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| 1 | Immunomodulatory effect of human amniotic epithelial cells on restoration of ovarian function in mice with autoimmune ovarian disease显示文摘Autoimmune ovarian disease(AOD)is considered to be a major cause of premature ovarian failure(POF).The immunomodulatory properties of human amniotic epithelial cells(hAECs)have been studied in many disease models.We previously reported that hAECs restored ovarian function in chemotherapy-induced POF mice,but the immunomodulatory mechanism of hAECs is still unclear.To investigate the effect of hAECs on recipient mice,especially on regulatory Treg cells,hAECs and hAEC-conditioned medium(hAEC-CM)were intravenously injected into AOD mice immunized with zona pellucida protein 3 peptides(pZP3).Ovarian function was evaluated through estrous cycle,hormone secretion,follicle development,and cell apoptosis analysis.Immune cells including CD3,CD4,CD8 and Treg cells in the spleens were tested by flow cytometry.To elucidate the effect of hAEC-CM on macrophage function,inflammation model in vitrowas established in RAW264.7 cells induced by lipopolysaccharide(LPS).hAECs and hAEC-CM regulated estrous cycles,promoted follicle development,ameliorated cell apoptosis and fibrosis in ovaries of AOD mice.In addition,hAECs significantly reversed the decrease of pZP3-induced Treg cells in the spleens.In vitro,hAEC-CM significantly inhibited the inflammatory reaction induced by LPS in RAW264.7 cells via up-regulating the expression of M2 macrophage genes.Further study demonstrated that hAECsecreted transforming growth factor-beta and macrophage inhibitory factor played important roles in the macrophage polarization and migration under inflammatory stimulation.Taken together,hAECs restored ovarian function by up-regulating Treg cells in the spleens and reduced the inflammatory reaction via modulating the activated macrophage function in a paracrine manner in the ovaries of AOD mice. | Qiuwan Zhang Yating Huang Junyan Sun Tingting Gu Xiaoyan Shao Dongmei Lai | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 14 |
| 2 | A method for the production and expedient screening of CRISPR/Cas9-mediated non-transgenic mutant plants显示文摘Developing CRISPR/Cas9-mediated non-transgenic mutants in asexually propagated perennial crop plants is challenging but highly desirable.Here,we report a highly useful method using an Agrobacterium-mediated transient CRISPR/Cas9 gene expression system to create non-transgenic mutant plants without the need for sexual segregation.We have also developed a rapid,cost-effective,and high-throughput mutant screening protocol based on Illumina sequencing followed by high-resolution melting(HRM)analysis.Using tetraploid tobacco as a model species and the phytoene desaturase(PDS)gene as a target,we successfully created and expediently identified mutant plants,which were verified as tetra-allelic mutants.We produced pds mutant shoots at a rate of 47.5%from tobacco leaf explants,without the use of antibiotic selection.Among these pds plants,17.2%were confirmed to be non-transgenic,for an overall non-transgenic mutation rate of 8.2%.Our method is reliable and effective in creating non-transgenic mutant plants without the need to segregate out transgenes through sexual reproduction.This method should be applicable to many economically important,heterozygous,perennial crop species that are more difficult to regenerate. | Longzheng Chen Wei Li Lorenzo Katin-Grazzini Jing Ding Xianbin Gu Yanjun Li Tingting Gu Ren Wang Xinchun Lin Ziniu Deng Richard J.McAvoy Frederick G.Gmitter Jr. Zhanao Deng Yunde Zhao Yi Li | 2018 | Horticulture Research2018，5，1： | 12 |
