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| 1 | pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery显示文摘Most of the conventional chemotherapeutic agents used for cancer chemotherapy suffer from multidrug resistance of tumor cells and poor antitumor efficacy.Based on physiological differences between the normal tissue and the tumor tissue,one effective approach to improve the efficacy of cancer chemotherapy is to develop pH-sensitive polymeric micellar delivery systems.The copolymers with reversible protonationedeprotonation core units or acid-liable bonds between the therapeutic agents and the micelle-forming copolymers can be used to form pH-sensitive polymeric micelles for extracellular and intracellular drug smart release.These systems can be triggered to release drug in response to the slightly acidic extracellular fluids of tumor tissue after accumulation in tumor tissues via the enhanced permeability and retention effect,or they can be triggered to release drug in endosomes or lysosomes by pH-controlled micelle hydrolysis or dissociation after uptake by cells via the endocytic pathway.The pH-sensitive micelles have been proved the specific tumor cell targeting,enhanced cellular internalization,rapid drug release,and multidrug resistance reversal.The multifunctional polymeric micelles combining extracellular pH-sensitivity with receptor-mediated active targeting strategies are of great interest for enhanced tumor targeting.The micelles with receptor-mediated and intracellular pH targeting functions are internalized via receptor-mediated endocytosis followed by endosomal-pH triggered drug release inside the cells,which reverses multidrug resistance.The pH sensitivity strategy of the polymeric micelles facilitates the specific drug delivery with reduced systemic side effects and improved chemotherapeutical efficacy,and is a novel promising platform for tumor-targeting drug delivery. | Yanhua Liu Wenping Wang Jianhong Yang Chengming Zhou Jin Sun | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，3： | 11 |
| 2 | Recent Progress in Distributed Optical Fiber Raman Photon Sensors at China Jiliang University显示文摘在在中国 Jiliang 大学(CJLU ) 的完整的分布式的纤维拉曼光子传感器的研究,生产和应用的最近的进步的简短评论被介绍。以便改进测量距离,精确性,空间分辨率,多参数大小的能力,和完整的分布式的纤维传感器系统的智力,一种新一代纤维传感器技术基于光纤维,非线性的散布熔化原则被建议。一系列新一代完整的分布式的纤维传感器被调查并且设计,它由新产生组成极端长的距离散布与一个纤维拉曼放大器综合的光子传感器的完整的分布式的纤维拉曼和瑞利,汽车修正完整的分布式的纤维拉曼光子温度传感器基于拉曼关联双来源,完整的分布式的纤维拉曼光子温度传感器基于编码的脉搏采购原料,完整的分布式的纤维拉曼光子温度传感器 | Zaixuan ZHANG | 2012 | Photonic Sensors2012，2，2： | 8 |
| 3 | Characterization of flavor fingerprinting of red sufu during fermentation and the comparison of volatiles of typical products显示文摘Traditional Chinese red sufu is a popular condiment,and typical flavor is an important indicator of sensory qualities in commercial products.In this study,the volatile aroma analysis of Wangzhihe red sufu(WRS)from different fermentation stages and four typical red sufu products from different locations was carried out by gas chromatography-mass spectrometry(GC–MS),gas chromatography-mass spectrometry/olfactory(GC–MS/O),electronic nose(E-nose)and sensory evaluation.Results showed that 106 volatile compounds were identified in Wangzhihe red sufu during fermentation process,in which phenolics and alcohols were dominant at molded and salted phetze stages,while esters and alcohols became predominate at post-fermentation stage.The volatile aroma substances varied at each fermentation stage.Furthermore,86 volatiles,including 16 aroma-active compounds,were detected in four typical red sufu products.The multivariate analysis results showed the difference in samples from different fermentation stages and typical red sufu products according to GC–MS and E-nose analysis.Combined with flavor omics,discriminant model was established for effective discrimination of samples from different fermentation stages and locations,as well as references to sufu maturity extent.The study presented a new strategy for quality evaluation of red sufu,which could be the supplement to quality evaluation standards. | Peng Wang Xiaoran Ma Wenping Wang Dandan Xu Xin Zhang Jian Zhang Yong Sun | 2019 | Food Science and Human Wellness2019，8，4： | 7 |
