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| 1 | Organochlorine compounds and polycyclic aromatic hydrocarbons in surface sediment from Baiyangdian Lake,North China:Concentrations,sources profiles and potential risk显示文摘Organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polycyclic aromatic hydrocarbons(PAHs) were determined in nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river(Fuhe River) in North China.Total concentrations of OCPs,PCBs and PAHs in sediments ranged from 5.4 to 707.6 ng/g,2.3 to 197.8 ng/g,and 101.3 to 6360.5 ng/g,respectively.The levels of contaminants in Fuhe River were significantly higher than those in Baiyandian Lake.For hexachlorocyclohexane(HCHs) and dichlorodiphenytrichloroethanes(DDTs),α-HCH and p,p-DDT were predominant isomers;while for PCBs,PCB 28/31,PCB 40/103,PCB 60,PCB 101,and PCB 118 were predominant congeners.Possible sources derived from historical usage for OCPs and incomplete combustion fuel,wood,and coal and exhaustion of boats or cars for PAHs.Risk assessment of sediment indicated that sediments in Fuhe River were likely to pose potential biological adverse impact. | Guocheng Hu Xiaojun Luo Fengchao Li Jiayin Dai Jianyang Guo Shejun Chen Cao Hong Bixian Mai Muqi Xu | 2010 | Journal of Environmental Sciences2010，22，2： | 42 |
| 2 | Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone显示文摘Objective:To compare radiofrequency ablation(RFA) or microwave ablation(MWA) and transcatheter arterial chemoembolization(TACE) with RFA or MWA monotherapy in hepatocellular carcinoma(HCC).Methods:A prospective,randomized,controlled trial was conducted on 94 patients with HCC ≤7 cm at a single tertiary referral center from June 2008 to June 2010 at the Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Southeast University.The patients were randomly assigned into the TACERFA or TACE-MWA(combined treatment group) and the RFA-alone or MWA-alone groups(control group).The primary end point was overall survival.The secondary end point was recurrence-free survival,and the tertiary end point was adverse effects.Results:Until the time of censor,17 patients in the TACE-RFA or TACE-MWA group had died.The median follow-up time of the patients who were still alive for the TACE-RFA or TACE-MWA group was 47.5±11.3 months(range,29 to 62 months).The 1-,3- and 5-year overall survival for the TACE-RFA or TACE-MWA group was 93.6%,68.1% and 61.7%,respectively.Twenty-five patients in the RFA or MWA group had died.The median follow-up time of the patients who were still alive for the RFA or MWA group was 47.0±12.9 months(range,28 to 62 months).The 1-,3- and 5-year overall survival for the RFA or MWA group was 85.1%,59.6% and 44.7%,respectively.The patients in the TACE-RFA or TACE-MWA group had better overall survival than the RFA or MWA group [hazard ratio(HR),0.526;95% confidence interval(95% CI),0.334-0.823;P=0.002],and showed better recurrence-free survival than the RFA or MWA group(HR,0.582;95% CI,0.368-0.895;P=0.008).Conclusions:RFA or MWA combined with TACE in the treatment of HCC ≤7 cm was superior to RFA or MWA alone in improving survival by reducing arterial and portal blood flow due to TACE with iodized oil before RFA. | Yongxiang Yi Yufeng Zhang Qiang Wei Liang Zhao Jianbo Han Yan Song Ying Ding Guilan Lu Junmao Liu Huaiying Ding Feng Dai Xiaojun Tang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 29 |
| 3 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 4 | A single Eu^(2+)-activated high-color-rendering oxychloride white-light phosphor for white-light-emitting diodes显示文摘Single-phased,high-color-rendering index(CRI)white-light phosphors are emerging as potential phosphor-converted white-light-emitting diodes(WLEDs)and as an alternative to blends of tricolor phosphors.However,it is a challenge to create a high CRI white light from a single-doped activator.Here,we present a high CRI(Ra 591)white-light phosphor,Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:Eu^(2+),composed of