| 3 | Chemical characteristics of size-resolved aerosols in winter in Beijing显示文摘Size-resolved aerosols were continuously collected by a Nano Sampler for 13 days at an urban site in Beijing during winter 2012 to measure the chemical composition of ambient aerosol particles. Data collected by the Nano Sampler and an ACSM(Aerodyne Aerosol Chemical Speciation Monitor) were compared. Between the data sets,similar trends and strong correlations were observed,demonstrating the validity of the Nano Sampler. PM10 and PM2.5concentrations during the measurement were 150.5 ± 96.0 μg/m3(mean ± standard variation)and 106.9 ± 71.6 μg/m3,respectively. The PM2.5/PM10 ratio was 0.70 ± 0.10,indicating that PM2.5dominated PM10. The aerosol size distributions showed that three size bins of 0.5–1,1–2.5 and 2.5–10 μm contributed 21.8%,23.3% and 26.0% to the total mass concentration(TMC),respectively. OM(organic matter) and SIA(secondary ionic aerosol,mainly SO42-,NO3-and NH4+) were major components of PM2.5. Secondary compounds(SIA and secondary organic carbon) accounted for half of TMC(about 49.8%) in PM2.5,and suggested that secondary aerosols significantly contributed to the serious particulate matter pollution observed in winter. Coal burning,biomass combustion,vehicle emissions and SIA were found to be the main sources of PM2.5. Mass concentrations of water-soluble ions and undetected materials,as well as their fractions in TMC,strikingly increased with deteriorating particle pollution conditions,while OM and EC(elemental carbon) exhibited different variations,with mass concentrations slightly increasing but fractions in TMC decreasing. | Kang Sun Yu Qu Qiong Wu Tingting Han Jianwei Gu Jingjing Zhao Yele Sun Qi Jiang Ziqi Gao Min Hu Yuanhang Zhang Keding Lu Stephan Nordmann Yafang Cheng Li Hou Hui Ge Masami Furuuchi Mitsuhiko Hata Xingang Liu | 2014 | Journal of Environmental Sciences2014，26，8： | 9 |
| 4 | Current applications and future prospects of nanotechnology in cancer immunotherapy显示文摘Cancer immunotherapy is an artificial stimulation of the immune system to recognize cancer cells and activate specific immune cells to target and attack cancer cells.In clinical trials, immunotherapy has recently shown impressive results in the treatment of multiple cancers.Thus, cancer immunotherapy has gained a lot of attention for its unique advantages and promising future.With extensive research on cancer immunotherapy, its safety and effectiveness has gradually been revealed.However, it is still a huge challenge to expand and drive this therapy while maintaining low toxicity, high specificity, and long-lasting efficacy.As a unique technology, nanotechnology has been applied in many fields, the advantages of which will promote the development of cancer immunotherapies.Researchers have tried to apply nanomaterials to cancer immunotherapy due to their advantageous properties,such as large specific surface areas, effective drug delivery, and controlled surface chemistry, to improve treatment efficacy.Here,we briefly introduce the current applications of nanomaterials in cancer immunotherapy, including adoptive cell therapy(ACT),therapeutic cancer vaccines, and monoclonal antibodies, and throw light on future directions of nanotechnology-based cancer immunotherapy. | Sen Yan Peng Zhao Tingting Yu Ning Gu | 2019 | Cancer Biology & Medicine2019，16，3： | 6 |
| 5 | Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China,2000-2014显示文摘Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China.Integron,a conserved DNA sequence,which is carried on episomal genetic structures,plays a very important role in development of antibiotic resistance.This systematic analysis was based on MEDLINE and EMBASE databases.We summarized the distribution and proportion of different types of gene cassette arrays of integrons(including class 1,2,3 and atypical class 1 integron) from clinical bacteria isolates in China.Fifty-six literatures were included