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| 1 | The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia显示文摘Introduction Stroke is an important disease that is prevalent worldwide [1-3].Ischemic stroke accounts for 80%of stroke cases. Currently,evidence-based effective treatments for ischemic stroke are limited,and only intravenous throm- bolysis with Alteplase (a commercially available throm- bolytic agent)within 4.5 h of stroke onset and thrombectomy and arterial thrombolysis within 6-24h of onset are effective [4,5].However,because these two treatments have strict indications and certain risks (reper- fusion injury and bleeding)[5-8],there is an urgent need to develop new treatment methods.Thus,comprehensive elucidation of the molecular mechanisms underlying ischemic brain damage and the search for key signaling pathways and protein molecules are important for guiding the clinical treatment of ischemic stroke. | Zhaofei Dong Kuang Pan Jingrui Pan Qingxia Peng Yidong Wang | 2018 | Neuroscience Bulletin2018，34，6： | 17 |
| 2 | Glacier retreat and its effect on stream flow in the source region of the Yangtze River显示文摘在冰河上在气候变化的效果上正在种担心融化并且水文学。在这篇文章,我们在长江的来源区域使用了二自然的小规模的盆, Tuotuo 河和 Buqu 河,中国,到表演,冰河的影响融化在溪流流动上。在在 1970, 1992 和 2009 的冰河和冰体积的程度的变化用遥感图象被评估。在一样的时间间隔上的冰河表面区域的变化用 Landsat TM/ETM+ 形象通过冰河轮廓和位置的描述被估计。在 2009,冰河表面区域分别地在 Tuotuo 河和 Baqu 河盆由 1970 价值中的 20.83% 个和 34.81% 减少了。在每盆的全部的 meltwater 供应被估计是 2.56 ?? | WU Shanshan YAO Zhijun HUANG Heqing LIU Zhaofei CHEN Yuansheng | 2013 | Journal of Geographical Sciences2013，23，5： | 13 |
| 3 | Spatial-temporal patterns of major ion chemistry and its controlling factors in the Manasarovar Basin, Tibet显示文摘因为它的唯一的地理环境,在南部的西藏的 Manasarovar 盆,在佛教被认为一块神圣陆地,引起了国际学术注意。在这研究,基于 43 水里的主要离子集中的实际大小,样品在年期间收集了 2005 和 2012,我们全身地在湖和 inflowing 河分析了水化学和它的控制因素的空间时间的模式。结果表明在 Manasarovar 盆的水是稍微碱的,与在 7.47.9 之间变化的 pH。分别地,在湖和河水的全部的溶解固体(TDS ) 的数量是约 325.4 和 88.7 mg/l 在西藏的高原在大多数表面水里比那降低。因为成为蒸气的结晶化的长期的效果,在湖, Na <啜class=“ a-plus-plus ”>+和 HCO <潜水艇class=“ a-plus-plus ”> 3 <啜class=“ a-plus-plus ”>有最高的集中,为全部的阳离子和阴离子内容中的46.8%个和86.8%的财务。在 inflowing 河里,然而,主导的离子是 Ca < 啜 class= “ a-plus-plus ” >2+ 和 HCO < 潜水艇 class= “ a-plus-plus ” > 3 < 啜 class= “ a-plus-plus ” > 为全部的阳离子和阴离子内容中的 59.6% 个和 75.4% 的 , 财务。水交换为如此的一个大湖是不够的,导致离子作文的一个显著空间变化。分别地湖,离子集中在湖的另外的方面上在比那显著地高的北方方面上有几条大 inflowing 河,与 468.9 和 254.9 mg/l 的 TDS。在复杂环境的影响下面,在水化学的空间变化在河里是甚至更重要的,与展出一个更高离子的内容的 upstreams。臼齿的比率在之间( Ca <啜class=“ a-plus-plus ”>2+ +Mg2+)并且( Na <啜class=“ a-plus-plus ”>+ +K+)比 1.0 高得多,表明水里的离子的主要来源是捱过的碳酸盐。尽管自然过程例如捱过的摇滚乐,是在盆控制主要离子化学的主要因素,在未来,我们需要对人为的影响给予更多的注意。 | YAO Zhijun WANG Rui LIU Zhaofei WU Shanshan JIANG Liguang | 2015 | Journal of Geographical Sciences2015，25，6： | 11 |
| 4 | Time-dependent safety of lining structures of circular tunnels in weak rock strata显示文摘Following tunnel excavation and lining completion,fractured surrounding rock deforms gradually over time;this results in a time-dependent evolution of the pressure applied to the lining structure by the surrounding rock.Thus,the safety of the tunnel lining in weak strata is strongly correlated with time.In this study,we developed an analytical method for determining the time-dependent pressure in the surrounding rock and lining structure of a circular tunnel under a hydrostatic stress field.Under the proposed method,the stress–strain relationship of the fractured surrounding rock is assumed to conform to that of the Burgers viscoelastic component,and the lining structure is assumed to be an elastomer.Based on these assumptions,the viscoelastic deformation of the surrounding rock,the elastic deformation of the lining structure,and the coordinated deformation between the surrounding rock and lining structure were derived.The proposed analytical method,which employs a time-dependent safety coefficient,was subsequently