|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 2 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 3 | The presence of phosphorylation form of D1 protein in its cross-linked aggregates in high light treated spinach leaves in vivo显示文摘In the present study, using specific antibody against D1 protein, we detected four ag- gregates of D1 protein in thylakoid membranes from spinach leaves illuminated at high light (800―2500 μmol photons·m?2·s?1) for 3 h. Their accumulations were dependent on the light intensity to which the leaves had been subjected. Further immunoblot analysis indicated that 70 kD aggregate was a prod- uct of D1 protein cross-linked with CP43, 65 and 60 kD aggregate were two cross-linked products be- tween D1 and D2 proteins, and 41 kD aggregate was one cross-linked D1 with α-subunit of cytochrome b559 (Cyt b559). This result provided the evidence for the existence of the aggregation of the D1 protein in vivo. The maximal level of D1/Cyt b559 aggregate occurred at 1000 μmol photons·m?2·s?1 but drastically decreased with further increasing light intensity. Im- munoblot analysis with phosphothreonine (Thr (P)) antibody indicated that D1/CP43 and D1/Cyt b559 aggregates contained the phosphorylated protein(s). In vitro dephosphorylation experiment also showed that D1/Cyt b559 and D1/CP43 aggregates lost the immunoreactivity with Thr (P) antibody after the phosphatase treatment of the membranes from high-light-illuminated leaves. Our results demon- strated that strong illumination of spinach leaves in- duced cross-linked products of D1 protein with its nearby polypeptides of PS Ⅱ , some of which con- tained the phosphorylated D1 protein. | WEI Huimin GUO Junwei ZHANG Shuang HUANG Bo LIU Yinqiu DU Linfang | 2006 | Chinese Science Bulletin2006，51，1： | 12 |
| 4 | Detection and identification of Vibrio parahaemolyticus by multiplex PCR and DNA-DNA hybridization on a microarray显示文摘In this paper,we developed a rapid and accurate method for the detection of Vibrio parahaemalyticus strains,using multiplex PCR and DNA—DNA hybridization.Multiplex PCR was used to simultaneously amplify three diagnostic genes(tlh,tdh and fla) that serve as molecular markers of V.parahaemolyticus.Biotinylated PCR products were hybridized to primers immobilized on a microarray,and detected by chemiluminesce with avidin—conjugated alkaline phosphatase.With this method,forty-five samples were tested.Eight known virulent strains (tlh^+/tdh^+/fla^+) and four known avirulent strains(tlh^+/tdh^-/fla^+) of the V.parahaemolyticus were successfully detected,and no non-specific hybridization and cross-hybridization reaction were found from fifteen closely-related strains(tlh^-/tdh^-/fla^+) of the Vibrio spp.In addition,all the other eighteen strains of non-Vibrio bacteria(tlh^-/tdh^-/fla^-) gave negative results.The DNA microarray successfully distinguished V. parahaemolyticus from other Vibrio spp.The results demonstrated that this was an efficient and robust method for identifying virulent strains of V.parahaemolyticus. | Rongzhi Wang Jiadong Huang Wei Zhang Guangmei Lin Junwei Lian Libin Jiang Hongcong Lin Songfa Wang Shihua Wang | 2011 | Journal of Genetics and Genomics2011，38，3： | 11 |
| 5 | Augmented reality registration algorithm based on nature feature recognition显示文摘This paper presents an improved key frame based augmented reality registration algorithm for real-time motion tracking in outdoor environment. In such applications, wide-baseline feature matching is a critical problem. In this paper, we apply randomized tree method to match key points extracted from the input image to those key frames as a classification problem. Extended Kalman filter is also utilized for jitter correction. A video see-through mobile augmented reality system is built for the on-site digital reconstruction of Yuanmingyuan Garden. Experimental results demonstrate that this algorithm is real-time, robust and effective for outdoor tracking. | CHEN Jing WANG YongTian GUO JunWei LIU Wei LIN JingDun XUE Kang LIU Yue DING GangYi | 2010 | Science China(Information Sciences)2010，53，8： | 11 |
| 6 | Recent developments in multimodality fluorescence imaging probes显示文摘Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging(OFI) probe integration with other imaging modalities such as X-ray computed tomography(CT), magnetic resonance imaging(MRI), positron emission tomography(PET), single-photon emission computed tomography(SPECT), and photoacoustic imaging(PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy. | Jianhong Zhao Junwei Chen Shengnan Ma Qianqian Liu Lixian Huang Xiani Chen Kaiyan Lou Wei Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 6 |
| 7 | Catalyzing polysulfide conversion by g-C3N4 in a graphene network for long-life lithium-sulfur batteries显示文摘 | Meng Wang Qinghua Liang Junwei Han Ying Tao Donghai Liu Chen Zhang Wei Lv Quan-Hong Yang | 2018 | Nano Research2018，11，6： | 4 |
