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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | The repeatability of superovulatory response and embryo recovery in sheep显示文摘 | Bari F Khalid M Wolf B Haresigh W Murray A Merrell B | 2001 | Theriogenology2001，56，1： | 1 |
| 3 | Effect of an angiotensin Ⅱ receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis显示文摘 | MOLTENI A WOLFE L F WARD W F | 2007 | Current Pharmaceutical Design2007，13，13： | 1 |
| 4 | CO2 enhanced coalbed methane production in the Netherlands显示文摘 | Hamelinck C N Faaij A P C Turkenburg W C F van Bergen Pagnier H J M Barzandji O H M Wolf K -H A A Ruijg G J | 2002 | Energy2002，27，7： | 1 |
| 5 | Conservation of methylation reprogramming in mammalian development:aberrant reprogramming in cloned embryos显示文摘 | Dean W Santos F Stojkovic M Zakhartchenko V Walter J Wolf E Reik W | 2001 | Proceedings of the National Academy of Sciences2001，98，13： | 1 |
| 6 | Hematologic and semen quality changes in bulls with experimental eperythrozoon infection显示文摘 | WELLES E G TYLER J W WOLFE D F | 1995 | Teriogenology1995，43，： | 1 |
| 7 | Eperythro-zoon infection in young bulls with scrotal and hindlimb edema,a herd outbreak显示文摘 | WELLES E G TYLER J W WOLFE D F | 1995 | Teriogenology1995，43，： | 1 |
| 8 | Regulation of mineral nitrogen uptake in plants显示文摘 | Nicolaus yon W Sonia Ga Wolf B F | 1997 | Plant and Soil1997，196，2： | 1 |
| 9 | Eye-to-hand coordination for vision-guided robot control application 显示文摘 | Wijiesoma S W Wolfe D F H Richards R J | 1993 | Int J of Robotics Research1993，12，1： | 1 |
| 10 | Load-displacement behavior in a distal radius fracture mode the effect of simulated healing on motion显示文摘 | Wolfe F W Lorenze M D Ausn G | 1999 | J bone Joint Surg AM1999，81，1： | 1 |
| 11 | Development of the paranasal sinuses in children:implications for paranasal sinus surgery显示文摘 | WOLF G ANDERHUBER W KUHN F | 1993 | Ann Otol Rhinol Laryngol1993，102，： | 1 |
| 12 | Familial influences and obesity-associated metabolic risk factors contribute to the variation in resting energy expenditure:The kiel obesity prevention study显示文摘 | Bosy W A Wolf A Buhrens F | 2008 | Aln J Clin Nutr2008，87，6： | 1 |
| 13 | Estrogen receptor distribution in enucleated breast cancer cell lines 显示文摘 | Welshons W V Cormier E M Wolf M F | 1988 | Endocrinology1988，122，： | 1 |
| 14 | Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos显示文摘 | SANTOS F WOLF E DEAN W | 2003 | Curr Biol2003，13，： | 1 |
| 15 | 显示文摘 | Cillessen M J F Prins M W J Wolf R M | 1997 | J Appl Phys1997，81，6： | 1 |
| 16 | Structural basis of ferroelectricity in the bismuth titanate family显示文摘 | Newnham R E Wolfe R W Dorrian J F | 1971 | Mater Res Bull1971，6，10： | 1 |
| 17 | Ferroelectric schorrky diode显示文摘 | Blom P W M Wolf R M Cillessen J F M | 1994 | Phys Rev Lett1994，73，： | 1 |
| 18 | Rheumatoid arthritis 显示文摘 | Scott D L Wolfe F Huizinga T W | 2010 | Lancet2010，376，9746： | 1 |
| 19 | Requirements of PECVD SiN(X):H layers for bulk passivation of mc-Si显示文摘 | DEKKERS H F W WOLF S D AGOSTINELLI G | 2006 | Solar Energy Materials & Solar Cells2006，90，1819： | 1 |
| 20 | Rheumatoid ar- thritis 显示文摘 | SCOOT D L WOLFE F HUIZINGA T W | 2010 | Lancet2010，376，9746： | 1 |
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