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| 1 | Gamma-glutamyl Transpeptidase to Platelet Ratio Predicts Liver Injury in Hepatitis B e Antigen-negative Chronic Hepatitis B Patients With Normal Alanine Aminotransferase显示文摘Background and Aims:Chronic hepatitis B virus(HBV)infection is a serious health problem worldwide.Evaluating liver injury in patients with hepatitis B e antigen(HBeAg)-negative chronic hepatitis B(CHB)with detectable HBV DNA and normal alanine aminotransferase(ALT)is crucial to guide their clinical management.We aimed to investigate the stages of liver inflammation and fibrosis as well as the predictive accuracy of gamma-glutamyl transpepti-dase-to-platelet ratio(GPR)in these patients.Methods:A total of 184 treatment-naïve HBeAg-negative CHB pa-tients with detectable HBV DNA and normal ALT were enrolled.The Scheuer scoring system was used to classify liver inflammation and fibrosis.Results:The distribution of patients with different liver inflammation grades were as follows:G0,0(0%);G1,97(52.7%);G2,68(37.0%);G3,12(6.5%);and G4,7(3.8%).The distribution of patients with different liver fibrosis stages were as follows:S0,22(12.0%);S1,72(39.1%);S2,42(22.8%);S3,19(10.3%);and S4,29(15.8%).The areas under the re-ceiver operating characteristic(AUROC)curves of GPR in predicting significant inflammation,severe inflammation,and advanced inflammation were 0.723,0.895,and 0.952,respectively.The accuracy of GPR was significantly superior to that of ALT in predicting liver inflammation.The AUROCs of GPR in predicting significant fibrosis,severe fibrosis,and cirrhosis were 0.691,0.780,and 0.803,respectively.The predictive accuracy of GPR was significantly higher than that of aminotransferase-to-platelet ratio index(APRI)and fibrosis index based on four factors(FIB-4)in identifying advanced fibrosis and cirrhosis,and it was superior to FIB-4 but comparable to APRI in identifying significant fibrosis.Conclusions:Nearly half of the HBeAg-negative CHB patients with detectable HBV DNA and normal ALT levels had significant liver inflammation or fibrosis.GPR can serve as an accurate predictor of liver inflammation and fibrosis in these patients. | Xiang-An Zhao Jian Wang Jie Wei Jiacheng Liu Guangmei Chen Li Wang Guiyang Wang Juan Xia Weihua Wu Shengxia Yin Xin Tong Xiaomin Yan Weimao Ding Xiaoxing Xiang Rui Huang Chao Wu | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 3 |
| 2 | Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation显示文摘Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro. | Junbo Gao Xingjie Zhang Kun Shang Weimao Zhong Ruihan Zhang Xiaochang Dai Xiaoli Li Qi Wang Yan Zou Weilie Xiao | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 3 | New Lignans from the Leaves and Stems of Schisandra chinensis and Their Anti-HIV-1 Activities显示文摘Six new lignans(1-6),as well as five known ones(7-11)were isolated from the leaves and stems of Schisandra chinensis.The structures of 1-6 were established on the basis of spectroscopic methods including 1D-and 2D-NMR techniques and CD experiments.Compound 1 was the first example of naturally occurring N-containing lignans featuring a nicotinoyl group.All the new compounds were evaluated for their anti-HIV-1 activities and showed EC50 values in the range 17.89-138.23μg/mL. | Yiming Shi Weimao Zhong Huan Chen Ruirui Wang Shanzhai Shang Chengqin Liang Zhonghua Gao Yongtang Zheng Weilie Xiao Handong Sun | 2014 | Chinese Journal of Chemistry2014，32，8： | 3 |
| 4 | Scholarly networks on resilience, vulnerability and adaptation within the human dimensions of global environmental change显示文摘 | Marco A. Janssen Michael L. Schoon Weimao Ke Katy B?rner | 2006 | Global Environmental Change2006，，3： | 2 |
| 5 | The effects of precipitant agent on structure and performance of LiNi1/3Co1/3Mn1/3O2 cathode material via a carbonate co-precipitation method显示文摘 | Yin Kui Fang Weimao Zhong Benhe | 2012 | Electrochimica Acta2012，85，： | 1 |
| 6 | Scholarly net works on resilience, vulnerability and adaptation within the human dimensions of global environmental change 显示文摘 | Janssen M A Schoon M L Ke Weimao | 2006 | Global Environmental Change2006，16，3： | 1 |
| 7 | Studying the emerging global brain: Analyzing and visualizing the impact of co-authorship teams显示文摘 | B?rner K Dall'Asta L Ke Weimao | 2005 | Complexity2005，10，4： | 1 |
| 8 | Partition-Based Cache Replacement to Manage Shared L2 Caches显示文摘The Least recently used(LRU) replacement has been widely employed by on-chip shared caches. With the increase of cache associativity, the performance gap between LRU and theoretical optimal replacement algorithm is significant, motivating us to design alternative replacement algorithms to improve cache performance. We propose a Partition-based cache replacement(PCR) algorithm to manage multi-core shared L2 caches. PCR takes into consideration recency and frequency information of cache access, and cache resource interference among multiple competing applications. PCR is effective to filter out the less frequently reused blocks through a dynamic insertion/promotion policy based on the target partitions, and ensures that some fraction of the working set is retained in the cache to contribute to more hits. Our evaluation shows that PCR improves performance of an 8-core system by an average of 11.3% over LRU-based cache. | FANG Juan WANG Jing LI Chengyan YAO Zhicheng KE Weimao | 2014 | Chinese Journal of Electronics2014，23，3： | 1 |