| 8 | 1000 Wh L^(-1)lithium-ion batteries enabled by crosslink-shrunk tough carbon encapsulated silicon microparticle anodes显示文摘Microparticulate silicon(Si),normally shelled with carbons,features higher tap density and less interfacial side reactions compared to its nanosized counterpart,showing great potential to be applied as high-energy lithium-ion battery anodes.However,localized high stress generated during fabrication and particularly,under operating,could induce cracking of carbon shells and release pulverized nanoparticles,significantly deteriorating its electrochemical performance.Here we design a strong yet ductile carbon cage from an easily processing capillary shrinkage of graphene hydrogel followed by precise tailoring of inner voids.Such a structure,analog to the stable structure of plant cells,presents‘imperfection-tolerance’to volume variation of irregular Si microparticles,maintaining the electrode integrity over 1000 cycles with Coulombic efficiency over 99.5%.This design enables the use of a dense and thick(3 m Ah cm^(-2))microparticulate Si anode with an ultra-high volumetric energy density of 1048 Wh L^(-1)achieved at pouch full-cell level coupled with a Li Ni_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode. | Fanqi Chen Junwei Han Debin Kong Yifei Yuan Jing Xiao Shichao Wu Dai-Ming Tang Yaqian Deng Wei Lv Jun Lu Feiyu Kang Quan-Hong Yang | 2021 | National Science Review2021，8，9： | 4 |
| 9 | Hydrogen bonding in hydrogenated amorphous silicon thin films prepared at different precursor gas temperatures with undiluted silane显示文摘Hydrogen bonding configurations and hydrogen content in hydrogenated amorphous silicon (a-Si:H) thin films prepared at different precursor gas temperatures with undiluted silane have been investigated by means of Fourier transform infrared (FTIR) spectroscopy.The results show that the gas temperature before precursor gases entering the glow-discharge zone re-markably influences the hydrogen bonding configurations and the hydrogen content in a-Si:H thin films.The hydrogen content decreases from 18% down to 11% when increasing the gas temperature from room temperature (RT) to 433 K.Meanwhile,the clustered hydrogen at the physical film surface or at the internal surfaces of the microvoids decreases,indicating that a-Si:H thin films are densified at higher precursor gas temperatures.For a-Si:H thin films deposited at gas temperature of 433 K,the isolated silicon-hydrogen bonding configuration is predominant in the testing films. | WU MaoYang LI Wei QIU YiJiao FU JunWei JIANG YaDong | 2011 | Science China(Technological Sciences)2011，54，9： | 4 |
| 10 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 11 | PEPT1-mediated prodrug strategy for oral delivery of peramivir显示文摘Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. | Yongbing Sun Wei Gan Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 12 | QoS-Aware Virtual Machine Scheduling for Video Streaming Services in Multi-Cloud显示文摘Video streaming services are trending to be deployed on cloud. Cloud computing offers better stability and lower price than traditional IT facilities. Huge storage capacity is essential for video streaming service. More and more cloud providers appear so there are increasing cloud platforms to choose. A better choice is to use more than one data center, which is called multi-cloud. In this paper a closed-loop approach is proposed for optimizing Quality of Service (QoS) and cost. Modules of monitoring and controlling data centers are required as well as the application feedback such as video streaming services. An algorithm is proposed to help choose cloud providers and data centers in a multi-cloud environment as a video service manager. Performance with different video service workloads are evaluated. Compared with using only one cloud provider, dynamically deploying services in multi-cloud is better in aspects of both cost and QoS. If cloud service costs are different among data centers, the algorithm will help make choices to lower the cost and keep a high QoS. | Wei Chen Junwei Cao Yuxin Wan | 2013 | Tsinghua Science and Technology2013，18，3： | 3 |
| 13 | Mapping Human Pluripotent Stem Cell-derived Erythroid Differentiation by Single-cell Transcriptome Analysis显示文摘There is an imbalance between the supply and demand of functional red blood cells(RBCs)in clinical applications.This imbalance can be addressed by regenerating RBCs using several in vitro methods.Induced pluripotent stem cells(iPSCs)can handle the low supply of cord blood and the ethical issues in embryonic stem cell research,and provide a promising strategy to eliminate immune rejection.However,no complete single-cell level differentiation pathway exists for the iPSC-derived erythroid differentiation system.In this study,we used iPSC line BC1 to establish a RBC regeneration system.The 10X Genomics single-cell transcriptome platform was used to map the cell lineage and differentiation trajectory on day 14 of the regeneration system.We observed that iPSC differentiation was not synchronized during embryoid body(EB)culture.The cells(on day 14)mainly consisted of mesodermal and various blood cells,similar to the yolk sac hematopoiesis.We identified six cell classifications and characterized the