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| 1 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 2 | Hierarchical construction of CNT networks in aramid papers for high-efficiency microwave absorption显示文摘Carbon nanotubes(CNTs)incorporated polymeric composites have been extensively investigated for microwave absorption at target frequencies to meet the requirement of radar cross-section reduction.In this work,a strategy of efficient utilization of CNT in producing CNT incorporated aramid papers is demonstrated.The layer-by-layer self-assembly technique is used to coat the surfaces of meta-aramid fibers and fibrils with CNT,providing novel raw materials available for the large-scale papermaking.The hierarchical construction of CNT networks resolves the dilemma of increasing CNT content and avoiding the agglomeration of CNT,which is a frequent challenge for CNT incorporated polymeric composites.The composite paper,which contains abundant heterogeneous interfaces and long-range conductive networks,is capable of reaching a high permittivity and dielectric loss tangent at a low CNT loading,its complex permittivity is,so far,adjustable in the range of(1.20−j0.05)to(25.17−j18.89)at 10 GHz.Some papers with optimal matching thicknesses achieve a high-efficiency microwave absorption with a reflection loss lower than−10 dB in the entire X-band. | You Wu Li Chen Yixuan Han Panbo Liu Haihong Xu Guanze Yu Yingying Wang Tao Wen Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，5： | 9 |
| 3 | A Survey of Bitmap Index Compression Algorithms for Big Data显示文摘With the growing popularity of Internet applications and the widespread use of mobile Internet, Internet traffic has maintained rapid growth over the past two decades. Internet Traffic Archival Systems(ITAS) for packets or flow records have become more and more widely used in network monitoring, network troubleshooting, and user behavior and experience analysis. Among the three key technologies in ITAS, we focus on bitmap index compression algorithm and give a detailed survey in this paper. The current state-of-the-art bitmap index encoding schemes include: BBC, WAH, PLWAH, EWAH, PWAH, CONCISE, COMPAX, VLC, DF-WAH, and VAL-WAH. Based on differences in segmentation, chunking, merge compress, and Near Identical(NI) features, we provide a thorough categorization of the state-of-the-art bitmap index compression algorithms. We also propose some new bitmap index encoding algorithms, such as SECOMPAX, ICX, MASC, and PLWAH+, and present the state diagrams for their encoding algorithms. We then evaluate their CPU and GPU implementations with a real Internet trace from CAIDA. Finally, we summarize and discuss the future direction of bitmap index compression algorithms. Beyond the application in network security and network forensic, bitmap index compression with faster bitwise-logical operations and reduced search space is widely used in analysis in genome data, geographical information system, graph databases, image retrieval, Internet of things, etc. It is expected that bitmap index compression will thrive and be prosperous again in Big Data era since 1980s. | Zhen Chen Yuhao Wen Junwei Cao Wenxun Zheng Jiahui Chang Yinjun Wu Ge Ma Mourad Hakmaoui Guodong Peng | 2015 | Tsinghua Science and Technology2015，20，1： | 5 |
| 4 | Insecurity of a Public Proof of Cloud Storage from Lattice Assumption显示文摘Cloud storage auditing is considered as a significant service to verify the integrity of the data stored in cloud. Liu et al. have proposed a proof of storage protocol with public auditing form lattice assumption, which can resist quantum computer attacks. They claim that the protocol enjoys desirable security properties, such as unforgeability and privacy preserving. We demonstrate that any malicious cloud service provider can cheat the third party auditor and the users, through generating the valid response proof which can pass the verification even if some other data blocks are lost by accident. And the primitive data blocks maybe recovered by any curious third party auditor through solving some linearly equations. Our work can help cryptographers and engineers design and implement more secure and efficient lattice-based public auditing scheme for the cloud storage data. | ZHANG Xiaojun XU Chunxiang ZHANG Yuan ZHANG Xiujie WEN Junwei | 2017 | Chinese Journal of Electronics2017，26，1： | 4 |
