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| 1 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 2 | Numerical simulation of strong ground motion for the M_s8.0 Wenchuan earthquake of 12 May 2008显示文摘The Wenchuan earthquake of 12 May 2008 is the most destructive earthquake in China in the past 30 years in terms of property damage and human losses. In order to understand the earthquake process and the geo-morphological factors affecting the seismic hazard, we simulated the strong ground mo-tion caused by the earthquake, incorporating three-dimensional (3D) earth structure, finite-fault rupture, and realistic surface topography. The simulated ground motions reveal that the fault rupture and basin structure control the overall pattern of the peak ground shaking. Large peak ground velocity (PGV) is distributed in two narrow areas: one with the largest PGV values is above the hanging wall of the fault and attributed to the locations of fault asperities and rupture directivity; the other is along the north-western margin of the Sichuan Basin and caused by both the directivity of fault rupture and the ampli-fication in the thick sediment basin. Rough topography above the rupture fault causes wave scattering, resulting in significantly larger peak ground motion on the apex of topographic relief than in the valley. Topography and scattering also reduce the wave energy in the forward direction of fault rupture but increase the PGV in other parts of the basin. These results suggest the need for a localized hazard as-sessment in places of rough topography that takes the topographic effects into account. Finally, had the earthquake started at the northeast end of the fault zone and ruptured to the southwest, Chengdu would have suffered a much stronger shaking than it experienced on 12 May, 2008. | ZHANG Wei SHEN Yang CHEN XiaoFei | 2008 | Science China Earth Sciences2008，51，12： | 26 |
| 3 | Risk factors and long-term health consequences of macrosomia:a prospective study in Jiangsu Province,China显示文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group(24.35±3.14 years,P = 0.000).The mean maternal body mass index(BMI) at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group(21.76±2.59 kg/m 2,P = 0.000).About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group(P = 0.000).Compared with women with normal weight(BMI:18.5-23.9 kg/m 2),women who were overweight(BMI:24-27.9 kg/m 2) or obese(BMI ≥ 28 kg/m 2),respectively,had a 1.69-fold(P = 0.000) and a 1.49-fold(P = 0.000) increased risks of having a neonate with macrosomia,while light weight(BMI<18.5 kg/m 2) women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years(P = 0.001 and P = 0.000).Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. | Shouyong Gu Xiaofei An Liang Fang Xiaomin Zhang Chunyan Zhang Jingling Wang Qilan Liu Yanfang Zhang Yongyue Wei Zhibin Hu Feng Chen Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，4： | 14 |
| 4 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 5 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 6 | Study on preparation and properties of CeO_2/epoxy resin composite coating on sintered NdFeB magnet显示文摘The CeO_2/epoxy resin composite coating was deposited on NdFeB substrate by cathode electrophoresis method for enhancing the anticorrosion and anti-wear performances. The morphologies and structures were characterized by a scanning electron microscope and an X-ray diffractometer. The micro hardness of the composite coating was evaluated by a microhardness tester. The corrosive behaviors of the coatings were studied by potentiodynamic polarization curve, electrochemical impedance spectroscopy and neutral salt spray tests. The concentration of CeO_2 nanoparticles(NPs) in the electrophoresis bath was optimized according to the coating structures and anticorrosion performances. The results show that CeO_2 NPs can enhance the microhardness of the composite coatings. Moreover, the nanoparticles disperse uniformly in the matrix when the concentration is lower than 30 g/L. The microhardness of CeO_2/epoxy resin(30 g/L) composite coating is about 63% higher than that of the blank epoxy resin coating. And the NSS time of the CeO_2/epoxy resin(30 g/L) composite coated sample can reach 1248 h.Meanwhile, the composite coatings possess no deteriorate influence on the magnetic properties of NdFeB substrates. The anticorrosion mechanisms of the composite coatings on the NdFeB substrate are deeply discussed. | Pengjie Zhang Minggang Zhu Wei Li Guangqing Xu Xiulian Huang Xiaofei Yi Jingwu Chen Yucheng Wu | 2018 | Journal of Rare Earths2018，36，5： | 8 |
