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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Analysis on water potential of Populus euphratica oliv and its meaning in the lower reaches of Tarim River,Xinjiang显示文摘Combined with materials measured on leaves water potential of Populus euphratica oliv in the process of ecological water delivery in the lower reaches of Tarim River, the influence of ground-water depths and soil salinity on leaves water potential of P. euphratica was analyzed. We found that there was evident negative correlation between the leaves water potential of P. euphratica and ground-water depths. The deeper the ground-water depths were, the lower the leaves water potential of P. euphratica was, the more serious drought stress P. euphratica suffered from. Besides, there was evident negative correlation between the soil salinity and the leaves water potential of P. euphratica. The bigger the soil salinity was, the lower the leaves water potential of P euphratica was, the more serious drought stress was indicated from which P. euphratica suffered. For sections rather distant for Daxihaizi Reservoir as well as for those places of wells rather distant from the river course, ground-water depths and the soil salinity were high; the leaves water potential of P. euphratica was low. The leaves water potential of P. euphratica can reflect the degree at which P. euphratica suffers from drought and salt stress, and has an important reference meaning in analyzing proper ground-water depths for the survival and growth of P. euphratic in the lower reaches of Tarim River. | FU Aihong CHEN Yaning LI Weihong | 2006 | Chinese Science Bulletin2006，51，A01： | 17 |
| 3 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 4 | Water use strategies of the desert riparian forest plant community in the lower reaches of Heihe River Basin, China显示文摘The object of this paper is the different plant communities in the Ejina desert riparian forest.Groundwater depth,soil moisture,plant water potential,relative leaf moisture content and water use efficiency was monitored,and the response of soil moisture and plant ecology to the groundwater depth and the water use efficiency of the different plant communities was analyzed.The results showed that:(1)Along with the groundwater depth increasing,predawn and midday water potential of the plants,with the exception of Reaumuria soongorica,did not decrease significantly,indicating that when the groundwater depth is less than3 m,the plant communities in the range of 4 km from the river way did not suffer or slightly suffer from water stress;(2)The distribution of higher soil moisture content within 0–3 m soil layer is suitable with the plants’root system,as indicated in the communities of coexisting overripe Populus euphratica or Taramrix chinensis,both of which can release excessive water into soil for shallow rooted shrubs or herbaceous plants when there is water shortage;(3)R.soongorica can absorb deep soil moisture through deep roots for their own survival;(4)The community consisting of Sophora alopecuroides,Karelinia caspica,T.chinensis,and overripe P.euphratica has the best species combination for restoring the damaged eco-environment in the lower reaches of Heihe River;(5)The order of plants’relative leaf water contents is K.caspica>S.alopecuroides>young P.euphratica>overripe P.euphratica>mature P.euphratica=T.chinensis coexisting with other species>single R.soongorica>single T.chinensis and the order of WUE is single T.chinensis>single R.soongorica>T.chinensis living in symbiosis with other species>S.alopecuroides=young P.euphratica>mature P.euphratica>overripe P.euphratica>K.caspica.Therefore,with ample soil moisture,the plant community helps rapid growth of T.chinensis,young P.euphratica and R.soongorica plants of less moisture content.Despite this they do not have much water storage capability,but have strong drought resistance,and higher moisture contents of S.alopecuroides and K.caspica,thus leaving them with poor drought resistance.Overall,the desert riparian forest plant community in the lower reaches of Heihe River helps the species of higher WUE live on it. | FU AiHong CHEN YaNing LI WeiHong | 2014 | Science China Earth Sciences2014，57，6： | 10 |