| 4 | Load-sharing Characteristic of Multiple Pinions Driving in Tunneling Boring Machine显示文摘The failure of the key parts, such as gears, in cutter head driving system of tunneling boring machine has not been properly solved under the interaction of driving motors asynchronously and wave tunneling torque load. A dynamic model of multi-gear driving system is established considering the inertia effects of driving mechanism and cutter head as well as the bending-torsional coupling. By taking into account the nonlinear coupling factors between ring gear and multiple pinions, the influence for meshing angle by bending-torsional coupling and the dynamic load-sharing characteristic of multiple pinions driving are analyzed. Load-sharing coefficients at different rotating cutter head speeds and input torques are presented. Numerical results indicate that the load-sharing coefficients can reach up to 1.2-1.3. A simulated experimental platform of the multiple pinions driving is carried out and the torque distributions under the step load in driving shaft of pinions are measured. The imbalance of torque distribution of pinions is verified and the load-sharing coefficients in each pinion can reach 1.262. The results of simulation and test are similar, which shows the correctness of theoretical model. A loop coupling control method is put forward based on current torque master slave control method. The imbalance of the multiple pinions driving in cutter head driving system of tunneling boring machine can be greatly decreased and the load-sharing coefficients can be reduced to 1.051 by using the loop coupling control method. The proposed research provides an effective solution to the imbalance of torque distribution and synchronous control method for multiple pinions driving of TBM. | WEI Jing SUN Qinchao SUN Wei DING Xin TU Wenping WANG Qingguo | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 7 |
| 5 | Nonselective etching of GaN/AlGaN heterostructures by Cl2/Ar/BCl3 inductively coupled plasmas显示文摘A systematic study of the nonselective and smooth etching of GaN/AIGaN het-erostructures was performed using C12/Ar/BCI3 inductively coupled plasmas (ICR).Nonselective etching can be realized by adjusting the BCI3 ratio in the Cl2/Ar/BCI3 mixture (20%—60%), increasing the ICR power and dc bias, and decreasing the chamber pressure. Surface morphology of the etched heterostructures strongly depends on the gas chemistry and the chamber pressure. Specifically, with the addition of 20% BCI3 to Cl2/Ar (4:1) gas mixture, nonselective etching of GaN/Al0.28Ga0.72N heterostructures at high etch rate is maintained and the surface root-mean-square (rms) roughness is reduced from 10.622 to 0.495 nm, which is smoother than the as-grown sample. Auger electron spectroscopy (AES) analysis shows that the effective removal of residual oxygen from the surface of AIGaN during the etching process is crucial to the nonselective and smooth etching of GaN/AIGaN herterostructures at high etch rate. | HAN Yanjun XUE Song WU Tong WU Zhen GUO Wenping LUO Yi HAO Zhibiao SUN Changzheng | 2004 | Science China(Technological Sciences)2004，47，2： | 6 |
