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| 1 | Bile acid receptors and gastrointestinal functions显示文摘Bile acids modulate several gastrointestinal(GI)functions including electrolyte secretion and absorption,gastric emptying,and small intestinal and colonic motility.High concentrations of bile acids lead to diarrhea and are implicated in the development of esophageal,gastric and colonic cancer.Alterations in bile acid homeostasis are also implicated in the pathophysiology of irritable bowel syndrome(IBS)and inflammatory bowel disease(IBD).Our understanding of the mechanisms underlying these effects of bile acids on gut functions has been greatly enhanced by the discovery of bile acid receptors,including the nuclear receptors:farnesoid X receptor(FXR),vitamin D receptor(VDR),pregnane X receptor(PXR),and constitutive androstane receptor(CAR);and G protein-coupled receptors(GPCRs):Takeda G protein-coupled receptor 5(TGR5),sphingosine-1-phosphate receptor 2(S1PR2),and muscarinic acetylcholine receptor M3(M3R).For example,various studies provided evidence demonstrating the anti-inflammatory effects of FXR and TGR5 activation in models of intestinal inflammation.In addition,the activation of TGR5 in enteric neurons was recently shown to increase colonic motility,which may lead to bile acid-induced diarrhea(BAD).Interestingly,TGR5 induces the secretion of glucagon-like peptide-1(GLP-1)from L-cells to enhance insulin secretion and modulate glucose metabolism.Because of the importance of these receptors,agonists of TGR5 and intestine-specific FXR agonists are currently being tested as an option for the treatment of diabetes mellitus and primary bile acid diarrhea,respectively.This review summarizes current knowledge of the functional roles of bile acid receptors in the GI tract. | Alexander L.Ticho Pooja Malhotra Pradeep K.Dudeja Ravinder K.Gill Waddah A.Alrefai | 2019 | Liver Research2019，3，1： | 13 |
| 2 | Long‐term survival after surgical management of neuroendocrine hepatic metastases显示文摘 | Evan S.Glazer Jennifer F.Tseng WaddahAl‐Refaie Carmen C.Solorzano PingLiu Katherine A.Willborn Eddie K.Abdalla Jean‐NicolasVauthey Steven A.Curley | 2010 | HPB2010，，6： | 1 |
| 3 | Design Of maximum density aggregate grading显示文摘 | Abdel-Jawad Waddah Sahnan Abdullah | 2002 | Construction and Building Material2002，，16： | 1 |
| 4 | Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications显示文摘 | Waddah A. Alrefai Ravinder K. Gill | 2007 | Pharmaceutical Research2007，，10： | 1 |
| 5 | Design of maximum density aggregate grading显示文摘 | Yahia A Abdel-Jawad Waddah Salman Abdullah | 2002 | Construction and Building Materials2002，，8： | 1 |
| 6 | Blood transfusion and cancer surgery outcomes: A continued reason for concern显示文摘 | Waddah B. Al-Refaie Helen M. Parsons Abraham Markin Jerome Abrams Elizabeth B. Habermann | 2012 | Surgery2012，，： | 1 |
| 7 | Long‐term survival after surgical management of neuroendocrine hepatic metastases显示文摘 | Evan S.Glazer Jennifer F.Tseng WaddahAl‐Refaie Carmen C.Solorzano PingLiu Katherine A.Willborn Eddie K.Abdalla Jean‐NicolasVauthey Steven A.Curley | 2010 | HPB2010，，6： | 1 |
| 8 | Fragmented Wide QRS on a 12-Lead ECG: A Sign of Myocardial Scar and Poor Prognosis显示文摘 | Mithilesh K. Das Hussam Suradi Waddah Maskoun Mark A. Michael Changyu Shen Jonathan Peng Gopi Dandamudi Jo Mahenthiran | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，4： | 1 |
| 9 | Fragmented Wide QRS on a 12-Lead ECG: A Sign of Myocardial Scar and Poor Prognosis显示文摘 | Mithilesh K. Das Hussam Suradi Waddah Maskoun Mark A. Michael Changyu Shen Jonathan Peng Gopi Dandamudi Jo Mahenthiran | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，4： | 1 |