in this study.Most of the strains were Gram-negative bacteria(94.1%,7,364/7,822) while only 5.9% strains were Grampositive bacteria.Class 1 integrons were detected in 54.2%(3956/7295) Gram-negative strains.aadA2 was the most popular gene cassette array detected from 60 Gram-positive bacteria while dfrA17-aadA5 were detected in 426 Gramnegative bacteria.This study identified 12 novel gene cassette arrays which have not been previously found in any species.All the novel gene cassette arrays were detected from Gram-negative bacteria.A regional characteristic of distribution of integrons was presented in this study.The results highlight a need for continuous surveillance of integrons and provide a guide for future research on integron-mediated bacteria resistance. | Wenying Xia Ting Xu Tingting Qin Pengpeng Liu Yun Liu Haiquan Kang Bing Gu Ping Ma | 2016 | The Journal of Biomedical Research2016，30，4： | 5 |
| 6 | Effects of soaking process on arsenic and other mineral elements in brown rice显示文摘One of the main food crops in the world,rice can accumulate high levels of arsenic from flooded paddy soils,which seriously threatens human health.Soaking,a common processing method for brown rice products,especially for brown rice noodles,was investigated in this study.Japonica rice(Dao Hua Xiang No.2)and Indica rice(Ye Xiang You No.3)were selected for studying the effects of soaking on arsenic concentrations,species,and distributions.Results revealed that soaking can efficiently remove arsenic in these two rice varieties,and the main part of removal is endosperm with the maximal rate of about 40%.Inorganic arsenic(I-As)(about 85%)is the main species of arsenic reduction.Meanwhile,the variations of four other elements(i.e.,Mg,Ca,Zn,and Fe)were analyzed.Collectively,the findings of this study indicate that soaking can efficiently remove arsenic in brown rice under controlled soaking conditions,which thereby reduces the arsenic intake for brown rice customers. | Fan Zhang Fengying Gu Huili Yan Zhenyan He Bolun Wang Hao Liu Tingting Yang Feng Wang | 2020 | Food Science and Human Wellness2020，9，2： | 5 |
| 7 | PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells显示文摘(CXCR4 ) CXC chemokine 受体 4 是被显示了调停的房间表面受体包括肺,胸,肾,和前列腺的许多稳固的肿瘤的转移肿瘤。在这研究,我们发现 et 变体基因 4 的 overexpression (PEA3 ) 能在人的 MDA-MB-231 和 MCF-7 乳癌房间提高 CXCR4 mRNA 水平和 CXCR4 倡导者活动。PEA3 支持了 CXCR4 表示和乳癌转移。染色质 immunoprecipitation 试金证明 PEA3 能与 PEA3 表示向量在房间 transfected 绑在 CXCR4 倡导者。PEA3 siRNA 在 MDA-MB-231 和 MCF-7 房间稀释了 CXCR4 倡导者活动和 PEA3 的绑定到 CXCR4 倡导者。这些结果显示 PEA3 能激活 CXCR4 倡导者抄写并且支持乳癌转移。 | Shengmei Gu Li Chen Qi Hong Tingting Yan Zhigang Zhuang Qiaoqiao Wang Wei Jin Hua Zhu Jiong Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 4 |
| 8 | The telomere-to-telomere genome of Fragaria vesca reveals the genomic evolution of Fragaria and the origin of cultivated octoploid strawberry显示文摘Fragaria vesca,commonly known as wild or woodland strawberry,is the most widely distributed diploid Fragaria species and is native to Europe and Asia.Because of its small plant size,low heterozygosity,and relative ease of genetic transformation,F.vesca has been a model plant for fruit research since the publication of its Illumina-based genome in 2011.However,its genomic contribution to octoploid cultivated strawberry remains a long-standing question.Here,we de novo assembled and annotated a telomere-to-telomere,gap-free genome of F.vesca‘Hawaii 4’,with all seven chromosomes assembled into single contigs,providing the highest completeness and assembly quality to date.The gap-free genome is 220785082 bp in length and encodes 36173 protein-coding gene models,including 1153 newly annotated genes.All 14 telomeres and seven centromeres were annotated within the seven chromosomes.Among the three previously recognized wild diploid strawberry ancestors,F.vesca,F.iinumae,and F.viridis,phylogenomic analysis showed that F.vesca and F.viridis are the ancestors of the cultivated octoploid strawberry F.