Sr5(PO4)3Cl as the beginning member and Sr_(5)(BO_(3))_(3)Cl as the end member.This work utilized the solid-solution method,and tunable Eu^(2+) emission was achieved.Color-tunable Eu^(2+) emissions in response to structural variation were observed in Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl solid solutions.This was further confirmed using X-ray Rietveld refinement,electron paramagnetic resonance spectroscopy,and in the photoluminescence spectra.The color-tunable emissions included the white light that originated from the combination of the blue emission of Sr_(5)(PO_(4))_(3)Cl:Eu^(2+) and an induced Eu^(2+) yellow emission at approximately 550 nm in the solid solution.Importantly,the white-light phosphors showed a greater R9590.2 under excitation at 365 nm.This result has rarely been reported in the literature and is greater than that of(R9514.3)commercial Y_(3)A_(l5)O_(12):Ce^(3+)-based WLEDs.These findings demonstrate the great potential of Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:0.04Eu^(2+) as a white-light phosphor for near-UV phosphor-converted WLEDs.These results also provide a shortcut for developing a high CRI white-light phosphor from a single Eu^(2+)-doped compound. | Peng-Peng Dai Cong Li Xin-Tong Zhang Jun Xu Xi Chen Xiu-Li Wang Yan Jia Xiaojun Wang Yi-Chun Liu | 2016 | Light(Science & Applications)2016，5，1： | 14 |
| 5 | Preparation and properties of CMAS resistant bixbyite structured high-entropy oxides RE_(2)O_(3)(RE=Sm,Eu,Er,Lu,Y,and Yb):Promising environmental barrier coating materials for Al_(2)O_(3)f/Al_(2)O_(3) composites显示文摘Y_(2)O_(3) is regarded as one of the potential environmental barrier coating(EBC)materials for Al_(2)O_(3)f/Al_(2)O_(3)ceramic matrix composites owing to its high melting point and close thermal expansion coefficient to Al_(2)O_(3).However,the relatively high thermal conductivity and unsatisfactory calcium-magnesium-aluminosilicate(CMAS)resistance are the main obstacles for the practical application of Y_(2)O_(3).In order to reduce the thermal conductivity and increase the CMAS resistance,four cubic bixbyite structured high-entropy oxides RE_(2)O_(3),including(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Eu_(0.2)Er_(0.2)Y_(0.2)Yb_(0.2))2O_(3),and(Sm_(0.2)Eu_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)were designed and synthesized,among which(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)bulks were prepared by spark plasma sintering(SPS)to investigate their mechanical and thermal properties as well as CMAS resistance.The mechanical properties of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) are close to those of Y_(2)O_(3) but become more brittle than Y_(2)O_(3).The thermal conductivities of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb02)2O_(3)(5.1 and 4.6 W·m^(-1)·K^(-1))are only 23.8%and 21.5%respectively of that of Y_(2)O_(3)(21.4 W·m^(-1)·K^(-1)),while their thermal expansion coefficients are close to those of Y_(2)O_(3) and A12O_(3).Most importantly,HE RE_(2)O_(3) ceramics exhibit good CMAS resistance.After being attacked by CMAS at 1350℃for 4 h,the HE RE_(2)O_(3) ceramics maintain their original morphologies without forming pores or cracks,making them promising as EBC materials for Al_(2)O_(3)f/Al_(2)O_(3) composites. | Yanan SUN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Yan XING Xiaojun ZHAO Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 10 |
| 6 | Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A,Z显示文摘H2A.Z 是在所有种类的高度保存的 histone 变体。H2A.Z 的染色质免职被改变复杂 SWR1 和它的哺乳动物的对应物 SRCAP 的酵母染色质明确地催化。然而, H2A.Z 被 non-histone 蛋白质优先地被认出的机制留下逃犯。这里,我们识别了 Anp32e,为 H2A.Z Anp32e 的新奇更高优核质特定的 histone 女伴优先地在 vitro 并且在 vivo 把 dimers 而非 H2A-H2B dimers 与 H2A.Z-H2B 联系并且分裂 non-nucleosomal 总数由 DNA 和 H2A-H2B 形成了。我们与 H2A.Z-H2B 在建筑群决定了 Anp32e 女伴领域(186-232 ) 的水晶结构更暗淡。在这结构,包含 Anp32e 残余 214-224 的区域,在另外的 Anp32 家庭蛋白质不在,明确地与扩大 H2A.Z α 交往; C 螺旋,哪个展览一个意外 conformational 变化。Anp32e 的染色体宽的介绍表明在 Anp32e 和 H2A.Z 房间 overexpressing Anp32e 之间的显著合作占有在 +1 nucleosomes 显示了强壮的全球 H2A.Z 损失,而房间显示的 Anp32e 弄空在 +1 nucleosomes 的中等全球 H2A.Z 增加。这建议 Anp32e 可以帮助解决 non-nucleosomal H2A.Z 总数并且也在 +1 nucleosomes,和后者便于 H2A.Z 的移动可以帮助 RNA 聚合酶 II 通过第一个 nucleosomal 障碍。 | Zhuo Mao Lu Pan Weixiang Wang Jian Sun Shah Shan Qiang Dong Xiaoping Liang Linchang Dai Xiaojun Ding She Chen Zhuqiang Zhang Bing Zhu Zheng Zhou | 2014 | Cell Research2014，24，4： | 6 |
