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| 1 | Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study显示文摘Background: The prognostic role of the V600 E mutation of v-raf murine sarcoma viral oncogene homolog B1(BRAF)in metastatic colorectal cancer(mCRC) is well established, but the therapeutic regimen targeting this disease is lacking. This study aimed to analyze the clinicopathologic features of and treatment efficacy of commonly used regimens on BRAF-mutated mCRCs.Methods: We collected and reviewed the medical records of mCRC patients treated at Peking University Cancer Hospital & Institute(Beijing, China) between July 2011 and July 2016. Kirsten rat sarcoma viral oncogene homolog(KRAS),neuroblastoma RAS viral oncogene homolog(NRAS), and BRAF mutational status was assayed using direct sequencing. The details of clinicopathologic characteristics of patients and their responses to FOLFOXIRI regimen or standard therapy were obtained by reviewing the medical records. The progression-free survival(PFS) and overall survival(OS)were assessed using Kaplan-Meier analysis and compared using the log-rank test.Results: Of 1694 patients studied, 75 had BRAF exon 15 mutations. Of these 75 patients, 71 had V600 E mutation, 1 had D594 G mutation, 2 had K601 E mutation, and 1 had a novel T599_V600 insAGA alteration. No patients had KRAS or NRAS mutations. Of 63 patients with BRAFV600 E-mutated mCRC and sufficient clinical data, 27(42.9%) had right-sided colon tumors, 19(30.2%) had left-sided colon tumors, and 17(26.9%) had rectal tumors; 26(41.3%) had peritoneal metastases, and 50(79.4%) had distant lymph node metastases.The patients with BRAF K601 E-and T599_V600 insAGA-mutated tumors had similar clinicopathologic features to those with BRAFV600 E-mutated tumors. Patients with the BRAFV600 E mutation benefited more from FOLFOXIRI regimen compared with patients who underwent standard therapy(overall response rate 83.3% vs. 14.0%; median PFS 6.4 months vs. 2.8 months, P = 0.220; median OS11.0 months vs. 6.9 months, P = 0.048).Conclusions: BRAFV600 E mutations were commonly identified in right-sided tumors and showed a high incidence of peritoneal and distant lymph nodes metastases.This subtype of mCRC was characterized by short OS and unique patterns of metastasis. Compared with standard treatment regimens, the FOLFOXIRI regimen had acceptable and manageable toxicities and favorable efficacy on patients with BRAF-mutated mCRC. | Xicheng Wang Qing Wei Jing Gao Jian Li Jie Li Jifang Gong Yanyan Li Lin Shen | 2017 | Chinese Journal of Cancer2017，36，11： | 6 |
| 2 | Bake hardening behavior of TRIP and DP steels显示文摘The bake hardening (BH) behavior of transformation-induced plasticity (TRIP) and dual-phase (DP) steels after different prestrains was studied. The experimental results indicate that TRIP steel exhibits good BH ability while DP steel does not, and pre-strain displays a strong effect on the BH values of both steels. The comparison of microstructures of the two steels showed that the hard second phase in the matrix might be harmful to the BH ability. For deformed specimens, baking resulted in a loss of uniform elongation, but there was no obvious decrease in uniform elongation for unprestrained specimens. | Jicheng Zhang Renyu Fu Mei Zhang Rendong Liu Xicheng Wei Lin Li | 2008 | Journal of University of Science and Technology Beijing2008，15，2： | 4 |
| 3 | Multi-scale finite element simulation on large deformation behavior of wood under axial and transverse compression conditions显示文摘Multi-scale finite element method is adopted to simulate wood compression behavior under axial and transverse loading. Representative volume elements (RVE) of wood microfibril and cell are proposed to analyze orthotropic mechanical behavior. Lignin, hemicellulose and crystalline-amorphous cellulose core of spruce are concerned in spruce nanoscale model. The equivalent elastic modulus and yield strength of the microfibril are gained by the RVE simulation. The anisotropism of the crystalline-amorphous cellulose core brings the microfibril buckling deformation during compression loading. The failure mechanism of the cell-wall under axial compression is related to the distribution of amorphous cellulose and crystalline cellulose. According to the spruce cell observation by scanning electron microscope, numerical model of spruce cell is established using simplified circular hole and regular hexagon arrangement respectively. Axial and transverse compression loadings are taken into account in the numerical simulations. It indicates that the compression stress-strain curves of the numerical simulation are consistent with the experimental results. The wood microstructure arrangement has an important effect on the stress plateau during compression process. Cell-wall buckling in axial compression induces the stress value drops rapidly. The wide stress plateau duration means wood is with large energy dissipation under a low stress level. The numerical results show that loading velocity affects greatly wood microstructure failure modes in axial loading. For low velocity axial compression, shear sliding is the main failure mode. For high velocity axial compression, wood occur fold and collapse. In transverse compression, wood deformation is gradual and uniform, which brings stable stress plateau. | Weizhou Zhong Zexiong Zhang Xiaowei Chen Qiang Wei Gang Chen Xicheng Huang | 2021 | Acta Mechanica Sinica2021，37，7： | 2 |
| 4 | The corpuscular method application in OOP child constraint system research and simulation显示文摘 | ZHAO Zhonghua ZHANG Meng WEI Xicheng | 2013 | Advanced Materials Research2013，664，： | 1 |
| 5 | Tensile deformation behavior of cold-rolled TRIP-aided steels over largerange of strain rates显示文摘 | Xicheng Wei Renyu Fu Lin Li | 2007 | Materials Science and Engineering2007，465，1215： | 1 |
| 6 | Friction and wear behavior of SUS 304 austenitic stainless steel against Al2O3 ceramic ball under relative high load显示文摘 | Meng Hua Xicheng Wei Jian Li | 2008 | Wear2008，265，： | 1 |
| 7 | Friction and wear behavior of SUS 304 austenitic stainless steel against Al2O3 ceramic ball under relative high load 显示文摘 | Meng Hua Xicheng Wei Jian Li | 2008 | Wear2008，265，： | 1 |
