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| 1 | Human colorectal cancer-specific CCAT1-L IncRNA regulates long-range chromatin interactions at the MYC locus显示文摘人的 8q24 基因沙漠包含多重 enhancers 形式织物特定的远程的染色质与 MYC oncogene 循环,但是染色质在 MYC 地点循环怎么被调整,仍然保持糟糕理解。这里,我们表明那长 noncoding RNA (lncRNA ) , CCAT1-L,从一个地点在人的 colorectal 癌症明确地被抄录 MYC 在上游的 515 kb。这 lncRNA 在 MYC transcriptional 规定起一个作用并且支持远程的染色质循环。重要地, CCAT1-L 地点位于强壮的超级提高以内并且离 MYC 空间地靠近。CCAT1-L 击倒在 MYC 倡导者和它的 enhancers 之间的减少的远程的相互作用。另外, CCAT1-L 与 CTCF 交往并且在这些环区域调制染色质符合构造。这些结果揭示一个重要角色一以前在在 MYC 地点的基因规定的 unannotated lncRNA。 | Jian-Feng Xiang Qing-Fei Yin Tian Chen Yang Zhang Xiao-Ou Zhang Zheng Wu Shaofeng Zhang Hai-Bin Wang Junhui Ge Xutiua Lu Li Yang Ling-Ling Chen | 2014 | Cell Research2014，24，5： | 67 |
| 2 | High-Sensitivity Temperature Sensor Based on Polarization Maintaining Fiber Sagnac Loop显示文摘A high-sensitivity all-fiber temperature sensor based on a Sagnac interferometer is demonstrated by splicing a section of polarization maintaining fiber(PMF)between two sections of standard single mode fibers(SMFs).In this sensor,the SMF-PMF-SMF structure in the Sagnac loop is bent into a circle to enhance the sensitivity.The length and curvature of the PMF in the loop are investigated and can be optimized to further increase the temperature sensitivity of the sensor. Results show that the radius of the circle has an important effect upon temperature sensitivity due to the bend-induced birefringence variation of the PMF.The SMF-PMF-SMF structure bent into a circle with a radius of 30mm exhibits a high-sensitivity temperature of 1.73nm/℃.The sensor is provided with the advantages of easy fabrication,low-insertion loss,and high sensitivity,which may find potential applications in the field of high precision temperature measurement. | Laipeng SHAO Junhui HU Hanglin LU Jing DU Tianyin WU Yiping WANG | 2019 | Photonic Sensors2019，9，1： | 10 |
| 3 | Hydraulic operating mechanisms for high voltage circuit breakers: Progress evolution and future trends显示文摘High voltage circuit breakers are the most important protection and control apparatus in power system. As a core part of circuit breakers,the operating mechanisms have a trend to be hydraulic-style in high voltage power grid. Compared with other hydraulic systems,the hydraulic operating mechanisms have the characteristics of high hydraulic pressure,high speed,high power and long-term waiting etc.,and it is because of the characteristics that the hydraulic operating mechanisms become difficult to be developed and have been arousing significant study interest from more and more researchers as well as their promising applications. Therefore,it is significant to summarize the hydraulic operating mechanisms on their development,characteristics,and key technologies etc. In this review,the evolution process and recent studies of hydraulic operating mechanisms at home and abroad are viewed. The review then focuses on the characteristics and key technologies of hydraulic operating mechanisms,especially on time and velocity characteristics,high-speed cylinder cushioning,fast response and great flow rate control valve,temperature compensation,system monitoring and fault diagnosis,intelligent operation,energy storage module,etc. In the end,the future trends of this field are presented. | LIU Wei XU Bing YANG HuaYong ZHAO HongFei WU JunHui | 2011 | Science China(Technological Sciences)2011，54，1： | 10 |
| 4 | Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis显示文摘Bacitracin,a new type of cyclic peptide antibiotic,is widely used as the feed additive in feed industry.Branched chain amino acids(BCAAs)are the key precursors for bacitracin synthesis.In this research,soybean meal was served as the raw material to supply precursor amino acids for bacitracin synthesis,and enhanced production of bacitracin was attempted by engineering BCAA transporter BrnQ and its regulator Lrp in the bacitracin industrial production strain Bacillus licheniformis DW2.Firstly,our results confirmed that Lrp negatively affected bacitracin