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| 1 | Electro-thermal analysis of induction motor with compound cage rotor used for PHEV显示文摘 | Weili L Junci C Xiaochen Z | 2010 | IEEE Transaction on Industrial Electronics2010，57，2： | 1 |
| 2 | A prelimina- ry report of penile transplantation显示文摘 | WEILIE H JUN L LICHAO Z | 2006 | Eur Urol2006，50，： | 1 |
| 3 | Effects of basic fibroblast growth factor on beta-catenin protein and mRNA expression during the proliferation of endogenous neural stem cells following focal cerebral ischemia显示文摘BACKGROUND:The Wnt/β-catenin signaling pathway plays an important role in neural development.β-catenin is an important component of the Wnt/β-catenin signaling pathway.The Wnt signaling pathway has been shown to regulate the interaction of neural stem cells with the extracellular matrix. OBJECTIVE:To investigate the effects of basic fibroblast growth factor(bFGF) onβ-catenin protein and mRNA expression,and on hippocampal neural stem cell proliferation in a rat model of cerebral ischemia/reperfusion. DESIGN,TIME AND SETTING:A randomized,controlled,neurobiology experiment was performed in Shenyang Medical College between August 2006 and August 2008. MATERIALS:A total of 72 healthy male Wistar rats,aged 3 months,were used in this study. bFGF was provided by Beijing SL Pharmaceutical Co.,Ltd.,China. METHODS:Rats were randomly divided into 3 groups:sham-operated,ischemia/reperfusion,and bFGF-treated(n=24 per group).Focal cerebral ischemia/reperfusion was induced in rats from the ischemia/reperfusion group and the bFGF-treated group by 2 hour right middle cerebral artery occlusion and 2 hour restoration of blood flow using the suture method.The ischemia/reperfusion and bFGF-treated groups were intraperitoneally administered 500 IU/mL of bFGF,or the same volume of physiological saline,once a day at postoperative days 1-3,and once every 3 days thereafter.Simultaneously,the sham-operated group underwent experimental procedures identical to the ischemia/reperfusion and bFGF-treated groups,with the exception of ischemia/reperfusion induction and drug administration.At 2 hours,2,6,13,and 20 days after ischemia/reperfusion induction,50 mg/kg bromodeoxyuridine(BrdU) was administered to each group,twice daily,to label proliferating neural stem cells. MAIN OUTCOME MEASURES:The effects of bFGF on BrdU labeling,andβ-catenin mRNA and protein expression,in neural stem cells were examined by immunohistochemistry,Western blot, RT-PCR,and in situ hybridization techniques. RESULTS:In the sham-operated group,only a few BrdU-immunoreactive neural stem cells were found.In the ischemia/reperfusion group,BrdU-immunoreactive cells began to increase from 3 days after ischemia/reperfusion induction,reached a peak level at 7 days,and gradually reduced from 21 days.At 3,7,14,and 21 days after ischemia/reperfusion induction,the numbers of BrdU-immunoreactive cells were significantly greater in the bFGF-treated group than in the ischemia/reperfusion group.The sham-operated group exhibited slight expression ofβ-catenin andβ-catenin mRNA.In the ischemia/reperfusion group,the expression ofβ-catenin andβ-catenin mRNA gradually increased with reperfusion time,peaked at 14 days after reperfusion, and gradually decreased thereafter;by 21 days,the expression was markedly lower.Following bFGF injection,the expression of hippocampal BrdU,β-catenin,andβ-catenin mRNA had apparently increased in each group. CONCLUSION:bFGF promotes neural stem cell proliferation,and the expression ofβ-catenin andβ-catenin mRNA in the ischemic brain tissue.These findings indicate that bFGF promotion of neural stem cell proliferation may be mediated by Wnt/β-catenin signaling pathway. | Xuesong Xing Weili Lü Liguang Sun | 2009 | Neural Regeneration Research2009，4，2： | 1 |
| 4 | A planar resonator antenna based on a woodpile EBG material显示文摘 | Horvath L Esselle K P | 2005 | IEEE Antennas and Propagation2005，53，： | 1 |
| 5 | A composite microporous gel polymer electrolyte prepared by ultra-violet cross-linking显示文摘 | WEILI L LIXING X DAN L | 2007 | European Polymer Journal2007，43，2： | 1 |
| 6 | A Planar Resonator Antenna Based on a Woodpile EBG Material显示文摘 | Weily A R Horvath L Esselle K P | 2005 | IEEE Trans On Antenna and Propagation2005，53，1： | 1 |
| 7 | Improving nutrient manage- ment for sustainable development of agriculture in China 显示文摘 | Jiyun J Bao L Weili Z | 1999 | Nutrient Disequilibria in Agroecosystems:concepts and case studies1999，，： | 1 |
| 8 | Biological significance of a small highly conserved region in the N terminus of the p53 tumor suppressor protein显示文摘 | Weili L Carol M Charles S | 2001 | J Mol Biol2001，313，4： | 1 |