| 7 | Broadband photonic radio frequency(RF) channelization based on coherent optical frequency combs and polarization I/Q demodulation显示文摘In this work,we analyze and demonstrate a novel photonic-assisted broadband and high-resolution radio frequency(RF) channelization scheme based on dual coherent optical frequency combs(OFCs),regular optical de-muxes,and polarization I/Q demodulators in theory and experiment.The use of two coherent combs avoids precise optical alignment,and a numerical filter in digital signal processor(DSP) enables an ideal rectangular frequency response in each channel without any ultra-narrow optical filters.Besides,due to the use of polarization I/Q demodulation,ambiguous frequency estimate in direct detection can be avoided and the amplitude,phase mismatch in traditional I/Q demodulation can be mitigated.In experiment,we use two coherent OFCs with the free spectrum range(FSR) of about 40 GHz to demonstrate the channelization scheme with seven channels,500 MHz channel spacing and frequency coverage from 3.75 GHz to 7.25 GHz.The input RF tones are accurately down-converted to an intermediate frequency(IF) with a maximum frequency error of 110 kHz.Meanwhile,crosstalk and spurious free dynamic range(SFDR) of the scheme are also discussed. | DAI YiTang XU Kun XIE XiaoJun YAN Li WANG RuiXin LIN JinTong | 2013 | Chinese Science Bulletin2013，58，7： | 5 |
| 8 | Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells显示文摘Stem cell therapy is an attractive approach for recovery from myocardial infarction(MI)but faces the challenges of rapid diffusion and poor survival after transplantation.Here we developed an injectable collagen scaffold to promote the long-term retention of transplanted cells in chronic MI.Forty-five minipigs underwent left anterior descending artery(LAD)ligation and were equally divided into three groups 2 months later(collagen scaffold loading with human umbilical mesenchymal stem cell(hUMSC)group,hUMSC group,and placebo group(only phosphate-buffered saline(PBS)injection)).Immunofluorescence staining indicated that the retention of transplanted cells was promoted by the collagen scaffold.Echocardiography and cardiac magnetic resonance imaging(CMR)showed much higher left ventricular ejection fraction(LVEF)and lower infarct size percentage in the collagen/hUMSC group than in the hUMSC and placebo groups at 12 months after treatment.There were also higher densities of vWf-,α-sma-,and cTnT-positive cells in the infarct border zone in the collagen/cell group,as revealed by immunohistochemical analysis,suggesting better angiogenesis and more cardiomyocyte survival after MI.Thus,the injectable collagen scaffold was safe and effective on a large animal myocardial model,which is beneficial for constructing a favorable microenvironment for applying stem cells in clinical MI. | Qiang Wangn Xiaojun He Bin Wang Jun Pan Chunying Shi Jie Li Liudi Wang Yannan Zhao Jianwu Dai Dongjin Wang | 2021 | Science China(Life Sciences)2021，64，2： | 5 |
| 9 | Generation of 84-fs pulses from a mode-locked Tm:CNNGG disordered garnet crystal laser显示文摘A mode-locked laser based on a Tm:CNNGG disordered crystal as an active medium and a single-walled carbon nanotube saturable absorber is demonstrated, operating at a central wavelength of 2018 nm. Transformlimited 84 fs pulses are generated with an average output power of 22 mW at a repetition rate of ~90 MHz.A maximum output power of 98 mW is obtained at a slightly longer pulse duration of 114 fs. | ZHONGBEN PAN YICHENG WANG YONGGUANG ZHAO HUALEI YUAN XIAOJUN DAI HUAQIANG CAI JI EUN BAE SUN YOUNG CHOI FABIAN ROTERMUND XAVIER MATEOS JOSEP MARIA SERRES PAVEL LOIKO UWE GRIEBNER VALENTIN PETROV | 2018 | Photonics Research2018，6，8： | 4 |