×ananassa,and F.vesca is its closest relative.Three subgenomes of F.×ananassa belong to the F.vesca group,and one is sister to F.viridis.We anticipate that this high-quality,telomere-to-telomere,gap-free F.vesca genome,combined with our phylogenomic inference of the origin of cultivated strawberry,will provide insight into the genomic evolution of Fragaria and facilitate strawberry genetics and molecular breeding. | Yuhan Zhou Jinsong Xiong Ziqiang Shu Chao Dong Tingting Gu Pengchuan Sun Shuang He Mian Jiang Zhiqiang Xia Jiayu Xue Wasi Ullah Khan Fei Chen Zong-Ming Cheng | 2023 | Horticulture Research2023，10，4： | 4 |
| 9 | Current status of in vivo bioanalysis of nano drug delivery systems显示文摘The development of nano drug delivery systems(NDDSs)provides new approaches to fighting against diseases.The NDDSs are specially designed to serve as carriers for the delivery of active pharmaceutical ingredients(APIs)to their target sites,which would certainly extend the benefit of their unique physicochemical characteristics,such as prolonged circulation time,improved targeting and avoiding of drugresistance.Despite the remarkable progress achieved over the last three decades,the understanding of the relationships between the in vivo pharmacokinetics of NDDSs and their safety profiles is insufficient.Analysis of NDDSs is far more complicated than the monitoring of small molecular drugs in terms of structure,composition and aggregation state,whereby almost all of the conventional techniques are inadequate for accurate profiling their pharmacokinetic behavior in vivo.Herein,the advanced bioanalysis for tracing the in vivo fate of NDDSs is summarized,including liquid chromatography tandemmass spectrometry(LC-MS/MS),Forster resonance energy transfer(FRET),aggregation-caused quenching(ACQ)fluorophore,aggregation-induced emission(AIE)fluorophores,enzyme-linked immunosorbent assay(ELISA),magnetic resonance imaging(MRI),radiolabeling,fluorescence spectroscopy,laser ablation inductively coupled plasma MS(LA-ICP-MS),and size-exclusion chromatography(SEC).Based on these technologies,a comprehensive survey of monitoring the dynamic changes of NDDSs in structure,composition and existing form in system(i.e.carrier polymers,released and encapsulated drug)with recent progress is provided.We hope that this review will be helpful in appropriate application methodology for investigating the pharmacokinetics and evaluating the efficacy and safety profiles of NDDSs. | Tingting Wang Di Zhang Dong Sun Jingkai Gu | 2020 | Journal of Pharmaceutical Analysis2020，10，3： | 3 |
| 10 | Self-template formation of porous yolk-shell structure Mo-doped NiCo2O4 toward enhanced lithium storage performance as anode material显示文摘Hollow ternary metal oxides have shown enormous potential in lithium-ion batteries(LIBs),which is ascribed to their complex chemical composition,abundant active defect sites,and the synergy effect be-tween metals.In this work,we synthesized Mo-doped NiCo_(2)O_(4) porous spheres with yolk-shell structure by using a simple self-templating method.Surprisingly,other than the yolk-shell structure we had ob-tained,the inner core of the yolk-shell was also porous,which could fully enhance the electrolyte infil-tration and promote the transmission of lithium ions(Li+)and electrons(e−).The diameter of the porous core in the yolk-shell sphere was about 530 nm,and the outer shell’s thickness was up to 110 nm.In addition,the unique pores in the core appeared in the diameter of about 85 nm.With this structure,the volume expansion of the anode could be well inhibited during charge/discharge.It exhibited prominent electrochemical performance with high reversible