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| 1 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 2 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 3 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 4 | Efficacy and Safety of Low Molecular Weight Heparin Prophylaxis for Venous Thromboembolism Following Lumbar Decompression Surgery显示文摘Objective To evaluate the efficacy and safety of low molecular weight heparin (LMWH) prophylaxis for venous thromboembolism (VTE) after lumbar decompression surgery. Methods Patients at high or the highest risk of VTE who underwent lumbar spine surgery in Peking Union Medical College Hospital from January 2004 to April 2011 were included in the present study. All the patients received a half dose of LMWH 6 hours after surgery followed by a full dose LMWH once per day until discharge. We recorded incidences of deep venous thrombosis (DVT), pulmonary embolism (PE), bleeding complications, and medication side effects. Results Seventy-eight consecutive patients were eligible and enrolled in this study. The mean hospital stat was 8.5±4.5 days. No symptomatic DVT, PE, or major bleeding events were observed. One patient developed wound ecchymosis, another developed wound bleeding, four had mild hepatic aminotransferase level elevation, and one developed a suspicious allergic reaction. Conclusion LMWH may be applied as an effective and safe prophylaxis for VTE in high-risk patients undergoing lumbar decompression surgery. | Zhi-jian Sun Yu Zhao Giu-xing Qiu Yi-peng Wang Xi-sheng Weng Hong Zhao Jian-xiong Shen Yu Jiang Ye Li Xiang Li | 2011 | Chinese Medical Sciences Journal2011，26，4： | 12 |
| 5 | Effects of high temperature on the microstructure and mechanical behavior of hard coal显示文摘Coal is a common porous sedimentary rock whose microstructure and mechanical behavior are often affected by high temperature.In order to deeply investigate the effect of high temperature on the structure and mechanical properties of coal,six groups of coal samples with different heating temperatures were prepared.Various testing methods,including ultrasonic test,scanning electron microscopy,nuclear magnetic resonance and uniaxial compression test,were used in this study.The results showed that the physical and chemical change processes of coal samples under high temperature can be divided into two stages:the stage of drying and degassing and the stage of pyrolysis of the coal matrix.With the increase of heating temperature,the total porosity of coal samples increases,while the integrity and the deformation resistance of coal samples decrease.In addition,the elastic modulus and uniaxial compressive strength of the coal sample decrease with the increase of heating temperature.The Poisson’s ratio decreases firstly and then increases with the increase of heating temperature. | Chengdong Su Jiadong Qiu Qiuhong Wu Lei Weng | 2020 | International Journal of Mining Science and Technology2020，30，5： | 11 |
| 6 | Promoting effect of microwave irradiation on CeO2-TiO2 catalyst for selective catalytic reduction of NO by NH3显示文摘In this work we prepared several CeO2-TiO2 catalysts for the NH3-SCR reactionusing co-precipitation with assistance of microwave irradiation.The catalytic NH3-SCR activities over CeO2-TiO2 catalysts at low temperatures are largely enhanced by the treatment of microwave irradiation,the operation temperature window is also broadened.For better understanding the promotion mechanism,the catalyst prepared by conventional co-precipitation with and without microwave irradiation treatment was characterized with H2-TPR,NH3-TPD,XPS,XRD and BET.Microwave irradiation treatment accelerates the crystallite rate of CeO2-TiO2 catalysts,and greatly enlarges their surface area by