regulatory transcription factor(TF)networks and cell-cell contacts underlying the system.iPSCs undergo two transformations during the differentiation trajectory,accompanied by the dynamic expression of cell adhesion molecules and estrogen-responsive genes.We identified erythroid cells at different stages,such as burst-forming unit erythroid(BFU-E)and orthochromatic erythroblast(ortho-E)cells,and found that the regulation of TFs(e.g.,TFDP1 and FOXO3)is erythroid-stage specific.Immune erythroid cells were identified in our system.This study provides systematic theoretical guidance for optimizing the iPSC-derived erythroid differentiation system,and this system is a useful model for simulating in vivo hematopoietic development and differentiation. | Zijuan Xin Wei Zhang Shangjin Gong Junwei Zhu Yanming Li Zhaojun Zhang Xiangdong Fang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 2 |
| 14 | Changes and postharvest regulation of activity and gene expression of enzymes related to cell wall degradation in ripening apple fruit显示文摘 | Jianmei Wei Fengwang Ma Shouguo Shi Xiudong Qi Xiangqiu Zhu Junwei Yuan | 2009 | Postharvest Biology and Technology2009，，2： | 2 |
| 15 | A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions显示文摘Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions(Ag^(+), Hg^(2+), Cu^(2+)). The probe shows divergent fluorescence(FL)/circular dichroism(CD) responses via divergent bond-cleavage cascade reactions(metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+(no hydrolysis), FL “turn-on” and CD “turn-off” for Hg^(+)(imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu^(2+)(lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments. | Junwei Chen Na Wang Hongjuan Tong Chao Song Huijuan Ma Yajun Zhang Feng Gao Huan Xu Wei Wang Kaiyan Lou | 2021 | Chinese Chemical Letters2021，32，12： | 2 |
| 16 | Effects of Olanzapine–Fluoxetine Combination Treatment of Major Depressive Disorders on the Quality of Life During Acute Treatment Period显示文摘 | Wei Qu Shanshan Gu Han Luo Qianying Tang Junwei Guo | 2014 | Cell Biochemistry and Biophysics2014，，3： | 1 |
| 17 | RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C.elegans显示文摘The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab proteins and their effectors in DCV exocytosis.RAB-27/AEX-6,but not RAB-3,was found to be required for peptide release from neurons.By analyzing the movement of DCVs approaching the plasma membrane using total internal reflection fluorescence microscopy,we demonstrated that RAB-27/AEX-6 is involved in the tethering of DCVs and that its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking. | FENG Wan Juan LIANG Tao YU JunWei ZHOU Wei ZHANG YongDeng WU ZhengXing XU Tao | 2012 | Science China(Life Sciences)2012，55，3： | 1 |
| 18 | Resampling Factor Estimation via Dual-Stream Convolutional Neural Network显示文摘The estimation of image resampling factors is an important problem in image forensics.Among all the resampling factor estimation methods,spectrumbased methods are one of the most widely used methods and have attracted a lot of research interest.However,because of inherent ambiguity,spectrum-based methods fail to discriminate upscale and downscale operations without any prior information.In general,the application of resampling leaves detectable traces in both spatial domain and frequency domain of a resampled image.Firstly,the resampling process will introduce correlations between neighboring pixels.In this case,a set of periodic pixels that are correlated to their neighbors can be found in a resampled image.Secondly,the resampled image has distinct and strong peaks on spectrum while the spectrum of original image has no clear peaks.Hence,in this paper,we propose a dual-stream convolutional neural network for image resampling factors estimation.One of the two streams is gray stream whose purpose is to extract resampling traces features directly from the rescaled images.The other is frequency stream that discovers the differences of spectrum between rescaled and original images.The features from two streams are then fused to construct a feature representation including the resampling traces left in spatial and frequency domain,which is later fed into softmax layer for resampling factor estimation.Experimental results show that the proposed method is effective on resampling factor estimation and outperforms some CNN-based methods. | Shangjun Luo Junwei Luo Wei Lu Yanmei Fang Jinhua Zeng Shaopei Shi Yue Zhang | 2021 | Computers, Materials & Continua2021，，1： | 1 |
| 19 | Targeting IL-22 and IL-22R protects against experimental osteoarthritis显示文摘Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA pathogenesis.Previous studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate. | Changhua Yi Yongxiang Yi Jie Wei Qingwen Jin Junwei Li Pradeep Kumar Sacitharan | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 20 | A novel catalyst for the selective hydrogenation of furfural to furfuryl alcohol显示文摘 | Xiangying Hao Wei Zhou Junwei Wang | 2005 | Chemistry letters2005，34，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员