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| 1 | De novo assembly and comparative analysis of root transcriptomes from different varieties of Panax ginseng C. A. Meyer grown in different environments显示文摘Panax ginseng C. A. Meyer is an important traditional herb in eastern Asia. It contains ginsenosides, which are primary bioactive compounds with medicinal properties. Although ginseng has been cultivated since at least the Ming dynasty to increase production, cultivated ginseng has lower quantities of ginsenosides and lower disease resistance than ginseng grown under natural conditions. We extracted root RNA from six varieties of fifth-year P. ginseng cultivars representing four different growth conditions, and performed Illumina paired-end sequencing. In total, 163,165,706 raw reads were obtained and used to generate a de novo transcriptome that consisted of 151,763 contigs(76,336 unigenes), of which 100,648 contigs(66.3%) were successfully annotated. Differential expression analysis revealed that most differentially expressed genes(DEGs) were upregulated(246 out of 258, 95.3%) in ginseng grown under natural conditions compared with that grown under artificial conditions. These DEGs were enriched in gene ontology(GO) terms including response to stimuli and localization. In particular, some key ginsenoside biosynthesis-related genes, including HMG-Co A synthase(HMGS), mevalonate kinase(MVK), and squalene epoxidase(SE), were upregulated in wild-grown ginseng. Moreover, a high proportion of disease resistance-related genes were upregulated in wild-grown ginseng. This study is the first transcriptome analysis to compare wild-grown and cultivated ginseng, and identifies genes that may produce higher ginsenoside content and better disease resistance in the wild; these genes may have the potential to improve cultivated ginseng grown in artificial environments. | ZHEN Gang ZHANG Lei DU YaNan YU RenBo LIU XinMin CAO FangRui CHANG Qi DENG Xing Wang XIA Mian HE Hang | 2015 | Science China(Life Sciences)2015，58，11： | 6 |
| 2 | The telomere-to-telomere genome of Fragaria vesca reveals the genomic evolution of Fragaria and the origin of cultivated octoploid strawberry显示文摘Fragaria vesca,commonly known as wild or woodland strawberry,is the most widely distributed diploid Fragaria species and is native to Europe and Asia.Because of its small plant size,low heterozygosity,and relative ease of genetic transformation,F.vesca has been a model plant for fruit research since the publication of its Illumina-based genome in 2011.However,its genomic contribution to octoploid cultivated strawberry remains a long-standing question.Here,we de novo assembled and annotated a telomere-to-telomere,gap-free genome of F.vesca‘Hawaii 4’,with all seven chromosomes assembled into single contigs,providing the highest completeness and assembly quality to date.The gap-free genome is 220785082 bp in length and encodes 36173 protein-coding gene models,including 1153 newly annotated genes.All 14 telomeres and seven centromeres were annotated within the seven chromosomes.Among the three previously recognized wild diploid strawberry ancestors,F.vesca,F.iinumae,and F.viridis,phylogenomic analysis showed that F.vesca and F.viridis are the ancestors of the cultivated octoploid strawberry F.×ananassa,and F.vesca is its closest relative.Three subgenomes of F.×ananassa belong to the F.vesca group,and one is sister to F.viridis.We anticipate that this high-quality,telomere-to-telomere,gap-free F.vesca genome,combined with our phylogenomic inference of the origin of cultivated strawberry,will provide insight into the genomic evolution of Fragaria and facilitate strawberry genetics and molecular breeding. | Yuhan Zhou Jinsong Xiong Ziqiang Shu Chao Dong Tingting Gu Pengchuan Sun Shuang He Mian Jiang Zhiqiang Xia Jiayu Xue Wasi Ullah Khan Fei Chen Zong-Ming Cheng | 2023 | Horticulture Research2023，10，4： | 4 |
