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| 1 | Optimization on conventional and electric air-cycle refrigeration systems of aircraft: A short-cut method and analysis显示文摘The air-cycle refrigeration system is widely used in commercial and military aircraft,and its efficiency greatly affects aircraft performance.Nowadays,this system requires a more efficient design and optimization method.In this paper,a short-cut optimization method with high efficiency and effectiveness is introduced for both conventional and electric air-cycle refrigeration systems.Based on the system characteristics,a four-layer parameter matching algorithm is designed which avoids computational difficulty caused by simultaneous equations.Fuel penalty is chosen as the objective function of optimization;design variables are reduced based on sensitivity analysis to improve optimization efficiency.The results show that the 3-variable optimization of the conventional air-cycle refrigeration system can obtain almost the same results as the traditional 6-variable optimization in that these two optimizations can both significantly reduce the fuel penalty.However,the computer running time of the 3-variable optimization is much shorter than that of the 6-variable optimization.The optimal fuel penalty of the electric air-cycle refrigeration system is lower than that of the conventional one.This study can provide reference for optimizing the aircycle refrigeration system of aircraft. | Hongsheng JIANG Sujun DONG Hainan ZHANG Fengming AI Zhiwei ZHANG Jun WANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 6 |
| 2 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 3 | SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance显示文摘Androgen deprivation therapy(ADT)is an important treatment strategy that can be used to delay the progression of prostate cancer.However,after an initial response,which varies significantly among patients,the disease eventually progresses despite the low levels of testosterone in the systemic circulation.1 The mechanism underlying the progression of prostate cancer to castration-resistant prostate cancer(CRPC)is not yet clear,and further investigation is needed. | Fei Liu Chao Wang Hai Huang Yue Yang Lihe Dai Sujun Han Nianzeng Xing Shancheng Ren | 2021 | Cellular & Molecular Immunology2021，18，3： | 5 |
| 4 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 5 | Haploidentical hematopoietic cell transplantation for severe acquired aplastic anemia: a case-control study of post-transplant cyclophosphamide included regimen vs. anti-thymocyte globulin & colony-stimulating factor-based regimen显示文摘Dear Editor,Haploidentical allogeneic hematopoietic stem cell transplantation(haplo-HSCT),a curative therapy for severe aplastic anemia(SAA)patients,has been used clinically for decades.Two models,not involving ex vitro T-cell depletion,have been adopted for haplo-HSCT in patients with SAA.The first is referred to as the'Beijing protocol'(Xu et al.,2017),and comprises a conditioning regimen using busulfex(BU),cyclophosphamide(CY). | Lanping Xu Bin Fu Wenjing Wang Yajing Xu Depei Wu Shunqing Wang Qifa Liu Linghui Xia Sujun Gao Ming Jiang Jianmin Wang Xi Zhang Hai Bai Huiren Chen Chunfu Li Xiaojun Huang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
| 6 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 7 | A digital open-loop Doppler processing prototype for deep-space navigation显示文摘A prototype based on digital radio technology with associated open-loop Doppler signal processing techniques has been developed to measure a spacecraft's line-of-sight velocity. The prototype was tested in China's Chang'E-1 lunar mission relying on S-band telemetry signals transmitted by the sat-ellite,with results showing that the residuals had a RMS value of ~3 mm/s (1σ ) using 1-sec integration,which is consistent with the Chinese conventional USB (Unified S-Band) tracking system. Such preci-sion is mainly limited by the short-term stability of the atomic (e.g. rubidium) clock at the uplink ground station. It can also be improved with proper calibration to remove some effects of the transmission media (such as solar plasma,troposphere and ionosphere),and a longer integration time (e.g. down to 0.56 mm/s at 34 seconds) allowed by the spacecraft dynamics. The tracking accuracy can also be in-creased with differential methods that may effectively remove most of the long-term drifts and some of the short-term uncertainties of the uplink atomic clock,thereby further reducing the residuals to the 1 mm/s level. Our experimental tracking data have been used in orbit determination for Chang'E-1,while other applications (such as the upcoming YH-1 Mars orbiter) based on open-loop Doppler tracking will be initiated in the future. Successful application of the prototype to the Chang'E-1 mission in 2008 is believed to have great significance for China's future deep space exploration. | JIAN NianChuan SHANG Kun ZHANG SuJun WANG MingYuan SHI Xian PING JingSong YAN JianGuo TANG GeShi LIU JunZe QIU Shi FUNG Lai-Wo ZHANG Hua WANG Zhen GOU Wei | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 2 |