| 7 | Highly conductive dodecaborate/MXene composites for high performance supercapacitors显示文摘With the increasingly prominent energy and environmental issues,the supercapacitors,as a highly efficient and clean energy conversion and storage devices,meet the requirements well.However,it is still a challenge to enhance the capacitance and energy density of supercapacitors.A novel and highly conductive dodecaborate/MXene composites have been designed for high performance supercapacitors.The surface charge property of MXene was modified by a simple ultrasonic treatment with ammonium ion,and the dodecaborate ion can be inserted into the inner surface of MXene by electrostatic adsorption.Due to the unique icosahedral cage conjugate structure formed by the B-B bond and the highly delocalized three-dimensionalπbond structure of the electrons,the negative charge is delocalied on the whole dodecaborate ion,which reduces the ability to bind to cations.Therefore,the cations can move easily,and the dodecaborate can act as a“lubricant”for ion diffusion between the MXene layers,which significantly improves the ion transfer rate of supercapacitors.The dodecaborate/MXene composites can achieve an extremely high specific capacitance of 366 F.g^-1 at a scan rate of 2 mV.s^-1,which is more than eight times higher than that of MXene(43 F1-)at the same scan rate.Our finding provides a novel route on the fabrication of the high performance supercapacitors. | Zhenxing Li Chang Ma Yangyang Wen Zhiting Wei Xiaofei Xing Junmei Chu Chengcheng Yu Kaili Wang Zhao-Kui Wang | 2020 | Nano Research2020，13，1： | 7 |
| 8 | Hierarchical nanostructured composite cathode with carbon nanotubes as conductive scaffold for lithium-sulfur batteries显示文摘Carbon nanotubes (CNTs) are excellent scaffolds for advanced electrode materials, resulting from their intrinsic sp2 carbon hybridization, interconnected electron pathway, large aspect ratio, hierarchical porous structures, and low cost at a large-scale production. How to make full utilization of the mass produced CNTs as building blocks for nanocomposite electrodes is not well understood yet. Herein, a composite cathode containing commercial agglomerated multi-walled CNTs and S for Li-S battery was fabricated by a facile melt-diffusion strategy. The hierarchical CNT@S coaxial nanocables exhibited a discharging capacity of 1020 and 740 mAh g-1 at 0.5 and 2.0 C, respectively. A rapid capacity decay of 0.7% per cycle at the initial 10 cycles and a slow decay rate of 0.14% per cycle for the later 140 cycles were detected. Such hierarchical agglomerated CNT@S cathodes show advantages in easy fabrication, environmentally benign, low cost, excellent scalability, and good Li ion storage performance, which are extraordinary composites for high performance Li-S battery. | Xiaofei Liu Qiang Zhang Jiaqi Huang Shumao Zhang Hongjie Peng Fei Wei | 2013 | Journal of Energy Chemistry2013，22，2： | 6 |
| 9 | ntercellular protein-protein interactions at synapses显示文摘 | Xiaofei Yang Dongmei Hou Wei Jiang Chen Zhang | 2014 | Protein & Cell2014，5，6： | 5 |
| 10 | Quantum information and many body physics with cold atoms显示文摘We review our recent theoretical advances in quantum information and many body physics with cold atoms in various external potential, such as harmonic potential, kagome optical lattice, triangular optical lattice, and honeycomb lattice. The many body physics of cold atom in harmonic potential is investigated in the frame of mean-field Gross-Pitaevskii equation. Then the quantum phase transition and strongly correlated effect of cold atoms in triangular optical lattice, and the interacting Dirac fermions on honeycomb lattice, are investigated by using cluster dynamical mean-field theory and continuous time quantum Monte Carlo method. We also study the quantum spin Hall effect in the kagome optical lattice. | ZHANG XiaoFei CHEN YaoHua LIU GuoCai WU Wei WEN Lin LIU WuMing | 2012 | Chinese Science Bulletin2012，57，16： | 4 |