| 9 | A prospective,randomized study comparing the percutaneous compression plate and the compression hip screw for the treatment of intertrochanteric fractures of the hip显示文摘 | Pevser A WeilY A Brocke L | 2007 | J Bone Joint Surg Br2007，89，9： | 1 |
| 10 | A planar resonator antenna based on a woodpile EBG material显示文摘 | WEILY AR HORVATH L ESSELLE KP | 2005 | IEEE Trans Antennas Propag2005，53，1： | 1 |
| 11 | A planar re- sonator antenna based on a woodpile EBG material 显示文摘 | Weily A R Horvath L Esselle K P | 2005 | IEEE Transactions on Antennas and Propagation2005，53，1： | 1 |
| 12 | Efficacy and safety of modified sequential three-step empirical therapy for chronic cough显示文摘 | Weili W Yu L Wang Y | 2010 | Respirology2010，15，5： | 1 |
| 13 | Dendrite growth characteristics within liquid Fe-Sb alloy显示文摘Bulk samples and small droplets of liquid Fe-10%Sb alloys are undercooled up to 429 K (0.24TL) and 568 K (0.32TL), respectively, with glass fluxing and free fall techniques. The high undercooling does not change the phase constitution, and only the αFe solid solution is found in the rapidly solidified alloy. The experimental results show that when the undercooling is below 296 K, the growth velocity of αFe dendrite rises exponentially with the increase of undercooling and reaches a maximum value 1.38 m/s. Subsequently, the growth velocity begins to decrease if undercooling further increases. The αFe phase grows into coarse dendrites under small undercooling conditions, whereas it becomes vermicular dendrites in highly undercooled melts. The solute trapping is closely related to the dendrite growth velocity and cooling rate rather than undercooling. Although the solute trapping can be remarkably suppressed by the rapid dendrite growth, the segregationless solidification is not observed in the present experiments due to the large solidification temperature range. | WANG WeiLi LüYongJun QIN HaiYan WEI BingBo | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 0 |
| 14 | Wnt pathway in the formation of ischemic brain injury Interventional pathway of basic fibroblast growth factor显示文摘BACKGROUND: Basic fibroblast growth factor (bFGF) can reduce neuronal apoptosis following ischemia/reperfusion (I/R) injury. Mechanism of the phenomenon should be elucidated. OBJECTIVE: The goal of this study was to observe the effect of bFGF on the expressions of Dickkopf-1(DKK-1) and β-catenin in the Wnt pathway in hippocampal tissue of rats following brain I/R injury, in order to investigate the role of Wnt pathway in the formation of ischemic brain injury. DESIGN: Randomized controlled experiment. SETTING: Shenyang Medical College. MATERIALS: Thirty healthy 3 months old male Wistar rats, weighing 300–350 g, were provided by the Experimental Animal Center of Shenyang Medical College. Thirty rats were randomized into sham-operation group, model group and treatment group. Goat anti-rat monoclonal antibody β-catenin was purchased from SANTA CRUZ Company. BFGF was developed by Beijing SL Pharmaceutical Co., Ltd. METHODS: This experiment was carried out in the Shenyang Medical College between November 2005 and May 2006. ①Focal brain I/R by suture-occluded method was modeled in rats in the treatment group and model group. Their middle cerebral artery was occluded 1 hour and reperfused for 24 hours. While in the sham-operation group, only the right common carotid artery and external carotid artery of rats were occluded for 90 minutes. ② The rats in the treatment group were intraperitoneally injected with 10 μg/kg bFGF, and those in the other groups were intraperitoneally injected with the same amount of saline. MAIN OUTCOME MEASURES: Following I/R 48 hours, the expressions of β-catenin and Dickkopf-1 mRNA in the neurons of hippocampal CA1 region by immunohistochemical SABC and RT-PCR. RESULTS: Following I/R 48 hours, the expressions of β-catenin and Dickkopf-1 mRNA in the neurons of hippocampal CA1 region was evaluated by means of immunohistochemical SABC and RT-PCR. ① Expression of DKK-1 mRNA in the sham-operation group was at low level, it was significantly higher in the model group compared to the sham-operation group; Expression of DKK-1 mRNA in the treatment group was significantly lower than that in the model group. ② Expression of β-catenin in the cerebral cortex and hippocampal cytoplasm of rats: The mean gray scale of β-catenin of model group was significantly lower than that of sham-operation group (74.27±2.65 vs. 111.36±5.39,P < 0.05); The mean gray scale of β-catenin of treatment group was significantly higher than that of model group (86.18±7.41 vs. 74.27± 2.65, P < 0.05). CONCLUSION: bFGF may influence Wnt pathway by participating in the regulation of DKK-1 mRNA and β-catenin expressions, and thereby protect neurons. | Xuesong Xing Weili Lü Li GUO | 2007 | Neural Regeneration Research2007，2，7： | 0 |
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