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| 1 | A four-gene signature-derived risk score for glioblastoma:prospects for prognostic and response predictive analyses显示文摘Objective: Glioblastoma(GBM) is the most common primary malignant brain tumor regulated by numerous genes, with poor survival outcomes and unsatisfactory response to therapy.Therefore, a robust, multi-gene signature-derived model is required to predict the prognosis and treatment response in GBM.Methods: Gene expression data of GBM from TCGA and GEO datasets were used to identify differentially expressed genes(DEGs)through DESeq2 or LIMMA methods.The DEGs were then overlapped and used for survival analysis by univariate and multivariate COX regression.Based on the gene signature of multiple survival-associated DEGs, a risk score model was established,and its prognostic and predictive role was estimated through Kaplan–Meier analysis and log-rank test.Gene set enrichment analysis(GSEA) was conducted to explore high-risk score-associated pathways.Western blot was used for protein detection.Results: Four survival-associated DEGs of GBM were identified: OSMR, HOXC10, SCARA3, and SLC39A10.The four-gene signature-derived risk score was higher in GBM than in normal brain tissues.GBM patients with a high-risk score had poor survival outcomes.The high-risk group treated with temozolomide chemotherapy or radiotherapy survived for a shorter duration than the low-risk group.GSEA showed that the high-risk score was enriched with pathways such as vasculature development and cell adhesion.Western blot confirmed that the proteins of these four genes were differentially expressed in GBM cells.Conclusions: The four-gene signature-derived risk score functions well in predicting the prognosis and treatment response in GBM and will be useful for guiding therapeutic strategies for GBM patients. | Mianfu Cao Juan Cai Ye Yuan Yu Shi Hong Wu Qing Liu Yueliang Yao Lu Chen Weiqi Dang XiangZhang Jingfang Xiao Kaidi Yang Zhicheng He Xiaohong Yao Yonghong Cui Xia Zhang Xiuwu Bian | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 2 | Effect of calcinations temperatures and precipitant on the catalytic performance of Au/ZnO catalysts for CO oxidation at ambient temperature and in humid circumstances显示文摘 | Gui Ying Wang Wen XiangZhang | 2003 | Applied Catalysis A:General2003，239，： | 1 |
| 3 | Stability and Deactivation of Au/Fe2O3 Catalysts for CO Oxidation at Ambient Temperature and Moisture显示文摘 | GuiYing Wang Wen XiangZhang Hong Lei Lian | 2002 | Kinetics and catalysts2002，43，2： | 1 |
| 4 | Decoupling China's Carbon Emissions Increase from Economic Growth: An Economic Analysis and Policy Implications 显示文摘 | Zhong Xiangzhang | 2000 | World Development2000，，28： | 1 |
| 5 | Can China afford to commit itself an emissions cap? An economic and political analysis显示文摘 | Zhong Xiangzhang | 2000 | Energy Economics2000，，22： | 1 |
| 6 | Naturematerials 显示文摘 | XiangZhang ZhaoweiLiu | 2008 | 72008，，： | 1 |
| 7 | A distributed estimator for on-road target tracking with lane estimation and identification显示文摘For ground target tracking with road constraints,the existing methods ignore the road width,which can lead to significant biases of the target state estimates when the road width is large.In this paper,based on the proposed novel two-dimensional(2D) road representation which additionally allows to model target lateral motion,a distributed estimator(DE) with lane estimation and identification is proposed.This estimator uses radar and image sensor based local estimates to provide a global estimate of the target displacement from the road axis.In local estimators,the updated lane estimations are used for iterations.The representative simulation results show that the proposed estimator achieves much better estimation performance than the mileage estimator(ME),and the lane identifier can effectively identify the lane which the target is in. | CHEN YangSheng The Thirty-Eighth Research Institute,China Electronics Technology Group Corporation,199 Xiangzhang Blvd,Hefei 230088,China | 2010 | Science China(Information Sciences)2010，53，12： | 1 |
| 8 | The association between the genetic polymorphism of HLA‐DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population显示文摘 | Rong‐BinYu XinHong Wei‐LiangDing Yong‐FeiTan Yong‐XiangZhang Nan‐XiongSun Guan‐LingWu Sheng‐WeiZhan Da‐FangGe | 2008 | Journal of Gastroenterology and Hepatology2008，，9： | 1 |
| 9 | An Expeditious Route for the Total Synthesis of Pondaplin Isolated from Annona glabra显示文摘A novel cyclic prenylated phenylpropanoid, pondaplin 1, was first synthesized in 26% overall yields through an expeditious route (7 steps) that employed highly regio- and stereoselective phenyltellurenylation to arylacetylene and palladium (II) chloride-catalyzed carbonylation of hydroxy styryl phenyl telluride as key steps. | QianCHENG YanWenZHANG XiangZHANG TakayukiORITANI | 2003 | Chinese Chemical Letters2003，14，12： | 0 |
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