used to estimate the durability of the lining structure of the Foling Tunnel in China.The derived attenuation curve of the safety coefficient with respect to time can assist engineers in predicting the remaining viable life of the lining structure.Unlike existing analytical methods,the method derived in this study considers the time dependency of the interaction between the surrounding rock and tunnel lining;hence,it is more suitable for the evaluation of lining lifetime. | Baoguo Liu Yu Song Zhaofei Chu | 2022 | International Journal of Mining Science and Technology2022，32，2： | 7 |
| 5 | Tiny But Mighty:Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease显示文摘Parkinson's disease(PD) is the second most common age-related neurodegenerative disorder after Alzheimer's disease. To date, the clinical diagnosis of PD is primarily based on the late onset of motor impairments. Unfortunately, at this stage, most of the dopaminergic neurons may have already been lost, leading to the limited clinical benefits of current therapeutics.Therefore, early identification of PD, especially at the prodromal stage, is still a main challenge in the diagnosis and management of this disease. Recently, microRNAs(miRNAs) in cerebrospinal fluid or peripheral blood have been proposed as putative biomarkers to assist in PD diagnosis and therapy. In this review, we systematically summarize the changes of miRNA expression profiles in PD patients, and highlight their putative roles in the diagnosis and treatment of this devastating disease. | Ying Wang Zhaofei Yang Weidong Le | 2017 | Neuroscience Bulletin2017，33，5： | 6 |
| 6 | Real-time rock mass condition prediction with TBM tunneling big data using a novel rock-machine mutual feedback perception method显示文摘Real-time perception of rock mass information is of great importance to efficient tunneling and hazard prevention in tunnel boring machines(TBMs).In this study,a TBM-rock mutual feedback perception method based on data mining(DM) is proposed,which takes 10 tunneling parameters related to surrounding rock conditions as input features.For implementation,first,the database of TBM tunneling parameters was established,in which 10,807 tunneling cycles from the Songhua River water conveyance tunnel were accommodated.Then,the spectral clustering(SC) algorithm based on graph theory was introduced to cluster the TBM tunneling data.According to the clustering results and rock mass boreability index,the rock mass conditions were classified into four classes,and the reasonable distribution intervals of the main tunneling parameters corresponding to each class were presented.Meanwhile,based on the deep neural network(DNN),the real-time prediction model regarding different rock conditions was established.Finally,the rationality and adaptability of the proposed method were validated via analyzing the tunneling specific energy,feature importance,and training dataset size.The proposed TBM-rock mutual feedback perception method enables the automatic identification of rock mass conditions and the dynamic adjustment of tunneling parameters during TBM driving.Furthermore,in terms of the prediction performance,the method can predict the rock mass conditions ahead of the tunnel face in real time more accurately than the traditional machine learning prediction methods. | Zhijun Wu Rulei Wei Zhaofei Chu Quansheng Liu | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 6 |
| 7 | Prevalence and phylogenetic characterization of canine coronavirus from diseased pet dogs in Beijing,China显示文摘Dear Editor,Canine coronavirus including canine coronavirus(CCoV)and canine respiratory coronavirus(CRCoV)have been recognized as pathogenic viruses to dogs worldwide,causing enteric and respiratory issues(Buonavoglia et al.,2006).Zoonotic transfer of the viruses from the animal kingdom to humans has been repeatedly observed over the past decade, | Shuai Lu Di Zhang Jianfang Zhou Zhaofei Xia Degui Lin Yongliang Lou Wenjie Tan Kun Qin | 2016 | Science China(Life Sciences)2016，59，8： | 5 |