| 5 | Study on an automatic multi-pin insertion system for preparing Z-pin composite laminates显示文摘As a three-dimensional layer enhancement technology, the Z-pin technology is suitable for manufacturing composite prepreg laminates and can also effectively improve their interlaminar properties. In order to manufacture Z-pin composite parts efficiently, this paper proposes a transitional insertion system, and according to the technical requirements of the transitional insertion process and the functional requirements of the transitional insertion platform, proposes a transition insertion plan which can insert multiple Z-pins into a carrier. A prototype machine has been designed and made, and a series of function debugging and verification experiments have been carried out on the machine. Some problems show up during the experiments, but based on the analysis of the reasons, this paper provides lots of solutions, and finally demonstrates the feasibility and practical value of the system. The results show that the system meets all technical requirements of the Z-pin insertion process. It is capable to insert multiple Z-pins into a foam carrier; as a result, the system is as much as 5 times more efficient than existing equipment, and the deviation for the insertion distance can be controlled within 0.3 mm. This Z-pin transitional insertion platform promotes the use of Z-pins in national defense and lays the foundation for commercializing the Z-pin technology. | Song Qinghua Li Yong Qi Junwei Wen Liwei Xiao Jun Ni Jinhui | 2014 | Chinese Journal of Aeronautics2014，27，2： | 2 |
| 6 | A novel synthesis of micrometer silica hollow sphere显示文摘 | Pan Wen Ye Junwei Ning Guiling | 2009 | Materials Research Bulletin2009，44，2： | 1 |
| 7 | Enhanced luminescent properties of long-persistent Sr 2 MgSi 2 O 7 :Eu 2+ , Dy 3+ phosphor prepared by the co-precipitation method显示文摘 | Wen Pan Guiling Ning Xu Zhang Jing Wang Yuan Lin Junwei Ye | 2008 | Journal of Luminescence2008，，12： | 1 |
| 8 | Hybrid Recommendation Based on Graph Embedding显示文摘In recent years,online reservation systems of country hotel have become increasingly popular in rural areas.How to accurately recommend the houses of country hotel to the users is an urgent problem to be solved.Aiming at the problem of cold start and data sparseness in recommendation,a Hybrid Recommendation method based on Graph Embedding(HRGE)is proposed.First,three types of network are built,including user-user network based on user tag,househouse network based on house tag,and user-user network based on user behavior.Then,by using the method of graph embedding,three types of network are respectively embedded into low-dimensional vectors to obtain the characterization vectors of nodes.Finally,these characterization vectors are used to make a hybrid recommendation.The datasets in this paper are derived from the Country Hotel Reservation System in Guizhou Province.The experimental results show that,compared with traditional recommendation algorithms,the comprehensive evaluation index(F1)of the HRGE is improved by 20% and the Mean Average Precision(MAP)is increased by 11%. | Cheng Zeng Haifeng Zhang Junwei Ren Chaodong Wen Peng He | 2021 | China Communications2021，18，11： | 1 |
| 9 | Effects of pH on the hydrolysis of lignocellulosic wastes and volatile fatty acids accumulation: The contribution of biotic and abiotic factors 显示文摘 | Chen Yi Wen Yue Zhou Junwei | 2012 | Bioresource Technology2012，，110： | 1 |
| 10 | Polypyrrole-decorated Ag-TiO2 nanofibers exhibiting enhanced photocatalytic activity under visible-Light illumination显示文摘 | YANG Yucheng WEN Junwei WEI Jianhong | 2013 | ACS Applied Materials & Interfaces2013，5，13： | 1 |
| 11 | CeO_(2)quantum-dots engineering 3D carbon architectures toward dendrite-free Na anode and reversible Te cathode for high-performance Na-Te batteries显示文摘Sodium-tellurium(Na-Te)battery,thanks to high theoretical capacity and abundant sodium source,has been envisaged as one promising battery technology,its practical application yet faces daunting challenges regarding how to mitigate the critical issues of uncontrollable dendrites growth at Na anode and polytellurides shuttling effect at Te cathode.We here report an elaborative design for fabrication of microsphere skeleton nanohybrids with three-dimensional(3D)hierarchical porous carbon loading CeO_(2)quantum dots(CeO_(2)-QDs/HPC),which feature highly favorable properties of sodiophilic and catalysis for hosting sodium and tellurium,respectively.The systematic investigations coupling with first-principle calculations demonstrate the CeO_(2)-QDs/HPC not only offers favorable structure and abundant electrocatalytic sites for