capacity(1338 mA h g^(−1) at 100 mA g^(−1)),satisfactory cycle life(1360 mA h g^(−1) after 200 cycles at 100 mA g^(−1)),and exceptional rate capability(820 mA h g^(−1) at 2000 mA g^(−1))as anode material in LIBs. | Yongqiang Ren Xiuyan Li Yinan Wang Qinghua Gong Shaonan Gu Tingting Gao Xuefeng Sun Guowei Zhou | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 11 | Drug resistance mutation profiles of the drug-nave and first-line regimen-treated HIV-1-infected population of Suzhou, China显示文摘Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance(TDR) and acquired drug resistance mutation(ADR) profiles, we collected blood specimens from 127 drug-naive and 117 first-line drugtreated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified po/fragments from 100 drug-naive and 20 drug-treated samples. We then determined the drugresistant mutations to protease(PR) and reverse-transcriptase(RT) inhibitors according to the Stanford drug resistance database. Overall, 11 and 13 individuals had transmitted(drug-naive group) and acquired(treated group) resistance mutations, respectively. Six transmitted drugresistant mutations were found, including two mutations(L33F and L76V) in the protease region and four(K70N/E and V179D/E) in the RT region. Only L76 V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors. All 13 treated participants who had major drug resistance mutations demonstrated intermediate to high resistance to efavirenz and nevirapine, and six had a treatment duration of less than three months. No major mutations to RT inhibitors were found, implying that the epidemic of transmitted resistance mutations was not significant in this area. Our results suggest that more frequent virus load and drug resistance mutation tests should be conducted for individuals receiving antiretroviral treatment, especially for newly treated patients. Our research provides insights into the occurrence of HIV-1 drug resistance in Suzhou and will help to optimize the treatment strategy for this population. | Tingting Li Feng Qian Ting Yuan Weilu Xu Li Zhu Jinlong Huang Haiyan Wang Yueping Zhu Yinling Wang Xiaohong Li Saihong Gu Zhuqing Tan Hui Chen Xiangrong Luo Wei Zhu Weniuan Lu Ping Xu Ming Li Yuying Chen Yong Gao Rongge Yang Chuanwu Zhu Binlian Sun | 2017 | Virologica Sinica2017，32，4： | 2 |
| 12 | Surface sulfur vacancies enhanced electron transfer over Co-ZnS quantum dots for efficient degradation of plasticizer micropollutants by peroxymonosulfate activation显示文摘Peroxymonosulfate(PMS)activation in heterogeneous processes is a promising water treatment technology.Nevertheless,the high energy consumption and low efficiency during the reaction are ineluctable,due to electron cycling rate limitation.Herein,a new strategy is proposed based on a quantum dots(QDs)/PMS system.Co-ZnS QDs are synthesized by a water phase coprecipitation method.The inequivalent lattice-doping of Co for Zn leads to the generation of surface sulfur vacancies(SVs),which modulates the surface of the catalyst to form an electronic nonequilibrium surface.Astonishingly,the plasticizer micropollutants can be completely degraded within only tens of seconds in the Co-Zn S QDs/PMS system due to this type of surface modulation.The interfacial reaction mechanism is revealed that pollutants tend to be adsorbed on the cobalt metal sites as the electron donors,where the internal electrons of pollutants are captured by the metal species and transferred to the surface SVs.Meanwhile,PMS adsorbed on the SVs is reduced to radicals by capturing electrons,achieving effective electron recovery.Dissolved oxygen(DO)molecules are also easily attracted to catalyst defects and are reduced to O_(2)^(·-),further promoting the degradation of pollutants. | Yuting Gu Tingting Gao Fagen Zhang Chao Lu Wenrui Cao Ziwei Fu Chun Hu Lai Lyu | 2022 | Chinese Chemical Letters2022，33，8： | 2 |