| 8 | Estimating the productive potential of five natural forest types in northeastern China显示文摘Background: There is a serious lack of experience regarding the productive potential of the natural forests in northeastern China, which severely limits the development of sustainable forest management strategies for this most important forest region in China. Accordingly, the objective of this study is to develop a first comprehensive system for estimating the wood production for the five dominant forest types.Methods: Based on a network of 384 field plots and using the state-space approach, we develop a system of dynamic stand models, for each of the five main forest types. Four models were developed and evaluated, including a base model and three extended models which include the effects of dominant height and climate variables. The four models were fitted, and their predictive strengths were tested, using the 'seemingly unrelated regression'(SUR) technique.Results: All three of the extended models increased the accuracy of the predictions at varying degrees for the five major natural forest types of northeastern China. The inclusion of dominant height and two climate factors(precipitation and temperature) in the base model resulted in the best performance for all the forest types. On average, the root mean square values were reduced by 13.0% when compared with the base model.Conclusion: Both dominant height and climate factors were important variables in estimating forest production. This study not only presents a new method for estimating forest production for a large region, but also explains regional differences in the effect of site productivity and climate. | Zhaofei Wu Zhonghui Zhang Juan Wang | 2019 | Forest Ecosystems2019，6，4： | 5 |
| 9 | Value of Multi-slice spiral CT in diagnosis of malignant gastrointestinal stromal tumors显示文摘这研究的目的是在恶意的胃肠的 stromal 肿瘤(大意) 的诊断调查多片螺线 CT (MSCT ) 的价值的目的。恶意的大意的 MSCT 图象的 27 个案例由外科和病理证明了的方法回顾地被分析。平原和提高的 CT 扫描被执行,多平面的重建在所有情况中被做。结果损害从胃发源(n = 11 ) ,小肠(n = 9 ) ,结肠(n = 4 ) ,直肠(n = 1 ) ,并且肠系膜(n = 2 ) 。质量的横向的直径是 4.2 22 厘米,边清楚地(n = 12 ) ,不清楚地(n = 15 ) 。团在形状 lobulated 主要是不规则的(n = 19 ) 。损害主要是平凡扫描上的异质,对在动脉的阶段的显著改进中等、持续性在静脉的阶段提高了。膀胱的坏死在所有损害被观察, 9 个案例是膀胱、稳固的混合质量。肝的转移(n = 4 ) ,肺的转移(n = 1 ) ,淋巴的转移(n = 2 ) 被检测。为地点和大意的病理学的特征的 MSCT 诊断的精确性率是 85.2%(23/27 ) 并且 77.8%(21/27 ) 。与多平面的重建图象相结合的结论二阶段的 MSCT 检查和轴的图象为恶意的大意的诊断有重要价值。 | Zhongheng He Fajin Lv Zhaofei Cao Mingxia Qian | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 5 |
| 10 | Rational design of glycerol dehydratase:Swapping the genes encoding the subunitsof glycerol dehydratase to improve enzymatic properties显示文摘1,3-propanediol (1,3-PD) is an important material for chemical industry,and there has been always much interest in the production of 1,3-PD using all possible routes. The genes encoding glyc-erol dehydratase (GDHt) from Citrobacter freundii,Klebsiella pneumoniae and metagenome were cloned and expressed in E. coli. All glycerol dehy-dratases but the one from metagenome could be detected to show enzyme activities. In order to im-prove the enzymatic properties of GDHts,the genes encoding α and β-γ subunits were cloned,and the enzyme characteristics were evolved by rational de-sign based on their 3D structures which were con-structed by homology modeling. Six heteroenzymes were obtained by swapping the α subunit genes of these three different-source-derived GDHts. The pH,thermal stability and Vmax of some heteroenzymes were dramatically improved by 2―5 times compared with the wild one (GDHtKP). The GDHt cloned from metagenome,originally proved to be with no enzyme activity,was converted into active enzyme by swap-ping its subunits with other different GDHts. In addi-tion,the effect of subtle 3D structural changes on the properties of the enzyme was also observed. | QI Xianghui SUN Liang LUO Zhaofei WU Jiequn MENG Xiaolei TANG Yue WEI Yutuo HUANG Ribo | 2006 | Chinese Science Bulletin2006，51，24： | 4 |
