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| 1 | Morphological Development of Fuel Droplets after Impacting Biomimetic Structured Surfaces with Different Temperatures显示文摘To improve the controllability for the evaporation process of fuel spray impinging on the cylinder wall,an experimental study on the development of morphological process of different fuel droplets on aluminium alloy surfaces is carried out.The metal surfaces with different wettability are prepared by laser etching and chemical etching for the experiments.In total,three different fuels are tested and compared under different surface temperatures,including diesel,n-butanol and dimethyl carbonate(DMC).The results show that under a lower wall temperature,the surface wettability,viscosity and surface tension of the fuels have significant effects on spreading and rebounding behaviour of the droplets.As the wall temperature rises over the boiling points of the fuel but below its Leidenfrost temperature,the contact angles between the fuels and surfaces are varying according to the surface wettability,boiling point and Leidenfrost temperature of the fuels.When the temperature of the surface exceeds the Leidenfrost temperature of all the fuels,after impacting the surfaces,different fuel droplets tend to have the same development pattern,regardless of the surface wettability.The rebound level is mainly affected by the amount of fuel vapour generated during the wall-hitting process.Viscosity,surface tension and other properties of the fuel have little effect on post-impacting behaviour of the droplet when the wall temperature is higher than the Leidenfrost temperature of the fuel. | Liang Guo Yuheng Gao Ningning Cai Degang Li Yuying Yan Wanchen Sun | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 2 | Ectopic expression of antifreeze protein gene from Ammopiptanthus nanus confers chilling tolerance in maize显示文摘Improved chilling tolerance is important for maize production. Previous efforts in transgenics and marker-assisted breeding have not achieved practical results. In this study, the antifreeze protein(AnAFP) from the super-xerophyte Ammopiptanthus nanus was aligned to KnS-type dehydrins.Phosphorylation in vitro and subcellular localization showed that AnAFP was phosphorylated by maize casein kinase II and translocated from nucleus to cytoplasm under chilling stress. AnAFP also increased lactate dehydrogenase activity. A parent line of commercial maize hybrids was transformed with the AnAFP gene. Based on thermal asymmetric interlaced PCR, one hemizygous and two homozygous integration sites were identified in one T_(1) line. Ectopic expression of AnAFP in transgenic lines was confirmed by quantitative real-time PCR, RNA-seq, and Western blotting. After chilling treatment, the transgenic lines showed significantly improved phenotype, higher kernel production, survival rate and biomass, and lower relative electrolyte leakage and superoxide dismutation than the untransformed line. Thus, ectopic expression of AnAFP gene improved chilling tolerance in the transgenic lines, which could be used to apply for further safety assessment for commercial breeding. | Yuanyuan Zhang Yang Cao Hongying Zheng Wenqi Feng Jingtao Qu Fengling Fu Wanchen Li Haoqiang Yu | 2021 | The Crop Journal2021，9，4： | 2 |
| 3 | Multi-agent reinforcement learning for cooperative lane changing of connected and autonomous vehicles in mixed traffic显示文摘Autonomous driving has attracted significant research interests in the past two decades as it offers many potential benefits,including releasing drivers from exhausting driving and mitigating traffic congestion,among others.Despite promising progress,lane-changing remains a great challenge for autonomous vehicles(AV),especially in mixed and dynamic traffic scenarios.Recently,reinforcement learning(RL)has been widely explored for lane-changing decision makings in AVs with encouraging results demonstrated.However,the majority of those studies are focused on a single-vehicle setting,and lane-changing in the context of multiple AVs coexisting with human-driven vehicles(HDVs)have received scarce attention.In this paper,we formulate the lane-changing decision-making of multiple AVs in a mixed-traffic highway environment as a multi-agent reinforcement learning(MARL)problem,where each AV makes lane-changing decisions based on the motions of both neighboring AVs and HDVs.Specifically,a multi-agent advantage actor-critic(MA2C)method is proposed with a novel local reward design and a parameter sharing scheme.In particular,a multi-objective reward function is designed to incorporate fuel efficiency,driving comfort,and the safety of autonomous driving.A comprehensive experimental study is made that our proposed MARL framework consistently outperforms several state-of-the-art benchmarks in terms of efficiency,safety,and driver comfort. | Wei Zhou Dong Chen Jun Yan Zhaojian Li Huilin Yin Wanchen Ge | 2022 | Autonomous Intelligent Systems2022，2，1： | 1 |