| 8 | Quantitative analysis of secretome from adipocytes regulated by insulin显示文摘Adipocyte 是经由肽和蛋白质的分泌物在另外的机关涉及精力的存储和版本,而且在精力新陈代谢的规定的不仅一个中央播放器。在胰岛素抵抗和类型的致病期间 2 糖尿病, adipocytes 受到胰岛素的增加的层次,它可以在 adipokines 的分泌物上有主要影响。我们承担了劈得开的编码同位素的亲密关系标签(cICAT ) ,没有标签的 quantitation 来临鉴别是差别的能分泌的因素由 3T3-L1 adipocytes 藏匿了与或没有胰岛素处理并且确定。cICAT 和没有标签的结果的联合,有 317 蛋白质,预言或注解同样能分泌的蛋白质。在这些能分泌的蛋白质之中, 179 蛋白质和 53 蛋白质分别地显著地起来调整、下面调整。77 的一个总数报导 adipokines 在我们的学习被确定,例如 adiponectin,组织蛋白酶 D, cystatin C, resistin,和 transferrin。这些 adipokines 的西方的污点分析从集体 spectrometry 证实了量的结果,并且由增加胰岛素剂量揭示了这些蛋白质的个性化的 secreting 模式。另外, 240 蛋白质是在我们的学习,其大多数在胰岛素处理之上起来调整从 3T3-L1 adipocytes 分泌了蛋白质最新被识别并且确定。进一步全面的生物信息学分析表明在细胞外的矩阵受体相互作用小径和 glycan 结构降级小径的能分泌的蛋白质由胰岛素刺激是显著地起来调整的。 | Hu Zhou Yuanyuan Xiao Rongxia Li Shangyu Hong Sujun Li Lianshui Wang Rong Zeng Kan Liao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 2 |
| 9 | IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells显示文摘Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T cells.We recently identified Tc9 cells as a new potent antitumor effector T cell subset.However,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further exploited.Here,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in vivo.IL-33 treatment also drives the cytotoxic activities of DC-induced Tc9 cells.Notably,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T cells.More importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 cells.Mechanistic studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T cells.Finally,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse model.Our study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications. | Ning Liu Yuxue Jiang Jintong Chen He Nan Yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin Sujun Gao Ying Yue Siqing Wang | 2019 | Cellular & Molecular Immunology2019，16，7： | 2 |
| 10 | Pharmaco- kinetics of guanfu base I, an active metabolite of guanfu base A, in rats显示文摘 | Li XiaoTian Wang GuangJi Wang SuJun | 2005 | Biol Pharm Bull2005，28，8： | 1 |
| 11 | SimuItane ous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies 显示文摘 | Wang SuJun Ruan JinXiu Zhao YanHong | 2008 | Biomed Chromatogr2008，22，1： | 1 |
| 12 | An efficient and scalable pairwise key pre-distribution scheme for sensor networks using deployment knowledge显示文摘 | Boqing Zhou Sujun Li Qiaoliang Li Xingming Sun Xiaoming Wang | 2008 | Computer Communications2008，，1： | 1 |
| 13 | Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism显示文摘 | Haoqiang Ying Alec C. Kimmelman Costas A. Lyssiotis Sujun Hua Gerald C. Chu Eliot Fletcher-Sananikone Jason W. Locasale Jaekyoung Son Hailei Zhang Jonathan L. Coloff Haiyan Yan Wei Wang Shujuan Chen Andrea Viale Hongwu Zheng Ji-hye Paik Carol Lim Alexande | 2012 | Cell2012，，3： | 1 |
| 14 | Molecular mapping of the blast resistance gene Pi49 in the durably resistant rice cultivar Mowanggu显示文摘 | Pingyong Sun Jinling Liu Yue Wang Nan Jiang Suhua Wang Yangshuo Dai Jia Gao Zhiqiang Li Sujun Pan Dan Wang Wei Li Xionglun Liu Yinghui Xiao Erming Liu Guo-Liang Wang Liangying Dai | 2013 | Euphytica2013，，1： | 1 |
| 15 | Dodecanol-poly(D,L-lactic acid)-b-poly(ethylene glycol)-folate(Dol-PLA-PEG-FA)nanoparticles:evaluation of cell cytotoxicity and selecting capability in vitro显示文摘 | Wang Sujun Luo Yanfeng Zeng Suyun Luo Chunhua Yang Li Liang Zhiqing Wang Yuanliang | | 0，，： | 1 |
| 16 | An Arabidopsis Promoter Microarray and its Initial Usage in the Identification of HY5 Binding Targets in Vitro显示文摘 | Ying Gao Jinming Li Elizabeth Strickland Sujun Hua Hongyu Zhao Zhangliang Chen Lijia Qu Xing Wang Deng | 2004 | Plant Molecular Biology2004，，5： | 1 |