| 10 | Fragmented Wide QRS on a 12-Lead ECG: A Sign of Myocardial Scar and Poor Prognosis显示文摘 | Mithilesh K. Das Hussam Suradi Waddah Maskoun Mark A. Michael Changyu Shen Jonathan Peng Gopi Dandamudi Jo Mahenthiran | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，4： | 1 |
| 11 | Influence of pore water chemistry on the swelling behavior of compacted clays显示文摘 | Waddah S Abdullah Khalid A Alshibli Mohammed S Al-Zou’bi | 1999 | Applied Clay Science1999，，5： | 1 |
| 12 | Laparoscopic Assisted versus Open Pancreaticoduodenectomy: Early Favorable Physical Quality of Life Measures显示文摘 | Russell C. Langan Jay A. Graham Anne B. Chin Aaron J. Rubinstein Kesha Oza Jeff A. Nusbaum John Smirniotopoulos Reilly Kayser Reena Jha Nadim Haddad Firas Al-Kawas John Carroll Jane Hanna Ann Parker Waddah B. Al-Refaie Lynt B. Johnson | 2014 | Surgery2014，，： | 1 |
| 13 | Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma?显示文摘 | Vikas Dudeja Elizabeth B. Habermann Anasooya Abraham Wei Zhong Helen M. Parsons Jennifer F. Tseng Waddah B. Al-Refaie | 2012 | Journal of Gastrointestinal Surgery2012，，2： | 1 |
| 14 | Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications显示文摘 | Waddah A. Alrefai Ravinder K. Gill | 2007 | Pharmaceutical Research2007，，10： | 1 |
| 15 | Interactions of Linoleic and Alpha-Linolenic Acids in the Development of Fatty Acid Alterations in Cystic Fibrosis显示文摘 | Waddah Katrangi Joshua Lawrenz Adam C. Seegmiller Michael Laposata | 2013 | Lipids2013，，4： | 1 |
| 16 | Resistance to acid degradation,sorptivity,and setting time of geopolymer mortars显示文摘Experimental evaluations were conducted to determine the water sorptivity,setting time,and resistance to a highly acidic environment,of mortar with alkali-activated ground granulated blast furnace slag(GBS)binder and also of combinations of fly ash and GBS binders.Binders were activated using mixtures of NaOH and Na_(2)SiO_(3)solutions.The molarity of NaOH in the mixtures ranged from 10 mol·L^(−1)to 16 mol·L^(−1),and the Na_(2)SiO_(3)/NaOH ratio was varied from 1.5 to 2.5.Mortar samples were produced using three binder combinations:1)GBS as the only binder;2)blended binder with a slag-to-fly ash ratio of 3:1;and 3)mixed binder with 1:1 ratio of slag to fly ash.Mortar samples were mixed and cured at(22±2)°C till the day of the test.The impact of activator solution alkalinity,activator ratio Na_(2)SiO_(3)/NaOH,GBS content on the rate of water absorption were evaluated.After 7,28,and 90 d of immersion in a 10%sulfuric acid solution,the resistance of a geopolymer matrix to degradation was assessed by measuring the change in sample weight.The influence of solution alkalinity and relative fly ash content on setting times was investigated.Alkali-activated mortar with a slag-to-fly ash ratio of 3:1 had the least sorptivity compared to the two other binder combinations,at each curing age,and for mortars made with each of the NaOH alkaline activator concentrations.Mortar sorptivity decreased with age and sodium hydroxide concentrations,suggesting the production of geopolymerization products.No reduction in weight of sample occurred after immersion in the strong acid H_(2)SO_(4)solution for three months,regardless of binder combination.This was due to the synthesis of hydration and geopolymerization products in the presence of curing water,which outweighed the degradation of the geopolymer matrix caused by sulfuric acid. | Osama A MOHAMED Rania AL-KHATTAB Waddah AL-HAWAT | 2022 | Frontiers of Structural and Civil Engineering2022，16，6： | 0 |
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