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| 1 | Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection显示文摘Foot-and-mouth disease virus(FMDV) rapidly causes cytopathic effects in susceptible cells. Incomplete viral clearance during the acute infection leads to persistent infection. The relationship between host gene expression and the persistent infection remains unclear. In this study, we analyzed the transcriptome profiles of BHK-21 cells acutely and persistently infected with FMDV to identify differences in gene expression. GO and KEGG enrichment analyses showed that the 8,378 differentially expressed genes were significantly enriched in categories including metabolism, biosynthesis, ribosome function, and endocytosis. In persistently infected BHK-21 cells, ribosome-and translation-related genes were significantly down-regulated. There were more differentially expressed immune-related genes during persistent infection than during acute infection. Two hundred and seventy-four genes were differentially expressed in both acutely and persistently infected BHK-21 cells. Among these genes, heat shock protein family B member 1(Hspb1) knockdown significantly inhibited FMDV replication. Our research provides a basis for further research to understand the mechanisms of persistent FMDV infection including the genes involved in FMDV replication. | Jiadai Li Lingling Han Yao Hao Yuncong Yuan Mingzhen Wang Xiu Xin Hailong Wang Fang Yu Congyi Zheng Chao Shen | 2020 | Virologica Sinica2020，35，1： | 4 |
| 2 | Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells显示文摘It has been reported that splenic stromal cells(SSCs)are capable of directly supporting the development of CD11c ^(lo)CD45RB^(+) IL-10-producing dendritic cells(DCs)from lineage-negative c-kit^(+) progenitor cells in the absence of exogenous cytokines.In vitro,DCs that differentiate on stromal cells suppress mixed leukocyte reaction responses and induce primary alloreactive CD4^(+) T cells to differentiate into IL-10-producing Tr1 cells.However,the precise mechanisms by which these SSCs exert their regulatory functions in vivo remain undefined.Furthermore,their possible contribution to the development of allograft transplantation tolerance has yet to be examined.Here,we have used both murine skin and cardiac allograft transplantation models to explore whether in vivo alloresponses can be regulated by infusion with donor-derived SSCs and to investigate the possible mechanisms by which SSCs exert regulatory effects to prevent allograft rejection.We show that intravenous SSC infusion prolonged murine skin allograft survival.The prolonged graft survival is associated with augmentation of the generation of regulatory DC subsets and CD4^(+) CD25^(+) Foxp3^(+) regulatory T cells(Tregs),as well as upregulation of the production of suppressive cytokines IL-10 and transforming growth factor(TGF)-b.Moreover,we found that indoleamine 2,3-dioxygenase and SSC-derived regulatory DCs contribute to allograft protection by infusion of donor-specific SSCs.Our data suggest that donor-derived SSCs could be used as a therapeutic target to promote transplantation tolerance. | Li Liu Lihua Duan Min Gong Hong Dai Quan Gong Fang Zheng Zheng Tan Congyi Wang Feili Gong Min Fang | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 3 | Realtime Style Transfer for Unlabeled Heterogeneous Human Motion 显示文摘 | Xia Shihong Wang Congyi Chai Jinxiang | 2015 | ACM Transactions on Graphics2015，34，4： | 1 |
| 4 | Minocycline upregulates Bcl-2 and protects against cell death in the mitochondria显示文摘 | Wang Jingzhao Wei Qingqing Wang Congyi | 2004 | J Biol Chem2004，279，19： | 1 |
| 5 | Homography-guided stereo matching for wide-baseline image interpolation显示文摘Image interpolation has a wide range of applications such as frame rate-up conversion and free viewpoint TV.Despite significant progresses,it remains an open challenge especially for image pairs with large displacements.In this paper,we first propose a novel optimization algorithm for motion estimation,which combines the advantages of both global optimization and a local parametric transformation model.We perform optimization over dynamic label sets,which are modified after each iteration using the prior of piecewise consistency to avoid local minima.Then we apply it to an image interpolation framework including occlusion handling and intermediate image interpolation.We validate the performance of our algorithm experimentally,and show that our approach achieves state-of-the-art performance. | Yuan Chang Congyi Zhang Yisong Chen Guoping Wang | 2022 | Computational Visual Media2022，8，1： | 1 |
| 6 | Construction of cytopathic PK-15 cell model of classical swine fever virus显示文摘No cytopathic effect (CPE) can be observed on classical swine fever virus (CSFV) infected cell culture in vitro. This brings an obstacle to the researches on reciprocity between CSFV and host cells. Based on the construction of full-length genomic infectious Cdna clone of Chinese CSFV standard virulent Shimen strain, partial deletion is intro- duced into genomic Cdna to obtain a 7.5 kb subgenomic Cdna. A new subgenomic CSFV is derived from transfection with the subgenomic Cdna on PK-15 cells pre-infected by CSFV Shimen virus. Typical CPE induced by this subgenomic virus is observed on PK-15 cells. Coexistence of wild- type and subgenomic virus in cytopathic cell culture is dem- onstrated by RT-PCR detection in cytopathic cells. For conclusion, the construction of cytopathic cell model exploited a new way for researches on the molecular mechanism of CSFV pathogenesis. | WU Haixiang, ZHANG Chuyu, ZHENG Congyi, WANG Jiafu, PAN Zishu, LI Lei, CAO Shen & Yl GuanghuiInstitute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaCorrespondence should be addressed to Zhang Chuyu (e-mail: avlab@ whu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，9： | 1 |
| 7 | Effect of the dummy gate on the capacitance characteristics of the LDMOSFETs显示文摘 | Zhu Congyi Fu Jun Wang Yudong | | 0，，01： | 1 |
| 8 | ON HOW CULTURAL KNOWLEDGE AFFECTS TOEFL SCORES显示文摘This paper presents a study of the effect of cultur-al background on TOEFL scores.It proceeds from therelation between culture and language,then illus-trates with actual questions from various sections ofTOEFL tests how American cultural background exertsa remarkable influence on TOEFL scores,and con-cludes with revelations with regard to English teachingin this country. | Zhang Congyi Zhong Quli Wang Shuaili Central South University,Jishou University | 2000 | Chinese Journal of Applied Linguistics2000，23，4： | 1 |
| 9 | Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)显示文摘 | WANG Congyi SHI Jingda YANG Ping | 2003 | Gene2003，，306： | 1 |
| 10 | Influence of degree of deacetylation on critical concentration of chitosan/dichloroacetic acid liquid-crystalline solution显示文摘 | Yanming Dong Congyi Xu Jianwei Wang | 2002 | Journal of Applied Polymer Science2002，83，6： | 1 |
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