| 9 | Studying the emerging global brain: Analyzing and visualizing the impact of co-authorship teams 显示文摘 | Borner K Dall' Asta L Ke Weimao | 2005 | Complexity : Special Issue on Understanding Complex Systems2005，10，4： | 1 |
| 10 | Preparation of true solutions of monomeric amyloidogenic protein/peptide:A critical prerequisite for aggregation kinetic study显示文摘Our dynamic laser light scattering(LLS) study shows that the current widely used protocols of dissolving amyloidogenic protein/peptide do not really result in a true solution;namely,there always exist a trace amount of interchain aggregates,which greatly affect the association kinetics,partially explaining why different kinetics were reported even for a solution with identical protein and solvent.Recently,using a combination of the conventional dissolution procedure and our newly developed ultra-filtration method,we have developed a novel protocol to prepare a true solution of amyloidogenic protein/peptide without any interchain aggregates.The resultant solutions remain in their monomeric state for at least one week,which is vitally important for further study of the very initial stage of the interchain association under the physiological conditions because more and more evidence suggests that it is those small oligomers rather than large fabric aggregates that are cytotoxic.In addition,this study shows that combining static and dynamic LLS can lead to more physical and microscopic information about the protein association instead of only the size distribution. | DIAO Shu ZHAO Hong WANG WeiMao WU Chi | 2012 | Science China Chemistry2012，55，1： | 1 |
| 11 | Advanced information retrieval Web services for digital libraries显示文摘 | Weimao Ke yueyu Fu Javed Mostafa | 2005 | Library Collecestions Acquisitions & Technical Serbvices2005，，29： | 1 |
| 12 | Preparation of true solutions of monomeric amyloidogenic protein/peptide:A critical prerequisite for aggregation kinetic study显示文摘Our dynamic laser light scattering(LLS) study shows that the current widely used protocols of dissolving amyloidogenic protein/peptide do not really result in a true solution;namely,there always exist a trace amount of interchain aggregates,which greatly affect the association kinetics,partially explaining why different kinetics were reported even for a solution with identical protein and solvent.Recently,using a combination of the conventional dissolution procedure and our newly developed ultra-filtration method,we have developed a novel protocol to prepare a true solution of amyloidogenic protein/peptide without any interchain aggregates.The resultant solutions remain in their monomeric state for at least one week,which is vitally important for further study of the very initial stage of the interchain association under the physiological conditions because more and more evidence suggests that it is those small oligomers rather than large fabric aggregates that are cytotoxic.In addition,this study shows that combining static and dynamic LLS can lead to more physical and microscopic information about the protein association instead of only the size distribution. | DIAO Shu ZHAO Hong WANG WeiMao WU Chi | 2012 | 中国科学:化学2012，42，2： | 0 |
| 13 | BTC-Shadow: an analysis and visualization system for exposing implicit behaviors in Bitcoin transaction graphs显示文摘1 Introduction A Bitcoin ledger comprises a sizable number of transaction records,which can be utilized to make it easier to track and analyze the traits and patterns of cryptocurrency-related transactions.To facilitate the visual analysis of Bitcoin,numerous tools with various aims have been developed.For example,MiningVis[1]and SuPoolVisor[2]are the analytics systems for Bitcoin mining pools,as well as[3-5]focus on the Bitcoin transaction graphs analysis.However,due to our previous research requirements for Bitcoin transaction graphs,none of the available tools can provide exploring the features of connection related to the address and observe significant visual patterns.Specifically,using these tools is challenging to navigate to abnormal node clusters effortlessly from large node groups and then analyze the local interlink characteristics between transaction nodes with interactive analytics. | Ding BAO Wei REN Yuexin XIANG Weimao LIU Tianqing ZHU Yi REN Kim-Kwang Raymond CHOO | 2023 | Frontiers of Computer Science2023，17，6： | 0 |
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