| 13 | Internal wave parameters retrieval from space-borne SAR image显示文摘基于散布成像的成像机制和微波为海洋的表面特征建模的海洋的内部波浪 SAR,我们开发了一个新方法从 SAR 形象提取内部波浪参数。第一,起始的风地从 NCEP 分析数据,海水密度和海洋的内部波浪被导出 pycnocline 深度从利未夫数据被估计,内部波浪导致的表面水流根据 KDV 方程被计算。NRCS 侧面然后被解决行动平衡方程并且使用海表面雷达反散射模型模仿。风和内部波浪 pycnocline 深度被一步一步地使用两分方法让模仿的数据接近 SAR 图象调整。然后,当在模仿的信号和 SAR 图象之间合适的最好出现时,风速度, pycnocline 深度,阶段速度,组速度和内部波浪的振幅能从 SAR 形象被检索。方法在 Dongsha 岛附近在一幅景色 SAR 图象上被测试,在华南海,结果证明模仿的海洋的内部波浪 NRCS 侧面象90%一样高在有关联系数的 SAR 图象上在对那的好同意,并且从 SAR 形象检索的海洋的内部波浪的振幅与 SODA 数据是可比较的。而且,阶段速度在华南海从另外的 16 幅景色 SAR 图象检索了在对描述在内部波浪阶段速度和水深度之间的关系的实验公式的好同意,根平均数平方和相对错误是不到 0.11 ms -1并且7%,分别地,显示 SAR 图象为在这份报纸开发的内部波浪参数检索和方法是有用的会聚、适用。 | Kaiguo FAN Bin FU Yanzhen GU Xingxiu YU Tingting LIU Aiqin SHI Ke XU Xilin GAN | 2015 | Frontiers of Earth Science2015，9，4： | 2 |
| 14 | Self-powered electronic paper with energy supplies and information inputs solely from mechanical motions显示文摘The electronic paper(E-paper)displays features such as flexibility,sunlight visibility,and low power consumption,which makes it ideal for Internet of Things(IoT)applications where the goal is to eliminate bulky power modules.Here,we report a unique self-powered E-paper(SPEP),where information inputs and energy supplies are all converted from mechanical motion by a triboelectric nanogenerator(TENG).The operation of an electrophoretic E-paper is first investigated,identifying the current density as a determinative parameter for driving pigment particle motion and color change.Electrical and optical responses of the E-paper driven by a slidingmode TENG are then found to be consistent with that under a current source mode.All-in-one monochromic and chromatic SPEPs integrated with a flexible transparent TENG are finally demonstrated,and a pixelated SPEP is discussed for future research.The sliding-driven mechanism of SPEP allows for a potential handwriting function,is free of an extra power supply,and promises undoubtedly a wide range of future applications. | YIFAN GU TINGTING HOU PENG CHEN JINXIN CAO CHONGXIANG PAN WEIGUO HU BO-RU YANG XIONG PU AND ZHONG LIN WANG | 2020 | Photonics Research2020，8，9： | 2 |
| 15 | Origin of High Efficiency and Long-Term Stability in Ionic Liquid Perovskite Photovoltaic显示文摘Environment-friendly protic amine carboxylic acid ionic liquids(ILs)as solvents is a significant breakthrough with respect to traditional highly coordinating and toxic solvents in achieving efficient and stable perovskite solar cells(PSCs)with a simple one-step air processing and without an antisolvent treatment approach.However,it remains mysterious for the improved efficiency and stability of PSCs without any passivation strategy.Here,we unambiguously demonstrate that the three functions of solvents,additive,and passivation are present for protic amine carboxylic acid ILs.We found that the ILs have the capability to dissolve a series of perovskite precursors,induce oriented crystallization,and chemically passivate the grain boundaries.This is attributed to the unique molecular structure of ILs with carbonyl and amine groups,allowing for strong interaction with perovskite precursors by forming C=O…Pb chelate bonds and N-H…I hydrogen bonds in both solution and film.This finding is generic in nature with extension to a wide range of IL-based perovskite optoelectronics. | Lingfeng Chao Tingting Niu Hao Gu Yingguo Yang Qi Wei Yingdong Xia Wei Hui Shouwei Zuo Zhaohua Zhu Chengjie Pei Xiaodong Li Jing Zhang Junfeng Fang Guichuan Xing Hai Li Xiao Huang Xingyu Gao Chenxin Ran Lin Song Li Fu Yonghua Chen Wei Huang | 2020 | Research2020，，1： | 2 |
