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| 1 | Recent advances in biological detection with magnetic nanoparticles as a useful tool显示文摘Magnetic nanoparticles have emerged as a powerful tool for magnetic resonance imaging, biodetection, drug delivery, and hyperthermia. This review focuses on the biological detection of magnetic nanoparticles as well as their physicochemical properties. Substantial progress in the sensitivity of detection has been made by developing variety of methods. Five applications of magnetic nanoparticles in biological detection are discussed in this review: magnetic separation, magnetic sensing, magnetic manipulation, magnetic catalysis, and signal enhancer for surface plasmon resonance(SPR). Finally, some future trends and perspectives in these research areas are outlined. | Liwei Lu Xiuyu Wang Chuanxi Xiong Li Yao | 2015 | Science China Chemistry2015，58，5： | 6 |
| 2 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 3 | Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease with a median survival time of 3–5 years.Inaccurate diagnosis,limited clinical therapy and high mortality together indicate that the development of effective therapeutics for IPF is an urgent need.In recent years,it was reported that DDRs are potential targets in anti-fibrosis treatment.Based on previous work we carried out further structure modifications and led to a more selective inhibitor 47 by averting some fibrosis-unrelated kinases,such as RET,AXL and ALK.Extensive profiling of compound 47 has demonstrated that it has potent DDR1/2 inhibitory activities,low toxicity,good pharmacokinetic properties and reliable in vivo anti-fibrosis efficacy.Therefore,we confirmed that discoidin domain receptors are promising drug targets for IPF,and compound 47 would be a promising candidate for further drug development. | Qi Wang Bixi Tang Dandan Sun Ying Dong Yinchun Ji Huanyu Shi Liwei Zhou Yueyue Yang Menglan Luo Qian Tan Lin Chen Yue Dong Cong Li Rongrong Xie Yi Zang Jingkang Shen Bing Xiong Jia Li Danqi Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 4 | Regional Effect of APS-sEPS on Intestinal Structure and Mucosal Immunity in Mice显示文摘[Objectives]The aim of this study was to investigate the effects of APS-sEPS(a polysaccharide compound of Astragalus polysaccharides and sulfated Epimedium polysaccharide)on intestinal mucosal immunity and structural morphology.[Methods]Firstly,the diarrhea model was established using the optimal dose of magnesium sulfate in mice.Then,the diarrhea mice were randomly divided into three groups and given either physiological saline(diarrhea model group)or injected with APS-sEPS or APS.The normal mice were selected as a control group.After administration,the duodenum,jejunum and ileum were processed microtome section,and observed for describing the small intestine morphology,villus height and crypt depth.The tissue homogenates of the duodenum,jejunum and ileum were gathered to detect the changes of sIgA,IL-4 and IL-10.[Results]The results indicated that APS-sEPS could effectively relieve diarrhea in mice.In the APS-sEPS group,the villus heights of duodenum,jejunum and ileum were increased and the depth of crypt was reduced.The contents of IL-4,IL-10 and sIgA in jejunum and ileum in APS-sEPS group were significantly higher than that in the control group(P<0.05).[Conclusions]These results indicated that APS-sEPS promoted the recovery of intestinal morphological structure and enhanced the mucosa immunity of the small intestine. | Lei CHENG Qing JIN Rong CHEN Wei ZHANG Niandong YAN Tao XIONG Xiaona ZHAO Liwei GUO | 2020 | Agricultural Biotechnology2020，9，6： | 0 |
| 5 | Preparation of Mo_(2)C by MPCVD and Its Photocatalytic Properties显示文摘Mo2C was prepared by microwave plasma chemical vapor deposition(MPCVD)technique with the power of 800 W and pressure of 18 kPa.Compared with traditional preparation methods,MPCVD has faster growth rate and higher purity of the products.The influence of growth time on the morphology and structure of Mo_(2)C was characterized by X-ray diffraction and Scanning Electron Microscopy.The photocatalytic performance of Mo_(2)C was tested.It was found that Mo_(2)C had good photocatalytic performance and the 6 h sample had the highest photodegradation rate,indicating the great potential of Mo_(2)C as photocatalyst. | HAO Jianxin CAI Kang FU Qiuming WENG Jun XIONG Liwei ZHAO Hongyang | 2021 | 真空与低温2021，27，5： | 0 |
