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| 1 | The association of benign prostatic hyperplasia with lower urinary tract stones in adult men: A retrospective multicenter study显示文摘Objective:To examine the relationship between benign prostatic hyperplasia(BPH)and the presence of lower urinary tract stones.Methods:We retrospectively reviewed the records of men with lower urinary tract stones who presented to three clinical centers in Korea over a 4-year period.We divided the patients into two groups based on the location of urinary stones:Group 1(bladder calculi)and Group 2(urethral calculi).We compared the characteristics of both groups and performed univariate and multivariate analyses with a logistic regression model to investigate the relationship between BPH and lower urinary tract stones.Results:Of 221 patients,194(87.8%)had bladder calculi and 27(12.2%)had urethral calculi.The mean age of Group 1 was higher than that of Group 2(68.9612.11 years vs.55.7414.20 years,p<0.001).The mean prostate volume of Group 1 was higher than that of Group 2(44.4727.14 mL vs.24.706.41 mL,respectively,p<0.001).Multivariate logistic regression showed that age(OR Z 1.075,95%CI:1.023e1.129)and prostate volume(OR Z 1.069,95%CI:1.017e1.123)were independently associated with increased risk for bladder calculi.Upper urinary tract stones and/or hydronephrosis conferred a 3-fold risk for urethral calculi(OR Z 3.468,95%CI:1.093e10.999).Conclusion:Age and prostate volume are independent risk factors for bladder calculi.In addition,men with upper urinary tract disease are at greater risk for urethral calculi,which may migrate from the upper urinary tract rather than from the bladder. | Jae Hung Jung Jinsung Park Won Tae Kim Hong Wook Kim Hyung Joon Kim Sungwoo Hong Hee Jo Yang Hong Chung | 2018 | Asian Journal of Urology2018，5，2： | 17 |
| 2 | Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum显示文摘Inflammatory myofibroblastic tumor (IMT) of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non-clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall. | Seong-Heum Park Jong-Han Kim Byung Wook Min Tae Jin Song Gil Soo Son Seung Joo Kim Sang Woo Lee Hwan-Hoon Chung Ju Han Lee Jun Won Um | 2008 | World Journal of Gastroenterology2008，14，1： | 8 |
| 3 | Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development显示文摘Cancer is one of the leading causes of death worldwide.Commonly used cancer treatments,including chemotherapy and radiation therapy,often have side effects and a complete cure is sometimes impossible.Therefore,prevention,suppression,and/or delaying the onset of the disease are important.The onset of gastroenterological cancers is closely associated with an individual's lifestyle.Thus,changing lifestyle,specifically the consumption of fruits and vegetables,can help to protect against the development of gastroenterological cancers.In particular,naturally occurring bioactive compounds,including curcumin,resveratrol,isothiocyanates,(-)-epigallocatechin gallate and sulforaphane,are regarded as promising chemopreventive agents.Hence,regular consumption of these natural bioactive compounds found in foods can contribute to prevention,suppression,and/or delay of gastroenterological cancer development.In this review,we will summarize natural phytochemicals possessing potential antioxidant and/or anti-inflammatory and anti-carcinogenic activities,which are exerted by regulating or targeting specific molecules against gastroenterological cancers,including esophageal,gastric and colon cancers. | Min-Yu Chung Tae Gyu Lim Ki Won Lee | 2013 | World Journal of Gastroenterology2013，19，7： | 7 |
| 4 | Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease显示文摘AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April 2011.We also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with DAIBD.An endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was evaluated.To determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were analyzed.RESULTS:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the DAIBD.An endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ulcers.However,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD variance.Patients with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the model.CONCLUSION:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD scores.However,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak. | Hyun Jung Lee Youn Nam Kim Hui Won Jang Han Ho Jeon Eun Suk Jung Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo Nam Jae Hee Cheon | 2012 | World Journal of Gastroenterology2012，18，40： | 5 |
