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140篇 您的检索式：作者名="Witte O"

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	题名	作者	年代	出处	被引量
1	葛根素和大豆甙元抑制^3H-氟硝西泮和体外大鼠脑膜的结合显示文摘目的从中药葛根中提取脑内苯并二氮杂卓(BZ)受体活性化合物。方法用体外的放射配体-受体结合法(RRA)和高压液相法(HPLC)提取、分离、纯化BZ受体活性化合物,用核磁共振和质谱仪确定活性化合物的结构。后用GABA比和Scatchardplot分析确定它们的作用特性。结果从葛根中提取、分离到葛根素和大豆甙元2种活性化合物。它们在体外可抑制3H-氟硝西泮和脑细胞膜的结合,IC50值分别为(18.46±2.34)μmol/L和(15.4±31.89)μmol/L。大豆甙元还可抑制3H-呱唑嗪和α1-肾上腺素受体的结合(IC50值为89μmol/L)。2种化合物的GABA比分别为1.11和1.12,提示2种黄酮化合物是BZ受体的拮抗剂或部分激动剂。Scatchardplot分析显示2种化合物对3H-氟硝西泮和脑膜结合的抑制是通过竞争性与非竞争性混合机制而实现的。结论葛根素和大豆甙元是脑内BZ受体的拮抗剂或部分激动剂。它们的抑制作用是通过竞争性与非竞争性混合机制而实现的。	沈行良 Witt MR Nielsen M Sterner O	2004	海南医学院学报2004，10，3：	3
2	Modeling Philadelphia chromosome positive leukemias显示文摘	WONG S WITTE O N	2001	Oncogene2001，20，40：	1
3	HDAC family:What are the cancer relevant targets?显示文摘	Witt O Deuhzer HE Milde T	2009	Cancer Lett2009，277，1：	1
4	Tackling antibiotic resistance显示文摘	Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr		0，，：	1
5	Commentary concerning demonstration of safety and efficacy of investigational anticancer agents in clinical trials显示文摘	O'Shaughnessy JA Wittes RE Burke G	1991	J Clin Oncol1991，9，：	1
6	Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals显示文摘	Andersson E A Pilgaard K Pisinger C Harder M N Grarup N Faerch K Sandholt C Poulsen P Witte D R Jorgensen T Vaag A Pedersen O and Hansen T		0，，12：	1
7	The Sea21 cell surface marker enriches for a prostate regenerating cell subpopulation that can initiate prostate tumorigenesis显示文摘	Xin L Lawson D A Witte O N	2005	Proc Natl Aead Sei USA2005，102，19：	1
8	Steel locus defines new multipotent growth factor 显示文摘	Witte O N	1990	Cell1990，63，：	1
9	Extended recombi- nant bacterial ghost system显示文摘	Lubitz W Witte A Eko F O	1999	J Biotechnol1999，73，：	1
10	Long-term efficacy of early versus delayed radiotherapy for low-grade astroeytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial 显示文摘	van den Bent M J Afra D de Witte O	2005	Lancet2005，366，9490：	1
11	Activation of the e-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties 显示文摘	Davis R L Konopka J B Witte O N	1985	Mol Cell Biol1985，5，1：	1
12	Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglima in adults: the EORTC 22845 randomised trial 显示文摘	Van den Bent M J Afra D De Witte O	2005	Lancet2005，366，9490：	1
13	Recurrent posterior reversible encephalopathy syndrome (PRES)显示文摘	Hagemann G Ugur T Witte O	2004	J Hum Hypertens2004，18，4：	1
14	Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways显示文摘	Witt O Sand K Pekrun A	2000	Blood2000，95，7：	1
15	Minimally invasive endoscopic unilateral transsphenoidal surgery for pituitary adenomas显示文摘	DE WITTE O CARLOT S DEVUYST E	2011	B-ENT2011，717，：	1
16	Valproic acid treatment of glioblastoma multiforme in a child显示文摘	Witt O Schweigerer L Driever PH	2004	Pediatr Blood Cancer2004，43，：	1
17	The dime- rization property of glutathione S-transferase partially reactivates Bcr-AbI lacking the oligomerization domain 显示文摘	Maru Y Afar D E Witte O N Shibuya M	1996	J BiolChem1996，271，15：	1
18	Commentary concerning demonstration of safety and efficacy of invest- igational anticancer agents in clinical trials显示文摘	O'Shaughnessy JA Wittes RE Burke G		J C1 in On- col0，，9：	1
19	Positron emission tomography with injection of methionine as a prognostic factor in glioma 显示文摘	Goldberg I Wikler D	2001	J Neurosurg2001，95，5：	1
20	Differential inhibition of human prostaglandin endoperoxide H synthases-1 and-2 by nonsteroidal anti-inflammatory drugs 显示文摘	Laneuville O Breuer D K De Witt D L	1994	Pharmacol Exp Ther1994，271，：	1

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