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| 1 | 为细菌的房间的一个非凡的紧、敏感的光可切换的基因表达式系统显示文摘 | Chen, Xianjun Liu, Renmei Ma, Zhengcai Xu, Xiaopei Zhang, Haoqian Xu, Jianhe Ouyang, Qi Yang, Yi | 2016 | Cell Research2016，26，7： | 7 |
| 2 | Study on mechanical parameters of fractured rock masses显示文摘The equivalent strength parameters of fractured rock masses are prerequisite for stability analysis of geotechnical engineering projects constructed in fractured rock masses which are encountered frequently in western china.Based on generated mesh of fractured rock masses,combined with statistic damage constitutive model of intact rock and damage model of structural plane,progressive failure of fractured rock masses is studied using finite element method(FEM) .Furthermore,Scale effect and anisotropy of compressive strength of fractured rock masses are studied.Study results show that the strength decreases and tend towards stability rapidly from intact rock to fractured rock masses,and the anisotropy of strength of fractured rock masses is not significant.At last,based on numerical simulation conducted on 10 m scale rock masses under different confining pressures,the equivalent strength parameters of fractured rock masses are gained and the results are compared with Hoek-Brown criteria.The method developed is helpful for determination of strength parameters of fractured rock masses. | CHEN WeiZhong 1,2,YANG JianPing 1,TAN XianJun 1 &YU HongDan 1 1 State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences,Wuhan 430071,China 2 Research Center of Geotechnical and Structural Engineering,Shandong University,Jinan 250061,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 5 |
| 3 | Wearable CNT/Ti_(3)C_(2)T_(x)MXene/PDMS composite strain sensor with enhanced stability for real-time human healthcare monitoring显示文摘Strain sensors with good stability are vital to the development of wearable healthcare monitoring systems.However,the design of strain sensor with both duration stability and environmental stability is still a challenge.In this work,we propose an ultra-stable and washable strain sensor by embedding a coupled composite film of carbon nanotube(CNT)and Ti_(3)C_(2)T_(x) MXene into polydimethylsiloxane(PDMS)matrix.The composite strain sensor with embedded microstructure and uneven surface makes it conformal to skin,while the CNT/MXene sensing layer exhibits a resistance sensitive to strain.This sensor shows reliable responses at different frequencies and with long-term cycling durability(over 1,000 cycles).Meanwhile,the CNT/MXene/PDMS composite strain sensor provides the advantages of superior anti-interference to temperature change and water washing.The results demonstrate less than 10%resistance changes as the temperature rises from-20 to 80℃or after sonication in water for 120 min,respectively.The composite sensor is applied to monitor human joint motions,such as bending of finger,wrist and elbow.Moreover,the simultaneous monitoring of the electrocardiogram(ECG)signal and joint movement while riding a sports bicycle is demonstrated,enabling the great potential of the as-fabricated sensor in real-time human healthcare monitoring. | Xiaowen Xu Yucheng Chen Pei He Song Wang Kai Ling Longhui Liu Pengfei Lei Xianjun Huang Hu Zhao Jianyun Cao Junliang Yang | 2021 | Nano Research2021，14，8： | 5 |
| 4 | Revisiting the methods for gas permeability measurement in tight porous medium显示文摘Permeability is a key parameter to describe fluid transport properties of porous medium; however, the permeability measurement is extremely difficult for tight porous medium, e.g. fine-grained rock or dense soil. In this paper, three methods for gas permeability measurement, i.e. steady state method, pulse decay method(PDM) and pressure oscillation method(POM), are first reviewed and then their advantages and drawbacks are discussed. Both analytical and numerical solutions of gas permeability are presented for the tight porous medium. The results show that the analytical method is relatively simple but only valid under certain conditions, whilst the numerical method is more robust and generic, which can take into account several factors such as porosity, saturation, gas leakage, and unconventional boundary conditions. The influence of the effective porosity on the permeability determination is further analyzed using the proposed numerical method. In this study, new pressure data interpretation procedures for PDM and POM are proposed, and the obtained results can serve as a guidance to define a proper method for permeability measurement of the tight porous medium. | Diansen Yang Wei Wang Weizhong Chen Xianjun Tan Lige Wang | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，2： | 3 |