| 5 | Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27显示文摘Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA. | Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won Tae Chung Yoo Jin Oh Jung Ha Kim Seung Hee Yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun Yoo | 2018 | Bone Research2018，6，3： | 3 |
| 6 | Intestinal Behet's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis显示文摘Behet’s disease(BD)is a chronic inflammatory disease affecting multiple organ systems,such as the skin,joints,blood vessels,central nervous system,and gastrointestinal tract.Intestinal BD is characterized by intestinal ulcerations and gastrointestinal symptoms.The medical treatment of intestinal BD includes corticosteroids and immunosupressants.There have been several reports of tumor necrosis factor-α (TNF-α)blockers being successful in treatment of refractory intestinal BD.Here,we report on a patient who was diagnosed with intestinal BD despite treatment with the fully humanized TNF-α blocker(adalimumab)for underlying ankylosing spondylitis.This patient achieved clinical remission and complete mucosal healing through the addition of a steroid and azathioprine to the adalimumab regimen. | Sook Hee Chung Soo Jung Park Sung Pil Hong Jae Hee Cheon Tae Il Kim Won Ho Kim | 2013 | World Journal of Gastroenterology2013，19，32： | 2 |
| 7 | New CT response criteria in non-small cell lung cancer: Proposal and application in EGFR tyrosine kinase inhibitor therapy显示文摘 | Ho Yun Lee Kyung Soo Lee Myung-Ju Ahn Hye Sun Hwang Ju Won Lee Keunchil Park Jin Seok Ahn Tae Sung Kim Chin A Yi Myung Jin Chung | 2010 | Lung Cancer2010，，： | 1 |
| 8 | S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial显示文摘 | Yong Sang Hong Young Suk Park Ho Yeong Lim Jeeyun Lee Tae Won Kim Kyu-pyo Kim Sun Young Kim Ji Yeon Baek Jee Hyun Kim Keun-Wook Lee Ik-Joo Chung Sang-Hee Cho Kyung Hee Lee Sang Joon Shin Hye Jin Kang Dong Bok Shin Sook Jung Jo Jae Won Lee | 2012 | Lancet Oncology2012，，11： | 1 |
| 9 | Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells显示文摘在这研究,我们调查了白果树 biloba 摘录(GBE ) 和 phosphodiesterase 类型的联合的效果 5 (PDE-5 ) 阴茎海绵体和下士的钾隧道活动的肌肉发达的音调上的禁止者弄平肌肉房间。从雄的新西兰白兔子的阴茎海绵体的脱衣为等轴的紧张研究在器官洗澡被装。在有 1 × 的收缩以后; 10 −5 mol l −1 新肾上素, GBE (0.01-1 mg ml −1) 和 mirodenafil (0.01-100 nmol l −1) 一起被增加进机关洗澡。在 electrophysiological 研究,整个房间的水流被常规补丁夹钳技术在人的阴茎海绵体的有教养的光滑的肌肉房间记录。阴茎海绵体以一种剂量依赖者方式响应 GBE 被放松(从 0.64 % ± 8.35 %在 0.01 mg ml −1 到 52.28 % ± 11.42 %在 1 mg ml −1) 。在有 0.03 的预告的处理以后; GBE 的 mg ml −1 , mirodenafil 的弛缓的效果根本被增加集中。在 tetraethylammonium (茶) 以后(1 mmol l −1) 管理,增加的效果被禁止(P< 0.01 ) 。GBE 的细胞外的管理增加了在一个剂量依赖者的外面的水流塑造的整个房间的 K + 。外面的水流的增加被 1 禁止; mmol l −1 茶。这些结果建议 GBE 能甚至在最低限度地有效的剂量增加 mirodenafil 的弛缓的力量。通过钾隧道的 K + 流动可能是涉及这 synergistic 松驰的机制之一。 | Jung Jun Kim Deok Hyun Han Soo Hyun Lim Tae Hun Kim Mee Ree Chae Kyung Jin Chung Sung Chul Kam Ju-Hong Jeon Jong Kwan Parks Sung Won Lee | 2011 | Asian Journal of Andrology2011，13，5： | 1 |
| 10 | Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: An 8-week, multicenter, randomized, open-label, dose-titration study in korean patients with hypercholesterolemia显示文摘 | Sang Hak Lee Namsik Chung Jun Kwan Doo-Il Kim Won Ho Kim Chee Jeong Kim Hyun Seung Kim Si Hoon Park Hong Seog Seo Dong Gu Shin Yung Woo Shin Wan-Joo Shim Tae Hoon Ahn Kyeong Ho Yun Myeong-Ho Yoon Kwang-Soo Cha Si-Wan Choi Seong Wook Han Min Su Hyon | 2007 | Clinical Therapeutics2007，，11： | 1 |
| 11 | On the uncertainty in the current waveform measurement of an ESD generator 显示文摘 | Kang Tae - Weon Chung Yeon - Choon Won Sung -Ho | 2000 | IEEE Transactions on Electromagnetic Compatibility2000，42，4： | 1 |
| 12 | Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea显示文摘AIM:To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease(IBD)patients.METHODS:We obtained clinical data on Crohn’s disease(CD)(n=691)and ulcerative colitis(n=1113)from a tertiary referral medical center between 2005and 2012.Seventeen patients(2.5%)with CD and27 patients(2.4%)with ulcerative colitis(UC)were identified as having a familial history of IBD,including the first and second degree relatives.For each control case,three times the number of age-,sex-,and diagnosis year-matched CD and UC patients,without a family history of IBD,were randomly selected in this case control study.RESULTS:There were no significant differences