|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 2 | Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism显示文摘Recent studies have been raising doubts on the safety of induced pluripotent stem cells(iPSCs)and proposing that the process of reprogramming brought about copy number variations(CNVs)in iPSCs.However,a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming.This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy. | Wensu Liu Ming Li Jing Qu Fei Yi Guang-Hui Liu | 2013 | Protein & Cell2013，4，2： | 1 |
| 3 | DNA methylome:Unveiling your biological age显示文摘Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate.Notably,they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy.This progress en-lightens us in many aspects particularly in applying this novel set of bio-markers on studying the mech-anism of aging rate using adult tissue-specifi c stem cells,building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA,and understanding the princi-ple and mechanism of 3D chromatin structure in epigenetic modulation. | Ming Li Wensu Liu Tingting Yuan Ruijun Bai Guang-Hui Liu Weizhou Zhang Jing Qu | 2013 | Protein & Cell2013，4，10： | 0 |
| 4 | Effects of ginsenoside on brain-derived neurotrophic factor and tyrosine kinase B mRNA expression in the hippocampal formation of aged rats显示文摘BACKGROUND: There are a limited number of studies involving the effects of ginsenosides, the active component of ginseng, on expression of hippocampal TrkB mRNA in aged rats. OBJECTIVE: To observe expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) mRNA in the hippocampal formation of aged rats, as well as changes after ginsenoside administrated. DESIGN, TIME AND SETTING: A randomized, controlled experiment was performed at the Department of Anatomy, College of Basic Medical Sciences, China Medical University in March 2005. MATERIALS: A total of 39 female, Wistar rats were randomly divided into 3 groups (n = 13 each): young (3-5 months old), aged (27 months old), and ginsenoside group (received 25mg/kg/d ginsenoside in the drinking water between 17 and 27 months of age). METHODS: Following anesthesia, the rats were exsanguinated and perfused transcardially with chilled, heparinized, 0.9% saline. The brains were removed and post-fixed in 40 g/L paraformaldehyde/phosphate buffer for 20 minutes, and further incubated in 30% sucrose/phosphate buffer overnight. MAIN OUTCOME MEASURES: In situ hybridization, immunohistochemistry, and image analysis were used to investigate expression of BDNF and TrkB mRNA in the hippocampal formation. RESULTS: The expression levels of BDNF in the hippocampal CA3 and CA1 of aged rats was significantly less than the young group (t = 2.879, 1.814, 1.984, P < 0.05). BDNF expression was significantly greater in the dentate gyrus of the ginsenoside group, compared with the aging group (t = 1.943, P < 0.01). The expression of TrkB mRNA in the hippocampal CA3, CA1, and dentate gyrus of aged rats was less than the young group (t = 3.540, 3.629, 17.905, P < 0.01). TrkB mRNA expression in the CA3 region and dentate gyrus of the ginsenoside group was significantly greater compared with the aging group (t = 1.293, 3.386, P < 0.05, 0.01). CONCLUSION: BDNF and TrkB mRNA expression in the hippocampal formation were reduced in the aged group. However, ginsenosides can increase BDNF and TrkB mRNA expression in the hippocampal formation. | Hong Lai Wensu Liu Zhaosheng Li Haihua Zhao Yongli Lü | 2008 | Neural Regeneration Research2008，3，7： | 0 |
| 5 | Synthesis of C_f/TiAl_3 Composite by Infiltration-In Situ Reaction显示文摘Infiltration-in situ reaction synthesis of Cf /TiAl3 composite was investigated. The as-cast material was obtained by titanium particles, carbon fibers and pure aluminum. Titanium particles and carbon fibers were mixed and pressed to form a preform firstly, and then molten pure aluminum was pressed into the preform, subsequently, cooled rapidly. In situ reaction samples were obtained by heating the as-cast material from 600 to 1000 °C for 1 h. The microstructural evolution of in situ reaction samples was analyzed by scanning electron microscopy and energy dispersive X-ray. In addition, the phase composition of products was inspected by X-ray diffraction. Experimental results showed that the dominant product of TiAl3 and a small amount of Al4C3 were formed at low temperature. While TiAl3 was not stable at high temperature, along with its decrease, TiC phase became favorable. In the final products, TiAl3 , TiC and Al4C3 were detected. Thus, the in situ reaction for Ti-Al-C system composite proceeded a formed-decomposed-precipitated mechanism. | Yanmei Liu Ziyang Xiu Yongliang Guo Longtao Jiang Wensu Yang Gaohui Wu | 2009 | Journal of Materials Science & Technology2009，25，6： | 0 |
| 6 | 灵长类特异表达的基因TMEM14B标记外侧放射状胶质细胞并且促进大脑皮层的扩张和折叠显示文摘文章简介课题组通过流式细胞分选技术从人类胚胎皮层中纯化出了不同类型的神经前体细胞,并且利用深度单细胞转录组测序的方法找出了灵长类特异表达的基因TMEM14B,它特异地存在于人脑的oRG细胞中。 | 刘静 Wensu Liu 杨璐 吴倩 Haofeng Zhang Ai Fang Long Li Xiaohui Xu Le Sun 张军 汤富酬 王晓群 | 2018 | 科学新闻2018，0，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员