adjusting their microstructures.The resistance to SO2 and H2O is also improved via regulating the hierarchical pore structure by the microwave irradiation.Microwave irradiation treatment can also improve the redox property and increase the acid sites over the catalyst surfaces.The result of in situ DRIFTS suggests that the microwave irradiation treatment generates more Br?nsted acid sites on CeO2-TiO2-2 h catalyst,helpful in SCR reactions.XPS results show that after microwave irradiation on the CeO2-TiO2 catalysts,the surface demonstrates an elevated concentration of chemisorbed oxygen,consequently leading to better oxidation of NO to NO2.Additionally,the molar ratio of Ce3+/Ce4+has been elevated after being treated by microwave irradiation,a vital factor in enhancing the NH3-SCR activities. | Jie Cheng Liyun Song Rui Wu Shining Li Yanming Sun Hongtai Zhu Wenge Qiu Hong He | 2020 | Journal of Rare Earths2020，38，1： | 11 |
| 7 | Long term follow up of clinical outcome between patellar resurfacing and nonresurfacing in total knee arthroplasty: Chinese experience显示文摘 | Feng Bin Weng Xisheng Lin Jin Jin Jin Qian Wenwei Wang Wei Qiu Guixing | 2014 | Chinese Medical Journal2014，，22： | 7 |
| 8 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 9 | Study on variational aerosol fields over Beijing and its adjoining areas derived from Terra-MODIS and ground sunphotometer observation显示文摘This paper presents a comprehensive observa-tion technique on derived aerosols data from mobile sun-photometer graph and Terra-Moderate Resolution Imaging Spectroradiometer (MODIS) observation. Research results suggest that after being treated by the variational technique with respect to sunphotometer observations, the Terra- MODIS remote sensing aerosol data are remarkably im-proved, thus for the first time revealing features of the influ-ence of aerosols and pollution emissions of Beijing and its adjoining areas (Hebei, Shandong, etc. provinces). The re-gional impact features of aerosols are related with the pe-ripheral U-shape topography of Beijing. Analyses with Hy-brid Single Particle Lagrangian Integrated Trajectory model (HYSPLIT-4) and meteorological data in the case studied confirm the pollutants diffusion process along the trajectory from the sources in the south-west region, and the regional aerosol impact features. | XU Xiangde ZHOU Xiuji WENG Yonghui TIAN Guoliang LIU Yujie YAN Peng DING Guoan ZHANG Yuxiang MAO Jietai QIU Hong | 2003 | Chinese Science Bulletin2003，48，18： | 7 |
| 10 | Primary effect of dual growing rod technique for the treatment of severe scoliosis in young children显示文摘在小孩子的很快进行的脊柱侧凸的背景处理是为脊骨外科医生的挑战。一些外科医生开始了在小孩子为很快进行的脊柱侧凸的处理使用双成长的杆技术并且完成了可接受的结果。这研究的目的是在中国决定这种新技术的主要结果和复杂并发症。受不了很快进行的脊柱侧凸的十一个孩子在北京联合医学院医院(PUMCH ) 与在 2004 年 11 月和 2009 年 3 月之间的双成长的杆技术被对待的方法。在有 0 等级的 Risser 符号的组有 10 女性和 1 男性。在起始的外科的吝啬的年龄是 6.1 年(范围, 2.1-10.9 年) 。十个病人作为先天的脊柱侧凸和 1 耐心的神经与肌的脊柱侧凸被诊断。所有病人有 1-4 变长过程(平均数, 1.8 过程) 在起始的手术以后。所有病人的 X 光线照相术的结果被调查。脊柱侧凸的花冠 Cobb 角度改善了从的结果(67.64 数?? | LI Qi-yi ZHANG Jian-guo QIU Gui-xing WANG Yi-peng SHEN Jian-xiong ZHAO Yu LI Shu-gang YU Bin WANG Xi WENG Xi-sheng | 2010 | Chinese Medical Journal2010，，2： | 6 |
| 11 | Drainage does not Promote Post-operative Rehabilitation After Bilateral Total Knee Arthroplasties Compared With Nondrainage显示文摘Objective To assess the effects of suction drainage versus nondrainage on the post-operative rehabilitation of patients receiving primary bilateral total knee arthroplasties(TKA).Methods A prospective study including 40 patients was conducted.These patients were diagnosed with osteoarthritis and underwent primary bilateral TKA between October 2007 and September 2009 with the same operation team.A suction drainage was placed by randomization in only one knee for each