in age or main symptom at diagnosis,extraintestinal manifestation,location/extent,behavior of disease activity,number of hospitalizations,number of operations,operation type,number of relapses,or oral medical treatment between familial and sporadic CD and UC patients.Median(min-max)follow-up periods after diagnosis of familial CD and sporadic CD patients were 84(24-312)and 36(8-240)mo,respectively(P=0.008).Familial CD patients more frequently used anti-tumor necrosis factor(TNF)antibodies compared to sporadic CD patients(17.6%vs 0%,P=0.014).CONCLUSION:In conclusion,a family history of IBD does not seem to be an important predictive factor affecting clinical characteristics or disease course even if there is a more frequent use of anti-TNF antibodies in familial CD patients compared to sporadic CD patients. | Sook Hee Chung Soo Jung Park Hye Sun Lee Sung Pil Hong Jae Hee Cheon Tae Ⅱ Kim Won Ho Kim | 2014 | World Journal of Gastroenterology2014，20，45： | 1 |
| 13 | The significance of laryngopharyngeal reflux in benign vocal mucosal lesions显示文摘 | Jae Ho Chung Kyung Tae Yong Seop Lee Jin Hyeok Jeong Seok Hyun Cho Kyung Rae Kim Chul Won Park Dong Soo Han | 2009 | Otolaryngology - Head and Neck Surgery2009，，： | 1 |
| 14 | Monoclonal antibody-based enzyme-linked immunosorbent assays for the detection of the organophosphorus insecticide isofenphos显示文摘 | Won Young Lee Eun Kyung Lee Yoo Jung Kim Won Chul Park Taeowan Chung Yong Tae Lee | 2005 | Analytica Chimica Acta2005，，1： | 1 |
| 15 | Cloning,Mutagenesis,and Expression of the Acetylcholinesterase Gene from a Strain of Musca domestica;the Change from a Drug-resistant to a Sensitive Enzyme显示文摘 | Chung Sei Kim Won Tae Kim Kyung Saeng Boo | 2003 | Molecules and Cells2003，，： | 1 |
| 16 | The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis显示文摘 | Jin Ha Lee Jae Hee Cheon Eun Soo Kim Moon Jae Chung Wonseok Kang Duk Hwan Kim You Jung Ha Jae Jun Park Tae Il Kim Won Ho Kim | 2010 | Digestive Diseases and Sciences2010，，5： | 1 |
| 17 | On the Uncertainty in the Current Waveform Measurement of an ESD Generator, Electromagnetic Compatibility显示文摘 | Sung - Ho Won Hyo - Tae Kim | 2000 | IEEE Transactions on2000，42，11： | 1 |
| 18 | Successful kidney transplantation from an expanded criteria donor with long-term extracorporeal membrane oxygenation treatment: A case report显示文摘BACKGROUND Due to a shortage of donor kidneys, many centers have utilized graft kidneys from brain-dead donors with expanded criteria. Kidney transplantation(KT)from donors on extracorporeal membrane oxygenation(ECMO) has been identified as a successful way of expanding donor pools. However, there are currently no guidelines or recommendations that guarantee successful KT from donors undergoing ECMO treatment. Therefore, acceptance of appropriate allografts from those donors is solely based on clinician decision.CASE SUMMARY We report a case of successful KT from a brain-dead donor supported by ECMO for the longest duration to date. A 69-year-old male received a KT from a 63-yearold brain-dead donor who had been on therapeutic ECMO treatment for the previous three weeks. The recipient experienced slow recovery of graft function after surgery but was discharged home on post-operative day 17 free from hemodialysis. Allograft function gradually improved thereafter and was comparatively acceptable up to the 12 mo follow-up, with serum creatinine level of 1.67 mg/d L.CONCLUSION This case suggests that donation even after long-term ECMO treatment could provide successful KT to suitable candidates. | Hye Won Seo Sua Lee Hwa Young Lee Sun Cheol Park Byung Ha Chung Chul Woo Yang Tae Hyun Ban | 2020 | World Journal of Clinical Cases2020，8，3： | 1 |
| 19 | The long-term course of ground-glass opacities detected on thin-section computed tomography显示文摘 | Sei Won Lee Cho-Sun Leem Tae Jung Kim Kyung Won Lee Jin-Haeng Chung Sanghoon Jheon Jae-Ho Lee Choon-Taek Lee | 2013 | Respiratory Medicine2013，，6： | 1 |
| 20 | Clinicopathologic Characteristics and Malignant Potential of Colorectal Flat Neoplasia Compared with that of Polypoid Neoplasia显示文摘 | Dong Hun Park M.D. Hyun Soo Kim M.D. Won Ho Kim M.D. Tae Il Kim M.D. Young Ho Kim M.D. Dong Il Park M.D. Hyo Jong Kim M.D. Suk-Kyun Yang M.D. Jeong-Sik Byeon M.D. Moon Sung Lee M.D. Il Kwun Chung M.D. Sung Ae Jung M.D. Yoon Tae Jeen M.D. Jai Hyun Choi M.D | 2008 | Diseases of the Colon & Rectum2008，，1： | 1 |
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