synthesis in DW2,and deletion of lrp improved intracellular BCAA accumulations,as well as the expression level of BCAA transporter BrnQ,which further led to a 14.71%increase of bacitracin yield,compared with that of DW2.On the contrary,overexpression of Lrp decreased bacitracin yield by 12.28%.Secondly,it was suggested that BrnQ acted as a BCAA importer in DW2,and overexpression of BrnQ enhanced the intracellular BCAA accumulations and 10.43%of bacitracin yield.While,the bacitracin yield decreased by 18.27%in the brnQ deletion strain DW2△brnQ.Finally,BrnQ was further overexpressed in lrp deletion strain DW2△lrp,and bacitracin yield produced by the final strain DW2△lrp::BrnQ was 965.34 U/mL,increased by 22.42%compared with that of DW2(788.48 U/mL).Collectively,this research confirmed that Lrp affected bacitracin synthesis via regulating the expression of BCAA transporter BrnQ and BCAA distributions,and provided a promising strain for industrial production of bacitracin. | Jiang Zhu Dongbo Cai Haixia Xu Ziwei Liu Bowen Zhang Fei Wu Junhui Li Shouwen Chen | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 6 |
| 5 | Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer显示文摘The dose-related adverse effects of MDM2-P5 3 inhibitors have caused significant concern in the development of clinical safe anticancer agents.Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2-P53 interaction.The design concept is inspired by the capacity of sub-stoichiometric catalytic PROTACs enabling to degrade an unwanted protein and the dual functions of MDM2 as an E3 ubiquitin ligase and a binding protein with tumor suppressor P53.The new homo-PROTACs are designed to induce self-degradation of MDM2.The results of the investigation have shown that PROTAC 11 a efficiently dimerizes MDM2 with highly competitive binding activity and induces proteasome-dependent self-degradation of MDM2 in A549 non-small cell lung cancer cells.Furthermore,markedly,enantiomer 11 a-1 exhibits potent in vivo antitumor activity in A549 xenograft nude mouse model,which is the first example of homo-PROTAC with in vivo therapeutic potency.This study demonstrates the potential of the homo-PROTAC as an alternative chemical tool for tumorigenic MDM2 knockdown,which could be developed into a safe therapy for cancer treatment. | Shipeng He Junhui Ma Yuxin Fang Ying Liu Shanchao Wu Guoqiang Dong Wei Wang Chunquan Sheng | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 4 |
| 6 | Structural dynamic responses of a stripped solar sail subjected to solar radiation pressure显示文摘The stripped solar sail whose membrane is divided into separate narrow membrane strips is believed to have the best structural efficiency.In this paper,the stripped solar sail structure is regarded as an assembly made by connecting a number of boom-strip components in sequence.Considering the coupling effects between booms and membrane strips,an exact and semianalytical method to calculate structural dynamic responses of the stripped solar sail subjected to solar radiation pressure is established.The case study of a 100 m stripped solar sail shows that the stripped architecture helps to reduce the static deflections and amplitudes of the steady-state dynamic response.Larger prestress of the membrane strips will decrease stiffness of the sail and increase amplitudes of the steady-state dynamic response.Increasing thickness of the boom will benefit to stability of the sail and reduce the resonant amplitudes.This proposed semi-analytical method provides an efficient analysis tool for structure design and attitude control of the stripped solar sail. | Junhui ZHANG Na WU An TONG Yinghua LIU | 2020 | Chinese Journal of Aeronautics2020，33，8： | 3 |