| 3 | Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal 13-glucuronidase activity显示文摘瞄准:Diclofenac 是 non-steroidal 反煽动性的药(NSAID ) ,它可以引起严肃的肠的不利反应(enteropathy ) 。在这研究,我们调查了 ciprofloxacin 的合作管理是否在 rats.Methods 影响了 diclofenac 和导致 diclofenac 的 enteropathy 的 pharmacokinetics:diclofenac 的 pharmacokinetics 在收到 diclofenac 以后在老鼠被估计(10 mg/kg, ig,或 5 mg/kg, iv ) ,与或没有 ciprofloxacin (20 mg/kg, ig ) 共同管理。在收到 6 口头的剂量或 diclofenac 的 15 静脉内的剂量以后,老鼠被牺牲,并且小肠被移开检验导致 diclofenac 的 enteropathy。β在肠的满意的、牛的肝和 E coli 的 -Glucuronidase 活动是 evaluated.Results:后面的口头或静脉内的管理, diclofenac 的 pharmacokinetic 侧面显示了废除的 ciprofloxacin 的典型 enterohepatic 循环,和合作管理 enterohepatic 发行量,在 diclofenac 的血浆内容导致了重要减小。在控制老鼠, β在小肠的内容的 -glucuronidase 活动是区域依赖者:近似 intestine<远侧的 intestine< ileal 阀门。ciprofloxac 的管理引起了 β 的重要减小;在远侧的小肠,并且特别地在 ileal 的 -glucuronidase 活动阀门。而且, ciprofloxacin (10-2000 μ mol/L ) dose-dependently 禁止的 β在远侧的小肠内容的 -glucuronidase 活动或 E coli 在 vitro 孵化了,但是没在在 vitro 孵化的近似的小肠内容或牛的肝影响那。在收到 6 口头的剂量或 diclofenac 的 15 静脉内的剂量以后,典型 enteropathy 与严重 enteropathy 被开发发生在远侧的小肠。ciprofloxacin 的合作管理显著地减轻了导致 diclofenac 的 enteropathy.Conclusion:ciprofloxacin 的合作管理稀释了 diclofenac 的 enterohepatic 循环并且在老鼠减轻了导致 diclofenac 的 enteropathy,部分经由肠的 β 的抑制; -glucuronidase 活动。 | Ze-yu ZHONG Bin-bin SUN Nan SHU Qiu-shi XIE Xiange TANG Zhao-li LING Fan WANG Kai-jing ZHAO Ping XU Mian ZHANG Ying LI Yang CHEN Li LIU Lun-zhu XIA Xiao-dong LIU | 2016 | Acta Pharmacologica Sinica2016，37，7： | 4 |
| 4 | Hepatitis B virus reactivation in a chronic myeloid leukemia patient treated with imatinib mesylate显示文摘 | WANG Ya-dan CUI Guo-hui LI Mian GOWREA Bhuveshwamath XIA Jia HU Yu | 2012 | Chinese Medical Journal2012，，14： | 4 |
| 5 | Surface functionalized N-C-TiO_(2)/C nanocomposites derived from metal-organic framework in water vapour for enhanced photocatalytic H generation显示文摘Surface-functionalized nitrogen/carbon co-doped polymorphic TiO_(2) phase junction nanoparticles uniformly distributed in porous carbon matrix were synthesized by a simple one-step pyrolysis of titanium based metal-organic framework(MOF),NH_(2)-MIL^(-1)25(Ti) at 700℃ under water vapour atmosphere.Introducing water vapour during the pyrolysis of NH_(2)-MIL^(-1)25(Ti) not only functionalizes the derived porous carbon matrix with carboxyl groups but also forms additional oxygen-rich N like interstitial/intraband states lying above the valence band of TiO2 along with the self-doped carbo n,which further narrows the energy band gaps of polymorphic TiO2 nanoparticles that enhance photocatalytic charge transfer efficiency.Without co-catalyst,sample N-C-TiO2/CArW demonstrates H_(2) evolution activity of 426 μmol gcat-1h^(-1),which remarkably outperforms commercial TiO_(2)(P-25) and N-C-TiO_(2)/CAr with a 5-fold and 3-fold H_(2) generation,respectively.This study clearly shows that water vapour atmosphere during the pyrolysis increases the hydrophilicity of the Ti-MOF derived composites by functionalizing porous carbon matrix with carboxylic groups,as well as enhancing the electrical conductivity and charge transfer efficiency due to the formation of additional localized oxygen-rich N like interstitial/intraband states.This work also demonstrates that by optimizing the anatase-rutile phase composition of the TiO2 polymorphs,tuning the energy band gaps by N/C co-doping and functionalizing the porous carbon matrix in the N-C-TiO2/C nanocomposites,the photocatalytic H_(2) generation activity can be further enhanced. | Mian Zahid Hussain Zhuxian Yang Bart van der Linden Zheng Huang Quanli Jia Erik Cerrato Roland A.Fischer Freek Kapteijn Yanqiu Zhu Yongde Xia | 2021 | Journal of Energy Chemistry2021，30，6： | 3 |
