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| 1 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 2 | Mineral association and graphite inclusions in nephrite jade from Liaoning, northeast China: Implications for metamorphic conditions and ore genesis显示文摘The Liaoning Province in the northeastern part of the North China Craton(NCC) hosts several tremolite jade(nephrite) deposits. Here we investigate the Sangpiyu tremolite jade deposit where the relationship between abundant graphite inclusions within the jade remains enigmatic. We employ petrography, electron probe microanalysis, X-ray-diffraction, and Raman spectroscopy to characterize the tremolite jade and its inclusion minerals. The Sangpiyu jade is predominately composed of tremolite with minor calcite, dolomite, serpentine, titanite, zoisite, allanite, chlorite,apatite, chromite and graphite. Raman spectroscopy of graphite inclusions shows that the D1/G intensity ratio ranges from 0.78 to 0.88 in deep green samples and from 0.05 to 0.23 in dark green samples. The ranges of D1/(D1 + G) integral area ratio for these types are from 0.0548 to 0.3037 and 0.5528 to 0.7355 respectively. The formation temperature of graphite inclusions in the dark green tremolite jade is computed as 549.8 ℃, whereas that for the deep green sample is about343.2 ℃. Our results suggest that the jade formation occurred in a multi-stage process through the action of hydrothermal fluids and metamorphism possibly in a subduction-related setting at moderate to high temperatures. | Cun Zhang Xiaoyan Yu Tianlong Jiang | 2019 | Geoscience Frontiers2019，10，2： | 11 |
| 3 | Extraction of Lithium from Salt Lake Brine with Triisobutyl Phosphate in Ionic Liquid and Kerosene显示文摘 | GAO Daolin YU Xiaoping GUO Yafei WANG Shiqiang LIU Mingming DENG Tianlong CHEN Yuwei BELZILE Nelson | 2015 | Chemical Research in Chinese Universities2015，31，4： | 10 |
| 4 | Effect of Mo on High-Temperature Fatigue Behavior of 15CrNbTi Ferritic Stainless Steel显示文摘In order to understand the effect of Mo element on the high-temperature fatigue behavior of 15 CrNbTi ferritic stainless steel, the stress-controlled fatigue tests have been performed for both 15 CrNbTi and 15Cr0.5MoNbTi ferritic stainless steels at 800 °C in laboratory air. The fatigue test results indicate that the fatigue resistance of 15Cr0.5MoNbTi steel is manifestly higher than that of 15 CrNbTi steel at the maximum stress below 57 MPa; the 15Cr0.5MoNbTi steel possesses a fatigue limit of 35 MPa, which is higher than that of 15 CrNbTi steel. The TEM observations reveal that the Mo element can suppress the formation of coarsened Fe3Nb3 C precipitates and result in the fatigue resistance enhancement.The dislocation networks formed during the cyclic load favor to improve the fatigue resistance of 15Cr0.5MoNbTi steel at800 °C. | Tianlong Liu Lijia Chen Hongyun Bi Xin Che | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 10 |
| 5 | Advanced treatment of wet-spun acrylic fiber manufacturing wastewater using three-dimensional electrochemical oxidation显示文摘A three-dimensional electrochemical oxidation(3D-EC) reactor with introduction of activated carbon(AC) as particle micro-electrodes was applied for the advanced treatment of secondary wastewater effluent of a wet-spun acrylic fiber manufacturing plant. Under the optimized conditions(current density of 500 A/m^2, circulation rate of 5 mL/min, AC dosage of 50 g, and chloride concentration of 1.0 g/L), the average removal efficiencies of chemical oxygen demand(COD_(cr)), NH3–N, total organic carbon(TOC), and ultraviolet absorption at 254 nm(UV_(254)) of the 3D-EC reactor were 64.5%, 60.8%, 46.4%, and 64.8%, respectively; while the corresponding effluent concentrations of COD_(cr), NH_3–N, TOC, and UV_(254) were 76.6, 20.1, and42.5 mg/L, and 0.08 Abs/cm, respectively. The effluent concentration of COD_(cr) was less than 100 mg/L, which showed that the treated wastewater satisfied the demand of the integrated wastewater discharge standard(GB 8978-1996). The 3D-EC process remarkably improved the treatment efficiencies with synergistic effects for COD_(cr), NH_3–N, TOC, and UV_(254) during the stable stage of 44.5%, 38.8%, 27.2%, and 10.9%, respectively, as compared with the sum of the efficiencies of a two-dimensional electrochemical oxidation(2D-EC) reactor and an AC adsorption process, which was ascribed to the numerous micro-electrodes of AC in the 3D-EC reactor. Gas chromatography mass spectrometry(GC–MS) analysis revealed that electrochemical treatment did not generate more toxic organics, and it was proved that the increase in acute biotoxicity was caused primarily by the production of free chlorine. | Tianlong Zheng, Qunhui Wang Zhining Shi Yue Fang Shanshan Shi Juan Wang Chuanfu Wu | 2016 | Journal of Environmental Sciences2016，28，12： | 8 |