| 5 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 6 | UBSS and blind parameters estimation algorithms for synchronous orthogonal FH signals显示文摘By using the sparsity of frequency hopping(FH) signals,an underdetermined blind source separation(UBSS) algorithm is presented. Firstly, the short time Fourier transform(STFT) is performed on the mixed signals. Then, the mixing matrix, hopping frequencies, hopping instants and the hooping rate can be estimated by the K-means clustering algorithm. With the estimated mixing matrix, the directions of arrival(DOA) of source signals can be obtained. Then, the FH signals are sorted and the FH pattern is obtained. Finally, the shortest path algorithm is adopted to recover the time domain signals. Simulation results show that the correlation coefficient between the estimated FH signal and the source signal is above 0.9 when the signal-to-noise ratio(SNR) is higher than 0 d B and hopping parameters of multiple FH signals in the synchronous orthogonal FH network can be accurately estimated and sorted under the underdetermined conditions. | Weihong Fu Yongqiang Hei Xiaohui Li | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 9 |
| 7 | Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity显示文摘The metabolic intermediate of acetaminophen(APAP)can cause severe hepatocyte necrosis,which triggers aberrant immune activation of liver non-parenchymal cells(NPC).Overzealous hepatic inflammation determines the morbidity and mortality of APAP-induced liver injury(AILI).Interleukin-1 receptor(IL-1R)signaling has been shown to play a critical role in various inflammatory conditions,but its precise role and underlying mechanism in AILI remain debatable.Herein,we show that NLRP3 inflammasome activation of IL-1βis dispensable to AILI,whereas IL-1α,the other ligand of IL-1R1,accounts for hepatic injury by a lethal dose of APAP.Furthermore,Kupffer cells function as a major source of activated IL-1αin the liver,which is activated by damaged hepatocytes through TLR4/MyD88 signaling.Finally,IL-1αis able to chemoattract and activate CD11b^(+)Gr-1^(+) myeloid cells,mostly neutrophils and inflammatory monocytes,to amplify deteriorated inflammation in the lesion.Therefore,this work identifies that MyD88-dependent activation of IL-1αin Kupffer cells plays a central role in the immunopathogenesis of AILI and implicates that IL-1αis a promising therapeutic target for AILI treatment. | Chao Zhang Jin Feng Jun Du Zhiyong Zhuo Shuo Yang Weihong Zhang Weihong Wang Shengyuan Zhang Yoichiro Iwakura Guangxun Meng Yang-Xin Fu Baidong Hou Hong Tang | 2018 | Cellular & Molecular Immunology2018，15，11： | 7 |
| 8 | Preparation of luminescent CdTe quantum dots doped core-shell nanoparticles and their application in cell recognition显示文摘Based on the reverse microemulsion technique, luminescent quantum dots doped core-shell nanoparticles have been prepared by employing silica as the shell and CdTe quantum dots as the core of the nanoparticles, which have an excellent solubility and dispersibility, especially amine and phosphonate groups have been modified on their surface synchronously. In comparison with CdTe quantum dots, these nanoparticles show superiority in chemical and photo-chemical stability. The quantum dots doped core-shell nanoparticles were successfully linked with lactobionic acid by amine group on it, which was used to recognize living liver cells. | LI Zhaohui WANG Kemin TAN Weihong LI Jun FU Zhiying WANG Yilin LIU Jianbo YANG Xiaohai | 2005 | Chinese Science Bulletin2005，50，16： | 5 |
| 9 | Preparation of Nano-sized Zirconium Carbide Powders through a Novel Active Dilution Self-propagating High Temperature Synthesis Method显示文摘High quality nano-sized zirconium carbide(Zr C) powders were successfully fabricated via a developed chemical active dilution self-propagating high-temperature synthesis(SHS) method assisted by ball milling pretreatment process using traditional cheap zirconium dioxide powder(ZrO2), magnesium powder(Mg) and sucrose(C12H22O11) as raw materials. FSEM, TEM, HRTEM, SAED, XRD, FTIR and Raman, ICPAES, laser particle size analyzer, oxygen and nitrogen analyzer, carbon/sulfur determinator and TG-DSC were employed for the characterization of the morphology, structure, chemical composition and thermal stability of the as-synthesized ZrC samples. The as-synthesized samples demonstrated high purity, low oxygen content and evenly distributed Zr C nano-powders with an average particle size of 50 nm. In addition, the effects of endothermic rate and the possible chemical reaction mechanism were also discussed. | 达奥运 龙飞 WANG Jilin XING Weihong WANG Yang ZHANG Fan 王为民 FU Zhengyi | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，4： | 5 |