| 11 | Effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on excisional wound healing in a rat's model显示文摘OBJEVTIVE: To investigate the effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on the excisional wound healing in a rat's model.METHODS: Rats were performed a surgical lesion with a 2.0 cm resected tissue in the dorsal fascia.Following, animals were randomly divided into model group, YNB group and APE group those were respectively treated with saline, 1 mg/mL of Yunnan Baiyao and 1 mg/mL of Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) extracts. Wound contractions in days 0, 3, 7, 14 and 21 were calculated by an image analyzer. Histological analysis was analyzed using hematoxilin and eosin.Levels of tumor necrosis factor-2(IL-2), IL-4, IL-10, transformαin(TNF-g growα), interleukinth factor-1(TGF-nd basic fibroblast growth factor(bFββ1) a-GF) were determined by real-time quantitative PCR.RESULTS: Compared with that of YNB group and APE gtoup, the skin of rats showed poor re-modeling and re-epithelization characterized by a significant decrease of neovascularization, epithelialization and fibroblast in the model group. In the APE group, levels of TNF-α-and IL-2 were significantly down-regulated and IL4 and IL-10 significantly upregulated in contrasted with that of model group.In addition, levels of TGF-roup were significantly iβ1 and bFGF in the APE gnduced compared with that of model group.CONCLUSION: The results suggest that the extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) promote wound healing in the rats, which is associated with enhancing antiinflammatory ability and inducing fibroblast formation. | Xia Xichao Ma Yuhong Wang Fuan Zheng Xinhua Liu Yang Zhang Junfeng Cui Juan Shi Bingqin Li Hongwen Liu Rongzhi Zhang Yaping Cheng Zhaofei Han Xiaolong | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 12 | Effects of Normalized Difference Vegetation Index and Related Wavebands′ Characteristics on Detecting Spatial Heterogeneity Using Variogram-based Analysis显示文摘Spatial heterogeneity is widely used in diverse applications, such as recognizing ecological process, guiding ecological restoration, managing land use, etc. Many researches have focused on the inherent scale multiplicity of spatial heterogeneity by using various environmental variables. How these variables affect their corresponding spatial heterogeneities, however, have received little attention. In this paper, we examined the effects of characteristics of normalized difference vegetation index (NDVI) and its related bands variable images, namely red and near infrared (NIR), on their corresponding spatial heterogeneity detection based on variogram models. In a coastal wetland region, two groups of study sites with distinct fractal vegetation cover were tested and analyzed. The results show that: 1) in high fractal vegetation cover (H-FVC) area, NDVI and NIR variables display a similar ability in detecting the spatial heterogeneity caused by vegetation growing status structure; 2) in low fractal vegetation cover (L-FVC) area, the NIR and red variables outperform NDVI in the survey of soil spatial heterogeneity; and 3) generally, NIR variable is ubiquitously applicable for vegetation spatial heterogeneity investigation in different fractal vegetation covers. Moreover, as variable selection for remote sensing applications should fully take the characteristics of variables and the study object into account, the proposed variogram analysis method can make the variable selection objectively and scientifically, especially in studies related to spatial heterogeneity using remotely sensed data. | WEN Zhaofei ZHANG Ce ZHANG Shuqing DING Changhong LIU Chunyue PAN Xin LI Huapeng SUN Yan | 2012 | Chinese Geographical Science2012，22，2： | 4 |