| 11 | Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma显示文摘Aberrant expression of microRNAs(miRNAs)was reported frequently in different human cancers.The major role of miRNA is targeting 30-UTR of coding gene and causing translational repression or mRNA degradation.miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression.But its expression in hepatocellular carcinoma(HCC)remains unclear.Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples,and reduced expression of miR-10b in HCC was related tovein invasion.High-level expression of RHOC was also related to vein invasion in HCC.But no correlation was found between miR-10b and RHOC expression.These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis. | Jingli Du Yulan Wang Hanjiang Fu Xiaofei Zheng Minggui Lin Mingzhou Guo Lixin Wei | 2014 | Chinese Science Bulletin2014，59，19： | 4 |
| 12 | Geochemical characteristics of hadal sediment in the northern Yap Trench显示文摘Two sediment cores were retrieved in the hadal zone of the Yap Trench,and their concentrations of six major elements Mg,Al,Ca,Ti,Mn and Fe and nine trace elements Sr,Ba,Pb,V,Cr,Co,Ni,Cu and Zn were determined in inductively coupled plasma atomic emission spectrometry(ICP-AES).According to the vertical distribution profiles of the 15 elements,the correlation of their concentrations,the ratios of Ni/Co,V/Cr,Fe/Al,and Ti/Al,and morphological characteristics of the sediment samples,the implications of the depositional environment and the sediment provenance were analyzed.The results show that the ratio of Ni/Co in all depths of the two sediment cores were below 5,and the ratio of V/Cr were lower than 2,indicating that the depositional environment of the hadal zone in the trench was oxidative and might have inflow of the Antarctic bottom oxygen-rich water.The sediment samples on the eastern side of the trench were siliceous mud mainly composed of diatoms,radiolarian,and sponge needles from surface to deep layer.The vertical profile of the elements,the concentration of TOC and the fossil record indicated that the sediment sample from station Dive113 was well mixed from surface to bottom layer.Based on the correlation of concentrations of the elements,the morphological characteristics of the sediment,and the ratios of Fe/Al and Ti/Al,we inferred that the sediment in the hadal zone of the trench had terrestrial,volcanic,biological,and authigenic sources.Major source of the sediment in the eastern side of the trench were terrestrial;whereas the sediment in the western side of the trench received more volcaniclastic input. | HUANG Yuhuan SUN Chengjun YANG Guipeng YUE Xin’an JIANG Fenghua CAO Wei YIN Xiaofei GUO Chaonan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 3 |
| 13 | Architecture of Co-layered double hydroxide nanocages/graphene composite electrode with high electrochemical performance for supercapacitor显示文摘A facile hydrolysis method was applied to fabricate high-performance Co-layered double hydroxide(LDH)nanocages/graphene composites for supercapacitors. The materials exhibit enhanced rate capability than the counterpart electrode free of graphene while maintaining a high specific capacitance. In addition,such Co-LDH nanocages/graphene composites display an excellent cycling stability; the capacitance retention of Co-LDH nanocages/graphene composite electrode remains 90.4% after 10000 cycles at a current density of 2 A g(-1). The integration of high capacity of double hydroxide and outstanding conductivity of graphene makes the delicately-designed composites promising candidates for electrode materials for supercapacitors. | Xianyu Chu Ting Deng Wei Zhang Dong Wang Xiaofei Liu Cai Zhang Tingting Qin Liyun Zhang Bingsen Zhang Chengmeng Chen Weitao Zheng | 2018 | Journal of Energy Chemistry2018，27，2： | 2 |
| 14 | A Breeding Method for New Lodging Resistant Rice Varieties Based on Phenotype显示文摘The concept of lodging resistance core traits and their screening principles were first proposed on the basis of previous research.Afterwards,a lodging resistance breeding method based on phenotypic trait index was proposed based on a case study of screening lodging resistant aromatic rice by Yuehesimiao and Xiangyaxiangzhan.In other words,the materials that meet the breeding goals could be selected quickly by constructing breeding population and referring to lodging resistance core traits in each generation.Eventually,the advantages and disadvantages of the method were analyzed in combination with the actual situation,in order to provide the reference for rice breeding researchers. | Wang Xiaofei He Xiuying Lu Zhanhua Liu Wei Lu Dongbai Wang Shiguang Xue Jiao | 2020 | Plant Diseases and Pests2020，11，4： | 2 |