| 6 | Experimental investigation on static/dynamic characteristics of a fast-response pressure sensitive paint显示文摘An optical-based technique using Pressure-Sensitive Paint(PSP) is a promising method to measure the distribution of surface pressure on an aerodynamic model. The static and dynamic characteristics of a fast-response PSP that is developed in the Chinese Academy of Sciences(CAS)are analyzed and tested to serve as the basis for experiments on unsteady surface measurement using a fast-response PSP. Two calibration systems used for this study are set up to investigate the temperature dependency, response time, and resolution. A data processing method, used for dynamic data, is analyzed and selected carefully to determine the optimum signal. Results show that the fastresponse PSP can be used normally at temperatures from 25 ℃ to 80 ℃. The effect of temperature on the accuracy of the measurement must be considered when temperatures are beyond the temperature range of 30–40 ℃. The dynamic calibration device with a solenoid valve can achieve a pressure jump within a millisecond order. The resolution is determined by the signal-to-noise ratio of the photo-multiplier tube. Results of the measurement show that the response time of the PSP decreases with a large pressure variation, and the response time is below 0.016 s when the pressure variation is under 40 kPa. | Ruiyu LI Limin GAO Tianlong ZHENG Guanhua YANG | 2018 | Chinese Journal of Aeronautics2018，31，6： | 8 |
| 7 | Structural insights into DndE from Escherichia coil B7A involved in DNA phosphorothioation modification显示文摘 | Wei Hu Chengkun Wang Jingdan Liang Tianlong Zhang Zhongpei Hu Zhijun Wang Wenxian Lan Fang Li Houming Wu Jianping Ding Geng Wu Zixin Deng Chunyang Cao | 2012 | Cell Research2012，22，7： | 7 |
| 8 | Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015显示文摘A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015.Based on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin.The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of Africa.The affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean flyways.These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans. | Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao | 2016 | Virologica Sinica2016，31，4： | 5 |
| 9 | Nuclear reprogramming: the zygotic transcription program is established through an“erase-and-rebuild” strategy显示文摘卵母细胞显示母亲特定的基因表达式侧面,它被换到当染色质的一个单倍体集合被传递到发展成一个胚胎的受精卵时, zygotic 介绍。位于这抄写 reprogramming 下面的机制当前是未知的。等到当抄写在幼芽的泡卵母细胞被关掉时,一般抄写因素和 transcriptional 管理者的一个范围从染色质被分裂,这里,我们表明那。染色质因素(CF ) 的全球分离破坏在染色质和 CF 之间的物理接触并且在功能的水平导致母亲的抄写节目的檫除。与染色质论坛分开的批评抄写因素和管理者遗体延长了时期,并且立即在专业版以后与染色质成为 re-associated 原子形成。Thisis 由象 DNA 和抄写那样的原子功能的重建跟随了速度集合。我们建议母亲的抄写节目在卵子发生期间被擦掉产生相对天真的染色质, zygotic 抄写节目是在授精以后的重建的重新。这个过程作为“ erase-and-rebuild ”被称为过程,它被用来重设抄写节目,和最可能的其它原子过程也,从母亲的到胚胎的。我们进一步在伴随的纸出现(高 T,等,房间物件 2007;17:135-150 .) 一样的策略也被采用到改编 transcriptional,这在体细胞介绍原子转移和单性生殖,建议这当模特儿在早胚胎开始期间对 transcriptional reprogramming 的所有形式普遍适用。从染色质的 CF 的排水量也为抄写沉默的现象提供解释在期间对 zygotic 转变母亲。 | Feng Sun Haiyan Fang Ruizhen Li Tianlong Gao Junke Zheng Xuejin Chen Wenqin Ying Hui Z Sheng | 2007 | Cell Research2007，17，2： | 5 |
| 10 | Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China显示文摘Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a degree comparable with that of the sympatric L. mandelli and the new species, we elevate L. idonea to species status, and retain L. seebohmi and L. montis as separate species, the latter with timorensis as a subspecies. Further research should focus on different populations of L. montis and the Mt Victoria population of L. mandelli. | Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei | 2015 | Chinese Birds2015，，2： | 4 |