| 13 | ^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor显示文摘In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor diagnosis.In this paper,we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography(SPECT/CT)in patients suffering from space occupying disease of esophagus.40 patients(34 males and 6 female;mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included,thus finally obtaining their definite pathologic diagnosis(malignant,n=32;benign,n=8).All patients underwent endoscopic,barium esophagography and SPECT/CT imaging preoperatively.The chest SPECT was performed at 4 h after administration of99mTc-3P4-RGD2 with a dose of 939±118 MBq.The diagnosis precision,sensitivity and specificity among these methods were compared.The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus(T/N).Meanwhile,the integrin αvβ3 expression was assessed immunohistochemically in postoperative esophageal tissues.31 patients were diagnosed as esophageal carcinoma;and 1,leiomyosarcoma;and 6.leimyoma;and 2,esophageal tuberculosis.The accuracy,sensitivity and specificity of barium esophagography,endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%,97.5/96.9/100%,and 90/90.6/87.5%,respectively.Abnormal accumulation of radiotracer in 29 malignant lesions is observed.The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79(mean 2.04).A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic.The99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification(P>0.05).There was a significant positive correlation between T/N ratio and positive cell percentage of integrin αvβ3(r=0.976),demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma. | GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei CHEN Zuowei ZHANG Haishan LI Dandan | 2013 | Nuclear Science and Techniques2013，24，4： | 3 |
| 14 | Toward the Next Generation of Retinal Neuroprosthesis: Visual Computation with Spikes显示文摘A neuroprosthesis is a type of precision medical device that is intended to manipulate the neuronal signals of the brain in a closed-loop fashion,while simultaneously receiving stimuli from the environment and controlling some part of a human brain or body.Incoming visual information can be processed by the brain in millisecond intervals.The retina computes visual scenes and sends its output to the cortex in the form of neuronal spikes for further computation.Thus,the neuronal signal of interest for a retinal neuroprosthesis is the neuronal spike.Closed-loop computation in a neuroprosthesis includes two stages:encoding a stimulus as a neuronal signal,and decoding it back into a stimulus.In this paper,we review some of the recent progress that has been achieved in visual computation models that use spikes to analyze natural scenes that include static images and dynamic videos.We hypothesize that in order to obtain a better understanding of the computational principles in the retina,a hypercircuit view of the retina is necessary,in which the different functional network motifs that have been revealed in the cortex neuronal network are taken into consideration when interacting with the retina.The different building blocks of the retina,which include a diversity of cell types and synaptic connections-both chemical synapses and electrical synapses(gap junctions)-make the retina an ideal neuronal network for adapting the computational techniques that have been developed in artificial intelligence to model the encoding and decoding of visual scenes.An overall systems approach to visual computation with neuronal spikes is necessary in order to advance the next generation of retinal neuroprosthesis as an artificial visual system. | Zhaofei Yu Jian K.Liu Shanshan Jia Yichen Zhang Yajing Zheng Yonghong Tian Tiejun Huang | 2020 | Engineering2020，6，4： | 3 |