| 6 | Vertical‐organic‐nanocrystal‐arrays for crossbar memristors with tuning switching dynamics toward neuromorphic computing显示文摘Memristors proposed by Leon Chua provide a new type of memory device for novel neuromorphic computing applications.However,the approaching of distinct multi‐intermediate states for tunable switching dynamics,the con-trolling of conducting filaments(CFs)toward high device repeatability and reproducibility,and the ability for large‐scale preparation devices,remain full of challenges.Here,we show that vertical‐organic‐nanocrystal‐arrays(VONAs)could make a way toward the challenges.The perfect one‐dimensional structure of the VONAs could confine the CFs accurately with fine‐tune resistance states in a broad range of 103 ratios.The availability of large‐area VONAs makes the fabrication of large‐area crossbar memristor arrays facilely,and the analog switching characteristic of the memristors is to effectively imitate different kinds of synaptic plasticity,indicating their great potential in future applications. | Fangxu Yang Lingjie Sun Qingxi Duan Huanli Dong Zhaokun Jing Yuchao Yang Rongjin Li Xiaotao Zhang Wenping Hu Leon Chua | 2021 | SmartMat2021，2，1： | 5 |
| 7 | Zinc Anode for Mild Aqueous Zinc-Ion Batteries: Challenges, Strategies, and Perspectives显示文摘The rapid advance of mild aqueous zinc-ion batteries(ZIBs)is driving the development of the energy storage system market.But the thorny issues of Zn anodes,mainly including dendrite growth,hydrogen evolution,and corrosion,severely reduce the performance of ZIBs.To commercialize ZIBs,researchers must overcome formidable challenges.Research about mild aqueous ZIBs is still developing.Various technical and scientific obstacles to designing Zn anodes with high stripping efficiency and long cycling life have not been resolved.Moreover,the performance of Zn anodes is a complex scientific issue determined by various parameters,most of which are often ignored,failing to achieve the maximum performance of the cell.This review proposes a comprehensive overview of existing Zn anode issues and the corresponding strategies,frontiers,and development trends to deeply comprehend the essence and inner connection of degradation mechanism and performance.First,the formation mechanism of dendrite growth,hydrogen evolution,corrosion,and their influence on the anode are analyzed.Furthermore,various strategies for constructing stable Zn anodes are summarized and discussed in detail from multiple perspectives.These strategies are mainly divided into interface modification,structural anode,alloying anode,intercalation anode,liquid electrolyte,non-liquid electrolyte,separator design,and other strategies.Finally,research directions and prospects are put forward for Zn anodes.This contribution highlights the latest developments and provides new insights into the advanced Zn anode for future research. | Jinzhang Yang Bosi Yin Ying Sun Hongge Pan Wenping Sun Baohua Jia Siwen Zhang Tianyi Ma | 2022 | Nano-Micro Letters2022，14，3： | 5 |
| 8 | SEMI ON-LINE SCHEDULING PROBLEM FOR MAXIMIZING THE MINIMUM MACHINE COMPLETION TIME ON TWO UNIFORM MACHINES显示文摘在这篇论文,我们在二一致 machinesM_i 上认为半是联机版本, i = 1,2,在最大的工作的处理时间预先被知道的地方。速度 s_i (s_1 = 1,1 ≤ s_2 = s ) 与机器 M_i 被联系。我们的目标是最大化 C_(min ) 。我们给 C_(min2 ) 算法并且证明它的竞争比率是至多(2s+1 )/(s+1 ) 。我们也宣称 C_(min 2 ) 算法是紧张的并且在 C_ 的竞争比率之间的差距(min 2 ) 算法和最佳的价值不比 0.555 大。我们的结果与一致,那给由,是明显的他为 s= 1。 | Runzi LUO Shijie SUN Wenping HUANG | 2006 | Journal of Systems Science & Complexity2006，19，1： | 4 |
| 9 | Linear Complexity of Least Significant Bit of Polynomial Quotients显示文摘Binary sequences with large linear complexity have been found many applications in communication systems.We determine the linear complexity of a family of p^2-periodic binary sequences derived from polynomial quotients modulo an odd prime p.Results show that these sequences have high linear complexity,which means they can resist the linear attack method. | ZHAO Chun'e MA Wenping YAN Tongjiang SUN Yuhua | 2017 | Chinese Journal of Electronics2017，26，3： | 2 |