| 10 | Au nanospheres modified boron-doped diamond microelectrode grown via hydrogen plasma etching solid doping source for dopamine detection显示文摘Boron doped diamond(BDD)electrode is a promising electrochemical material for detecting dopamine level in the human’s body.In this work,we developed a new doping source-graphite and solid boron oxide powders to synthesize BDD film with microwave plasma chemical vapor deposition,so as to avoid using toxic or corrosive dopants,such as boroethane and trimethylborate.The synthesized BDD film is pinhole free and with high doping density of 8.44×10^20 cm^-3 calculated from the Raman spectroscopy.Subsequently,Au nanospheres were decorated on the surface of BDD film to improve electrochemical performance of the BDD film.The Au nanoparticles modified BDD electrode demonstrates an excellent electrochemical response,a high sensitivity(in the range of 5μM-1 m M),and a low detection limit(~0.8μM)for detecting dopamine. | Kaili Yao Xiaojun Tan Bing Dai Jie Bai Qiaoyang Sun Wenxin Cao Jiwen Zhao Lei Yang Jiecai Han Jiaqi Zhu | 2020 | Journal of Materials Science & Technology2020，47，14： | 4 |
| 11 | Physical structure and vertical distribution of chlorophyll a in winter sea ice from the northwestern Weddell Sea, Antarctica显示文摘The investigation on sea-ice biology in combination with physics, chemistry and ecology was carried out in the northwestern Weddell Sea, Antarctica, during the cruise ANT/XX III-7 on board POLARSTERN in the austral winter (August-October) in 2006. The distribution of chlorophyll a was measured and related to sea ice texture. The mean concentrations of chlorophyll a in the sea ice varied considerably with ice texture. The concentration of chlorophyll a per core ranged from 2.10– 84.40 μg/dm 3 with a mean of 16.56 μg/dm 3 . And the value of R (chlorophyll a / gross chlorophyll) ranged from 0.79–0.83. These high winter chlorophyll values indicate that primary production is considerable and confirms that there is significant primary production in Antarctic sea ice during winter. Thus this constitutes a major proportion of southern ocean primary production and carbon flux before the sea ice retreats. | DAI Fangfang WANG Zipan YAN Xiaojun LI Zhijun ALLHUSEN Erika DIECKMANN Gerhard | 2010 | Acta Oceanologica Sinica2010，29，3： | 2 |
| 12 | Preface显示文摘Owing to the fast economic growing and the concern over greenhouse gases and air pollution,the development of nuclear energy is one important option to meet the expanded energy consumption in our future.To achieve that goal,continuing and reliable supplies of uranium are critical to future nuclear power projects.As is well known,global terrestrial reserves of uranium are limited and the deposits in China are relatively small.Given the projected big growth in nuclear power in the future,reliable supply of uranium at a reasonable price is essential for China. | DAI YiTang XU Kun XIE XiaoJun YAN Li WANG RuiXin LIN JinTong | 2013 | Science China Chemistry2013，56，11： | 2 |
| 13 | Analysis of in- dica-and japonica-specific markers of Oryza sativa and their appli- cations显示文摘 | Dai Xiaojun Yang Yuanzhu Chert Liangbi | 2012 | Plant Syst Evol2012，298，： | 1 |
| 14 | Establishment of customized mouse stem cell lines by sequential nuclear transfer显示文摘治疗学的克隆,胚胎的干细胞(转换字符) 由此从原子转移(NT ) 被导出胚胎,可以在再生药的新时代起一个主要作用。Inthis 学习我们建立了四十原子转移 -- 从不同施主房间类型或段落的 NTembryos 被导出的转换字符(NT 转换字符) 线。我们发现 NT 转换字符能够形成胚胎植物或动物身体。另外, NT 转换字符表示了 pluripotency 干细胞标记试管内并且能区分进胚胎的纸巾体内。从施主房间能形成完整的术语的早经过 R1 的 NT 胚胎开发了小狗,而那些为为实时出生是必要的 reprogramming 从迟了的经过 R1 ES 施主房间失去了潜力。我们随后建立了近来从 NT 胚囊被开发的 sequentialNT-R1-ESC 线经过 R1 转换字符施主。然而,当在他们的早段落用作原子转移施主时,这些 NT-R1-ESC 排队,没能导致实时小狗。这显示用顺序的 NT 转换字符的治疗学的克隆过程不能救居住在以前的施主代的发展缺乏。 | Chunli Zhao Ruqiang Yao Jie Hao Chenhui Ding Yong Fan Xiangpeng Dai Wei Li Tang Hai Zichuan Liu Yang Yu Yingying Wang Xiaojun Hou Weizhi Ji Qi Zhou Alice Jouneau Fanyi Zeng Liu Wang | 2007 | Cell Research2007，17，1： | 1 |