| 5 | Down-regulation of GPR137 expression inhibits proliferation of colon cancer cells显示文摘G 联合蛋白质的受体(GPR ) 是高度与 oncogenesis 和癌症转移有关。G 联合蛋白质的受体(GPR137 ) 137 大约 10 年以前开始作为新奇孤儿 GPR 被报导。一些孤儿 GPR 在人的癌症被含有。这研究的目的是在人的结肠癌调查 GPR137 的角色。GRP137 的表示层次被量的聚合酶链反应和西方的污点分析在不同结肠癌房间线分析。调停 Lentivirus 的短发卡 RNA 明确地被设计在结肠癌房间将 GPR137 表示击倒。房间生存能力被 methylthiazoletetrazolium 和殖民地形成试金测量。另外,房间周期特征被流动 cytometry 调查。GRP137 表示在不同层次在所有七根结肠癌房间线被观察。GPR137 的 mRNA 和蛋白质层次在在 lentivirus 感染以后的 HCT116 和 RKO 房间是下面调整的。GPR137 的调停 Lentivirus 的 silencing 减少了增长率和殖民地数字。在导致的两根房间线的 GPR137 击倒在 G 0/G1 阶段的房间周期拘捕。这些结果显示 GPR137 在结肠癌房间增长起一个重要作用。GPR137 在结肠癌房间的信号 transduction 小径上的效果的更好的理解可以提供卓见进结肠癌的新奇基因治疗。 | Kai Zhang Zhen Shen Xianjun Liang Tongjun Liu Tiejun Wang Yang Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 3 |
| 6 | The Dynamic Experiment on Treating Acid Mine Drainage with Iron Scrap and Sulfate Reducing Bacteria Using Biomass Materials as Carbon Source显示文摘The study is aimed at the problem of high content of Cr^(6+),Cr^(3+)and SO_(4)^(2-)is high and low pH value in acid mine drainage(AMD).Moreover,treatment of AMD by sulfate reducing bacteria(SRB)requires the addition of carbon source,while the treating effectiveness is not good enough on its own.The sugarcane slag,the corn cob and the sunflower straw were selected as the SRB carbon source cooperating with iron scrap to construct the dynamic columns 1,2 and 3.The mechanism of removing Cr^(6+),Cr^(3+),SO_(4)^(2-)and H+and the regularity of sustained release of carbon source and TFe release was studied in AMD.The removal efficiency of heavy metal ions,the ability of sustained release of carbon source,and the ability of adjusting acid by the three dynamic columns were compared.The result shows that the average removal rates of Cr^(6+),Cr^(3+)and SO_(4)^(2-)in effluent of dynamic column 1,filled by sugarcane slag,iron scrap and SRB,were 96.9%,67.1%and 54.3%.The average release of TFe and chemical oxygen demand(COD)were 4.4 and 287.3 mg/L.Its average pH was 6.98.Compared with the performance of dynamic columns 1,2 and 3,dynamic column 1 performed best in removing Cr^(6+),Cr^(3+)and SO_(4)^(2-)from AMD and controlling the release of COD and TFe,adjusting the pH of the solution.The study is of significance in treatment of AMD by taking for biomass materials as SRB carbon source in cooperation with iron scrap. | Xianjun Wang Junzhen Di Yanrong Dong Yu Yang Bing Liang Fankang Meng Tingting Wang Wenbo An Zengxin Li Jianzhi Guo | 2021 | Journal of Renewable Materials2021，9，1： | 2 |
| 7 | Jacobian matrix for the inversion of P-and S-wave velocities and its accurate computation method显示文摘The optimization inversion method based on derivatives is an important inversion technique in seismic data processing,where the key problem is how to compute the Jacobian matrix.The computation precision of the Jacobian matrix directly influences the success of the optimization inversion method.Currently,all AVO(Amplitude Versus Offset) inversion techniques are based on approximate expressions of Zoeppritz equations to obtain derivatives.As a result,the computation precision and application range of these AVO inversions are restricted undesirably.In order to improve the computation precision and to extend the application range of AVO inversions,the partial derivative equation(Jacobian matrix equation(JME) for the P-and S-wave velocities inversion) is established with Zoeppritz equations,and the derivatives of each matrix entry with respect to Pand S-wave velocities are derived.By solving the JME,we obtain the partial derivatives of the seismic wave reflection coefficients(RCs) with respect to P-and S-wave velocities,respectively,which are then used to invert for P-and S-wave velocities.To better understand the behavior of the new method,we plot partial derivatives of the seismic wave reflection coefficients,analyze the characteristics of these curves,and present new understandings for the derivatives acquired from in-depth analysis.Because only a linear system of equations is solved in our method,the computation of Jacobian matrix is not only of high precision but also is fast and efficient.Finally,the theoretical foundation is established so that we can further study inversion problems involving layered structures(including those with large incident angle) and can further improve computational speed and precision. | LIU FuPing MENG XianJun WANG YuMei SHEN GuoQiang YANG ChangChun | 2011 | Science China Earth Sciences2011，54，5： | 2 |