| 10 | Analysis on the change of water potential of Populus euphratica Oliv.and P.Russkii Jabl under different irrigation volumes in temperate desert zone显示文摘The measurement of plant water potential is considered to be a direct approach to confirming the irrigation time in present irrigation systems.In this current study,two shelter forests species in the Junggar Basin (Central Asia),Populus euphratica and P.Russkii Jabl,were studied.We monitored leaf water potential (ψl),stem water potential (ψs) and soil water potential (ψsoil) under different irrigation conditions.The characteristics of the variation in leaf and stem water potential (ψl and ψs) of P.euphratica and P.Russkii Jabl,as well as the impact of soil water potential (ψsoil) on the leaf and stem water potential (ψl and ψs) under different irrigation conditions were discussed.Our results showed the following.(1) With increased irrigation,the intensity of drought stress on P.euphratica and P.Russkii Jabl decreased.(2) The intensity of drought stress experienced was less for P.Russkii Jabl than for P.euphratica under the same irrigation conditions.(3) The more intense the drought,the less sensitive was P.Russkii Jabl,but the more sensitive was P.euphratica,and vice versa.(4) For the P.euphratica community the soil water potential (Ψsoil) at 60 cm depth responded to variation in irrigation more strongly than at 30 and 90 cm depths.For the P.Russkii Jabl community the soil water potential (ψsoil) in the shallow surface layer responded to irrigation variation more strongly than that in deep layers.(5) In the event of relatively sufficient soil water,predawn stem water potential (ψpds) of plant was a reasonable indicator reflecting soil water potential (ψsoil).(6) The water demand of P.euphratica and P.Russkii Jabl shelter forests can be met with different irrigation policies:large volume and less frequency for P.euphratica but small volume and more frequency for P.Russkii Jabl. | FU AiHong CHEN YaNing LI WeiHong | 2010 | Chinese Science Bulletin2010，55，10： | 4 |
| 11 | Regional relationship between the Jiang-Huai Meiyu and the equatorial surface-subsurface temperature anomalies显示文摘The Jiang-Huai Meiyu rainy season can be distinguished into the Jiangnan Meiyu spell and the Huaihe Meiyu spell. The Jiangnan Meiyu spell appears on the last ten days in June and the Huaihe Meiyu spell lasts from early July to middle July. An inter-decadal transition was observed in 1998 respectively from the anomalies of Jiangnan Meiyu rainfall,the sea surface temperature (SST),and the subsurface tem-perature in the equatorial Pacific. Since the beginning of the 21st century,opposite trends and biennial oscillations of the Meiyu rainfall are observed in the Jiangnan and Huaihe basins. Before the strong La Nia of 1999―2000,the positive SST anomalies usually occurred in the eastern equatorial Pacific. Since the beginning of the 21st century,a precursory warming signal of SST anomaly comes from the subsurface temperature which is centrally exposed near the dateline in the central equatorial Pacific. The above-normal Meiyu rainfall in 2003,2005 and 2007 over the Huaihe basin followed the prior winter-spring positive SST anomaly near the dateline. A relationship shows that the more Jiangnan (Huaihe) Meiyu follows the winter-spring warm water in the eastern (central) equatorial Pacific. | QIAN WeiHong ZHU Jiang WANG YongGuang FU JiaoLan | 2009 | Chinese Science Bulletin2009，54，1： | 4 |