| 7 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 8 | The Earth's inner core deviation to plate movement显示文摘Under the premise of the Earth’s layer structure and mass distribution, the solid inner core cannot be stable in the center of the sphere. Thus, the deviation of the inner core is towards the sphere’s center and the liquid outer core must have asymmetrical thermal convection. Based on the two suggestions, a concise and self-consistent global motion model can be built. The model consists of the following cycle: an asymmetrical thermal convection structure in the outer core led by the dislocation of the inner core→the plume is in special upwell position because of differential activation→the formation and split of lithosphere→the split plates drift and assemble in a new location, the mass of which causes the inner core to deviate towards this direction again→the new asymmetry is formed. As this circulation continues, a definite and periodical motion emerges/forms. Its nonlinear features result in the Earth’s motion with simple mechanisms but complex behavior. Ultraterrestrial events may disturb or | Dinghua Huang Jinping Wu Yichun Duan Hao Guo Heng Zhang Lingqing Yao Fan Zhang Bin Li Junhui Wang Hongfu Yin | 2001 | Chinese Science Bulletin2001，46，19： | 2 |
| 9 | Techno-economic Analysis of Contingency Reserve Allocation Scheme for Combined UHV DC and AC Receiving-End Power System显示文摘In a UHV DC and AC combined system the UHVDC’s blocking fault becomes the most serious load balance contingency of the receiving end power system due to its large capacity.The amount of contingency reserve thus is largely increased.This paper proposes three distinct schemes for allocating contingency reserve to cover the power shortage caused by UHVDC’s blocking fault,and compares the economic cost of these schemes.An operation simulation method using a unit commitment technique is proposed for evaluating the operation costs associated with increasing contingency reserve.A real case study for a Jiangsu Province power system in China is presented to demonstrate that the best scheme is to share the contingency reserve with neighborhood power systems through the transmission capacity of UHVAC lines. | Di Wu Ning Zhang Chongqing Kang Yi Ge Zhenjian Xie Junhui Huang | 2016 | CSEE Journal of Power and Energy Systems2016，2，2： | 2 |
| 10 | Atmospheric carbonyls in a heavy ozone pollution episode at a metropolis in Southwest China:Characteristics,health risk assessment,sources analysis显示文摘Ambient carbonyls were continuously observed in the field during a heavy ozone pollution episode in Chengdu, China from August 4 to August 19, 2019, and the pollution characteristics, atmospheric photochemical reactivity, human health risk, and sources of carbonyls were analyzed. Fifteen carbonyls were quantified with average total mixing ratios of 20.38 ppbv Formaldehyde(9.86 ppbv), acetone(4.41 ppbv), and acetaldehyde(3.57 ppbv) were the three most abundant carbonyls. During the heavy ozone pollution episode, the concentration of carbonyls was found to be higher on pollution days than on the clean days, and relatively higher in the daytime, especially at noon on the pollution days. This was influenced by the intensity of photochemical reactions and precipitation. The “weekend effect” with the concentration of carbonyls was higher on the weekends than on the weekdays was pointed out. Formaldehyde, acetaldehyde and hexaldehyde were the dominant oxidative species during the observation. The carcinogenic and non-carcinogenic risk values of formaldehyde and acetaldehyde were higher on pollution days than on clean days, and these values were higher compared with those of other cities in China and abroad. Long-term exposure to these compounds should therefore be avoided. Diagnostic ratios and correlation analysis together with backward trajectory analysis showed that primary emission and secondary formation accounted 66%-76% and 24%–34% of carbonyls in Chengdu, respectively, with primary emission being the main sources of carbonyls, and carbonyls from the surrounding cities and emission from natural sources also had a significant contribution to the carbonyls in Chengdu. | Jiemeng Bao Hong Li Zhenhai Wu Xin Zhang Hao Zhang Yunfeng Li Jun Qian Junhui Chen Liqun Deng | 2022 | Journal of Environmental Sciences2022，34，3： | 1 |