| 15 | Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion显示文摘Background:Vascular cognitive impairment caused by chronic cerebral hypoperfusion(CCH)has become a hot issue worldwide.Aerobic exercise positively contributes to the preservation or restoration of cognitive abilities;however,the specific mechanism has remained inconclusive.And recent studies found that neurogranin(Ng)is a potential biomarker for cognitive impairment.This study aims to investigate the underlying role of Ng in swimming training to improve cognitive impairment.Methods:To test this hypothesis,the clustered regularly interspaced short palindromic repeats(CRISPR)-associated protein 9(Cas9)system was utilized to construct a strain of Ng conditional knockout(Ng cKO)mice,and bilateral common carotid artery stenosis(BCAS)surgery was performed to prepare the model.In Experiment 1,2-month-old male and female transgenic mice were divided into a control group(wild-type littermate,n=9)and a Ng cKO group(n=9).Then,2-month-old male and female C57BL/6 mice were divided into a sham group(C57BL/6,n=12)and a BCAS group(n=12).In Experiment 2,2-month-old male and female mice were divided into a sham group(wild-type littermate,n=12),BCAS group(n=12),swim group(n=12),BCAS+Ng cKO group(n=12),and swim+Ng cKO group(n=12).Then,7 days after BCAS,mice were given swimming training for 5 weeks(1 week for adaptation and 4 weeks for training,5 days a week,60 min a day).After intervention,laser speckle was used to detect cerebral blood perfusion in the mice,and the T maze and Morris water maze were adopted to test their spatial memory.Furthermore,electrophysiology and Western blotting were conducted to record long-term potential and observe the expressions of Ca^(2+)pathway-related proteins,respectively.Immunohistochemistry was applied to analyze the expression of relevant markers in neuronal damage,inflammation,and white matter injury.Results:The figures showed that spatial memory impairment was detected in Ng cKO mice,and a sharp decline of cerebral blood flow and an impairment of progressive spatial memory were observed in BCAS mice.Regular swimming training improved the spatial memory impairment of BCAS mice.This was achieved by preventing long-term potential damage and reversing the decline of Ca^(2+)signal transduction pathway-related proteins.At the same time,the results suggested that swimming also led to improvements in neuronal death,inflammation,and white matter injury induced by CCH.Further study adopted the use of Ng cKO transgenic mice,and the results indicated that the positive effects of swimming training on cognitive impairments,synaptic plasticity,and related pathological changes caused by CCH could be abolished by the knockout of Ng.Conclusion:Swimming training can mediate the expression of Ng to enhance hippocampal synaptic plasticity and improve related pathological changes induced by CCH,thereby ameliorating the spatial memory impairment of vascular cognitive impairment. | Huawei Lin Jiayong Zhang Yaling Dai Huanhuan Liu Xiaojun He Lewen Chen Jing Tao Chaohui Li Weilin Liu | 2023 | Journal of Sport and Health Science2023，12，1： | 1 |
| 16 | Comparision of aroma compounds in naturally fermented and inoculated Chinese soy- bean pastes by GC-MS and GC-Olfactomotry analysis显示文摘 | ZHAO Jianxin DAI Xiaojun LIU Xiaoming | 2011 | Food Control2011，22，6： | 1 |
