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| 1 | On the mechanical behavior of the human biliary system显示文摘This paper reviews the progress made in understanding the mechanical behaviour of the biliary system. Gallstones and diseases of the biliary tract affect more than 10% of the adult population. The complications of gallstones, i.e. acute pancreatitis and obstructive jandice, can be lethal, and patients with acalculous gallbladder pain often pose diagnostic difficulties and undergo repeated ultrasound scans and oral cholecystograms. Moreover, surgery to remove the gallbladder in these patients, in an attempt to relieve the symptoms, gives variable results. Extensive research has been carried out to understand the physiological and pathological functions of the biliary system, but the mechanism of the pathogenesis of gallstones and pain production still remain poorly understood. It is believed that the mechanical factors play an essential role in the mechanisms of the gallstone formation and biliary diseases. However, despite the extensive literature in clinical studies, only limited work has been carried out to study the biliary system from the mechanical point of view. In this paper, we discuss the state of art knowledge of the fluid dynamics of bile flow in the biliary tract, the solid mechanics of the gallbladder and bile ducts, recent mathematical and numerical modelling of the system, and finally the future challenges in the area. | Xiaoyu Luo Wenguang Li Nigel Bird Swee Boon Chin NA Hill Alan G Johnson | 2007 | World Journal of Gastroenterology2007，13，9： | 9 |
| 2 | Closed-loop P-type Iterative Learning Control of Uncertain Linear Distributed Parameter Systems显示文摘An iterative learning control problem for a class of uncertain linear parabolic distributed parameter systems is discussed,which covers many processes such as heat and mass transfer,convection diffusion and transport.Under condition of allowing system state initially to have error in the iterative process a closed-loop P-type iterative learning algorithm is presented,and the sufficient condition of tracking error convergence in L2 norm is given.Next,the convergence of the tracking error in L2 and W1,2 space is proved by using Gronwall-Bellman inequality and Sobolev inequality.In the end,a numerical example is given to illustrate the effectiveness of the proposed method. | Xisheng Dai Senping Tian Yunjian Peng Wenguang Luo | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，3： | 8 |
| 3 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 4 | A Real-Time System for Monitoring Distant Dynamic Displacement of Structures显示文摘把技术基于数字图象处理,一个即时系统被开发监视并且检测设计结构的动态排水量。由用一个自我规划的软件处理图画,在某个坐标系统的一个目标的即时坐标能也被获得,并且推进动态排水量数据和目标罐头的曲线被完成。数据的也就是说自动的聚会并且即时处理能被这个系统同时执行。首先,为这个系统,一种未触动过的监视技术被采用,罐头它监视或检测目标几到几百米分开;第二,它有灵活安装状况和亚毫米度的好监视精确;第三,它是合适的为动态、伪动态、静态大工程结构监视。通过大桥的几测试和应用程序,系统的好可靠性和优势被证明。 | CHEN Junfeng ZHAO Wenguang LUO Hongbin LI Penghui WEN Yinping | 2008 | Geo-Spatial Information Science2008，11，1： | 4 |
| 5 | Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis显示文摘The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge.The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation.Herein,we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen(PCEI)and multifunctional PCEI-based F127-ε-polypeptide-alginic(FEA)dressing(FEA-PCEI)for accelerating wound healing and hair follicle neogenesis.PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization.The FEA-PCEI dressing showed the temperature-response gelation,injectability,robust antibacterial activity,light-damage-resistant,homeostasis ability,and good cytocompatibility.The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability,reduce the scar formation,and promote the hair follicle neogenesis.This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials. | Wenguang Liu Min Wang Wei Cheng Wen Niu Mi Chen Meng Luo Chenxi Xie Tongtong Leng Long Zhang Bo Lei | 2021 | Bioactive Materials2021，6，3： | 4 |
| 6 | E-DSDV routing protocol for mobile ad hoc network for underwater electrocommunication显示文摘Dear editor,We realized the dynamic networking of underwater electrocommunication for the first time through experiments [1–3].The E-DSDV routing protocol based on underwater electrocommunication also belongs to the proactive routing protocol [4]. | Ruijun LIU Qinghao WANG Chen WANG Guangming XIE Wenguang LUO | 2021 | Science China(Information Sciences)2021，64，12： | 1 |
| 7 | Investigation of the impact of hydrodynamic conditions on sediment resuspension in shallow lakes显示文摘In this study,we sampled the original sediment columns from three points located in the eastern,central,and western areas of Chaohu Lake,and then investigated sediment resuspension under hydraulic disturbances in the laboratory. The results showed that when the hydraulic disturbance is weak and sediment surface shear stress is small (<0.02 N/m²),sediment surface layer moves alone. When the hydraulic disturbance is moderate and sediment surface shear stress is within a threshold (3.7 N/m²),only a small proportion of the surface sediments begins to move. However,when the hydraulic disturbance is further strengthened and sediment surface shear stress is larger than the threshold value,surface sediments move smoothly. By the experimental results,we found that the plankton layer is about 1 mm (1.56% of the maximum