| 4 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 5 | Characteristics of particle size distributions about emissions in a common-rail diesel engine with biodiesel blends显示文摘 | AN Puzun SUN Wanchen LI Guoliang | | 0，，： | 1 |
| 6 | The development and benefits of metformin in various diseases显示文摘Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety,low cost,and outstanding hypoglycemic effect clinically.The mechanisms underlying these benefits are complex and still not fully understood.Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin,leading to reduced ATP production and activation of AMP-activated protein kinase(AMPK).Meanwhile,many novel targets of metformin have been gradually discovered.In recent years,multiple pre-clinical and clinical studies are committed to extend the indications of metformin in addition to diabetes.Herein,we summarized the benefits of metformin in four types of diseases,including metabolic associated diseases,cancer,aging and age-related diseases,neurological disorders.We comprehensively discussed the pharmacokinetic properties and the mechanisms of action,treatment strategies,the clinical application,the potential risk of metformin in various diseases.This review provides a brief summary of the benefits and concerns of metformin,aiming to interest scientists to consider and explore the common and specific mechanisms and guiding for the further research.Although there have been countless studies of metformin,longitudinal research in each field is still much warranted. | Ying Dong Yingbei Qi Haowen Jiang Tian Mi Yunkai Zhang Chang Peng Wanchen Li Yongmei Zhang Yubo Zhou Yi Zang Jia Li | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 7 | Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy显示文摘The aim of this paper is to construct a specific and high-performance gene therapy system for glioma.We constructed a combined promoter 6HRE-GFAP(Hypoxia Responsive Element,Glial Fibrillary Acidic Protein)by gene recombination techniques according to the hypoxia microenvironment in glioma and tested its efficacy and specificity in cultured cells,and then constructed GFAP-Baxαgene expressing system and determined its promoting of apoptosis in glioma cells.Our primary results showed that in U251 and BT325 cell lines,the activity of GFAP promoter was 16.40 and 4.73-fold of the promoter of hTERT(Human Telomerase Reverse Transcriptase),respectively.The activities of 6HREGFAP-promoter increased by 3.08 and 1.30-fold under 2%O_(2) condition compared with those under 18%O_(2) condition,while under 0.2%O_(2) condition increased by 8.90 and 2.69-fold,respectively.The glioma cells showed typical apoptotic signs 90 hours after the transient transfection of GFAP-Baxα.In these primary experiments,it showed that 6HRE-GFAPBaxαsystem could promote glioma cell apoptosis.It was specific and effective for glioma gene therapy. | TIAN Yongji LI Guilin GAO Jun WANG Renzhi KONG Yanguo ZHANG Zhenxing LI Shifang TIAN Shiqiang DOU Wanchen ZHANG Bo | 2007 | Frontiers of Medicine2007，1，1： | 0 |
| 8 | Evaporation Characteristics and Morphological Evolutions of Fuel Droplets After Hitting Different Wettability Surfaces显示文摘To solve the wall-wetting problem in internal combustion engines,the physical and chemical etching methods are used to prepare different wettability surfaces with various microstructures.The evaporation characteristics and morphological evolution processes of diesel and n-butanol droplets after hitting the various surfaces are investigated.The results show that the surface microstructures increase the surface roughness(Ra),enhancing the oleophilic property of the oleophilic surfaces.Compared with n-butanol droplets,the same surface shows stronger oleophobicity to diesel droplets.When a droplet hits an oleophilic property surface with a lower temperature,the stronger the oleophilicity,the shorter the evaporation time.For oleophilic surfaces,larger Ra leads to a higher Leidenfrost temperature(TLeid).The low TLeid caused by enhanced oleophobicity,dense microstructures and increased convex dome height facilitates droplet rebound and promotes the evaporation of the wall-impinging droplets into the cylinder.The evaporation rate of the droplets is not only related to the characteristics of the solid surfaces and the fuel droplets but also affected by the heat transfer rate to the droplets in different boiling regimes.The spreading diameter of a droplet on an oleophobic surface varies significantly less with time than that on an oleophilic surface under the same surface temperature. | Yanling Chen Liang Guo Ningning Cai Wanchen Sun Yuying Yan Degang Li Han Wang Rong Xuan | 2023 | Journal of Bionic Engineering2023，20，2： | 0 |
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