| 6 | Metal-organic framework derived multi-functionalized and co-doped TiO_(2)/C nanocomposites for excellent visible-light photocatalysis显示文摘Multi-functionalized and co-doped TiO_(2)/C nanocomposites were derived from the pyrolysis of Ti-MOFs at 800℃under different gaseous atmospheres and their photocatalytic performance were investigated.The gaseous atmosphere during pyrolysis plays a critical role in determining the structural,textural,optical and physicochemical properties of the derived TiO_(2)/C composites due to the synergistic effect of nitrogen-containing species,carboxylate and sulfur functionalized porous carbon as well as N/S co-doped TiO_(2)nanoparticles.All the Ti-MOFs derived TiO_(2)/C composites exclusively possess homogeneously distributed TiO_(2)nanoparticles in a functionalized disc-like porous carbon matrix and demonstrate much enhanced adsorption and photodegradation performance than commercial TiO_(2)under the same conditions.The adsorption of methylene blue(MB)in dark on these TiO_(2)/C composites are dominated with pseudo second-order kinetic model and the high adsorption capacity of MB in dark on composite TiO_(2)/C derived from MIL-125(Ti)in argon is due to its high surface area with predominant mesoporous carbon matrix in the composite.The composite N-O-TiO_(2)/C derived from NH2-MIL-125(Ti)in water vapor exhibited the highest photodegradation activity with 99.7%MB removal in 3 h under visible light due to the optimal anatase/rutile phasejunction,together with the formation of photoactive oxygen-rich N-O like interstitial/intraband states above the valence band of TiO_(2),as well as the presence of N-containing species and-OH/-COOH multi-functional groups with superhydrophilic nature of the composite.This simple one-step and easily modifiable approach can be further employed to modulate homogeneously dispersed multi-functionalized and co-doped metal oxide/carbon nanocomposites for various environment and energy-related applications. | Mian Zahid Hussain Zhuxian Yang Ahmed M.E.Khalil Shahzad Hussain Saif Ullah Awan Quanli Jia Roland A.Fischer Yanqiu Zhu Yongde Xia | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 7 | Functional Characterization of a Putative Nitrate Transporter Gene Promoter from Rice显示文摘干旱是影响植物生长和开发的最重要的不能生活的压力之一。表示分析揭示了那 OsNRT1.3,在米饭的通常认为的硝酸盐 transporter 基因,被干旱导致。如果 OsNRT1.3 倡导者能对干旱应力作出回应,证实,在上游的 2019 bp OsNRT1.3 的顺序被克隆。三 OsNRT1.3 倡导者碎片被 5'-deletion 产生,并且熔化了基因到 beta-glucuronidase (GUS ) 。妄想的基因被介绍进米饭植物。 NRT2019::GUS , NRT1196::GUS 和 NRT719::GUS 证明在在所有转基因的米饭的种子,根,叶子和花的类似的表示模式,和 GUS 活动由不同 OsNRT1.3 倡导者碎片交谈了显著地起来由干旱应力调整了,显示那个 OsNRT1.3 倡导者对应力和在上游的 719 bp OsNRT1.3 定序的干旱作出回应包含干旱反应元素。 | Ting-Zhang HU Kai-Ming CAO Mian XIA Xi-Ping WANG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，11： | 2 |
| 8 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 9 | Developmental regulation of the gene for chimeric calcium/calmodulin-dependent protein kinase in anthers显示文摘 | B. W. Poovaiah Mian Xia Zhihua Liu Wuyi Wang Tianbao Yang P. V. Sathyanarayanan Vincent R. Franceschi | 1999 | Planta1999，，2： | 1 |
| 10 | Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase显示文摘 | Peng Y Mian IS | 2000 | Mol Cell Biol2000，20，： | 1 |
| 11 | Developmental regulation of the gene for chimeric calcium/calmodulin-dependent protein kinase in anthers显示文摘 | B. W. Poovaiah Mian Xia Zhihua Liu Wuyi Wang Tianbao Yang P. V. Sathyanarayanan Vincent R. Franceschi | 1999 | Planta1999，，2： | 1 |
| 12 | Identification of functionally important d omains in the N-terminal region of telomerase reverse transcriptase 显示文摘 | Peng Y Mian IS Lue NF | | Mol Cell Biol0，20，14： | 1 |
| 13 | Chimeric calcium/calmodulin-dependent protein kinase in tobacco: differential regulation by calmodulin isoforms显示文摘 | Zhihua Liu Mian Xia B.W. Poovaiah | 1998 | Plant Molecular Biology1998，，5： | 1 |
| 14 | Enhanced bioproduction of chitin in engineered Pichia pastoris显示文摘Biopolymer chitin and its derivatives have a wide range of applications in different fields.Chitin is primarily produced from marine crustacean by strong acid and strong alkali treatment.To reduce the environmental hazardous in the production of chitin,post-fermentation fungal biomass waste like fungi cell walls provides a viable alternative source for chitin.In this study,improved chitin content in yeast cell wall was achieved by overexpressing chitin biosyntheic pathway related genes.The chitin content was 51.5μg/mg cell wall and 