| 17 | Hewei Jiangni granule alleviates visceral hypersensitivity in a rat model of non-erosive reflux disease via transient receptor potential channel signaling显示文摘Objective:To uncover the underlying mechanism of Hewei Jiangni granule(HWJNG)on non-erosive reflux disease(NERD)treatment by examining histological changes,gastrointestinal neurochemicals release and visceral hypersensitivity-related receptor expression in NERD model rats.Methods:A NERD rat model was established via a combination of basal sensitization and acid perfusion.HWJNG treatments at different doses were then administered.Pathological changes to tissues,mast cell(MC)activation,serum levels of esophageal visceral hypersensitivity-related neurochemicals,and transient receptor potential(TRP)receptor mRNA and protein levels were investigated.Results:Compared with the control group,the expression of tryptase in MCs,the changes of intercellular space,and the serum levels of substance P(SP),calcitonin gene-related peptides(CGRP)and proteinaseactivated receptor 2(PAR2)increased in the model group(all P<.05).The expression of TRP vanilloid 1(Trpv1)mRNA decreased in esophagus and dorsal root ganglia(DRG)of the model group(P=.030&P=.013),and the expression of TRP melastatin channel subfamily member 8(Trpm8)mRNA decreased in the esophagus of model group(P<.01).The level of esophageal TRPV1 protein increased in the model group(P<.01)and the level of TRPM8 protein decreased in esophagus and DRG of the model group(both P<.05).Compared with the model group,the serum levels of SP,CGRP,and PAR2 in the mediumdose HWJNG group showed significant decreases(all P<.05).The expression of Trpv1 mRNA in esophagus and DRG of the HWJNG groups and the Omeprazole group remarkably decreased(all P<.05),as was the expression of Trpm8 mRNA in esophagus of the HWJNG groups(all P<.05).Conclusion:HWJNG alleviated visceral hypersensitivity in NERD model rats by regulating TRP-mediated signaling.Our results indicate that HWJNG has potential as a therapeutic agent for NERD. | Jiali Liu Fushun Kou Xiang Tan Yi Dai Chune Xie Xiaohong Li Lei Shi Tangyou Mao Xiaojun Shi Junxiang Li | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 1 |
| 18 | Exploring the genetic characteristics of 93-11 and Nipponbare recombination inbred lines based on the Golden Gate SNP assay显示文摘Understanding genetic characteristics in rice populations will facilitate exploring evolutionary mechanisms and gene cloning. Numerous molecular markers have been utilized in linkage map construction and quantitative trait locus(QTL) mappings. However, segregation-distorted markers were rarely considered, which prevented understanding genetic characteristics in many populations. In this study, we designed a 384-marker Golden Gate SNP array to genotype 283 recombination inbred lines(RILs) derived from 93-11 and Nipponbare Oryza sativa crosses. Using 294 markers that were highly polymorphic between parents, a linkage map with a total genetic distance of 1,583.2 c M was constructed, including 231 segregation-distorted markers. This linkage map was consistent with maps generated by other methods in previous studies. In total, 85 significant quantitative trait loci(QTLs) with phenotypic variation explained(PVE) values?5% were identified. Among them, 34 QTLs were overlapped with reported genes/QTLs relevant to corresponding traits, and 17 QTLs were overlapped with reported sterility-related genes/QTLs. Our study provides evidence that segregation-distorted markers can be used in linkage map construction and QTL mapping. Moreover, genetic information resulting from this study will help us to understand recombination events and segregation distortion. Furthermore, this study will facilitate gene cloning and understanding mechanism of inter-subspecies hybrid sterility and correlations with important agronomic traits in rice. | Renbo Yu Wei Yan Manzhong Liang Xiaojun Dai Haodong Chen Yunong Sun Xingwang Deng Xiangding Chen Hang He Liangbi Chen | 2016 | Science China(Life Sciences)2016，59，7： | 1 |
| 19 | Prepara- tion and optical properties of novel transparent Al-doped- ZnO/epoxy nanocomposites 显示文摘 | Luo Yongsong Yang Jiaoping Dai Xiaojun | 2009 | The Journal of Physical Chemistry C2009，113，21： | 1 |
| 20 | Brominated flame retardants, polychlorinated biphenyls, and organochlorine pesticides in captive Giant Panda ( Ailuropoda melanoleuca) and Red Panda ( Ailurus fulgens ) from China 显示文摘 | HU Guocheng LUO Xiaojun DAI Jiayin | 2008 | Environ Sci Technol2008，42，： | 1 |
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