|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers显示文摘 | Li, Fei Feng, Yan Fang, Rong Fang, Zhaoyuan Xia, Jufeng Han, Xiangkun Liu, Xin-Yuan Chen, Haiquan Liu, Hongyan Ji, Hongbin | 2012 | Cell Research2012，22，5： | 11 |
| 3 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 4 | Ultrastructure of anterior uterus of the oviduct and the stored sperm in female soft-shelled turtle,Trionys sinensis显示文摘 | Han Xiangkun Zhangli Bao Huijun | 2008 | The Anatomical Record2008，291，： | 1 |
| 5 | Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation显示文摘Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates AST.Using the classical AST mouse model(Kras LSL-G12D/+;Lkb1flox/flox,KL),we here comprehensively analyze the temporal transcriptomic dynamics of lung tumors at different stages by dynamic network biomarker(DNB)and identify the tipping point at which the Wnt signaling is abruptly suppressed by the excessive accumulation of reactive oxygen species(ROS)through its downstream effector FOXO3A.Bidirectional genetic perturbation of the Wnt pathway using two different Ctnnb1 conditional knockout mouse strains confirms its essential role in the negative regulation of AST.Importantly,pharmacological activation of the Wnt pathway before but not after the tipping point inhibits squamous transdifferentiation,highlighting the irreversibility of AST after crossing the tipping point.Through comparative transcriptomic analyses of mouse and human tumors,we find that the lineage-specific transcription factors(TFs)of adenocarcinoma and squamous cell carcinoma form a“Yin-Yang”counteracting network.Interestingly,inactivation of the Wnt pathway preferentially suppresses the adenomatous lineage TF network and thus disrupts the“Yin-Yang”homeostasis to lean towards the squamous lineage,whereas ectopic expression of NKX2-1,an adenomatous lineage TF,significantly dampens such phenotypic transition accelerated by the Wnt pathway inactivation.The negative correlation between the Wnt pathway and AST is further observed in a large cohort of human lung adenosquamous carcinoma.Collectively,our study identifies the tipping point of AST and highlights an essential role of the ROS-Wnt axis in dynamically orchestrating the homeostasis between adeno-and squamous-specific TF networks at the AST tipping point. | Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 6 | Investigation of dynamics of discrete framed structures by a numerical wave-based method and an analytical homogenization approach显示文摘In this article, the analytical homogenization method of periodic discrete media(HPDM)and the numerical condensed wave finite element method(CWFEM) are employed to study the longitudinal and transverse vibrations of framed structures. The valid frequency range of the HPDM is re-evaluated using the wave propagation feature identified by the CWFEM. The relative error of the wavenumber by the HPDM compared to that by the CWFEM is illustrated in functions of frequency and scale ratio. A parametric study on the thickness of the structure is carried out where the dispersion relation and the relative error are given for three different thicknesses. The dynamics of a finite structure such as natural frequency and forced response are also investigated using the HPDM and the CWFEM. | Zhou Changwei Sun Xiangkun Mohamed Ichchou Abdel-Malek Zine Jean-Pierre Lainé Stephane Hans Claude Boutin | 2017 | Chinese Journal of Aeronautics2017，30，1： | 0 |
| 7 | Design and dynamic analysis of a scissors hoop-rib truss deployable antenna mechanism显示文摘As the support mechanism of space-borne antennas,space deployable antenna mechanism belongs to complex multi-closed-loop coupling mechanism,configuration design and dynamic analysis are more difficult than general parallel mechanism.In this paper,an unequal-length scissors mechanism(ULSM)is proposed by changing the position of the internal rotational joint through a basic scissors mechanism.A scissors hoop-rib truss deployable antenna mechanism(SHRTDAM)is constructed by replacing the parabolic rib with the ULSM.Kinematic analysis of SHRTDAM is conducted,and the degree of freedom(DOF)of the whole antenna mechanism is analyzed based on screw theory,the result showed that it has only one DOF.Velocity and acceleration characteristics of SHRTDAM are obtained by the screw derivative and rotation transformation.Based on Lagrange equation,dynamic model of this mechanism is established,the torque required to drive the mechanism is simulated and verified by Adams and MATLAB software.In addition,a ground experiment prototype of 1.5-m diameter was fabricated and a deployment test is conducted,which demonstrated the mobility and deployment performance of the whole mechanism.The mechanism proposed in this paper can provide a good reference for the design and analysis of large aperture space deployable antennas. | Bo Han Xiangkun Li Jian Sun Yundou Xu Jiantao Yao Yongsheng Zhao | 2023 | Defence Technology(防务技术)2023，24，6： | 0 |
| 8 | Author Corrections: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsnupx0fovbocw6bu5.ffgz.tsg.suse.edu.cn/10.1038/cr.2014.10,published online 24 January 2014 In the original version of this article,1 there is an error in Fig.2G.Specifically,in the Ctrl group of Fig.2G,the A549 microscope image was mistakenly used with the CRL-5872 microscope image.The correct image has been provided.The authors regret this error. | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2021 | Cell Research2021，31，10： | 0 |
