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| 1 | Randomized controlled trial of sodium phosphate tablets vs polyethylene glycol solution for colonoscopy bowel cleansing显示文摘AIM:To compare efficacy,patient compliance,acceptability,satisfaction,safety,and adenoma detection rate of sodium phosphate tablets(NaP,CLICOLONTM)to a standard 4 L polyethylene glycol(PEG)solution for bowel cleansing for adults undergoing colonoscopy.METHODS:In this multicenter,randomized,prospective,investigator-blind study,the relatively young(19-60years)healthy outpatients without comorbidity were randomly assigned to one of two arms.All colonoscopy were scheduled in the morning.The NaP group was asked to take 4 tablets,5 times the evening before and4 tablets,3 times early on the morning of the colonoscopy.The PEG group was asked to ingest 2 L of solution the evening before and 2 L early in the morning of the procedure.Adequacy of bowel preparation was scored using the Boston bowel preparation scale.RESULTS:No significant differences were observed between the NaP group(n=158)and PEG group(n=162)in bowel cleansing quality(adequate preparation93.0%vs 92.6%,P=0.877),patient compliance(P=0.228),overall adverse events(63.3%vs 69.1%,P=0.269),or adenoma detection rate(34.8%vs 35.2%,P=0.944).Patient acceptability,satisfaction,and patient rating of taste were higher in the NaP group than in the PEG group(P<0.001).CONCLUSION:NaP tablets,compared with PEG solution,produced equivalent colon cleansing,did not cause more side effects,and had better patient acceptability and satisfaction in the relatively young(age<60years)healthy individuals without comorbidity.An oral tablet formulation could make bowel preparation less burdensome,resulting in greater patient participation in screening programs. | Yoon Suk Jung Chang Kyun Lee Hyo Jong Kim Chang Soo Eun Dong Soo Han Dong Ⅱ Park | 2014 | World Journal of Gastroenterology2014，20，42： | 9 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease显示文摘AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April 2011.We also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with DAIBD.An endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was evaluated.To determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were analyzed.RESULTS:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the DAIBD.An endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ulcers.However,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD variance.Patients with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the model.CONCLUSION:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD scores.However,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak. | Hyun Jung Lee Youn Nam Kim Hui Won Jang Han Ho Jeon Eun Suk Jung Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo Nam Jae Hee Cheon | 2012 | World Journal of Gastroenterology2012，18，40： | 5 |
| 4 | Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors显示文摘BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management.AIM To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions.METHODS In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the diagnosis.The time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the cases.RESULTS Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeated IFND cases and resulted in low diagnostic accuracy even on retrospective blinded review.CONCLUSION More than two clinical and pathologic factors each had significant cut-off values for gastric carcinoma diagnosis; in such cases, endoscopic resection should be considered. | Mi Jung Kwon Ho Suk Kang Hyeon Tae Kim Jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong Hyeok Kim Hye-Rim Park Soo Kee Min Jin won Seo Ji-Young Choe | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 5 | Risk factors for tuberculosis after gastrectomy in gastric cancer显示文摘AIM: To examine incidence of tuberculosis(TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric cancer.METHODS: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios(SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were analyzed.RESULTS: Among the 1776 gastrectomy patients, 0.9%(16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher thanthat in the general population(SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio(OR) = 7.1, P < 0.001], lower body mass index(BMI)(kg/m2; OR = 1.21, P = 0.043) and gastrectomy extent(total gastrectomy vs subtotal gastrectomy)(OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate analysis.CONCLUSION: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer. | Won Jai Jung Young Mok Park Joo Han Song Kyung Soo Chung Song Yee Kim Eun Young Kim Ji Ye Jung Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Sung Hoon Noh Ji Yeong An Young Ae Kang | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 6 | Comparison of Clevudine and Entecavir for Treatment-naive Patients With Chronic Hepatitis B Virus Infection: Two-Year Follow-up Data显示文摘 | Eileen L. Yoon Hyung Joon Yim Hyun Jung Lee Young Sun Lee Jeong Han Kim Eun Suk Jung Ji Hoon Kim Yeon Seok Seo Jong Eun Yeon Hong Sik Lee Soon Ho Um Kwan Soo Byun | 2011 | Journal of Clinical Gastroenterology2011，，10： | 3 |