| 11 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 12 | Emission-Reductive and Multi-Objective Coordinative Optimization of Binary Feed for Atmospheric and Vacuum Distillation Unit显示文摘A genetic algorithm based multi-objective coordinative optimization strategy is developed to optimize the operation of a binary feed atmospheric and vacuum distillation system, in which the objective functions cover the economic benefit, the furnace energy consumption and the CO_2 emissions, and meanwhile the simultaneous effect of binary feed composition is also investigated. A cross-call integration of software is developed to implement the optimization algorithm,and once the maximum economic benefit, the minimum furnace energy consumption and the minimum CO_2 emissions are obtained, the Pareto-optimal solution set is worked out, with the practical problems of the refinery being solved. The optimization result shows that under the same furnace energy consumption and the CO_2 emissions as the existing working condition, the economic benefit still allows for a considerable potential of increment by adjusting the heavy oil proportion of the binary feed crude oil. | Huang Xiaoqiao Zhao Tianlong Li Na Ma Zhanhua Song Lijuan Li Jun | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，4： | 3 |
| 13 | Discovery and Geological Significance of Neoproterozoic Metamorphic Granite in Jimo, Shandong Province, Eastern China显示文摘During the 1:50000 regional geological survey in Jimo,east Shandong Province,Paleoproterozoic metamorphic supracrustal rocks and Neoproterozoic metamorphic plutonite were newly discovered. These rocks displayed inclusions which had occurred in the Mesozoic granite,and the main lithologies are schist,granulite,marble,and granitic gneiss. Geochemical analyses suggest that Neoproterozoic metamorphic plutonite are characterized by high-K,metaluminous to weakly peraluminous. They are enriched in LILE and depleted in HFSE,with moderately enrichment of LREE,weak fractionation of LREE from HREE and negative Eu anomalies. The surface age of plutonic rocks in the survey area is 770.2±2.4 Ma,representing the age of magma crystallization,which is agreement with the the Neoproterozoic magmatic event after Rodinia supercontinent in the northern margin of Southern China continental block. In addition,the age of sporadic distribution(298 Ma and 269 Ma) is mixed zircon age,representing the rocks experienced metamorphism in Indosinian period. According to the associated mineral assemblages,and the characteristic metamorphic minerals and temperature pressure conditions,four metamorphic facies were identified,including amphibolitic,epidote amphibolite,greenschist,and mid-high pressure greenschist. Analysis of tectonic setting suggests that granitic gneiss is formed in an extensional environment and was involved from the continental margin magmatic arc to intraplate environment. Jimo is distributed in the east of Zhuwu fault,and has the same Spatial distribution location with the Weihai uplift UHP metamorphic belt rocks. The metamorphic rocks in Jimo area have similar geochemical characteristics of elements,tectonic setting and retrograde metamorphism with that in the Sulu UHP metamorphic belt. Therefore,Zhuwu fault may be the boundary fault of Sulu UHP metamorphic belt. | ZHU Decheng Lü Dawei SHEN Xiaoli YANG Qing LI Dandan REN Tianlong YANG Shipeng | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 14 | Goal directed fluid therapy with LiDCOrapid in a parturient with WPW syndrome and cardiac dysfunction undergoing emergent cesarean section显示文摘 | Xiao Wei Duan Qingfang Zhao Lei Wang Fengying Wang Tianlong | 2014 | Chinese Medical Journal2014，，14： | 3 |
| 15 | Crystal structure of the Egol-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORCl signaling显示文摘 | Katie Powis Tianlong Zhang Nicolas Panchaud Rong Wang Claudio De Virgilio Jianping Ding | 2015 | Cell Research2015，25，9： | 3 |