| 10 | A branched dihydrophenazine-based polymer as a cathode material to achieve dual-ion batteries with high energy and power density显示文摘Organic electrode materials have exhibited good electrochemical performance in batteries,but their voltages and rate capabilities still require improvement to meet the increasing demand for batteries with high energy and power density.Herein,we design and synthesize a branched dihydrophenazine-based polymer(p-TPPZ)as a cathode material for dual-ion batteries(DIBs)through delicate molecular design.Compared with the linear dihydrophenazine-based polymer(p-DPPZ,with a theoretical capacity of 209 mAh g^(−1)),p-TPPZ possessed a higher theoretical capacity of 233 mAh g^(−1)and lower highest occupied molecular orbital energy levels,which resulted in a high actual capacity(169.3 mAh g^(−1)at 0.5 C),an average discharge voltage of 3.65 V(vs.Li+/Li)and a high energy density(618.2 Wh kg^(−1),based on the cathode materials).The branched structure of p-TPPZ led to a larger specific surface area than that of p-DPPZ,which was beneficial for the electrolyte infiltration and fast ionic transport,contributing to the high power density.Due to the fast reaction kinetics,even at a power density of 23,725 W kg^(−1)(40 C),the energy density still reached 474.5 Wh kg^(−1).We also made a detailed investigation of the p-TPPZ cathode’s charge storage mechanism.This work will stimulate the further molecular design to develop organic batteries with both high energy and power density. | Shuaifei Xu Huichao Dai Shaolong Zhu Yanchao Wu Mingxuan Sun Yuan Chen Kun Fan Chenyang Zhang Chengliang Wang Wenping Hu | 2021 | eScience2021，1，1： | 2 |
| 11 | Crystal structure of a secreted lipase from Gibberella zeae reveals a novel “double-lock” mechanism显示文摘Fusarium graminearum(sexual stage:Gibberella zeae)is the causative agent of Fusarium Head Blight(FHB),which is one of the most destructive plant disease of cereals,accounting for high grain yield losses,especially for wheat and maize.Like other fungal pathogens,several extracellular enzymes secreted by G.zeae are known to be involved in host infection.Among these secreted lipases,G.zeae lipase(GZEL),which is encoded by the FGL1 gene,was demonstrated to be crucial to G.zeae pathogenicity.However,the precise mechanism of GZEL remains unclear due to a lack of detailed structural information.In this study,we report the crystal structure of GZEL at the atomic level.The structure of GZEL displays distinct structural differences compared to reported homologues and indicates a unique“double lock”enzymatic mechanism.To gain insight into substrate/inhibitor recognition,we proposed a model of GZEL in complex with substrate and the lipase inhibitor ebelactone B(based on the reported structures of GZEL homologues),which defines possible substrate binding sites within the catalytic cleft and suggests an“anti sn-l”binding mode.These results pave the way to elucidating the mechanism of GZEL and thus provide clues for the design of anti-FHB inhibitors. | Zhiyong Lou Ming Li Yuna Sun Ye Liu Zheng Liu Wenping Wu Zihe Rao | 2010 | Protein & Cell2010，1，8： | 2 |
| 12 | Chelating polymer modified P84 nanofiltration(NF)hollow fiber membranes for high efficient heavy metal removal显示文摘 | Gao Jie Sun Shipeng Zhu Wenping | 2014 | Water Research2014，63，15： | 1 |
| 13 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 14 | Multiwall carbon nanotube-based acetylcholinesterase biosensor 显示文摘 | SUN Xia WANG Xiangyou ZHAO Wenping | 2010 | Sens Lett2010，8，2： | 1 |
| 15 | Multiwall carbon nanotube-based acetylcholinesterase biosensor for detecting organophosphorous pesficides显示文摘 | SUN Xia WANG Xiangyou ZHAO Wenping | 2010 | Sens Lett2010，8，2： | 1 |
| 16 | Reversible Magnesium Metal Anode Enabled by Cooperative Solvation/Surface Engineering in Carbonate Electrolytes显示文摘Magnesium metal anode holds great potentials toward future high energy and safe rechargeable magnesium battery technology due to its divalent redox and dendrite-free nature. Electrolytes based on Lewis acid chemistry enable the reversible Mg plating/stripping,while they fail to match most cathode materials toward highvoltage magnesium batteries. Herein,reversible Mg plating/stripping is achieved in conventional carbonate electrolytes enabled by the cooperative solvation/surface engineering. Strongly electronegative Cl from the MgCl_(2) additive of electrolyte