| 16 | 100 Hertz frame-rate switching threedimensional orbital angular momentum multiplexing holography via cross convolution显示文摘The orbital angular momentum(OAM)of light has been implemented as an information carrier in OAM holography.Holographic information can be multiplexed in theoretical unbounded OAM channels,promoting the applications of optically addressable dynamic display and high-security optical encryption.However,the frame-rate of the dynamic extraction of the information reconstruction process in OAM holography is physically determined by the switching speed of the incident OAM states,which is currently below 30 Hz limited by refreshing rate of the phase-modulation spatial light modulator(SLM).Here,based on a cross convolution with the spatial frequency of the OAM-multiplexing hologram,the spatial frequencies of an elaborately-designed amplitude distribution,namely amplitude decoding key,has been adopted for the extraction of three-dimensional holographic information encoded in a specific OAM information channel.We experimentally demonstrated a dynamic extraction frame rate of 100 Hz from an OAM multiplexing hologram with 10 information channels indicated by individual OAM values from-50 to 50.The new concept of cross convolution theorem can even provide the potential of parallel reproduction and distribution of information encoded in many OAM channels at various positions which boosts the capacity of information processing far beyond the traditional decoding methods.Thus,our results provide a holographic paradigm for high-speed 3D information processing,paving an unprecedented way to achieve the high-capacity short-range optical communication system. | Weijia Meng Yilin Hua Ke Cheng Baoli Li Tingting Liu Qinyu Chen Haitao Luan Min Gu Xinyuan Fang | 2022 | Opto-Electronic Science2022，1，9： | 2 |
| 17 | Novel amperometric assay for drug–DNA interaction based on an inhibitory effect on an electrocatalytic activity of DNA–Cu(II) complex显示文摘 | Tingting Gu Yasushi Hasebe | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 18 | Synthesis and characterization of a novel MPEG–chitosan diblock copolymer and self-assembly of nanoparticles显示文摘 | XiangYe Kong XingYi Li XiuHong Wang TingTing Liu YingChun Gu Gang Guo Feng Luo Xia Zhao YuQuan Wei ZhiYong Qian | 2009 | Carbohydrate Polymers2009，，1： | 1 |
| 19 | Current progress in the development of prophylactic and therapeutic vaccines显示文摘Vaccines are essential public health tools and play an important role in reducing the burden of infectious diseases in the population.Emerging infectious diseases and outbreaks pose new challenges for vaccine development,requiring the rapid design and production of safe and effective vaccines against diseases with limited resources.Here,we focus on the development of vaccines in broad fields ranging from conventional prophylactic vaccines against infectious diseases to therapeutic vaccines against chronic diseases and cancer,providing a comprehensive overview of recent advances in eight different vaccine forms(live attenuated vaccines,inactivated vaccines,polysaccharide and polysaccharide conjugate vaccines,recombinant subunit vaccines,virus-like particle and nanoparticle vaccines,polypeptide vaccines,DNA vaccines,and m RNA vaccines)and the therapeutic vaccines against five solid tumors(lung cancer,breast cancer,colorectal cancer,liver cancer and gastric cancer),three infectious diseases(human immunodeficiency virus,hepatitis B virus and human papillomavirus-induced diseases)and three common chronic diseases(hypertension,diabetes mellitus and dyslipidemia).We aim to provide new insights into vaccine technologies,platforms,applications and understanding of potential next-generation preventive and therapeutic vaccine technologies,paving the way for the vaccines design in the future. | Tingting Li Ciying Qian Ying Gu Jun Zhang Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 20 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
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