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| 1 | Calcium-Dependent Protein Kinase CPK21 Functions in Abiotic Stress Response in Arabidopsis thaliana显示文摘钙依赖者蛋白质 kinases (CDPK ) 包括察觉到领域和 kinase 受动器领域的钙在一个分子以内在被联合的植物 serine/threonine 蛋白质 kinases 的一个家庭。到目前为止,在不能生活的应力发信号的生物功能仅仅为很少 CDPK isoforms 被报导了,而为这些 CDPK 的内在的生物化学的机制主要仍然是未知的。这里,我们证明从 Arabidopsis thaliana 的 CPK21 生物化学地响应 hyperosmotic 应力在 vivo 被激活。cpk21 的 Loss-of-function 幼苗对 hyperosmotic 应力更容忍,变异的植物关于标记基因表示和代谢物累积显示出增加的压力回答。在互补在 cpk21 异种背景衬里的转基因的 Arabidopsis,在哪个任何一个 CPK21 野类型,或带氨基酸的替换的全身的酶变体稳定地被表示,压力 responsitivity 被 CPK21 然而并非与 kinase 恢复不活跃的变体。生物化学的描述在 planta,综合并且净化的 CPK21 蛋白质表明在钙绑定领域以内,与 C 终端 EF3 主题和 EF4 主题相比的 N 终端 EF1 主题和 EF2 主题在他们对调整钙的 kinase 活动的贡献不同,为 N 终端 EF 手对建议一个关键角色。我们的数据为在不能生活的应力发信号作出贡献的 CPK21 提供证据并且建议 N 终端 EF 手对是控制 CPK21 的特性的一个察觉到钙的决定因素函数。 | Sandra Franz Britta Ehlert Anja Liese Joachim Kurth Anne-Claire Cazale Tina Romeis | 2011 | Molecular Plant2011，4，1： | 27 |
| 2 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 3 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 4 | Mutation analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2,compared with TSC1,disease in multiple organs显示文摘 | Sergiusz Jozwiak David Neal Franz | 2001 | Am J Hum Genet2001，68，： | 1 |
| 5 | Epoxidized soy bean oil (ESBO) migrating from the gaskets of lids into food packed in glass jars显示文摘 | Anja Fankhauser-Noti Katell Fiselier Sandra Biedermann Maurus Biedermann Koni Grob Franz Armellini Karl Rieger Ingun Skjevrak | 2005 | European Food Research and Technology2005，，： | 1 |
| 6 | Heavy metal removal from MSW fly ash by means of chlorination and thermal treatment: Influence of the chloride type显示文摘 | Benedikt Nowak Sandra Frías Rocha Philipp Aschenbrenner Helmut Rechberger Franz Winter | 2011 | Chemical Engineering Journal2011，，： | 1 |
| 7 | The CFSE Distribution Assay is a Powerful Technique for the Analysis of Radiation-Induced Cell Death and Survival on a Single-Cell Level显示文摘 | FRANZ R?DEL SANDRA FRANZ AHMED SHERIFF | 2005 | Strahlenther Onkol2005，7，： | 1 |
| 8 | The optimisation of ultrasonic cleaning procedures for dairy fouled ultrafiltration membranes显示文摘 | Shobha Muthukumaran Sandra Kentish Sharan Lalchandani Muthupandian Ashokkumar Raymond Mawson Geoff W. Stevens Franz Grieser | 2004 | Ultrasonics - Sonochemistry2004，，1： | 1 |
| 9 | Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs显示文摘 | Sandra L. Dabora Sergiusz Jozwiak David Neal Franz Penelope S. Roberts Andres Nieto Joon Chung Yew-Sing Choy Mary Pat Reeve Elizabeth Thiele John C. Egelhoff Jolanta Kasprzyk-Obara Dorota Domanska-Pakiela David J. Kwiatkowski | 2001 | The American Journal of Human Genetics2001，，1： | 1 |
| 10 | Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition显示文摘Skin injury releases damage-associated molecular patterns(DAMPs)represented by tissue-components and intracellular contents as well as changes in the levels of certain molecules and metabolites that signal the“non-homeostatic”state of the tissue.In addition,microorganisms entering a wound release molecules,which are sensed as“non-self”(pathogen-associated molecular patterns,PAMPs).Together,DAMPs and PAMPs initiate a complex and coordinated repair process aimed at restoring homeostasis.The exciting work from Liu et al.reports of an additional novel mechanism by which a“non-homeostatic”state in murine cutaneous wounds elicits a response through IL-24 to mediate repair(Fig.1). | Ruben A.Ferrer Marta Torregrossa Sandra Franz | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 11 | Management of cataract surgery in Lowe syndrome显示文摘AIM: To evaluate the ophthalmic and anesthesiologic management of cataract surgery in children with Lowe syndrome receiving lens removal, the development and management of secondary glaucoma.METHODS: This retrospective case series included 12 eyes of 6 children with genetically verified Lowe syndrome receiving cataract removal. Information regarding the type and duration of surgery and total anesthesia time were recorded. Additionally, intra-and postoperative complications were noted as well as clinical examinations such as visual acuity and funduscopy. RESULTS: All children received simultaneous bilateral cataract surgery at the mean age of 8.98±3.58 wk. Lensectomy combined with posterior capsulotomy and anterior vitrectomy was performed in all children. The mean time for cataract surgery per eye was 35.83±8.86 min, whereas the total time of surgery was 153.33±22.11 min. The mean extubation time and duration at recovery room was 42.33±22.60 min and 130.00±64.37 min, respectively. During surgery, a decrease of oxygen saturation below 93% was found in only one child. During the postoperative followup, nystagmus(6 children) and strabismus(5 children) was commonly found in contrast to no case of visual axis opacification. Secondary glaucoma developed in five eyes of three children, which was treated with topical eye drops in only one child. A trabeculectomy was performed in both eyes of one child, whereas removal of syechia and an iridectomy in one eye of one child. CONCLUSION: Bilateral simultaneous cataract surgery under general anesthesia is a safe surgical procedure in Lowe syndrome children. The glaucoma screening with intraocular pressure measurements is crucial in the postoperative management of Lowe syndrome patients to avoid additional visual impairment. | Katharina Eibenberger Sandra Rezar-Dreindl Franz Pusch Ursula Schmidt-Erfurth Eva Stifter | 2022 | International Journal of Ophthalmology(English edition)2022，15，7： | 0 |
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