impairs the Mg…O = C interaction to reduce the Mg^(2+) desolvation barrier for accelerated redox kinetics,while the Mg^(2+)-conducting polymer coating on the Mg surface ensures the facile Mg^(2+) migration and the e ective isolation of electrolytes. As a result,reversible plating and stripping of Mg is demonstrated with a low overpotential of 0.7 V up to 2000 cycles. Moreover,benefitting from the wide electrochemical window of carbonate electrolytes,high-voltage(> 2.0 V) rechargeable magnesium batteries are achieved through assembling the electrode couple of Mg metal anode and Prussian blue-based cathodes. The present work provides a cooperative engineering strategy to promote the application of magnesium anode in carbonate electrolytes toward high energy rechargeable batteries. | Caiyun Wang Yao Huang Yunhao Lu Hongge Pan Ben Bin Xu Wenping Sun Mi Yan Yinzhu Jiang | 2021 | Nano-Micro Letters2021，13，12： | 1 |
| 17 | Northeast power system simulator(NEPSS)显示文摘1.IntroductionThe Northeast Power System is one of the four bulk powersystems in China,which covers the provinces of Liaoning,Jilin,Heilongjiang and a small part of Inner Mongolia.The total installedcapacity in 1990 was 21,300 MW and the peak demand was 13,600MW.The Control Center is in Shenyang.The dispatching automationsystem which is mainly composed of a dual computer system(2XVAX785)was installed and put into operation in 1988.The plan | Gu Yongchang Wang Xinfeng Li Wenping Sun Guosheng Electrical Engineering Department of Tsinghua UniversityYang Songqi Xu Muliang Yang Kexuan Huang Yingju Electric Power Dispatching and Communication Bureau of Northeast Power Administration.P.R.China | 1992 | Electricity1992，，4： | 1 |
| 18 | Travel Attractions Recommendation with Travel Spatial-Temporal Knowledge Graphs显示文摘 | Weitao Zhang Tianlong Gu Wenping Sun Yochum Phatpicha Liang Chang Chenzhong Bin | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 1 |
| 19 | Improving a PenmanMonteith evapotranspiration model by incorporating soil moisture control on soil evaporation in semiarid areas显示文摘PenmanMonteith(PM)theory has been successfully applied to calculate land surface evapotranspiration(ET)for regional and global scales.However,soil surface resistance,related to soil moisture,is always difficult to determine over a large region,especially in arid or semiarid areas.In this study,we developed an ET estimation algorithm by incorporating soil moisture control,a soil moisture index(SMI)derived from the surface temperature and vegetation index space.We denoted this ET algorithm as the PM-SMI.The PM-SMI algorithm was compared with several other algorithms that calculated soil evaporation using relative humidity,and validated with Bowen ratio measurements at seven sites in the Southern Great Plain(SGP)that were covered by grassland and cropland with low vegetation cover,as well as at three eddy covariance sites from AmeriFlux covered by forest with high vegetation cover.The results show that in comparison with the other methods examined,the PM-SMI algorithm significantly improved the daily ET estimates at SGP sites with a root mean square error(RMSE)of 0.91 mm/d,bias of 0.33 mm/d,and R^(2) of 0.77.For three forest sites,the PM-SMI ET estimates are closer to the ET measurements during the non-growing season when compared with the other three algorithms.At all the 10 validation sites,the PMSMI algorithm performed the best.PM-SMI 8-day ET estimates were also compared with MODIS 8-day ET products(MOD16A2),and the latter showed negligible bias at SGP sites.In contrast,most of the PM-SMI 8-day ET estimates are around the 1:1 line. | Liang Sun Shunlin Liang Wenping Yuan Zhongxin Chen | 2013 | International Journal of Digital Earth2013，6，S01： | 1 |
| 20 | Control point adjustment for B-spline curve approximation显示文摘 | YANG Huaiping WANG Wenping SUN Jiaguang | 2004 | Computer-Aided Design2004，36，7： | 1 |
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