| 15 | Effects of Sm-doping on microstructure,magnetic and microwave absorption properties of BiFeO_(3)显示文摘In this paper,polycrystalline samples of Bi_(1-x)Sm_(x)FeO_(3)(x=0,0.05,0.1,0.15) were successfully synthesized by sol-gel method.The effects of Sm concentration on the crystal structure,morphology,chemical states,magnetic properties and microwave absorption performance were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),a vibrating sample magnetometer(VSM) and a Vector network analyzer(VNA),respectively.The results show that the rare earth Sm doping causes the crystal structure to change.When x≤0.1,Bi_(1-x)Sm_(x)FeO_(3) is the distorted rhombohedral structure with space group R3c.With the increase of Sm doping amount to x=0.15,the phase structure of Bi_(1-x)Sm_(x)FeO_(3) changes from rhombohedral structure to cubic structure with the space group Pm3 m.The particle size decreases with the increase of the Sm doping amount.The analysis results show that Sm doping can effectively reduce the oxygen vacancies and significantly improve its magnetic properties.The results exhibit that moderately doped rare earth Sm element can effectively improve microwave absorption properties of Bi_(1-x)Sm_(x)FeO_(3) powders.When Sm doping amount of x is 0.1,the Bi_(0.9)Sm_(0.1)FeO_(3) compound has good microwave absorption performance,and the minimum reflection loss value of Bi_(0.9)Sm_(0.1)FeO_(3) powder reaches about-32.9 dB at11.7 GHz,and its effective absorption bandwidth(RL <-10 dB) is 2.6 GHz with the optimal matching thickness of 2.0 mm. | Chuang Tian Qingrong Yao Zhaofei Tong Huaiying Zhou Guanghui Rao Jianqiu Deng Zhongmin Wang Jiang Wang | 2021 | Journal of Rare Earths2021，39，7： | 3 |
| 16 | Climate warming shifts the time interval between flowering and leaf unfolding depending on the warming period显示文摘The timing of flowering(FL)and leaf unfolding(LU)determine plants’reproduction and vegetative growth.Global warming has substantially advanced FL and LU of temperate and boreal plants,but their responses to warming differ,which may influence the time interval between FL and LU(ΔLU-FL),thereby impacting plant fitness and intraspecific physiological processes.Based on twigs collected from two flowering-first tree species,Populus tomentosa and Amygdalus triloba,we conducted a manipulative experiment to investigate the effects of winter chilling,spring warming and photoperiod on theΔLU-FL.We found that photoperiod did not affect theΔLU-FL of Amygdalus triloba,but shortenedΔLU-FL by 5.1 d of Populus tomentosa.Interestingly,spring warming and winter chilling oppositely affected theΔLU-FL of both species.Specifically,low chilling accumulation extended theΔLU-FL by 3.8 and 9.4 d for Populus tomentosa and Amygdalus triloba,but spring warming shortened theΔLU-FL by 4.1 and 0.2 d℃^(-1).Our results indicate that climate warming will decrease or increase theΔLU-FL depending on the warming periods,i.e.,spring or winter.The shifted time interval between flowering and leaf unfolding may have ecological effects including affecting pollen transfer efficiency and alter the structure and functioning of terrestrial ecosystem. | Shuxin Wang Zhaofei Wu Yufeng Gong Shubiao Wang Wei Zhang Shanshan Zhang Hans J.De Boeck Yongshuo H.Fu | 2022 | Science China(Life Sciences)2022，65，11： | 2 |