patient,while the other knee as self-control.Pain visual analogue scale score,extremity swelling,wound healing,range of motion and incidence of early post-operative complications between the drained and nondrained group were compared statistically.Results Each patient was followed up for 12 months.Placing drainage did not relieve the pain,extremity swelling,ecchymosis,or reduce the incidence of early complications(all P>0.05).Conclusions Suction drainage in TKA does not exhibit substantial advantages in promoting post-operative rehabilitation after unsophisticated TKA,compared with nondrainage.On the other hand,it might complicate the surgical operation,and increase the incidence of post-operative hemorrhage and retrograde infection.Thus we do not recommend suction drainage in unsophisticated TKA. | Yu Fan Yong Liu Jin Lin Xiao Chang Wei Wang Xi-sheng Weng Gui-xing Qiu | 2013 | Chinese Medical Sciences Journal2013，28，4： | 6 |
| 12 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 13 | Clinical observations of osteoporotic vertebral compression fractures by using mineralized collagen modified polymethylmethacrylate bone cement显示文摘To investigate the clinical outcomes of the treatment of osteoporotic vertebral compression fractures(OVCFs)by using mineralized collagen(MC)modified polymethylmethacrylate(PMMA)bone cement.52 cases(52 vertebras)who sustained OVCF treated with MC modified PMMA bone cement from July 2014 to December 2015 were reviewed retrospectively.All the cases(52 patients,52 vertebras)included 8 males and 44 females with an average age of 74.83(ranging from 57-to 90-years old).The visual analogue scale(VAS),vertebral body height,Cobb angle,CT values preand post-operation as well as incidence of complications were used to be observed.All the patients underwent the surgery were successfully followed-up with an average period of 13.54 months(ranging from 6 to 23 months).The patients can ambulate at the second day after the operation.The VAS scores 2 days after the operation and during the last follow-up were significantly decreased compared with that before the operation(P<0.05);the average vertebral height and local Cobb angle had significant recovery(P<0.05);the CT value of the treated vertebra significantly increased compared with that before the operation(P<0.05).MC with good osteogenic activity and degradation properties can effectively improve the mechanical properties and biocompatibility of the PMMA bone cement,thus obtain better clinical results. | XiWang Jian-Ming Kou Yang Yue An-Ze Shao Xue-Jun Jia Jian-Wen Hou Chong Gao Zhi-Ye Qiu Xiu-Mei Wang Xi-Sheng Weng | 2017 | Regenerative Biomaterials2017，4，2： | 5 |
| 14 | A hybrid coercivity mechanism for exchange-coupled nanocomposite permanent magnets显示文摘We propose a hybrid coercivity mechanism for exchange-coupled hard/soft multilayers, which incorporates elements of both the traditional nucleation and pinning mechanisms based on both threedimensional(3 D) and one-dimensional(1 D) micromagnetic calculations. The magnetic reversal starts with the nucleation of the domain wall near the defects or soft phases, which ends by the pinning usually in the same place. Therefore, pinning near the nucleation centers are the dominant coercivity mechanism for both exchange-coupled nanocomposites and so-called single-phased permanent magnets. Our proposed coercivity mechanism and calculated results agree very well with available experimental data,especially the recently reported high energy products achieved in NdFeB and SmCo based hard/soft multilayers. The hybrid coercivity mechanism can be readily extended to single-phased permanent magnets with defects and other magnetic systems. | Lei Qiu Li Zhao Xiaojiao Weng Laichuan Shen Guoping Zhao Fang Wang Linhua Xie | 2019 | Journal of Rare Earths2019，37，10： | 4 |
