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| 1 | Lancet:世界心脏联盟全球心血管疾病预防展望显示文摘动脉粥样硬化性心血管疾病是世界头号致死致残因素,不成比例地影响着中低收入国家(LMIC)的居民。二十世纪六七十年代,心血管疾病被视为高收入国家的常见病,此后通过采取更好的预防措施(如改变生活方式、控制风险因素等),并广泛应用简单有效的紧急事件处理和二级预防措施,心血管疾病的年龄标准化死亡率得以减半。然而,即便在发达国家,所采取的这些行之有效的策略仍远远不够,如果在大多数高收入国家中推广,未来二十年心血管疾病的发生率将进一步降低。 | Yusuf S Wood D Ralston J Reddy KS | 2015 | 疾病监测2015，30，5： | 14 |
| 2 | Return to sport following tibial plateau fractures: A systematic review显示文摘AIM To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods.METHODS A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords 'tibial', 'plateau', 'fractures', 'knee', 'athletes', 'sports', 'non-operative', 'conservative', 'operative', 'return to sport'. All studies which recorded return rates and times to sport following tibial plateau fractures were included. RESULTS Twenty-seven studies were included: 1 was a randomised controlled trial, 7 were prospective cohort studies, 16 were retrospective cohort studies, 3 were case series. One study reported on the outcome of conservative management(n = 3); 27 reported on the outcome of surgical management(n = 917). Nine studies reported on Open Reduction Internal Fixation(ORIF)(n = 193), 11 on Arthroscopic-Assisted Reduction Internal Fixation(ARIF)(n = 253) and 7 on Frame-Assisted Fixation(FRAME)(n = 262). All studies recorded 'return to sport'rates. Only one study recorded a 'return to sport' time. The return rate to sport for the total cohort was 70%. For the conservatively-managed fractures, the return rate was 100%. For the surgically-managed fractures, the return rate was 70%. For fractures managed with ORIF, the return rate was 60%. For fractures managed with ARIF, the return rate was 83%. For fractures managed with FRAME was 52%. The return rate for ARIF was found to be significantly greater than that for ORIF(OR 3.22, 95%CI: 2.09-4.97, P < 0.001) and for FRAME(OR 4.33, 95%CI: 2.89-6.50, P < 0.001). No difference was found between the return rates for ORIF and FRAME(OR 1.35, 95%CI: 0.92-1.96, P = 0.122). The recorded return time was 6.9 mo(median), from a study reporting on ORIF.CONCLUSION Return rates to sport for tibial plateau fractures remain limited compared to other fractures. ARIF provides the best return rates. There is limited data regarding return times to sport. Further research is required to determine return times to sport, and to improve return rates to sport, through treatment and rehabilitation optimisation. | Greg A J Robertson Seng J Wong Alexander M Wood | 2017 | World Journal of Orthopedics2017，8，7： | 10 |
| 3 | Safety of epinephrine for anaphylaxis in the emergency setting显示文摘BACKGROUND:While epinephrine is the recommended first-line therapy for the reversal of anaphylaxis symptoms,inappropriate use persists because of misunderstandings about proper dosing and administration or misconceptions about its safety.The objective of this review was to evaluate the safety of epinephrine for patients with anaphylaxis,including other emergent conditions,treated in emergency care settings.METHODS:A MEDLINE search using PubMed was conducted to identify articles that discuss the dosing,administration,and safety of epinephrine in the emergency setting for anaphylaxis and other conditions.RESULTS:Epinephrine is safe for anaphylaxis when given at the correct dose by intramuscular injection.The majority of dosing errors and cardiovascular adverse reactions occur when epinephrine is given intravenously or incorrectly dosed.CONCLUSION:Epinephrine by intramuscular injection is a safe therapy for anaphylaxis but training may still be necessary in emergency care settings to minimize drug dosing and administration errors and to allay concerns about its safety. | Joseph P Wood Stephen J Traub Christopher Lipinski | 2013 | World Journal of Emergency Medicine2013，4，4： | 7 |
| 4 | 基质诱导的自体软骨细胞移植一例显示文摘 | 张仲文 杨造成 侯世科 白建鹏 杨传铎 高春华 匡正达 叶启彬 郑铭豪 David J Wood | 2006 | 中华外科杂志2006，44，4： | 7 |