| 17 | Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity显示文摘Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines,the epidemic prevention and control are still challenging.Here,we employ a capsid and antigen structure engineering(CASE)strategy to manufacture an adenoassociated viral serotype 6-based vaccine(S663V-RBD),which expresses trimeric receptor binding domain(RBD)of spike protein fused with a biological adjuvant RS09.Impressively,the engineered S663V-RBD could rapidly induce a satisfactory RBD-specific IgG titer within 2 weeks and maintain the titer for more than 4 months.Compared to the licensed BBIBP-CorV(Sinopharm,China),a single-dose S663V-RBD induced more endurable and robust immune responses in mice and elicited superior neutralizing antibodies against three typical SARS-CoV-2 pseudoviruses including wild type,C.37(Lambda)and B.1.617.2(Delta).More interestingly,the intramuscular injection of S663V-RBD could overcome pre-existing immunity against the capsid.Given its effectiveness,the CASE-based S663VRBD may provide a new solution for the current and next pandemic. | Fuhua Wu Shuang Luo Yongshun Zhang Yangsen Ou Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen Guangsheng Du Xun Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 18 | 典型黑土区坡耕地退化程度诊断与评价显示文摘为了对黑土区坡耕地退化程度进行全面、综合、客观的诊断与评价,通过文献计量法和频度分析法对国内外耕地退化评价文献内的高频指标进行了统计分析,建立了适用于东北典型黑土区坡耕地退化程度诊断与评价的指标体系(TIS)。同时以拜泉县为研究区域,通过聚类分析建立了土壤退化程度诊断与评价最小指标集(MIS)。结果表明:(1)TIS共包括物理、化学、生物和侵蚀特征因子4类共11项指标:腐殖质层厚度、黏粒含量、有机质含量、pH值、坡度、垄坡角、沟壑密度、容重、水稳性大团聚体含量、土壤阳离子交换量和作物产量,其中前6项指标组成了MIS。(2)研究区未退化土壤占12%,轻度退化土壤占12%,中度及以上退化土壤占76%。坡度可能是影响研究区土壤退化的主要因素之一,坡度与垄坡角之间存在协同关系。此外,施用农药、化肥以及连作导致土壤酸化问题突出。 | 张守昊 孙蕾 JAMSHIDI Abdul Hakim 牛勇 刘霞 FAN Zhaofei | 2022 | 水土保持研究2022，29，2： | 2 |
| 19 | Methylprednisolone inhibits Nogo-A protein expression after acute spinal cord injury显示文摘Oligodendrocyte-produced Nogo-A has been shown to inhibit axonal regeneration. Methylprednisolone plays an effective role in treating spinal cord injury, but the effect of methylprednisolone on Nogo-A in the injured spinal cord remains unknown. The present study established a rat model of acute spinal cord injury by the weight-drop method. Results showed that after injury, the motor behavior ability of rats was reduced and necrotic injury appeared in spinal cord tissues, which was accompanied by increased Nogo-A expression in these tissues. After intravenous injection of high-dose methylprednisolone, although the pathology of spinal cord tissue remained unchanged, Nogo-A expression was reduced, but the level was still higher than normal. These findings implicate that methylprednisolone could inhibit Nogo-A expression, which could be a mechanism by which early high dose methylprednisolone infusion helps preserve spinal cord function after spinal cord injury. | Zhaozong Fu Hai Lu Jianming Jiang Hui Jiang Zhaofei Zhang | 2013 | Neural Regeneration Research2013，8，5： | 2 |
| 20 | Influence of the pore structure of Ce/MgAl hydrotalcite-derived mixed oxides on its SO_x pick-up capacity显示文摘The sulfur-transfer catalyst is widely used to remove the sulfur oxides (SOx ) from the flue gas in the fluid catalytic cracking (FCC) units. This paper reports the influence of the pore structure of the Ce/MgAl hydrotalcite-derived mixed oxides on its SO x pick-up capacity. The Ce/MgAl hydrotalcites precursors were synthesized by the separate nucleation and aging steps (SNAS), and then were calcined in air at 800℃ to prepare the Ce/MgAl mixed oxides. And in our preparations, the pore structures of the Ce/MgAl mixed oxides were controlled by modifying the aging time of the hydrotalcites precursors. It is found that with the aging time of 4 to 6 h produced the largest pore volume (the largest total pore volume and the least pore less than 10 nm) and resulted in the largest SOx pick-up capacity. | XU XiangYu JIANG Lei Lü Zhi SONG JiaQing LI ZhaoFei | 2013 | Chinese Science Bulletin2013，58，14： | 1 |
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