| 15 | Effects of SO2 Treatment of Commercial Catalysts on Selective Catalytic Reduction of NOx by NH3显示文摘 | HUANG Qinghua SONG Liyun HE Hong QIU Wenge SU Yaochao | 2016 | Chemical Research in Chinese Universities2016，32，3： | 4 |
| 16 | Selective anterior thoracolumbar/lumbar fusion and instrumentation in adolescent idiopathic scoliosis patients显示文摘在有结构的主要 TL/L 的病人弄弯的青春期的自发的脊柱侧凸(AIS ) 和一个 nonstructural 未成年者的背景选择前面的 thoracolumbar/lumbar (TL/L ) 熔化和乐器学胸的曲线很少被报导。我们由考察经历的 AIS 病人的医药记录和X射线学调查这些 patients.Methods 的修正结果选择前面的 TL/Lfusion 和乐器学, Cobb 角度,专业的修正率和次要的曲线,花冠平衡,最低 instrumented 椎骨( LIV )倾斜,花冠圆盘角度立即在 LIV ( LIVDA )和X光线照相术的肩膀高度( RSH )下面被测量并且 analyzed.Results 四十个病人被包括。为主要 TL/L 曲线,在操作前后的吝啬的花冠 Cobb 角度是在一个单个中心的 22 个病人经历了的邻近的 segments.Methods 的 43.9rative 地位布赖恩的 discectomy 和培植颈的圆盘。吝啬的后续时期是 60 个月(57-69 月) 。二十个病人经历了单人赛级的关节造形术,二在二个层次经历了关节造形术。外科的层次包括的 C3/4 (3 个层次) , C4/5 (2 个层次) , C5/6 (18 个层次) 和 C6/7 (1 水平) 。X 光线照相术的评估在 X 光检查检查上在基线并且在最后的 follow-up.Results 包括了动态 X 光检查检查和磁性的回声成像(MRI ) ,在操作水平的运动(ROM ) 的范围是 7.2 賀? 賀? | YU Bin ZHANG Jian-guo QIU Gui-xing LU Wen-can WANG Yi-peng SHEN Jian-xiong FEI Qi LI Qi-yi WENG Xi-sheng | 2010 | Chinese Medical Journal2010，，21： | 4 |
| 17 | SINS model in the management of biosafety level 2 laboratories: exploration and practice显示文摘A significant number of biosafety level 2(BSL-2)laboratories have been established in many countries for studies of various types of pathogenic agents and other infectious biological materials.The harmonized management of biological risks in such diverse laboratories thus appears as a real challenge.Zhejiang Province in China has taken the initiative to establish a comprehensively integrated laboratory biosafety management system called SINS(Standardization,Informatization,Normalization and Systematization).The SINS model system has been introduced and adopted in 1,721 BSL-2 laboratories in Zhejiang Province,and thus lead to an increase in the number of biosafety committees from 20%to more than 95%from 2007 to 2018,and the number of biosafety laboratory managers who knows biosafety-related laws and regulations increase from 52.7%to 83.7%from 2009 to 2017.Such achievements indicate that the successful implementation of SINS model has increased the effective control of biological risks in BSL-2 laboratories of the Zhejiang Province.SINS model and its main effects on leading the improvement of laboratory biosafety management was presented in this review.The SINS model helps to strengthen laboratory biosafety and thus effectively reduces occurrence of biosafety-related incidences.This model can potentially be used by other regions or countries where harmonized biosafety management system is still under-developing. | Xiaoxia Qiu Jingqing Weng Zhenggang Jiang Congcong Yan Hua Gu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 18 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 19 | Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion显示文摘The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the 'one stone two bird' agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic. | Min Liu Zhifeng Li Jianhui Xiong Yefei Jiang Ting Tang Jinkai Qiu Junwei Yao Seik Weng Ng Chenghui Zeng | 2021 | Journal of Rare Earths2021，39，10： | 3 |
| 20 | Lung function after growing rod surgery for progressive early-onset scoliosis: a preliminary study显示文摘背景肺的问题经常与早发作的脊柱侧凸(曙光女神)发生在病人 .However ,在有在种杆外科以后的曙光女神的病人的肺功能一直不是学习是与种杆和它的可能的关联词 factors.Methods 为曙光女神在治疗以后调查肺功能的这的 documented.The 目的有曙光女神的八个病人与从2002年9月在北京联合医学院医院种杆外科到被对待2009年9月 .Four 病人完成了最后的熔化 | JIANG Yu ZHAO Yu WANG Yi-peng QIU Gui-xing WENG Xi-sheng LI Ye | 2011 | Chinese Medical Journal2011，，23： | 3 |
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