| 11 | Structure transition comparison between the amorphous nanosize particles and coarse - grained polycrystailine of cobalt显示文摘 | Changsheng Xie Junhui Hu Run Wu | | 0，，： | 1 |
| 12 | Pressure measurement and characteristic analysis on a 252 k V puffer-type SF6circuit breaker显示文摘 | GUAN Yonggang LIU Weidong WU Junhui | 2013 | IEEE Transactions on Power Delivery2013，28，4： | 1 |
| 13 | Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma显示文摘Background:Increased hypoxia-inducible factor 2α(HIF2α)activation is a common event in clear cell renal cell carcinoma(ccRCC)progression.However,the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated.We conducted this study to access the potential link between junction plakoglobin(JUP)and HIF2αin ccRCC.Methods:Affinity purification and mass spectrometry(AP-MS)screening,glutathione-s-transferase(GST)pull-down and co-immunoprecipitation(Co-IP)assays were performed to detect the interacting proteins of HIF2α.Quantitative PCR(qPCR)and Western blotting were used to detect the expression of JUP in human ccRCC samples.Luciferase reporter assays,chromatin immunoprecipitation(ChIP),cycloheximide chase assays,and ubiquitination assays were conducted to explore the regulation of JUP on the activity of HIF2α.Cell Counting Kit-8(CCK-8)assays,colony formation assays,transwell assays,and xenograft tumor assays were performed to investigate the effect of JUP knockdown or overexpression on the tumorigenicity of renal cancer cells.Results:We identified JUP as a novel HIF2α-binding partner and revealed an important role of JUP in recruiting von Hippel-Lindau(VHL)and histone deacetylases 1/2(HDAC1/2)to HIF2α to regulate its stability and transactivation.JUP knockdown promoted and overexpression suppressed the tumorigenicity of renal cell carcinoma in vitro and in vivo.Importantly,the low expression of JUP was found in clinical ccRCC samples and correlated with enhanced hypoxia scores and poor treatment outcomes.Conclusion:Taken together,these data support a role of JUP in modulating HIF2α signaling during ccRCC progression and identify JUP as a potential therapeutic target. | Ke Chen Jin Zeng Yi Sun Wei Ouyang Gan Yu Hui Zhou Yangjun Zhang Weimin Yao Wei Xiao Junhui Hu Jinchun Xing Kefeng Xiao Lily Wu Zhiqiang Chen Zhangqun Ye Hua Xu | 2021 | Cancer Communications2021，41，4： | 1 |
| 14 | Correlations between thermal,crystal and textural properties of rice gels made by southern early long-grain paddy显示文摘 | Liang Lanlan Wu Junhui Chen Wei | | 0，，： | 1 |
| 15 | Provenance System Analysis of the Nantun Formation of the Huhehu Sag in Hailar Basin显示文摘Huhehu Sag is a new battlefield for the future oil and gas exploration in the Hailar Basin.At present,exploration of this area stays at a low level and the understanding of the provenance system of the Nantun Formation is comparatively weak.So,to carry out the detailed depiction of the provenance system in the study area is significant for the sedimentary system reconstruction,for the prediction of reservoir distribution and favorable areas.Based on comprehensive analysis of paleogeomorphy,light-heavy mineral and seismic reflection features,sandstone thickness and sandstone percentage,this paper analyzes in detail the provenance system of the Nantun Formation in Huhehu Sag from various angles and levels.It shows that provenances of the Huhehu Sag mainly originated from the eastern Xilinbeier Salient and western Bayan Mountain Uplift.The provenances surrounding the lake basin converged to the center of the basin,among which,the steep slope belt and the gentle slope belt are the main provenances,and the southern uplift is a secondary one.The distribution framework of the provenance fundamentally determines the distribution rules of the depositional system and its sand body developing during the Nantun period. | LI Junhui MENG Qi'an LU Shuangfang ZHU Defeng WU Haibo LIU He ZHANG Dazhi | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 1 |