122.9μg/mg cell wall in strain GS-1.10(gfat,uap and chs1 genes overexpression)and strain GS-2.6(gfat,gna1,agm1,uap and chs1 genes overexpression),which were 44.3%and 244.4%higher than that in control strain GS115,respectively.By overexpressing another chitin synthase gene(chs3),the chitin content in strain GS-3.10 was further increased to 136.2μg/mg cell wall,which was 10.8%and 281.6%higher than that in GS-2.6 and in control GS115,respectively.Moreover,chitin yield was further improved by various culture conditions optimization,and reached 162.4μg/mg cell wall,which was 4.43 times of that in the starting strain GS115.The final titer of chitin was 2.23 g/L culture broth in 84 h fed-batch fermentation in a 5 L bioreactor.To our knowledge,this is the first report of chitin production in engineered Pichia pastoris via biosynthetic pathway enhancement. | Xue Zhang Chunyue Zhang Mian Zhou Quanming Xia Liqiang Fan Liming Zhao | 2022 | Food Bioscience2022，47，3： | 1 |
| 15 | Measuring binding kinetics of surface- bound molecules using the Surface plasmon resonance technique显示文摘 | Bao- Xia Li Juan Chen Mian Long | 2008 | Analytical Biochemistry2008，377，： | 1 |
| 16 | Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase显示文摘 | XIA J PENG Y MIAN I S | 2000 | Mol Cell Biol2000，，20： | 1 |
| 17 | Identitication of functionally important domains in the N-terminal region of telomerase reverse transcriptase显示文摘 | XIA J PENG Y MIAN I S | 2000 | Mol Cell Biol2000，，20： | 1 |
| 18 | Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase显示文摘 | Peng Y Mian IS | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 19 | Adsorption of Copper (II) onto activated carbons from sewage sludge by microwave-induced phosphoric acid and zinc chloride activation显示文摘 | Xuejiang Wang Xia Liang Yin Wang Xin Wang Mian Liu Daqiang Yin Siqing Xia Jianfu Zhao Yalei Zhang | 2011 | Desalination2011，，1： | 1 |
| 20 | Bimetallic Fe-Mo sulfide/carbon nanocomposites derived from phosphomolybdic acid encapsulated MOF for efficient hydrogen generation显示文摘To tackle the energy crisis and achieve more sustainable development,hydrogen as a clean and renewable energy resource has attracted great interest.Searching for cheap but efficient catalysts for hydrogen production from water splitting is urgently needed.In this report,bimetallic Fe-Mo sulfide/carbon nanocomposites that derived from a polyoxometalate phosphomolybdic acid encapsulated metal-organic framework MIL-100(PMA@MIL-100)have been generated and their applications in electrocatalytic hydrogen generation were explored.The PMA@MIL-100 precursor is formed via a simple one-pot hydrothermal synthesis method and the bimetallic Fe-Mo sulfide/carbon nanocomposites were obtained by chemical vapor sulfurization of PMA@MIL-100 at high temperatures.The nanocomposite samples were fully characterized by a series of techniques including X-ray diffraction,Fourier-transform infrared analysis,thermogravimetric analysis,N2 gas sorption,scanning electron microscopy,transmission electron microscopy,X-ray photoelectron spectroscopy,and were further investigated as electrocatalysts for hydrogen production from water splitting.The hydrogen production activity of the best performed bimetallic Fe-Mo sulfide/carbon nanocomposite exhibits an overpotential of-0.321 V at 10 m A cm^(-2)and a Tafel slope of 62 m V dec^(-1)with a 53%reduction in overpotential compared to Mo-free counterpart composite.This dramatic improvement in catalytic performance of the Fe-Mo sulfide/carbon composite is attributed to the homogeneous distribution of the nanosized iron sulfide,MoS_(2)particles,and the formation of Fe-Mo-S phases in the S-doped porous carbon matrix.This work has demonstrated a potential approach to fabricate complex heterogeneous catalytic materials for different applications. | Zheng Huang Zhuxian Yang Mian Zahid Hussain Quanli Jia Yanqiu Zhu Yongde Xia | 2021 | Journal of Materials Science & Technology2021，，25： | 0 |
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