| 12 | Low-Complexity Signal Detection Based on Relaxation Iteration Method in Massive MIMO Systems显示文摘Minimum mean square error(MMSE) detection algorithm can achieve nearly optimal performance when the number of antennas at the base station(BS) is large enough compared to the number of users. But the traditional MMSE involves complicated matrix inversion. In this paper, we propose a modified MMSE algorithm which exploits the channel characteristics occurring in massive multiple-input multipleoutput(MIMO) channels and the relaxation iteration(RI) method to avoid the matrix inversion. A proper initial solution is given to accelerate the convergence speed. In addition, we point out that the channel estimation scheme used in channel hardening-exploiting message passing(CHEMP) receiver is very appropriate for our proposed detection algorithm. Simulation results verify that the proposed algorithm can achieve very close performance of the traditional MMSE algorithm with a small number of iterations. | GUO Ruohan LI Xiaohui FU Weihong HEI Yongqiang | 2015 | China Communications2015，12，S1： | 3 |
| 13 | Active control of EIT-like response in a symmetry-broken metasurface with orthogonal electric dipolar resonators显示文摘The active control of electromagnetic response in metamaterial and mutual coupling between resonant building blocks is of fundamental importance in realizing high-quality metamaterials. In this work, we propose and experimentally demonstrate the tunabilities of symmetry-broken metasurfaces made of orthogonal electric dipolar resonators. The metasurface with vertical and horizontal wires is integrated with a PIN diode for active control.It is found that the electromagnetically induced transparency(EIT)-like spectrum appears due to the destructive or constructive interferences between the two electric dipolar modes when the structural symmetry broken is introduced to the metasurface. Different from previous works on the EIT-like effect, there is only electric dipole response in our metasuface. The microscopic response of the metasurface is numerically calculated to illustrate the mode coupling between the orthogonal electric dipolar resonators. By applying temporal coupled-mode theory,the interaction between the electromagnetic wave and the symmetry-broken metasurface is described, and the characteristic parameters of the resonator system, which determine the electromagnetic response of the metasurface, are acquired. | RUISHENG YANG QUANHONG FU YUANCHENG FAN WEIQI CAI KEPENG QIU WEIHONG ZHANG FULI ZHANG | 2019 | Photonics Research2019，7，9： | 3 |
| 14 | Source Recovery in Underdetermined Blind Source Separation Based on Artificial Neural Network显示文摘We propose a novel source recovery algorithm for underdetermined blind source separation, which can result in better accuracy and lower computational cost. On the basis of the model of underdetermined blind source separation, the artificial neural network with single-layer perceptron is introduced into the proposed algorithm. Source signals are regarded as the weight vector of single-layer perceptron, and approximate ι~0-norm is taken into account for output error decision rule of the perceptron, which leads to the sparse recovery. Then the procedure of source recovery is adjusting the weight vector of the perceptron. What's more, the optimal learning factor is calculated and a descent sequence of smoothed parameter is used during iteration, which improves the performance and significantly decreases computational complexity of the proposed algorithm. The simulation results reveal that the algorithm proposed can recover the source signal with high precision, while it requires lower computational cost. | Weihong Fu Bin Nong Xinbiao Zhou Jun Liu Changle Li | 2018 | China Communications2018，15，1： | 3 |
| 15 | Photosynthesis of Populus euphratica and its response to elevated CO_2 concentration in an arid environment显示文摘The photosynthetic characterization of Populus euphratica and its response to the elevated carbon dioxide concentration ([CO2]) were analyzed based on its net photosynthetic rate (Pn), stomatal conductance (gs), intercellular CO2 concentration (Ci), transpiration rate (Tr), and water use effciency (WUE) at different groundwater depths measured by a portable gas exchange system (LI-6400) in the lower reaches of the Tarim River. The results showed that the elevation of [CO2] decreased the gs, and increased the Pn, Ci and WUE of P. euphratica. However, the effects of the elevated [CO2] on gs, Pn, Ci and WUE varied considerably with groundwater depth. The response of photosynthesis to rising [CO2] was stronger at the greater groundwater depth (more than 6 m) than that at the shallower groundwater depth (less than 6 m). The critical groundwater depth required to maintain the normal survival of P. euphratica was less than 6 m. When the groundwater depth increased to more than 6 m, P. euphratica encountered moderate water stress, and the plant suffered severe water stress when the groundwater depth increased to more than 7 m. | Honghua Zhou Yaning Chen Weihong Li Yapeng Chen Lixin Fu | 2009 | Progress in Natural Science:Materials International2009，19，4： | 2 |