| 15 | An effective framework for asynchronous incremental graph processing显示文摘Although many graph processing systems have been proposed, graphs in the real-world are often dynamic. It is important to keep the results of graph computation up-todate. Incremental computation is demonstrated to be an efficient solution to update calculated results. Recently, many incremental graph processing systems have been proposed to handle dynamic graphs in an asynchronous way and are able to achieve better performance than those processed in a synchronous way. However, these solutions still suffer from sub-optimal convergence speed due to their slow propagation of important vertex state (important to convergence speed) and poor locality. In order to solve these problems, we propose a novel graph processing framework. It introduces a dynamic partition method to gather the important vertices for high locality, and then uses a priority-based scheduling algorithm to assign them with a higher priority for an effective processing order. By such means, it is able to reduce the number of updates and increase the locality, thereby reducing the convergence time. Experimental results show that our method reduces the number of updates by 30%, and reduces the total execution time by 35%, compared with state-of-the-art systems. | Xinqiao LV Wei XIAO Yu ZHANG Xiaofei LIAO Hai JIN Qiangsheng HUA | 2019 | Frontiers of Computer Science2019，13，3： | 2 |
| 16 | Reconstruction of incomplete satellite SST data sets based on EOF method显示文摘As for the satellite remote sensing data obtained by the visible and infrared bands inversion, the clouds coverage in the sky over the ocean often results in missing data of inversion products on a large scale, and thin clouds di?cult to be detected would cause the data of the inversion products to be abnormal. Alvera et al.(2005) proposed a method for the reconstruction of missing data based on an Empirical Orthogonal Functions (EOF) decomposition, but his method couldn’t process these images presenting extreme cloud coverage(more than 95%), and required a long time for recon- struction. Besides, the abnormal data in the images had a great effect on the reconstruction result. Therefore, this paper tries to improve the study result. It has reconstructed missing data sets by twice applying EOF decomposition method. Firstly, the abnormity time has been detected by an- alyzing the temporal modes of EOF decomposition, and the abnormal data have been eliminated. Secondly, the data sets, excluding the abnormal data, are analyzed by using EOF decomposition, and then the temporal modes undergo a filtering process so as to enhance the ability of reconstruct- ing the images which are of no or just a little data, by using EOF. At last, this method has been applied to a large data set, i.e. 43 Sea Surface Temperature (SST) satellite images of the Changjiang River (Yangtze River) estuary and its adjacent areas, and the total reconstruction root mean square error (RMSE) is 0.82°C. And it has been proved that this improved EOF reconstruction method is robust for reconstructing satellite missing data and unreliable data. | DING Youzhuan WEI Zhihui MAO Zhihua WANG Xiaofei PAN Delu | 2009 | Acta Oceanologica Sinica2009，28，2： | 2 |
| 17 | Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis显示文摘Decabromodiphenyl ether (decaBDE),as a flame retardant,is widely produced and used.To study the thyroid disruption by technical decaBDE at low concentrations,Xenopus laevis tadpoles were exposed to technical decaBDE mixture DE-83R (1-1000 ng/L) in water from stage 46/47 (free swimming larvae,system of Nieuwkoop and Faber) to stage 62.DE-83R at concentration of 1000 ng/L significantly delayed the time to metamorphosis (presented by forelimb emergence,FLE).Histological examination showed that DE83R at all tested concentrations caused histological alterations-multilayer follicular epithelial cell and markedly increased follicle size accompanied by partial colloid depletion and increase in the peripheral colloid vacuolation,in thyroid glands.All tested concentrations of DE-83R also induced a down-regulation of thyroid receptor mRNA expression.These results demonstrated that technical decaBDE disrupted the thyroid system in X.laevis tadpoles.Analysis of polybrominated diphenyl ethers (PBDEs) (sum of 39 congeners) in X.laevis indicated that mean concentrations of total PBDEs in X.laevis exposed to 1,10,100,1000 ng/L were 11.0,128.1,412.1,1400.2 ng/g wet weight,respectively.Considering that PBDEs burden of X.laevis tadpoles was close to PBDEs levels in amphibians as reported in previous studies,our study has raised new concerns for thyroid disruption in amphibians of technical decaBDE at environmentally relevant concentrations. | Xiaofei Qin Xijuan Xia Zhongzhi Yang Shishuai Yan Yaxian Zhao Rongguo Wei Yan Li Mi Tian Xingru Zhao Zhanfen Qin Xiaobai Xu | 2010 | Journal of Environmental Sciences2010，22，5： | 2 |
