4篇
您的检索式：作者名="Wennan Zhao"
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| 1 | Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy显示文摘The phosphatidylinositol 3-kinase(PI3K) pathway is frequently activated in human cancers.Class I PI3 Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate(PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate(PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin(m TOR) to play key roles in carcinogenesis. Therefore, PI3 K has become an important anticancer drug target, and currently there is very high interest in the pharmaceutical development of PI3 K inhibitors. Idelalisib has been approved in USA and Europe as the first-in-class PI3 K inhibitor for cancer therapy. Dozens of other PI3 K inhibitors including BKM120 and ZSTK474 are being evaluated in clinical trials. Multifaceted studies on these PI3 K inhibitors are being performed, such as single and combinational efficacy, resistance, biomarkers,etc. This review provides an introduction to PI3 K and summarizes key advances in the development of PI3 K inhibitors. | Wennan Zhao Yuling Qiu Dexin Kong | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 19 |
| 2 | Automation and optimization of liquid-phase microextraction by gas chromatography显示文摘 | Gangfeng Ouyang Wennan Zhao Janusz Pawliszyn | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 3 | Auto-mation and optimization of liquid-phase microextraction by gaschromatography显示文摘 | Gangfeng Ouyanga Wennan Zhao Janusz Pawliszyn | 2007 | J Chromatography A2007，1138，： | 1 |
| 4 | Effect of Chemical Cross-linking on Properties of Gelatin/Hyaluronic Acid Composite Hydrogels显示文摘 | Zhihua Zhou Zhongmin Yang Tianlong Huang Lihua Liu Qingquan Liu Yanmin Zhao Wennan Zeng Qingfeng Yi Dafu Cao | 2013 | Polymer-Plastics Technology and Engineering2013，，1： | 1 |
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