| 8 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 9 | Antihepatofibrotic effect of Guizhifuling pill(桂枝茯苓丸) on carbon tetrachloride-induced liver fibrosis in mice显示文摘OBJECTIVE: To evaluate the protective effects and the underlying mechanism of Guizhifuling pill(桂枝茯苓丸, GZFL) on carbon tetrachloride(CCl4)-induced hepatic fibrosis in mice. METHODS: Male ICR mice by intraperitoneally administered with 20% CCl4(mixed 1∶4 in soybean oil) to induce liver fibrosis. Mice that underwent CCl4 were orally with GZFL. Using hematoxylin and eosin and Masson staining to examine the pathological changes in liver tissue. Serum biochemical parameters, antioxidant enzyme activity and proinflammatory cytokines was assessed. Nuclear factor-kappa B(NF-κB) pathway and nuclear factor-erythroid 2-related factor 2(Nrf2) family members were evaluated by Western blotting. RESULTS: Our findings indicated that GZFL could effectively suppress the progression of liver fibrosis in mice, which was determined based on the improvement in liver function and reduction of collagen deposition. GZFL treatment also decreased the level of cytokines and increased the activity of antioxidant enzymes in liver tissue. Moreover, GZFL exerted anti-inflammatory and antioxidant effects through regulating the Nrf2-mediated antioxidant system and inhibiting the NF-κB pathway. CONCLUSIONS: GZFL may prevent the progression of liver fibrosis by regulating the Nrf2/heme oxygenase-1 and NF-κB signaling pathways, thereby highlighting its role in the management of liver fibrosis. | XU Baogui ZHENG Jiawen TIAN Xiaoxiao YUAN Falei LIU Zhongliang YANG Zuisu DING Xianjun | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 10 | The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis显示文摘The endoplasmic reticulum(ER) membrane protein complex(EMC) regulates the synthesis and quality control of membrane proteins with multiple transmembrane domains. One of the membrane spanning subunits, EMC3, is a core member of the EMC complex that provides essential hydrophilic vestibule for substrate insertion. Here, we show that the EMC subunit Emc3 plays critical roles in the retinal vascular angiogenesis by regulating Norrin/Wnt signaling. Postnatal endothelial cell(EC)-specific deletion of Emc3 led to retarded retinal vascular development with a hyperpruned vascular network, the appearance of bluntended, aneurysm-like tip endothelial cells(ECs) with reduced numbers of filopodia and leakage of erythrocytes at the vascular front. Diminished tube formation and cell proliferation were also observed in EMC3 depleted human retinal endothelial cells(HRECs). We then discovered a critical role for EMC3 in expression of FZD4 receptor of β-catenin signaling using RNA sequencing, real-time quantitative PCR(RT-q PCR) and luciferase reporter assay. Moreover, augmentation of Wnt activity via lithium chloride(Li Cl) treatment remarkably enhanced β-catenin signaling and cell proliferation of HRECs. Additionally, Li Cl partially reversed the angiogenesis defects in Emc3-c KO mice. Our data reveal that Emc3 plays essential roles in angiogenesis through direct control of FZD4 expression and Norrin/β-catenin signaling. | Mu Yang Shujin Li Wenjing Liu† Xiao Li Yunqi He Yeming Yang Kuanxiang Sun Lin Zhang Wanli Tian Lixin Duan Huafu Chen Dezhong Yao Zhenglin Yang Xianjun Zhu | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 11 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 12 | Laboratory investigations on the mechanical properties degradation of granite under freeze–thaw cycles显示文摘 | Xianjun Tan Weizhong Chen Jianping Yang Junjie Cao | 2011 | Cold Regions Science and Technology2011，，3： | 2 |
| 13 | Formation of Field Reversed Configuration (FRC) on the Yingguang-I device显示文摘As a hybrid approach to realizing fusion energy,Magnetized Target Fusion(MTF)based on the Field Reversed Configuration(FRC),which has the plasma density and confinement time in the range between magnetic and inertial confinement fusion,has been recently widely pursued around the world.To investigate the formation and confinement of the FRC plasma injector for MTF,the Yingguang-I,which is an FRC test device and contains a multi-bank program-discharged pulsed power sub-system,was constructed at the Institute of Fluid Physics(IFP),China.This paper presents the pulsed power components and their parameters of the device in detail,then gives a