| 18 | Assessment of strong earthquake risk in the Chinese mainland from 2021 to 2030显示文摘The long-term earthquake prediction from 2021 to 2030 is carried out by researching the active tectonic block boundary zones in the Chinese mainland.Based on the strong earthquake recurrence model,the cumulative probability of each target fault in the next 10 years is given by the recurrence period and elapsed time of each fault,which are adopted from relevant studies such as seismological geology,geodesy,and historical earthquake records.Based on the long-term predictions of large earthquakes throughout the world,this paper proposes a comprehensive judgment scheme based on the fault segments with the seismic gap,motion strongly locked,sparse small-moderate earthquakes,and apparent Coulomb stress increase.This paper presents a comprehensive analysis of the relative risk for strong earthquakes that may occur in the coming 10 years on the major faults in the active tectonic block boundary zones in the Chinese mainland.The present loading rate of each fault is first constrained by geodetic observations;the cumulative displacement of each fault is then estimated by the elapsed time since the most recent strong earthquake. | Zhigang Shao Yanqiang Wu Lingyun Ji Faqi Diao Fuqiang Shi Yujiang Li Feng Long Hui Zhang Wuxing Wang Wenxin Wei Peng Wang Xiaoxia Liu Qi Liu Zhengyang Pan Xiaofei Yin Yue Liu Wei Feng Zhenyu Zou Jia Cheng Renqi Lu Yueren Xu Xi Li | 2023 | Earthquake Research Advances2023，3，1： | 2 |
| 19 | Effects of bias voltage on coating structures and anticorrosion performances of PA-PVD Al coated NdFeB magnets显示文摘Al coated NdFeB magnets were prepared by plasma-assisted-physical-vapor-deposition(PA-PVD)method fo r enhancing the corro sion resistance.Mo rphologies and structures were characterized by an Xray diffractometer and a scanning electron microscope.Corrosion behaviors of the samples with different bias voltages were studied by electrochemical methods and neutral salt spray test,respectively.The bias voltage during the deposition process was optimized according to the coating structures and corrosion resistances.The density and flatness of Al coating increase with increasing the bias voltage,and at the same time the thickness decreases.The coating density and thickness turn to be stable when bias voltage is 1800 V.Also,the corrosion behaviors of PA-PVD Al coatings in different media,such as NaOH,HNO_(3) and NaCl solutions,were studied.The self-corrosion potentials(E_(corr)) of PA-PVD Al coatings almost keep constant in NaOH and HNO_(3) solutions with diffe rent concentrations.However,the self-corrosion current densities(J_(corr)) decrease with the increasing concentrations.E_(corr) shifts to negative potential and J_(corr)decreases gradually when increasing the concentration of NaCl solution.The corrosion mechanisms of Al coatings are discussed based on the corrosion behaviors in different media. | Yujie Cao Pengjie Zhang Wei Sun Weifeng Zhang Hanzhong Wei Jiquan Wang Bingshan Li Xiaofei Yi Guangqing Xu Yucheng Wu | 2021 | Journal of Rare Earths2021，39，6： | 2 |
| 20 | In vitro transcribed sgRNA causes cell death by inducing interferon release显示文摘Dear editor The clustered regularly in terspaced short palindromic repeats (CRISPR) and the CRISPR-associated proteins 9 (Cas9) systems are powerful tools for gene editing. Ribonucleoprotein (RNP) complex composed of Cas9 pro? tein and sgRNA binds to specific genomic loci and gen erate DNA double strand breaks. While plasmids expressing Cas9 protein and sgRNA are routinely transfected into various cell lines to perform gene editing (Cong et al., 2013;Mali et al., 2013;Ran et al., 2013), direct delivery of Cas9-sgRNA RNP has shown higher efficiency and lower off-target effects (Kim et al., 2014), especially in human primary cells such as T cells (Hendel et al., 2015;Schumann et al., 2015). SgRNA can be gen erated by either in vitro transcript! on (IVT) or chemical syn thesis. IVT is widely used to gen erate sgRNAs, since it can be easily performed in most labs. | Wei Mu Na Tang Chen Cheng Wen Sun Xiaofei Wei Haoyi Wang | 2019 | Protein & Cell2019，10，6： | 2 |
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