facilitating interconversion between Te and NaxTe as a cathode host,but also can function as dendrite inhibitor anode host for reversible sodium electro-plating/deposition.Such Na-Te battery exhibits admiring electrochemical performance with an impressive specific capacity of 392 mAh g1,a long cycling stability over 1000 cycles,as well as remarkably high energy density of 192 Wh kg1 based on the total mass of anode and cathode.Such proof-of-concept bifunctional host design for active electrode materials can render a new insight and direction to the development of high-performance Na-Te batteries. | Yangjie Liu Junwei Li Xiang Hu Jun Yuan Guobao Zhong Lu Zhang Junxiang Chen Hongbing Zhan Zhenhai Wen | 2022 | InfoMat2022，4，10： | 1 |
| 12 | Performance of Al?1Mg?1Zn?0.1Ga?0.1Sn as anode for Al-air battery显示文摘 | Jingling Ma Jiuba Wen Junwei Gao Quanan Li | 2014 | Electrochimica Acta2014，，： | 1 |
| 13 | A General Self-Sacrifice Template Strategy to 3D Heteroatom-Doped Macroporous Carbon for High-Performance Potassium-Ion Hybrid Capacitors显示文摘Potassium-ion hybrid capacitors(PIHCs)tactfully combining capacitor-type cathode with battery-type anode have recently attracted increasing attentions due to their advantages of decent energy density,high power density,and low cost;the mismatches of capacity and kinetics between capacitor-type cathode and battery-type anode in PIHCs yet hinder their overall performance output.Herein,based on prediction of density functional theory calculations,we find Se/N co-doped porous carbon is a promising candidate for K+storage and thus develop a simple and universal self-sacrifice template method to fabricate Se and N co-doped three-dimensional(3D)macroporous carbon(Se/N-3DMpC),which features favorable properties of connective hier-archical pores,expanded interlayer structure,and rich activity site for boosting pseudocapacitive activity and kinetics toward K^(+)storage anode and enhancing capacitance performance for the reversible anion adsorption/desorption cath-ode.As expected,the as-assembled PIHCs full cell with a working voltage as high as 4.0 V delivers a high energy density of 186 Wh kg^(−1) and a power output of 8100 W kg^(−1) as well as excellent long service life.The proof-of-concept PIHCs with excellent performance open a new avenue for the development and application of high-performance hybrid capacitors. | Junwei Li Xiang Hu Guobao Zhong Yangjie Liu Yaxin Ji Junxiang Chen Zhenhai Wen | 2021 | Nano-Micro Letters2021，13，9： | 1 |
| 14 | Electrochemically-induced highly reactive PdO^(*) interface on modulated mesoporous MOF-derived Co_(3)O_(4) support for selective ethanol electro-oxidation显示文摘Herein,Pd nanoparticles loaded Co_(3)O_(4)catalysts(Pd@Co_(3)O_(4))are constructed from zeolitic imidazolate framework-67(ZIF-67)for the ethanol oxidation reaction(EOR).It is demonstrated for the first time that the electrochemical conversion of Co_(3)O_(4)support would result in the charge distribution alignment at the Pd/Co_(3)O_(4)interface and induce the formation of highly reactive Pd-O species(PdO^(*)),which can further catalyze the consequent reactions of the intermediates of the ethanol oxidation.The catalyst,Pd@Co_(3)O_(4)-450,obtained under the optimized conditions exhibits excellent EOR performance with a high mass activity of 590 mA mg-1,prominent operational stability,and extraordinary capability for the electro-oxidation of acetaldehyde intermediates.Importantly,the detailed mechanism investigation reveals that Pd@Co_(3)O_(4)-450 could be benefit to the C-C bond cleavage to promote the desirable C1 pathway for the ethanol oxidation reaction.The present strategy based on the metal-support interaction of the catalyst might provide valuable inspiration for the design of high-performing catalysts for the ethanol oxidation reaction. | Yuling Chen Yali Wen Qun Zhou Lina Shen Fanghui Du Pai Peng Yu Chen Junwei Zheng | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 15 | Heterogeneous epidemic modelling within an enclosed space and corresponding Bayesian estimation显示文摘Since March 11th,2020,COVID-19 has been a global pandemic for more than one years due to a long and infectious incubation period.This paper establishes a heterogeneous epidemic model that divides the incubation period into infectious and non-infectious and employs the Bayesian framework to model the‘Diamond Princess’enclosed space incident.The heterogeneity includes two different identities,two transmission methods,two different-size rooms,and six transmission stages.This model is also applicable to similar mixed structures,including closed schools,hospitals,and communities.As the COVID-19 pandemic continues,our mathematical modeling can provide management insights to the governments and policymakers on how the COVID-19 disease has spread and what prevention strategies still need to be taken. | Conghua Wen Junwei Wei Zheng Feei Ma Mu He Shi Zhao Jiayu Ji Daihai He | 2022 | Infectious Disease Modelling2022，7，2： | 0 |
