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74篇 您的检索式:作者名="Wandel M"
    题名 作者 年代 出处 被引量
1Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz 2021Bioactive Materials2021,6,12:7
2Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer显示文摘Church TR Wandell M Lofton-Day C 2014Gut2014,63,2:1
3Color Image Fidelity Metrics Evaluated Using Image Distortion Maps显示文摘ZHANG X M WANDELL B A 1998Signal Processing1998,70,3:1
4显示文摘Aner S M Wandeler R Gobel U 1997Journal of Catalysis1997,169,:1
5Eating location is associated with the nutritional quality of the diet in Norwegian adults 显示文摘Myhre J Lken E Wandel M 2014Public Health Nutr2014,17,4:1
6Prospec-tive evaluation of methylated SEPT9 in plasma for detection of a-symptomatic colorectal cancer 显示文摘CHURCH T R WANDELL M LOFTON DAY C 2014Gut2014,63,2:1
7Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer显示文摘Church TR Wandell M Lofton-Day C 2014Gut2014,63,2:1
8Single-dose effect of nitrenclipine on blood pressure of hemoclialysis patients with hypertension 显示文摘Wandel E Weber M Zschiedrich H 1987J Cardiovasc Pharmacol1987,9,9:1
9Understanding consumer concern about food-re-lated health risks显示文摘Wandel M 0,,07:1
10Enzyme-linked immunosorbent assay for determination of antibodiesto the envelope glycoprotein of rabies virus显示文摘GRASSI M WANDELER A I PETERHANS E 1989J Clini Mi-crabiol1989,27,5:1
11Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer显示文摘Church TR Wandell M Lofton-Day C 2014Gut2014,63,2:1
12Disper- sion-compensating fibers 显示文摘GRUNER-NIELSEN L WANDEL M KRISTENSEN P 2005Lightwave Technology Journal of2005,23,11:1
13A Spatical Extension to Cielab for Digital Color Image Reproduction显示文摘Zhang X M Wandell B A 1996So- ciety of Information Display Symposium Technical Digest1996,27,:1
14Rendering high dynamic range images显示文摘 Wandell B A 2001In Proceedings of the SPIE:Image Sensors2001,3965,:1
15查看详情显示文摘Onken C A Ferrarese L Merritt D Peterson B M Pogge R W Vestergaard M Wandel A 0,,:1
16Thirdparty Logistics: is There a Future?显示文摘 Van Laarhoven P G Wandel S 1999International Journal of Logistics Management1999,10,1:1
17Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection:a systematic review and meta-analysis显示文摘Müller M Wandel S Colebunders R 2010Lancet Infect Dis2010,10,4:1
18Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 (MMP-1) and intercellular adhesion molecule-1(ICAM-1) in vitro显示文摘Wandel E Grasshoff A Mittag M 2000Exp Dermatol2000,9,1:1
19Age perceptions and physical activity amongmiddle-aged men in three occupational groups 显示文摘WANDEL M ROOS G 2006Soc Sci Med2006,62,16:1
20Dispersion-compensating fibers显示文摘L Griiner-Nielsen M Wandel P Kristensen C J(c)rgensen L V J(O)rgensen B Edvold B Pálsdóttir and D Jakobsen 0,,:1
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