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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 3 | A rough sets based charac- teristic relation approach for dynamic attribute generalization in data mining 显示文摘 | Li T R Ruan D Geert W | 2007 | Knowledge-based Systems2007，20，5： | 1 |
| 4 | A rough sets based characteristic relation approach for dynamic attribute generalization in data mining显示文摘 | LI T R RUAN D GEERT W | 2007 | Knowledge-Based Systems2007，20，5： | 1 |
| 5 | Brorninated flame retar- dants and polyehlorinated biphenyls in fish from the river显示文摘 | Laurence R Alin C D Geert G | 2008 | Environment International2008，34，： | 1 |
| 6 | A pilot study of computed tomography-detected asymptomatic pulmonary filling defects after hip and knee arthroplasties显示文摘 | Gandhi R Salonen D Geerts W H et a/ | 2012 | J Arthroplasty2012，27，： | 1 |
| 7 | Venous thromboembolism andits prevention in critical care 显示文摘 | Geerts W Cook D Selby R | 2011 | J Crit Care2011，17，1： | 1 |
| 8 | A Pilot study of computed tomography-detected asymptomatic pulmonary filling defects after hip and knee arthroplasties显示文摘 | Gandhi R Salonen D Geerts WH | 2012 | J Arthroplasty2012，27，： | 1 |
| 9 | A pilot study of com- puted tomography-detected asymptomatic pulmonary filling de- fects after hip and knee arthroplasties 显示文摘 | Gandhi R Salonen D Geerts WH | 2012 | J Arthroplasty2012，27，： | 1 |
| 10 | Methanol degradation in granular sludge reactors at sub-optimal metal concentrations: role of iron, nickel and cobalt 显示文摘 | Zandvoort M H Geerts R Lettinga G et d | 2003 | Enzyme Miero Technol2003，33，23： | 1 |
| 11 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 1 |
| 12 | The metagenome of the marine anammox bacterium ‘Candidatus Scalindua profunda’ illustrates the versatility of this globally important nitrogen cycle bacterium 显示文摘 | Van De Vossenberg J Woebken D Maalcke WJ Wessels HJ Dutilh BE Kartal B Janssen-Megens EM Roeselers G Yan J Speth D Gloerich J Geerts W Van Der Biezen E Pluk W Francoijs KJ Russ L Lam P Malfatti SA Tringe SG Haaijer SC Op Den Camp HJ Stunnenberg HG Amann R Kuypers MM Jetten MS | 2013 | Environ Microbiol2013，15，5： | 1 |
| 13 | A rough sets based characteristic relation approach for dynamic attribute generalization in data mining显示文摘 | Li T R Ruan D Geert W | 2007 | Knowledge-Based Systems2007，20，5： | 1 |
| 14 | Venous thromboembolism and its prevention in critical care 显示文摘 | Geerts W Cook D Selby R | 2002 | J Crit Care2002，17，2： | 1 |
| 15 | A comparison of lowdose heparin with low molecular weight heparin as prophylaxia against venous thromboembolism after major trauma显示文摘 | Geerts W Jay R Code D | 1996 | N Engl J Med1996，335，： | 1 |
| 16 | The metagenome of the marine anammox bacterium 'Candidatus Scalinduaprofunda' illustrates the versatility of this globally important nitrogen cycle bacterium 显示文摘 | van de Vossenberg J Woebken D Maalcke WJ Wessels HJ Dutilh BE Kartal B Janssen-Megens EM Roeselers K Yan J Speth D Gloericb J Geerts W van der Biezen E Pluk W Francoijs KJ Russ L Lain P Malfatti SA Tringe SG Haaijer SC Op den Camp HJ Stunnenberg HG Amann R Kuypers MM Jetten MS | 2012 | Environ Microbiol2012，15，5： | 1 |
| 17 | A rough sets based characteris- tic relation approach for dynamic attribute generalization in data mining 显示文摘 | Li T R Ruan D Geert W | 2007 | Knowledge-Based Systems2007，20，5： | 1 |
| 18 | Prevention of venous thrombo-embolism:American College of Chest Physicians Evi-dence-Based Clinical Practice Guidelines(8th edition)显示文摘 | Geerts W H Bergqvist D Pineo G F Heit J A SamamaC M Lassen M R | 2008 | Chest2008，，： | 1 |
| 19 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 1 |
| 20 | Hepatitis C virus envelope proteins: immunogenicity in humans and their role in diagnosis and vaccine development显示文摘 | Geert L R | 1995 | J Viral Hep1995，5，： | 1 |
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