| 16 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 17 | Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin显示文摘Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression. | Chunyun Pu Shaorong Tian Sanxiu He Weihong Chen Yuanyuan He Hongyan Ren Jing Zhu Jun Tang Xiaolan Huang Ying Xiang Yixiao Fu Tingxiu Xiang | 2022 | Genes & Diseases2022，9，4： | 2 |
| 18 | Review:Natural Polymer Electrolytes for Lithium Ion Batteries显示文摘Polymer electrolytes are attractive materials towards achieving safe,flexible and high-performance energy storage devices( ESDs) such as lithium ion batteries( LIBs). Conventional polymer electrolytes are confronted with big challenges to achieve high ionic conductivity,good mechanical properties,excellent biocompatibility and environmental friendliness. In this context,natural polymeric materials have appealing merits of multi-functionality,ease of accessibility,good mechanical strength,etc. making them promising candidates to substitute conventional polymer electrolytes. Recently,the rational design and fabrication of advanced natural bio-based polymer electrolytes have made important progresses. In this review, we summarize recent developments in terms of polymer electrolytes using natural polymers for several application purposes. This review also involves the merits and demerits of the different natural polymers that have been investigated thus far. The insights on state-of-the-art for natural polymer electrolytes and possible solutions for further improvement of them are discussed as well in this review. | Xuewei Fu Yu Wang Louis Scudiero Weihong Zhong | 2018 | Journal of Harbin Institute of Technology(New Series)2018，25，1： | 1 |
| 19 | Multiple Center Research on Relationship Between Screening Quality and Detection of Cervical Cancer—Six Provinces,China,June–December 2021显示文摘The coverage and quality of screening are essential for reducing the incidence of cervical precancers and cervical cancer.This multicenter study aimed to investigate the relationship between screening quality and the detection of cervical precancers and cervical cancer.The study was conducted from June to December 2021 in six hospitals across six provinces.The 2,945 participants were non-pregnant women who underwent colposcopy examinations.The average age of participants was 40.9±11.5 years old.Only 6.9%of participants had received human papillomavirus(HPV)vaccination.A total of 92.6%of participants had abnormal cervical screening results.Of the participants,577 had high-grade squamous intraepithelial lesions(HSIL)or worse(≥HSIL),with a detection rate of 19.6%.Univariate analysis indicated that a lack of cervical cancer screening history in the past five years,as well as positive cervical screening and abnormal colposcopic impression,were independent associated factors of the≥HSIL detection rate.A multivariable logistic regression showed that positive cervical screening[odds ratio(OR)=1.75,95%confidence interval(CI):1.07–2.86]was a risk factor for detecting≥HSIL.Low-grade,high-grade,and cancer of colposcopic impression were associated with a higher risk for detecting≥HSIL(OR=2.94,95%CI:2.13–4.08;OR=36.64,95%CI:26.07–51.48).It is important to disseminate health knowledge to improve public awareness of cervical cancer prevention and to enhance the capacity building of professional staff to improve the quality of cervical cancer screening. | Xiaosong Zhang Weihong Chen Xinxin Zhu Hui Bi Qingping Zhao Yunfeng Fu Lina Zhang Chunmei Zhang Ning Huang | 2023 | China CDC weekly2023，5，14： | 1 |
| 20 | Climatic regime shift and decadal anomalous events in China显示文摘 | Weihong Qian Xiang Lin Yafen Zhu Yuan Xu Jiaolan Fu | 2007 | Climatic Change2007，，2： | 1 |
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