| 7 | MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer显示文摘 | Ji Heon Noh Young Gyoon Chang Min Gyu Kim Kwang Hwa Jung Jeong Kyu Kim Hyun Jin Bae Jung Woo Eun Qingyu Shen Seung-Jin Kim So Hee Kwon Won Sang Park Jung Young Lee Suk Woo Nam | 2013 | Cancer Letters2013，，2： | 2 |
| 8 | Prognostic implications of EGFR and HER-2 alteration assessed by immunohistochemistry and silver in situ hybridization in gastric cancer patients following curative resection显示文摘 | Ho Suk Oh Dae-Woon Eom Gil Hyun Kang Yong Chel Ahn Sang Jin Lee Ji-Hoon Kim Hyuk Jai Jang Eun Jung Kim Kwang Hoon Oh Heui June Ahn | 2014 | Gastric Cancer2014，，3： | 2 |
| 9 | Nonalcoholic fatty liver disease is associated with coronary artery calcification显示文摘 | Donghee Kim Su‐Yeon Choi Eun Ha Park Whal Lee Jin Hwa Kang Won Kim Yoon Jun Kim Jung‐Hwan Yoon Sook Hyang Jeong Dong Ho Lee Hyo‐suk Lee Joseph Larson Terry M. Therneau W. Ray Kim | 2012 | Hepatology2012，，2： | 2 |
| 10 | Clinical Application of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Progressive Hemifacial Atrophy (Parry-Romberg Disease) With Microfat Grafting Techniques Using 3-Dimensional Computed Tomography and 3-Dimensional Camera显示文摘 | Kyung Suk Koh Tae Suk Oh Hoon Kim In Wook Chung Kang Woo Lee Hyo Bo Lee Eun Jung Park Jae Seob Jung Il Seob Shin Jeong Chan Ra Jong Woo Choi | 2012 | Annals of Plastic Surgery2012，，3： | 2 |
| 11 | The Accuracy of Noninvasive Methods in Predicting the Development of Hepatocellular Carcinoma and Hepatic Decompensation in Patients With Chronic Hepatitis B显示文摘 | Young Eun Chon Eun Suk Jung Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Kyu Sik Jung Seung Up Kim | 2012 | Journal of Clinical Gastroenterology2012，，6： | 2 |
| 12 | TomatoNet A Genome-wide Co-functional Network for Unveiling Complex Traits of Tomato, a Model Crop for Fleshy Fruits显示文摘 | Hyojin Kim Bong Suk Kim Jung Eun Shim Sohyun Hwang Sunmo Yang Eiru Kim Aniafi S. Iver-Pascuzzi2 Insuk Lee | 2017 | Molecular Plant2017，10，4： | 1 |
| 13 | Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis显示文摘 | Eun Yeon Joo Seung Bong Hong Woo Suk Tae Jee Hyun Kim Sun Jung Han Dae Won Seo Kyung-Han Lee Myoung-Hee Kim Seunghwan Kim Mann Hyung Lee Byung Tae Kim | 2005 | European Journal of Nuclear Medicine and Molecular Imaging2005，，10： | 1 |
| 14 | Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP‐BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer显示文摘 | Areumnuri Kim Jung‐Eun Lee Seung‐Sook Lee Cherin Kim Sun‐Joo Lee Won‐Suk Jang Sunhoo Park | 2013 | Int J Cancer2013，，4： | 1 |
| 15 | Impact of Baseline Plaque Components on Plaque Progression in Nonintervened Coronary Segments in Patients With Angina Pectoris on Rosuvastatin 10 mg/day显示文摘 | Young Joon Hong Myung Ho Jeong Yun Ha Choi Eun Hye Ma Jum Suk Ko Min Goo Lee Keun Ho Park Doo Sun Sim Nam Sik Yoon Hyun Ju Youn Kye Hun Kim Hyung Wook Park Ju Han Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2010 | The American Journal of Cardiology2010，，9： | 1 |
| 16 | Comparison of the methods for tumor response assessment in patients with hepatocellular carcinoma undergoing transarterial chemoembolization显示文摘 | Eun Suk Jung Ji Hoon Kim Eileen L. Yoon Hyun Jung Lee Soon Jae Lee Sang Jun Suh Beom Jae Lee Yeon Seok Seo Hyung Joon Yim Tae-Seok Seo Chang Hee Lee Jong Eun Yeon Jong-Jae Park Jae Seon Kim Young Tae Bak Kwan Soo Byun | 2013 | Journal of Hepatology2013，，6： | 1 |
| 17 | HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘 | Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda | 2006 | Digestive Diseases and Sciences2006，，8： | 1 |
| 18 | Plaque Characteristics in Culprit Lesions and Inflammatory Status in Diabetic Acute Coronary Syndrome Patients显示文摘 | Young Joon Hong Myung Ho Jeong Yun Ha Choi Jum Suk Ko Min Goo Lee Won Yu Kang Shin Eun Lee Soo Hyun Kim Keun Ho Park Doo Sun Sim Nam Sik Yoon Hyun Ju Yoon Kye Hun Kim Hyung Wook Park Ju Han Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2009 | JACC: Cardiovascular Imaging2009，，3： | 1 |
| 19 | Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: Matched case–control study显示文摘 | Jeong Il Yu Doo Ho Choi Won Park Seung Jae Huh Eun Yoon Cho Young Hyuk Lim Jin Suk Ahn Jung Hyun Yang Suk Jin Nam | 2010 | The Breast2010，，3： | 1 |
| 20 | HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘 | Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda | 2006 | Digestive Diseases and Sciences2006，，8： | 1 |
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