| 17 | Experimental investigation on boiling heat transfer characteristics of Al_2O_3-water nanofluids in swirl microchannels subjected to an acceleration force显示文摘Experiments were carried out to investigate the boiling heat transfer characteristics of Al_2O_3-water nanofluids in swirl microchannels under terrestrial gravity and acceleration fields. A centrifuge with a two-meter long rotational arm was used to simulate the acceleration magnitude up to 9 g and three various acceleration directions. Three test sections with different geometric parameters were applied. The volume concentration of Al_2O_3 nanoparticles with an average diameter of 13 nm was varied from 0.07% to 0.1%. The mass flow rate and vapor quality were in ranges of 3–6 kg/h and 0.4–1.0%, respectively. The effects of the mass flow rate, microchannel aspect ratio,vapor quality, nanoparticle volume concentration, and acceleration direction and magnitude were analyzed in a systematic manner. Experimental results showed that the acceleration direction and magnitude had significant influences on the boiling heat transfer. The heat transfer under configuration C was found to be superior to that under configurations A and B. Moreover, the heat transfer coefficient increased with increases of the mass flow rate and the volume concentration and decreased with the aspect ratio. | Sujun DONG Hongsheng JIANG Yongqi XIE Xiaoming WANG Zhongliang HU Jun WANG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 1 |
| 18 | Comparative risk of acute kidney injury among cancer patients treated with immune checkpoint inhibitors显示文摘With the development and introduction of immune checkpoint inhibitors(ICIs)in cancer patients,immune-related side effects have increasingly attracted attention.However,the risks of immune-related renal toxicity are poorly characterized.In this study,we performed a network meta-analysis(NMA)of ICI-related randomized clinical trials(RCTs)to elucidate the comparative risk of acute kidney injury(AKI)in cancer patients receiving different ICIs.We also sought to identify other factors potentially affecting the risk of AKI.PubMed and EMBASE were searched for peer-reviewed trial reports published between January 2000 and May 2021.Eligible studies were RCTs studying ICIs in cancer patients and reporting AKI data.We performed a frequentist NMA to evaluate the risk ratios for grade 1-5 and grade 3-5 AKI between the treatment groups.We also assessed the absolute incidence of AKI in the ICI-containing arm using traditional direct meta-analysis.Once significant heterogeneity was detected in a traditional direct meta-analysis,multivariable meta-regression analysis was applied to identify factors that significantly affected the absolute incidence of AKI.A total of 85 RCTs were included in this study.In the NMA for the risk of grade 1-5 and 3-5 AKI,ipilimumab showed a significantly higher risk than avelumab and durvalumab,whereas 1 mg/kg nivolumab plus 3 mg/kg ipilimumab(N1I3)showed a significantly higher risk than other groups.In terms of treatment ranking,durvalumab±low-dose tremelimumab and avelumab were consistently among the top three safest treatments for grade 1-5 or 3-5 AKI,whereas N1I3,ipilimumab and tremelimumab were consistently among the top three treatments with the highest risk for grade 1-5 or 3-5 AKI.Compared with other cancers,renal cell carcinoma and urothelial carcinoma showed a significantly higher risk of AKI.The incidence of AKI was significantly higher with ICI+chemotherapy than with ICI monotherapy.In this NMA involving largescale up-to-date ICI trials,we demonstrated the comparative safety of existing ICI drugs for grade 1-5 and grade 3-5 AKI.Based on data from the ICI arms of these trials,we also revealed several potential risk factors for immune-related AKI,including tumor type and treatment paradigm. | Fei Liu ZixianWang Xiaofan Li Zhen Zhang Yue Yang Junquan Chen Dinghua Chen Lingling Wu Xiangyu Liu Sujun Han Fangming Wang Wasilijiang Wahafu Yibo Gao Shancheng Ren Nianzeng Xing Guangyan Cai Xiangmei Chen | 2023 | Cancer Communications2023，43，2： | 1 |
| 19 | Trafficability analysis of lunar mare terrain by means of the discrete element method for wheeled rover locomotion显示文摘 | Wen Li Yong Huang Yi Cui Sujun Dong Jun Wang | 2009 | Journal of Terramechanics2009，，3： | 1 |
| 20 | Dodecanoled-polyt d , lIactic acid) - b-poly (ethylene glycol) -folate (Dol- PLA- PEG- F A) nanoparticles , evaluation of cell cytotoxicity and selecting capability in vitro显示文摘 | Wang Sujun Luo Yanfeng Zeng Suyun | 2013 | Colloids and Surfaces B: Biointerfaces2013，102，： | 1 |
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