| 16 | Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish显示文摘Hematopoietic stem and progenitor cells(HSPCs)are able to self-renew and can give rise to all blood lineages throughout their lifetime,yet the mechanisms regulating HSPC development have yet to be discovered.In this study,we characterized a hematopoiesis defective zebrafish mutant line named smu07,which was obtained from our previous forward genetic screening,and found the HSPC expansion deficiency in the mutant.Positional cloning identified that slc20a1b,which encodes a sodium phosphate cotransporter,contributed to the smu07 blood phenotype.Further analysis demonstrated that mutation of slc20a1b affects HSPC expansion through cell cycle arrest at G2/M phases in a cell-autonomous manner.Our study shows that slc20a1b is a vital regulator for HSPC proliferation in zebrafish early hematopoiesis and provides valuable insights into HSPC development. | Jiakui Chen Gaofei Li Junwei Lian Ning Ma Zhibin Huang Jianchao Li Zilong Wen Wenqing Zhang Yiyue Zhang | 2021 | Science China(Life Sciences)2021，64，12： | 0 |
| 17 | New Early Triassic paleo-magnetic data from Huangben section,Guangdong and its tectonic implications显示文摘A paleomagnetic study was carried out on a total of 122 oriented cores from Daye Formation of the Huangben section, Guangdong Province. Rock magnetic investigations show that low-titanium magnetite is a dominant carrier. Detailed progressive thermal demagnetization isolated 2―3 components. The low temperature component clusters around the present geomagnetic field direction. An intermediate temperature component is isolated at 100―400℃ and is interpreted as a Yanshanian remagnetization. A high-temperature characteristic remanent mag- netization (ChRM) is obtained at 400―530℃ with D = 51.1°,I = 15.3°,α95 = 5.0° and passes generalized fold test and reversal test, suggesting high tempera- ture component is a primary remanence. Its corre- spondent pole position is 38.5°N, 212.7°E (dp = 2.6, dm = 5.1), which overlaps contemporaneous pole of Yangtze Block at 95% confidence level. Therefore, we believe that Huanan and Yangtze blocks were not separated in the Early Triassic. Compared to other published Early Triassic paleomagnetic data from Huanan Block, the inclinations are very close but the declinations are greatly variable. In stereo-projection, all the Early Triassic poles from Huanan Block lie along a small circle around the Huanan Block, im- plying that local micro-blocks rotations lead to the inconsistence of Early Triassic paleomagnetic direc- tions. | SHEN Zhongyue DING Jinghai YE Changhe WEN Junwei WANG Zhaoliang CHEN Zhifei | 2006 | Chinese Science Bulletin2006，51，15： | 0 |
| 18 | COMBAT:A New Bitmap Index Coding Algorithm for Big Data显示文摘Bitmap indexing has been widely used in various applications due to its speed in bitwise operations.However,it can consume large amounts of memory.To solve this problem,various bitmap coding algorithms have been proposed.In this paper,we present COMbining Binary And Ternary encoding(COMBAT),a new bitmap index coding algorithm.Typical algorithms derived from Word Aligned Hybrid(WAH)are COMPressed Adaptive inde X(COMPAX)and Compressed'n'Composable Integer Set(CONCISE),which can combine either two or three continuous words after WAH encoding.COMBAT combines both mechanisms and results in more compact bitmap indexes.Moreover,querying time of COMBAT can be faster than that of COMPAX and CONCISE,since bitmap indexes are smaller and it would take less time to load them into memory.To prove the advantages of COMBAT,we extend a theoretical analysis model proposed by our group,which is composed of the analysis of various possible bitmap indexes.Some experimental results based on real data are also provided,which show COMBAT’s storage and speed superiority.Our results demonstrate the advantages of COMBAT and codeword statistics are provided to solidify the proof. | Yinjun Wu Zhen Chen Yuhao Wen Wenxun Zheng Junwei Cao | 2016 | Tsinghua Science and Technology2016，21，2： | 0 |
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