| 6 | Detection Scheme of Positive Sequence Components Based on Operation Period Delay Filter显示文摘Fast and accurate acquisition of positive sequence components of unbalanced grid voltage is an essential requirement to ensure the safety operation of the grid-connected inverter.To improve the extraction speed of positive sequence components of unbalanced voltage,this study proposes a sampling period delay filter(SPDF)to quickly separate positive and negative sequence components by delaying two sampling periods of grid voltage in dq frame.With the SPDF method,only one coordinate transformation is required and the computational burden can be reduced apparently.Then,the noise immunity performance of the proposed SPDF algorithm is investigated;and the corresponding solution,operation period delay filter(OPDF),can guarantee the desired fast response performance under the premise of limiting the amplified noise within the acceptable range.Finally,the feasibility and priority of the above two algorithms have been verified by the simulation and experimental results. | Liwei Du Liansong Xiong Mingxian Li Zhen Tang Liancheng Xiu Xun Ma | 2023 | CSEE Journal of Power and Energy Systems2023，9，1： | 0 |
| 7 | The recent research progress of polyphenol-derived biomaterials in wound repair显示文摘The clinical requirements for wound care are increasing daily, and the global wound dressing market is expanding;however, the research and development of new wound dressings are imminent. Natural biomolecules such as polyphenols, have been widely used in this field of vision. Owing to their unique anti-oxidative, adhesive, antibacterial and other bioactive functions, researchers have developed a series of wound dressings with excellent performance and applied them to a variety of biomaterials, such as hydrogels, nanofibers, films and scaffolds. They can effectively promote angiogenesis and fibroblast migration and proliferation, scavenge active oxygen free radicals, inhibit excessive in-flammatory reactions at wound sites and ultimately accelerate wound healing. The authors summarise the latest progress in polyphenol-derived biomaterials in skin wound repair to provide inspiration for future wound dressing research. | Shuya Zhao Lu Han Liwei Yan Xiong Lu | 2023 | Biosurface and Biotribology2023，9，4： | 0 |
| 8 | Novel photo-theranostic GdB_(6) nanoparticles for fluorescence imaging and NIR-photothermal therapy显示文摘The development of multifunctional theranostic nano-agents is an important resolution for personalized treatment of cancer.In this work,we synthesized a new kind of gadolinium boride nanoparticles(GBN)by a microwave-assisted chemical etching method,and discovered their optical characteristics including fluorescence imaging and near-infrared(NIR)photothermal conversion capability.Bright greenishyellow fluorescence enabled for intracellular localization,while effective NIR-photothermal conversion supported photothermal therapy(PTT).In vitro and in vivo results indicated that GBN exhibited a superior antitumor performance and high biocompatibility.This study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment. | Yuqi Chen Mengna Jiang Liwei Xiong Xianxian Yao Mingjian Fan Danyang Chen Qi Jiang Zhaokui Jin Qianjun He | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
| 9 | Influence of Ca Content on Microstructure and Mechanical Properties of Extruded Mg–Al–Ca–Mn Alloys显示文摘Herein,the effects of Ca content on microstructure,texture and mechanical properties of extruded Mg–3Al–0.4Mn–xCa(x=0.4,0.8 and 1.2 wt%)rods are systematically investigated.The results reveal that the alloy,with Ca content of 0.8 wt%,exhibits the highest strength and ductility,possessing an ultimate tensile strength of 267.57 MPa and elongation(EL)of 16%.This is mainly due to the gradual transformation of typical fiber texture into a texture with a[10-11]component parallel to the extrusion direction(ED),which increases the Schmid factor of pyramidal slip and enhances the activation rate of pyramidal(c+a)slip.Simultaneously,the as-formed spherical phases and segregation of Ca at grain boundaries render a significant influence on the strength and ductility of the alloy. | Weiying Huang Jianhua Chen Zhen Jiang Xi Xiong Wei Qiu Jian Chen Xianwei Ren Liwei Lu | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，3： | 0 |
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