| 16 | Moso bamboo expansion decreased soil heterotrophic respiration but increased arbuscular mycorrhizal mycelial respiration in a subtropical broadleaved forest显示文摘Moso bamboo(Phyllostachys Pubescens)expansion into adjacent forests has been widely reported to affect plant diversity and its association with mycorrhizal fungi in subtropical China,which will likely have significant impacts on soil respiration.However,there is still limited information on how Moso bamboo expansion changes soil respiration components and their linkage with microbial community composition and activity.Based on a mesh exclusion method,soil respirations derived from roots,arbuscular mycorrhizal(AM)mycelium,and free-living microbes were investigated in a pure Moso bamboo forest(expanded),an adjacent broadleaved forest(nonexpanded),and a mixed bamboo-broadleaved forest(expanding).Our results showed that bamboo expansion decreased the cumulative CO_(2)effluxes from total soil respiration,root respiration and soil heterotrophic respiration(by 19.01%,30.34%,and 29.92%on average),whereas increased those from AM mycelium(by 78.67%in comparison with the broadleaved forests).Bamboo expansion significantly decreased soil organic carbon(C)content,bacterial and fungal abundances,and enzyme activities involved in C,N and P cycling whereas enhanced the interactive relationships among bacterial communities.In contrast,the ingrowth of AM mycelium increased the activities ofβ-glucosidase and N-acetyl-β-glucosaminidase and decreased the interactive relationships among bacterial communities.Changes in soil heterotrophic respiration and AM mycelium respiration had positive correlations with soil enzyme activities and fungal abundances.In summary,our findings suggest that bamboo expansion decreased soil heterotrophic respiration by decreasing soil microbial activity but increased the contribution of AM mycelial respiration to soil C efflux,which may potentially increase soil C loss from AM mycelial pathway. | Wenhao Jin Jiaying Tu Qifeng Wu Liyuan Peng Jiajia Xing Chenfei Liang Shuai Shao Junhui Chen Qiufang Xu Hua Qin | 2023 | Forest Ecosystems2023，10，3： | 1 |
| 17 | 显示文摘 | Jun Wu Changsheng Xie Junhui Hu | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 18 | Resveratrol inhibits high glucose induced collagen upregulation in cardiac fibroblasts through regulating TGF-β1–Smad3 signaling pathway显示文摘 | Junhui Liu Xiaozhen Zhuo Weimin Liu Zhaofei Wan Xiao Liang Shanshan Gao Zuyi Yuan Yue Wu | 2015 | Chemico-Biological Interactions2015，，： | 1 |
| 19 | Nanostructured Materials显示文摘 | Xie Changsheng Hu Junhui Wu Run | 1999 | 11(8):10611999，11，8： | 1 |
| 20 | Research Progress of Seafloor Pockmarks in Spatio-Temporal Distribution and Classification显示文摘Seafloor pockmarks are important indicators of submarine methane seepages and slope instabilities.In order to promote the understanding of submarine pockmarks and their relationship with sediment instabilities and climate changes,here we summarize the research results of pockmarks in the spatio-temporal distributions and shaping factors.Most of pockmarks occur along active or passive continental margins during the last 25 kyr B.P..Circular and ellipse are the most common forms of pockmarks,whereas pockmarks in a special crescent or elongated shape are indicators of slope instabilities,and ring-shape pockmarks are endemic to the gas hydrate zones.Further researches should be focused on the trigger mechanism of climate changes based on the pockmarks in the high latitudes formed during the deglaciation periods,and the role of gas hydrates in the seafloor evolution should be elucidated.In addition,the feature of pockmarks at their early stage(e.g.,developing gas chimneys and gas driving sedimentary doming)and the relations between pockmarks and mass movements,mud diapirs could be further studied to clarify the influences of rapid methane release from submarine sediments on the atmospheric carbon contents. | XU Cuiling XU Guoqiang XING Junhui SUN Zhilei WU Nengyou | 2020 | Journal of Ocean University of China2020，19，1： | 1 |
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