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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | HRS/ EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association(EHRA) 显示文摘 | ACKERMAN M J PRIORI S G WILLEMS S | 2011 | Heart Rhythm2011，8，8： | 1 |
| 3 | Thermodynamics of Alon II:Phase Relations显示文摘 | Willems H X Hendrix M De With G | 1992 | Journal of the European Ceramic Society1992，10，4： | 1 |
| 4 | 显示文摘 | Tourwe D G Biesemans M Willem R | 2008 | Progress in Organic Coatings2008，63，： | 1 |
| 5 | Neurokinin 1 receptor expression and substance P physiological actions are developmentally regulated in the rabbit retina显示文摘 | Casini G Dal Monte M Fornai F Bosco L Willems D Yang Q | 2004 | Neuroscience2004，124，1： | 1 |
| 6 | Outcome of Pregnancy in Women With Congenital Heart Disease显示文摘 | Willem Drenthen M D Petronella G | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 7 | Effects of earthworms on nitrogen mineralization显示文摘 | Willems J J G M Marinissen J C Y Blair J | 1996 | Biol Fertil Soils1996，28，： | 1 |
| 8 | Uptake,metabolism and distribution of nitrogen in crop plants traced by enriched and natural 15 N:progress over the last 30 years显示文摘 | Tadakatsu Yoneyama Osamu Ito Willem M H G Engelaar | 2003 | Phytochemistry Reviews2003，2，： | 1 |
| 9 | Antibodies to β2-glycoprotein I associated with antiphospholipid syndrome suppress the inhibitory activity of tissue factor pathway inhibitor显示文摘 | Salemink I Blezer R Willems G M | 2000 | Thromb Haemost2000，84，： | 1 |
| 10 | Significance of initial ST segment elevation and depression for the management of thrombolytic therapy in acute myocardial infarction显示文摘 | WILLEMS J L WILLEMS R J WILLEMS G M | 1990 | Circulation1990，82，： | 1 |
| 11 | Production of translucent γ-aluminum oxynitride,thermodynamics of AlON Ⅱ:phase reactions显示文摘 | WILLEMS H X HENDRIX M M R M WITH G | 1992 | J Eur Ceram Soc1992，10，4： | 1 |
| 12 | On image pre-processing for PIV of single-and two-phase flows over reflecting objects显示文摘 | Deen N G Willems P van Sint A M Kuipers J A M Lammertink R G H Kemperman A J B Wessling M van der Meer W G J | 2010 | Experiments in Fluids2010，49，2： | 1 |
| 13 | Use of particle imaging velocimetry to measure liquid velocity profiles in liquid and liquid/gas flows through spacer filled channels显示文摘 | Willems P Deen N G Kemperman A J B Lammertink R G H Wessling M van Sint A M Kuipers J A M van der Meer W G J | 2010 | Journal of Membrane Science2010，362，12： | 1 |
| 14 | Revascularization and bone remodeling of frozen allografts stimulated by intramedullary sus- tained delivery of FG-2 and VEGF显示文摘 | WILLEMS W F LARSEN M GIUSTI G | 2011 | Journal of Orthopaedic Re- search2011，29，9： | 1 |
| 15 | HRS/EHRA expert Consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies显示文摘 | ACKERMAN M J PRIORI S G WILLEMS S | 2011 | Heart Rhythm2011，8，： | 1 |
| 16 | Starch digestion rate in the small intestine of broiler chickens differs among feedstuffs显示文摘 | Weurding R E Veldman A Willem A Veen G van der Aar P J Verstegen M W A | 2001 | Journal of Nutrition2001，131，： | 1 |
| 17 | Thromhogenieity of polysaceharide-coated surfares显示文摘 | Keuren J F W Wielders S J H Willems G M | 2003 | Biomaterials2003，24，： | 1 |
| 18 | In vitro starch digestion correlates well with rate and extent of starch digestion in broiler chickens显示文摘 | Weurding R E Veldman A Willem A Veen G van der Aar P J Verstegen M W A | 2001 | Journal of Nutrition2001，131，： | 1 |
| 19 | HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society(HRS)and the European Heart Rhythm Association(EHRA)显示文摘 | ACKERMAN M J PRIORI S G WILLEMS S | 2011 | Heart Rhythm2011，8，： | 1 |
| 20 | A major quantitative trait locus for cadmium tolerance in Arabidopsis halleri colocalizes with HMA4,a gene encoding a heavy metal ATPase显示文摘 | Courbot M Willems G Motte P | 2007 | Plant Physiol2007，144，： | 1 |
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