| 5 | Lower limb stress fractures in sport:Optimising their management and outcome显示文摘Stress fractures in sport are becoming increasing more common,comprising up to 10%of all of sporting injuries.Around 90%of such injuries are located in the lower limb.This articles aims to define the optimal management of lower limb stress fractures in the athlete,with a view to maximise return rates and minimise return times to sport.Treatment planning of this condition is specific to the location of the injury.However,there remains a clear division of stress fractures by'high'and'low'risk.'Low risk'stress fractures are those with a low probability of fracture propagation,delayed union,or non-union,and so can be managed reliably with rest and exercise limitation.These include stress fractures of the PosteroMedial Tibial Diaphysis,Metatarsal Shafts,Distal Fibula,Medial Femoral Neck,Femoral Shaft and Calcaneus.'High risk'stress fractures,in contrast,have increased rates of fracture propagation,displacement,delayed and non-union,and so require immediate cessation of activity,with orthopaedic referral,to assess the need for surgical intervention.These include stress fractures of the Anterior Tibial Diaphysis,Fifth Metatarsal Base,Medial Malleolus,Lateral Femoral Neck,Tarsal Navicular and Great Toe Sesamoids.In order to establish the optimal methods for managing these injuries,we present and review the current evidence which guides the treatment of stress fractures in athletes.From this,we note an increased role for surgical management of certain high risk stress fractures to improve return times and rates to sport.Following this,key recommendations are provided for the management of the common stress fracture types seen in the athlete.Five case reports are also presented to illustrate the application of sportfocussed lower limb stress fracture treatment in the clinical setting. | Greg A J Robertson Alexander M Wood | 2017 | World Journal of Orthopedics2017，8，3： | 7 |
| 6 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 7 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 8 | A plant molecular DNA minipreparation version 显示文摘 | Dellaporta S L Wood J Hicks J B | 1983 | Plant Mol Biol Rep1983，1，： | 2 |
| 9 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 10 | Invariant pattem recognition:a review 显示文摘 | Wood J | 1996 | Pattern Recognition1996，29，1： | 2 |
| 11 | 年龄相关性线粒体功能障碍加速动脉粥样硬化形成显示文摘老化是动脉粥样硬化的最强危险因素之一。然而,老化是否独立于慢性高血脂症而增加动脉粥样硬化的风险尚不清楚。该研究旨在确定高血脂症诱导前的血管老化是否会加速动脉粥样硬化的形成。研究者分析了幼年和老年正常血脂野生型(wild type,WT)、无疾病小鼠的主动脉,发现老化导致白细胞介素(interleukin,IL)6水平升高和线粒体功能障碍,并与线粒体自噬增加和其相关蛋白Parkin增加相关。在主动脉组织培养中,研究者发现随着老化的出现,线粒体功能障碍与IL-6存在正反馈关系。研究者通过诱导低密度脂蛋白受体的肝脏特异性降解,再结合10周的西方食物喂养,在老年和幼年小鼠中诱发急性高血脂症,发现老年WT小鼠的动脉粥样硬化增强。高血脂症进一步降低了老年小鼠的线粒体功能,增加了主动脉中Parkin的水平,但幼鼠则没有。 | 刘青(译) 叶鹏(摘、审校) Tyrrell DJ Blin M Song J Wood S Zhang M Beard DA Goldstein D | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 12 | Multiscale modeling of spatially variable water and energy balance process显示文摘 | Famiglietti J S Wood E F | 1998 | Water Resources Research1998，30，11： | 2 |
| 13 | The sand erosion performance of coatings 显示文摘 | Wood R J K | 1999 | Mater1999，20，： | 1 |
| 14 | Extraction of high-viscosty gums from oats显示文摘 | WOOD P J SIDDIQUI L R PATON 19 | 1978 | Cereal Chem1978，55，6： | 1 |
| 15 | Sorption of polynuclear aromatic hydrocarbons by sediments and soil 显示文摘 | MEANS J C WOOD S HASSETT J J | 1980 | Environ Sci Technol1980，14，12： | 1 |
| 16 | A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island显示文摘 | Choi J D Underkoffler L A Wood A J | 2005 | Mol Cell Biol2005，25，13： | 1 |
| 17 | Potted - plant/growth media interactions and capacities for removal of volatiles from indoor air 显示文摘 | Wood R A Orwell R L Tartan J | 2002 | Journal of Horticulture Science & Biotechnology2002，77，1： | 1 |
| 18 | Microalgae and Antarctic seaice显示文摘 | Bunt J S Wood Z J F | 1963 | Nature1963，199，2： | 1 |
| 19 | Effects of breed,diet and muscle on fat deposition and eating quality in pigs显示文摘 | Wood J D Nute G R Richardson R I | 2004 | Meat Science2004，67，4： | 1 |
| 20 | Specificity in the interaction of direct dyes with polysaccharides显示文摘 | Wood P J | 1980 | Carbohydr Res1980，85，： | 1 |
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