12 | Homeobox B8 Targets Sterile Alpha Motif Domain-Containing Protein 9 and Drives Glioma Progression显示文摘Gliomas are the most commonly occurring tumors of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant and aggressive brain cancer in adults. Further understanding of the mechanisms underlying the aggressive nature of GBM is urgently needed. Here we identified homeobox B8(HOXB8), a member of the homeobox family, as a crucial contributor to the aggressiveness of GBM. Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate. We next showed that HOXB8 promotes the proliferation and migration of glioblastoma cells and is crucial for the activation of the PI3K/AKT pathway and expression of epithelial–mesenchymal transition-related genes, possibly through direct binding to the promoter of SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) and activating its transcription. Collectively, we identified HOXB8 as a critical contributor to the aggressiveness of GBM, which provides insights into a potential therapeutic target for GBM and opens new avenues for improving its treatment outcome. | Wenping Ma Hongze Jin Wenjie Liu Xiaojuan Li Xingang Zhou Xinwu Guo Runfa Tian Qi Cui Junjie Luo Yueying Jiao Youtao Yu Haifeng Yang Hongshan Zhao | 2020 | Neuroscience Bulletin2020，36，4： | 2 |
| 13 | Linear Complexity of Least Significant Bit of Polynomial Quotients显示文摘Binary sequences with large linear complexity have been found many applications in communication systems.We determine the linear complexity of a family of p^2-periodic binary sequences derived from polynomial quotients modulo an odd prime p.Results show that these sequences have high linear complexity,which means they can resist the linear attack method. | ZHAO Chun'e MA Wenping YAN Tongjiang SUN Yuhua | 2017 | Chinese Journal of Electronics2017，26，3： | 2 |
| 14 | Reaction and characterization studies of an industrial Cr-free ironbased catalyst for high temperature water gas shift reaction 显示文摘 | Liu Quansheng Ma Wenping He Runxia | 2005 | Catalysis Today2005，106，14： | 1 |
| 15 | Study on reduction of Co/AC catalyst in slurry bed显示文摘 | Ding Yunjie Luo Hongyuan | 2001 | J Fuel Chem Tech2001，29，4： | 1 |
| 16 | A Survey on Quantum Cryptography显示文摘Quantum cryptography(QC) as an important technology to protect the security of the future network communication, has gained extensive attention from both academia and industry in recent years. This paper provides a concise up-to-date review of QC, including Quantum key distribution(QKD), Quantum authentication, Quantum public-key cryptography(QPKC), and so on. Our aim is to pave a comprehensive and solid starting ground for interested readers. We firstly clarify the definition of QC. Secondly, we present the current understanding of QC from different levels, including the basic knowledge of quantum information processing, QC protocols and the attacks in QC. Finally, we discuss the challenges and opportunities in this hopeful field. | LI Jian LI Na ZHANG Yu WEN Shuang DU Wei CHEN Wei MA Wenping | 2018 | Chinese Journal of Electronics2018，27，2： | 1 |
| 17 | Hierarchically Designed SiOx/SiOy Bilayer Nanomembranes as Stable Anodes for Lithium Ion Batteries显示文摘 | Lin Zhang Junwen Deng Lifeng Liu Wenping Si Steffen Oswald Lixia Xi Manab Kundu Guozhi Ma Thomas Gemming Stefan Baunack Fei Ding Chenglin Yan Oliver G. Schmidt | 2014 | Adv Mater2014，，26： | 1 |
| 18 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 19 | Study of activated carbon supported iron catalysts for the Fischer-Tropsch synthesis显示文摘 | Wenping Ma Yunjie Ding Jing Yang Xing Liu Liwu Lin | 2005 | Reaction Kinetics and Catalysis Letters2005，，1： | 1 |
| 20 | Attrition resistance and catalytic performance of spray-dried iron Fischer-Tropsch catalysts in a stirred-tank slurry reactor 显示文摘 | Dragomir B Bukur Ma Wenping Victor Carreto Vazquez | 2004 | Ind Eng Chem Res2004，43，6： | 1 |
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