| 9 | Targeting HSPA1A in ARID2-deficient lung adenocarcinoma显示文摘Somatic mutations of the chromatin remodeling gene ARID2 are observed in~7%of human lung adenocarcinomas(LUADs).However,the role of ARID2 in the pathogenesis of LUADs remains largely unknown.Here we find that ARID2 expression is decreased during the malignant progression of both human and mice LUADs.Using two Kras^(G12D)-based genetically engineered murine models,we demonstrate that ARID2 knockout significantly promotes lung cancer malignant progression and shortens overall survival.Consistently,ARID2 knockdown significantly promotes cell proliferation in human and mice lung cancer cells.Through integrative analyses of Ch IP-Seq and RNA-Seq data,we find that Hspa1 a is up-regulated by Arid2 loss.Knockdown of Hspa1 a specifically inhibits malignant progression of Arid2-deficient but not Arid2-wt lung cancers in both cell lines as well as animal models.Treatment with an HSPA1 A inhibitor could significantly inhibit the malignant progression of lung cancer with ARID2 deficiency.Together,our findings establish ARID2 as an important tumor suppressor in LUADs with novel mechanistic insights,and further identify HSPA1 A as a potential therapeutic target in ARID2-deficient LUADs. | Xue Wang Yuetong Wang Zhaoyuan Fang Hua Wang Jian Zhang Longfu Zhang Hsinyi Huang Zhonglin Jiang Yujuan Jin Xiangkun Han Shenda Hou Bin Zhou Feilong Meng Luonan Chen Kwok-Kin Wong Jinfeng Liu Zhiqi Zhang Xin Zhang Haiquan Chen Yihua Sun Liang Hu Hongbin Ji | 2021 | National Science Review2021，8，10： | 0 |
| 10 | Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance显示文摘肺癌症是世界范围的癌症相关的死亡的领先的原因。指向的治疗作为到好预后的一个障碍在药抵抗看台的大多数情况,而是发展中是有益的。多重机制被探索例如基因改变,激活绕过发信号,并且 phenotypic 转变。这些内在或外来的动态规定在遇见在不同刺激下面发信号的要求便于肿瘤房间幸存。这评论介绍有药抵抗的肺癌症粘性和异质和他们的关联。当癌症粘性和异质在药抵抗的发展起一个必要作用时,他们的操作可以把一些灵感带到癌症预后和治疗。那是说,肺癌症粘性和异质与不仅挑战而且机会介绍我们。 | Yingjiao Xue Shenda Hou Hongbin Ji Xiangkun Han | 2017 | Protein & Cell2017，8，3： | 0 |
| 11 | Reverse Droop Control-based Smooth Transfer Strategy for Interface Converters in Hybrid AC/DC Distribution Networks显示文摘Hybrid AC/DC distribution networks are promising candidates for future applications due to their rapid advancement in power electronics technology.They use interface converters(IFCs)to link DC and AC distribution networks.However,the networks possess drawbacks with AC voltage and frequency offsets when transferring from grid-tied to islanding modes.To address these problems,this paper proposes a simple but effective strategy based on the reverse droop method.Initially,the power balance equation of the distribution system is derived,which reveals that the cause of voltage and frequency offsets is the mismatch between the IFC output power and the rated load power.Then,the reverse droop control is introduced into the IFC controller.By using a voltage-active power/frequency-reactive power(U-P/f-Q)reverse droop loop,the IFC output power enables adaptive tracking of the rated load power.Therefore,the AC voltage offset and frequency offset are suppressed during the transfer process of operational modes.In addition,the universal parameter design method is discussed based on the stability limitations of the control system and the voltage quality requirements of AC critical loads.Finally,simulation and experimental results clearly validate the proposed control strategy and parameter design method. | Wenyuan Cao Minxiao Han Xiangkun Meng Wenqiang Xie Zmarrak Wali Khan Josep M.Guerrero Gibran David Agundis Tinajero | 2023 | CSEE Journal of Power and Energy Systems2023，9，1： | 0 |
| 12 | Facile construction of a multilayered interface for a durable lithium‐rich cathode显示文摘Layered lithium-rich manganese-based oxide(LRMO)has the limitation of inevitable evolution of lattice oxygen release and layered structure transformation.Herein,a multilayer reconstruction strategy is applied to LRMO via facile pyrolysis of potassium Prussian blue.The multilayer interface is visually observed using an atomic-resolution scanning transmission electron microscope and a high-resolution transmission electron microscope.Combined with the electrochemical characterization,the redox of lattice oxygen is suppressed during the initial charging.In situ X-ray diffraction and the high-resolution transmission electron microscope demonstrate that the suppressed evolution of lattice oxygen eliminates the variation in the unit cell parameters during initial(de)lithiation,which further prevents lattice distortion during long cycling.As a result,the initial Coulombic efficiency of the modified LRMO is up to 87.31%,and the rate capacity and long-term cycle stability also improved considerably.In this work,a facile surface reconstruction strategy is used to suppress vigorous anionic redox,which is expected to stimulate material design in high-performance lithium ion batteries. | Zhou Xu Yifei Yuan Qing Tang Xiangkun Nie Jianwei Li Qing Sun Naixuan Ci Zhenjie Xi Guifang Han Lijie Ci Guanghui Min | 2023 | Carbon Energy2023，5，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员