content of suspended matter (SSCmax)),which is the major contribution of individual sediment initiation. The new sediment layer is about 19–22 mm (20.9% of the SSCmax),which considerably affects sediment resuspension in shallow lakes. The consolidated layer is about 22 mm below the bed surface,which requires high shear stress and is hard to be transferred to the water column. The quantified experimental observation results are further verified with the theoretical results. | Wenguang Luo Jing Lu Senlin Zhu Yao Yue Lingjun Xiao | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 8 | Palladium-catalyzed cascade synthesis of spirocyclic oxindoles via regioselective C2-H arylation and C8-H alkylation of naphthalene ring显示文摘A simultaneous C2-H arylation and C8-H alkylation of naphthalene ring has been achieved by palladiumcatalyzed cascade reaction of N-(2-halophenyl)-2-(naphthalen-1-yl)acrylamides with aryl iodides,which provides an efficient method for synthesizing various aryl-substituted spirocyclic oxindoles.The protocol enables three C-C bonds formation via an intramolecular Heck reaction and sequentially regioselective C-H bond activation. | Xiai Luo Wenguang Li Haiyan Lu Guobo Deng Yuan Yang Chunming Yang Yun Liang | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
| 9 | Numerical Study of Interaction Efficiency for a 170GHz Megawatt-Level Coaxial-Gyrotron显示文摘The beam-wave interaction efficiency of a 170GHz megawatt-level corrugated coaxial-gyrotron operating with TE_(31,12) mode was studied numerically. According to the self-consistent nonlinear theory, the efficiencies of two types of coaxial resonator were calculated and compared. Taking into account electronic velocity spread and cavity wall resistivity, the beam-wave interactions of improved cavity were investigated. The relationships between efficiency and magnetic field, voltage, current, beam radius, velocity ratio, and parameters of groove are presented. The results show that the voltage and magnetic field have great influence on efficiency, but the current and velocity spread do slightly. The optimized geometry parameters can improve efficiency, reduce the impact of velocity spread on efficiency, and achieve around 48.6% electronic efficiency and 1.7MW output power at 5% velocity spread and 6.896×10^(-8) Ωm resistivity. | QIN Mimi YANG Kuo LUO Wenguang LUO Yong HUANG Yong | 2016 | Chinese Journal of Electronics2016，25，5： | 0 |
| 10 | Building a High-Performance Graph Storage on Top of Tree-Structured Key-Value Stores显示文摘Graph databases have gained widespread adoption in various industries and have been utilized in a range of applications,including financial risk assessment,commodity recommendation,and data lineage tracking.While the principles and design of these databases have been the subject of some investigation,there remains a lack of comprehensive examination of aspects such as storage layout,query language,and deployment.The present study focuses on the design and implementation of graph storage layout,with a particular emphasis on tree-structured key-value stores.We also examine different design choices in the graph storage layer and present our findings through the development of TuGraph,a highly efficient single-machine graph database that significantly outperforms well-known Graph DataBase Management System(GDBMS).Additionally,TuGraph demonstrates superior performance in the Linked Data Benchmark Council(LDBC)Social Network Benchmark(SNB)interactive benchmark. | Heng Lin Zhiyong Wang Shipeng Qi Xiaowei Zhu Chuntao Hong Wenguang Chen Yingwei Luo | 2024 | Big Data Mining and Analytics2024，7，1： | 0 |
| 11 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy显示文摘Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets. | Shuxin Liang Changlei Bao Zi Yang Shiyun Liu Yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang Luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 12 | A survey of cloud resource management for complex engineering applications显示文摘 | Haibao CHEN Song WU Hai JIN Wenguang CHEN Jidong ZHAI Yingwei LUO Xiaolin WANG | 2016 | Frontiers of Computer Science2016，10，3： | 0 |
| 13 | Specific killing effect of diphtheria toxin A fragment under control of DF3 promotor on human breast cancer cells显示文摘Objective: To study the effects of recombinant expression vector containing human breast cancer DF3 promotor and diphtheria toxin A fragment on human breast cancer cells. Methods: Constructing recombinant expression vector PGL3-DF3-DTA and transfecting it into human breast cancer cells of DF3 positive and negative. By means of RT-PCR to measure the expression of DTA in human breast cancer cells. MTT color-imetry was used to examine the effect of PGL3-DF3-DTA on growth of human breast cancer cells. By experiment on nude mice to observe the killing effect of PGL3-DF3-DTA on human breast cancer cells. Results: Recombinant expression vector PGL3-DF3-DTA was highly expressed in human breast cancer cell line of DF3 positive, and it could kill the human breast cancer cells not only in vitro but also in vivo. Conclusion: Recombinant expression vector PGL3-DF3-DTA could produce specific killing effect on human breast cancer cell line of DF3 positive. | Ming Cai Wenguang Huang Wei Luo Sheng Pan Tao Yin | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，2： | 0 |
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