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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Eine verbesserte Technik der Protargolimpragnation für Ciliaten显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，6，： | 1 |
| 3 | B-crystallin competes with Alzheimer's disease b-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35显示文摘 | Bram K Wilbert C | 2006 | FEBSL Letters2006，580，： | 1 |
| 4 | Eine verbesserte Technik der Protargolimpragnation für Ciliaten显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，6，： | 1 |
| 5 | Eine verbesserte Technik der Protargolimprfignation ftir Ciliaten 显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，64，6： | 1 |
| 6 | Eine verbesserte Technik der Protargolimprigrta- tion for Ciliaten 显示文摘 | Wilbert N | 1975 | Mikrokosmos1975，64，： | 1 |
| 7 | Eine verbesserte Technik der Protargolimpragnation far Ciliaten 显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，6，： | 1 |
| 8 | Morphological investigations on some free living ciliatres (Protozoa, Ciliophora) from China seas with description of a new hypotrichous genus, Hemigastrostyla nov gen显示文摘 | Song W Wilbert N | 1997 | Arch Protistenkd1997，148，： | 1 |
| 9 | Considerations on the position of Uronychia and related euplotids based on the data of ontogeny and 18S rRNA gene sequence analyses, with morphogenetic redescription of Uronychia setigera Calkins, 1902 (Ciliophora: Euplotida) 显示文摘 | Song W Wilbert N Chen Z | 2004 | Acta Protozoologica2004，43，： | 1 |
| 10 | Operational performance of the TIMED doppler interferometer (TIDI) 显示文摘 | WILBERT R S RICK J N TIMOTHY L K | 2003 | Proceedings of SPIE2003，5175，： | 1 |
| 11 | Eine verbesserte technik der protargolimpragnation for Ciliaten显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，64，： | 1 |
| 12 | Invariant object recog- nition and pose estimation with slow feature analysis 显示文摘 | Franzius M Wilbert N Wiskott L | 2011 | Neural Computation2011，23，9： | 1 |
| 13 | Eine verbesserte Technik der Protargolimpragnation fttr Ciliaten显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，64，6： | 1 |
| 14 | Ciliated protozoa (Ciliophora) from Arctic sea ice显示文摘 | AGATHA S SPINDLER M WILBERT N | 1993 | Acta Protozool1993，32，： | 1 |
| 15 | Eine verbesserte Technik der Protargolimpragna- tion far ciliaten显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，，： | 1 |
| 16 | Eine verbesserte Technik der Protargolim- pragnation fur Ciliaten 显示文摘 | Wilbert N | 1975 | Mikrokosmos1975，64，： | 1 |
| 17 | Eine verbesserte Technik der Protargolimpragnation far Ciliaten 显示文摘 | WILBERT N | 1975 | Mikrokosmos1975，6，： | 1 |
| 18 | Eine verbesserte technik der protargolimpragnation ftir eiliaten显示文摘 | | 1975 | Mikrokosmos1975，64，： | 1 |
| 19 | Taxonomy and ecology of the ciliate fauna (Protozoa, Ciliophora) in the endopagial and pelagial of the Weddell Sea, Antarctica 显示文摘 | Petz W Song W B Wilbert N | 1995 | Stapfia1995，40，： | 1 |
| 20 | AlphaB - crystallincompetes with Alzheimer,s disease b - amyloid peptide for peptide3/peptide interactions and induces oxidation of Abeta - Met35 显示文摘 | Saravanakumar N Bram K Wilbert C | 2006 | FEBSL Letters2006，580，25： | 1 |
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