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| 1 | Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]显示文摘There is a rapidly growing demand to use silicon and silicon nitride(Si3N4) integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip. | Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie Utsav Deepak Dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets | 2015 | Photonics Research2015，3，5： | 7 |
| 2 | Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions显示文摘 | Judy A. Cossins John M. Clements Janice Ford Karen M. Miller Rod Pigott Wim Vos P. Van Der Valk C. J. A. De Groot | 1997 | Acta Neuropathologica1997，，6： | 1 |
| 3 | Empirical estimates of the rate of depreciation of education显示文摘 | Wim Groot | | 0，，： | 1 |
| 4 | Overeducation in the labor market:a meta-analysis 显示文摘 | Wim Groot Henriette Maassen van den Brink | 2000 | economics of education review2000，，19： | 1 |
| 5 | Firm-related training tracks:A random effects ordered probit model显示文摘 | Wim Groot Henriette Maassen van den Brink | 2003 | Economics of Education Review2003，22，： | 1 |
| 6 | A Meta-analysis of the effect of education on social capital 显示文摘 | Jian Huang Henriatte Maassen Van den Brink Wim Groot | 2009 | Economics of Education Review2009，28，4： | 1 |
| 7 | Cost-effectiveness of Adding FDG-PET or CT to the Diagnostic Work-up of Patients With Stage III Melanoma显示文摘 | Esther Bastiaannet Carin A. Uyl-de Groot Adrienne H. Brouwers Eric J. van der Jagt Otto S. Hoekstra Wim Oyen Fred Verzijlbergen Bart van Ooijen John F. Thompson Harald J. Hoekstra | 2012 | Annals of Surgery2012，，4： | 1 |
| 8 | Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut显示文摘 | Michel Groot Antoi P. W. Meeuwis Peter J. M. Kok Frans H. M. Corstens Wim J. G. Oyen | 2005 | European Journal of Nuclear Medicine and Molecular Imaging2005，，1： | 1 |
| 9 | Measuring generalised transport costs as an indicator of accessibility changes over time显示文摘 | Carl Koopmans Wim Groot Pim Warffemius Jan Anne Annema Sascha Hoogendoorn-Lanser | 2013 | Transport Policy2013，，： | 1 |
| 10 | Overeducation in the Labor Market: a Metaanalysis显示文摘 | Wim Groot Henriette Maassen van den Brink(2000) | 2000 | Economics of Education Review2000，，： | 1 |
| 11 | Overeducation in the Labor Market: a Metaanalysis显示文摘 | Henriette Maassen van den Brink (2000) | 2000 | Economics of Education Review2000，，： | 1 |
| 12 | Group Incentives for Teachers and Their Effects on Student Learning: A Systematic Review of Theory and Evidence 显示文摘 | Nyasha Tirivayi Henriette Maasen Van Den Brink and Wim Groot | 2014 | School Effectiveness and School Improvement2014，，4： | 1 |
| 13 | Firm - related trainingtracks:a random effects ordered prohit model显示文摘 | Wim Groot Henriette Maassen van den Brink | 2003 | Economics of Educa-tion Review2003，22，6： | 1 |
| 14 | Access to biologicals in Crohn's disease in ten European countries显示文摘AIM To analyze access(availability, affordability and acceptability) to biologicals for Crohn's disease(CD) in ten European countries and to explore the associations between these dimensions, the uptake of biologicals and economic development.METHODS A questionnaire-based survey combined with desk research was carried out in May 2016. Gastroenterologists from the Czech Republic, France, Germany, Hungary, Latvia, Poland, Romania, Slovakia, Spain and Sweden were invited to participate and provide data on the availability of biologicals/biosimilars, reimbursement criteria, clinical practice and prices, and use of biologicals. An availability score was developed to evaluate the restrictiveness of eligibility and administrative criteria applied in the countries. Affordability was defined as the annual cost of treatment as a share of gross domestic product(GDP) per capita. Correlations with the uptake of biologicals, dimensions of access and GDP per capita were calculated.RESULTS At the time of the survey, infliximab and adalimumab were reimbursed in all ten countries, and vedolizumab was reimbursed in five countries(France, Germany, Latvia, Slovakia, Sweden). Reimbursement criteria were the least strict in Sweden and Germany, and the strictest in Hungary, Poland and Slovakia. Between countries, the annual cost of different biological treatments differed 1.6-3.3-fold. Treatments were the most affordable in Sweden(13%-37% of the GDP per capita) and the least affordable in the Central and Eastern European countries, especially in Hungary(87%-124%) and Romania(141%-277%). Biosimilars made treatments more affordable by driving down the annual costs. The number of patients with CD on biologicals per 100000 population was strongly correlated with GDP per capita(0.91), although substantial differences were found in the uptake among countries with similar economic development. Correlation between the number of patients with CD on biologicals per 100000 population and the availability and affordability was also strong(-0.75,-0.69 respectively). CONCLUSION Substantial inequalities in access to biologicals were largely associated with GDP. To explain differences in access among countries with similar development needs further research on acceptance. | Márta Péntek Peter L Lakatos Talitha Oorsprong László Gulácsi Milena Pavlova Wim Groot Fanni Rencz Valentin Brodszky Petra Baji Crohn’s Disease Research Group | 2017 | World Journal of Gastroenterology2017，23，34： | 0 |
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