| 16 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 17 | Pilot-scale experiments on multilevel contact oxidation treatment of poultry farm wastewater using saran lock carriers under different operation model显示文摘A pilot-scale multilevel contact oxidation reactors system, coupled with saran lock carriers,was applied for the treatment of poultry farm wastewater. The removal efficiencies of CODcr, ammonia, and the total nitrogen as well as the elimination performance of CODcr and total nitrogen along the three-level contact oxidation tanks under six designed operational models were investigated. Based on the performance of the nitrogen removal of the saran lock carriers and the distribution of anoxic–aerobic interspace under the suitable operation model, the mechanism of nitrogen removal of the system was also explored. The results revealed that the intermittent aeration under parallel model is the most suitable operation model, while the removal efficiencies of CODcr, ammonia, and the total nitrogen were 86.86%, 84.04%, and 80.96%, respectively. The effluent concentration of CODcr,ammonia, and the total nitrogen were 55.6 mg/L, 8.3 mg/L, and 12.0 mg/L, which satisfy both the discharge standard of pollutants for livestock and poultry breeding industry(GB18596–2001) and the first grade of the integrated wastewater discharge standard(GB 8978–1996). Moreover, the mechanism for the nitrogen removal should be attributed to the plenty of anoxic–aerobic interspaces of the biofilm and the three-dimensional spiral structure of the saran lock carriers, where the oxygen-deficient distribution was suitable for the happening of the simultaneous nitrification and denitrification process. Therefore, the multilevel contact oxidation tanks system is an effective pathway for the treatment of the poultry farm wastewater on the strength of a suitable operation model and novel carriers. | Tianlong Zheng Peng Li Xiaoyu Ma Xiaohong Sun Chuanfu Wu Qunhui Wang Ming Gao | 2019 | Journal of Environmental Sciences2019，31，3： | 2 |
| 18 | Phase Equilibrium and Phase Diagram of the Ternary System(MgCl2 + MgB2O4 + H2O) at 288 and 298 K显示文摘1 Introduction The brines with high concentrations of magnesium and boron resources are widely distributed in the Qaidam Basin of the Qinghai-Tibet plateau,China(Zheng&Tang,1988).Although some works on the ternary | GUO Yafei SUN Shiru GAO Diaolin YU Xiaoping WANG Shiqiang DENG Tianlong | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 2 |
| 19 | Anesthesia management for a patient with anti-NMDA receptor encephalitis undergoing ovarian tumor resection显示文摘Anti-N-Methyl-D-aspartate (NMDA) receptor (Anti-NMDA-R) encephalitis presents a series of psychiatric syndromes,including confusion,seizures,hypoventilation and autonomic nerve dysfunction.Only a few literatures about the anesthesia management for patients with anti-NMDA receptor encephalitis were reported,1 it is wise to understand the development of disease and the effect of anesthetics on brain function in the presence of NMDA receptors' abnormality.Herein we reported a case of the intra-operative anesthesia management and monitoring. | Lang Yu Wang Tianlong Lan Fei Xiao Wei | 2014 | Chinese Medical Journal2014，，11： | 2 |
| 20 | A new type of micro-disseminated gold deposits in association with diabase found in Yunnan and Guizhou provinces and Guangxi Zhuang Autonomous Region——Their geological characteristics and metallogenic conditions显示文摘With the continuous development of gold ore prospecting and exploration in recent years a new type of micro-disseminated gold deposits have been found in the regions of Southwest Guizhou Province and Northwest Guangxi Zhuang Autonomous Region,with the orebodies directly occurring in diabase or in the contact zone between diabase and strata.The orebodies are strictly controlled by fault structures.The discovery of this type of gold deposits has brought about new prospects for gold ore prospecting in the Yunnan-Guizhou-Guangxi Golden Triangle region.From the preliminary analysis of the geological characteristics of the Qiaoxiang gold deposit in Wangmo County,in combination with the results of research work in the adjacent areas in recent years,this paper roughly described the geological characteristics and metallogenic conditions of this type of gold ore deposits with an attempt to make more and more geologists pay enough attention to this type of gold ore deposits,so as to promote gold ore prospecting in Guizhou Province to develop toward a variety of types of gold deposits in all round way. | LI Zhuyun LAN Tianlong RAN Ruide CHENG Guofan | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 2 |
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