brief description of progress in experiments of FRC formation.Experimental results of the pulsed power sub-system show that the peak current/magnetic field of 110 kA/0.3 T,10 kA/1.2 Tand 1.7 MA/3.4 Twere achieved in the bias,mirror and q-pinch circuits with quarter cycle of 80 ms,700 ms and 3.8 ms respectively.The induced electric field in the neutral gas was greater than 0.25 kV/cm when the ionization bank was charged to 70 kV.With H_(2) gas of 8 Pa,the plasma target of density 10^(16) cm^(-3),separatrix radius 4 cm,half-length 17 cm,equilibrium temperature 200 eV and lifetime 3 ms(approximately the half pulse width of the reversed field)have been obtained through the q-pinch method when the bias,mirror,ionization and θ-pinch banks were charged to 5 kV,5 kV,55 kV and ±45 kV respectively.The images from the high-speed end-on framing camera demonstrate the formation processes of FRC and some features agree well with the results with the two-dimension magneto hydrodynamics code(2D-MHD). | Qizhi Sun Xianjun Yang Yuesong Jia Lulu Li Dongfan Fang Xiaoming Zhao Weidong Qin Zhengfen Liu Wei Liu Jun Li Yuan Chi Xiaoguang Wang | 2017 | Matter and Radiation at Extremes2017，2，5： | 2 |
| 14 | The association of interleukin-16 gene polymorphisms with IL-16 serum levels and risk of nasopharyngeal carcinoma in a Chinese population显示文摘 | Xue Qin Qiliu Peng Xiaoxia Lao Zhiping Chen Yu Lu Xianjun Lao Cuiju Mo Jingzhe Sui Junrong Wu Limin Zhai Shi Yang Shan Li Jinmin Zhao | 2014 | Tumor Biology2014，，3： | 2 |
| 15 | Haze trends over the capital cities of 31 provinces in China, 1981–2005显示文摘 | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou John J. Qu Xianjun Hao | 2009 | Theoretical and Applied Climatology (-)2009，，3： | 1 |
| 16 | Biological hydrogen production by anaerobic sludge at various temperatures显示文摘 | MU Yang ZHENG Xianjun YU Hanqing | 2006 | International Journal of Hydrogen Energy2006，31，6： | 1 |
| 17 | Biological hydrogen production by anaerobic sludge at various temperatures显示文摘 | MU Yang ZHENG Xianjun YU Hanqing | 2006 | International Journal of Hydrogen Energy2006，31，6： | 1 |
| 18 | Hydrogen-rich gas from catalytic steam gasification of municipal solid waste (MSW): influence of catalyst and temperature on yield and product composition 显示文摘 | He Maoyun Hu Zhiquan Xiao Bo Li Jianfen Guo Xianjun Luo Siyi Yang Fan Feng Yu Yang Guangjun Liu Shiming | 2009 | International Journal of Hydrogen Energy2009，34，1： | 1 |
| 19 | Biological hydrogen production by anaerobic sludge at various temperatures 显示文摘 | MU Yang ZHENG Xianjun YU Hanqing | 2006 | Int J Hydrogen Energy2006，31，6： | 1 |
| 20 | Zircon U-Pb geochronology of the Chinese continental crust: a preliminary analysis of the Elsevier science database显示文摘The amount of zircon U-Pb geochronological data for China has grown rapidly in recent years.Nearly 410,000 items of zircon U-Pb geochronological data,representing more than 7,000 relevant articles in the Elsevier Science Database,have been collected to a database in this research.Statistics on the ages and absolute errors of these collated data,yielded smallest standard errors for(206Pb/238U),(207Pb/235U),and(207Pb/206Pb)ages within respective time intervals of<1388.96 Ma,1388.96–3282.52 Ma,and>3282.52 Ma.The ages and their absolute errors were determined using three main geochronology methods,based on laser ablation inductively coupled mass spectrometer(LA-ICP-MS),sensitive high-resolution ion microprobe(SHRIMP),and secondary ion mass spectrometer(SIMS)measurements.We compared the influence of these different methods on errors for each age interval.In addition,using a Gaussian model of multi-peak fitting of zircon U-Pb age frequencies,we identified seven growth peaks in zircons from the Chinese continental crust,which are 48.60 Ma,131.49 Ma,249.91 Ma,444.27 Ma,835.95 Ma,1860.65 Ma,and 2505.54 Ma.It is clear that there are correspondences between these ages and various geological events,namely,the Wutai movement,Lvliang movement,Jinning movement,Caledonian movement,Indo-China movement,Yanshan movement,and Himalayaorogeny movement,respectively.The time and spatial distributions of these zircons correspond to distinct geological events on the Chinese continent,reflecting its crustal evolution. | Yujing Wu Xianjun Fang Sisi Liao Lizhi Xue Zhe Chen Jiangnan Yang Yamin Lu Kun Ling Shengyi Hu Shuyuan Kong Yiwei Xiong Huacheng Li Xiuqi Shang Rui Ji Xueyun Lu Biao Song Lei Zhang Jianqing Ji | 2019 | Big Earth Data2019，3，1： | 1 |
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