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| 1 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 2 | Lancet:世界心脏联盟全球心血管疾病预防展望显示文摘动脉粥样硬化性心血管疾病是世界头号致死致残因素,不成比例地影响着中低收入国家(LMIC)的居民。二十世纪六七十年代,心血管疾病被视为高收入国家的常见病,此后通过采取更好的预防措施(如改变生活方式、控制风险因素等),并广泛应用简单有效的紧急事件处理和二级预防措施,心血管疾病的年龄标准化死亡率得以减半。然而,即便在发达国家,所采取的这些行之有效的策略仍远远不够,如果在大多数高收入国家中推广,未来二十年心血管疾病的发生率将进一步降低。 | Yusuf S Wood D Ralston J Reddy KS | 2015 | 疾病监测2015，30，5： | 14 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | A plant molecular DNA minipreparation version 显示文摘 | Dellaporta S L Wood J Hicks J B | 1983 | Plant Mol Biol Rep1983，1，： | 2 |
| 5 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 6 | 年龄相关性线粒体功能障碍加速动脉粥样硬化形成显示文摘老化是动脉粥样硬化的最强危险因素之一。然而,老化是否独立于慢性高血脂症而增加动脉粥样硬化的风险尚不清楚。该研究旨在确定高血脂症诱导前的血管老化是否会加速动脉粥样硬化的形成。研究者分析了幼年和老年正常血脂野生型(wild type,WT)、无疾病小鼠的主动脉,发现老化导致白细胞介素(interleukin,IL)6水平升高和线粒体功能障碍,并与线粒体自噬增加和其相关蛋白Parkin增加相关。在主动脉组织培养中,研究者发现随着老化的出现,线粒体功能障碍与IL-6存在正反馈关系。研究者通过诱导低密度脂蛋白受体的肝脏特异性降解,再结合10周的西方食物喂养,在老年和幼年小鼠中诱发急性高血脂症,发现老年WT小鼠的动脉粥样硬化增强。高血脂症进一步降低了老年小鼠的线粒体功能,增加了主动脉中Parkin的水平,但幼鼠则没有。 | 刘青(译) 叶鹏(摘、审校) Tyrrell DJ Blin M Song J Wood S Zhang M Beard DA Goldstein D | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 7 | Multiscale modeling of spatially variable water and energy balance process显示文摘 | Famiglietti J S Wood E F | 1998 | Water Resources Research1998，30，11： | 2 |
| 8 | Ferroelectric thin films 显示文摘 | SWARTZ S L WOOD V E | 1992 | Condensed Matter News1992，1，5： | 2 |
| 9 | Assessment of intubating conditions in adults after inducaion with propofol and varying doses of remifentanil显示文摘 | Crant S Noble S Woods A | 1998 | Br J Anaesth1998，81，4： | 1 |
| 10 | Sorption of polynuclear aromatic hydrocarbons by sediments and soil 显示文摘 | MEANS J C WOOD S HASSETT J J | 1980 | Environ Sci Technol1980，14，12： | 1 |
| 11 | Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation显示文摘 | Wood SJ Steavenson S | 1999 | J Biol Chem1999，274，14： | 1 |
| 12 | Microalgae and Antarctic seaice显示文摘 | Bunt J S Wood Z J F | 1963 | Nature1963，199，2： | 1 |
| 13 | Regulatory T cells in transplantation tolerance显示文摘 | Wood K J Sakaguchi S | 2003 | Nat Rev Immunol2003，3，3： | 1 |
| 14 | The use of the Memo- kath slent in the treatment of detmsor sphincter dyssynergia in spinal cord injury patients: a single-centre seven-year ex- perience显示文摘 | Hamid R Arya M Wood S | 2003 | Eur Urol2003，43，5： | 1 |
| 15 | C/C composite materials for aircraftbrakes显示文摘 | Awasthi S Wood J L | 1988 | Advanced Ceramic Materials1988，3，： | 1 |
| 16 | Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment 显示文摘 | Dennog C Gedik C Wood S | 1999 | Mutat Res1999，431，2： | 1 |
| 17 | Effects of dimethyl sulfoxide and glycine on cryopreservation induced damage ot plasma membranes and mitochondria to striped bass (Morone saxatilis) sperm显示文摘 | He S Woods L C | 2004 | Cryobiology2004，48，3： | 1 |
| 18 | Selectivity and stoichiometry of copper oxide in propylene oxidation显示文摘 | Wood B J Wise H Yolles R S | 1969 | J Catalys1969，15，： | 1 |
| 19 | A plant DNA minipreparation: version Ⅱ显示文摘 | Dellaporta S L Wood J Hicks J B | 1983 | Plant Mol Biol Rep1983，4，1： | 1 |
| 20 | Full-scale tests of bridge components strengthened using carbon fiber-reinforced polymer composites显示文摘 | BRENA S F WOOD S L KREGER M E | 2003 | ACI Structural Journal2003，100，6： | 1 |
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