| 8 | Study of preparation and tribological properties of rare earth nanoparticles in lubricating oil 显示文摘 | Liu Rende Wei Xicheng Tao Dehua | 2010 | Tribology International2010，43，： | 1 |
| 9 | QoS-awared replica placement techniques in data grid applications显示文摘Quality of service is one of the most important factors for successful grid applications. However, individual QoS constraint (IQC) and QoS-awared replica placement have not yet been well addressed in the existing data grid. Existing QoS-awared replica placement algorithms neither can support multiple QoS attributes, nor have good scalability. In this paper, a three-phrase QoS-awared replica placement algorithm based on matrix, namely TP-GABMAC, is presented to solve these problems. Furthermore, a replica ring mechanism is introduced to maintain replica consistency and manage update conflicting. Experiments and analysis demonstrate that the proposed algorithms are not only stable and scalable, but also work well under different network topologies, access patterns and workloads. | XIAO Nong, FU Wei & LU XiCheng School of Computer, National University of Defense Technology, Changsha 410073, China | 2010 | Science China(Information Sciences)2010，53，8： | 1 |
| 10 | Tensile deformation behavior of cold-rolled TRIP-aided steels over large range of strain rates显示文摘 | Xicheng Wei Renyu Fu Lin Li | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 11 | Peroneal Tenography to Evaluate Lateral Hiedfoot Pain After Calcaneal Fracture显示文摘 | Wei Chen Xicheng Li Yanling Su | 2011 | Faot and ankle imernational2011，32，8： | 1 |
| 12 | Friction and wear behavior of SUS 304 austenitic stainless steel against Al2O3 ceramic ball under relative high load显示文摘 | Meng Hua Xicheng Wei Jian Li | 2008 | Wear2008，265，： | 1 |
| 13 | Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial显示文摘We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March 2016.They were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or placebo.Their clinical and immunological parameters were monitored during the 96-week follow-up study.We found that hUC-MSC treatment was safe and well-tolerated.Compared with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control group.Kaplan-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three groups.In summary,hUC-MSC treatment is safe.However,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study. | Lifeng Wang Zheng Zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang Mi Zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou Ming Shi Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 14 | Effect of heating temperature on the microstructure evolution of a Zn-Al-Mg coating on press-hardened steel显示文摘This paper addresses the microstructure evolution in the Zn-1.2Al-1.2Mg coating of press-hardened steel during heat treatment at temperatures ranging from 600 ℃ to 900 ℃.The presence of aluminum in the coating leads to substantial variation in the chemical composition and microstructure within the heat-treated layer.As the heat treatment temperature increases, the original Fe_(2)Al_(5) barrier layer between the coating layer and steel substrate is progressively dissolved and replaced by the aggregates of a new(FeAl) phase.At higher heat treatment temperatures, the(FeAl) phase gradually migrates to the subsurface layer of the coating.Meanwhile, Zn/Fe interdiffusion induces Γ-Fe_(3)Zn_(10)-phase formation in the original coating layer and α-Fe(Zn) solid solution formation at the zinc-substrate interface.These microstructure features suppress the high-temperature oxidation and evaporation of Zn. | BI Wenzhen JIN Xinyan WEI Xicheng | 2023 | Baosteel Technical Research2023，17，1： | 0 |
| 15 | Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer显示文摘Objective:Immune checkpoint inhibitors(ICIs)have achieved remarkable results in cancer treatments.However,there is no effective predictive biomarker for gastrointestinal(GI)cancer.Methods:We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort(MSK-GI,n=227),the Janjigian cohort(n=40),and the Peking University Cancer Hospital&Institute cohort(PUCH,n=80)to determine the possible associations between DNA damage response and repair(DDR)gene mutations and clinical outcomes.Data from The Cancer Genome Atlas database were analyzed to determine the possible correlations between DDR gene mutations and the tumor microenvironment.Results:In the MSK cohort,the presence of≥2 DDR gene mutations was correlated with prolonged overall survival(OS).The Janjigian and PUCH cohorts further confirmed that subgroups with≥2 DDR gene mutations displayed a prolonged OS and a higher durable clinical benefit.Furthermore,the DDR gene mutation load could be considered as an independent prognostic factor,and exhibited a potential predictive value for survival in GI cancer patients treated with ICIs.Mechanistically,we showed that the presence of≥2 DDR gene mutations was correlated with higher levels of tumor mutation burden,neoantigen,and T cell infiltration.Conclusions:The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs,which could serve as a potential biomarker to guide patient selection for immunotherapy. | Yujiao Wang Xi Jiao Shuang Li Huan Chen Xin Wei Chang Liu Jifang Gong Xiaotian Zhang Xicheng Wang Zhi Peng Changsong Qi Zhenghang Wang Yanni Wang Na Zhuo Jianling Zou Henghui Zhang Jian Li Lin Shen Zhihao Lu | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 16 | An engineering approach to improve the accuracy of one-step simulation for vehicle forming-to-crashworthiness integrated evaluation显示文摘To improve the accuracy of the vehicle crashworthiness simulation,it is necessary as well as important to integrate the valid forming effects of key parts.It has been agreed by many that one-step simulation results should be used only as a qualitative trend of the part but not as an engineering result for further structural analysis,especially for a relatively complex part.The study shows that it is inaccurate to analyze the forming effects with one-step simulation based on the geometry of the final part through comparison with the incremental simulation and verification with the actual part,whether in thickness or in plastic strain.However,incremental simulation is very time consuming and infeasible in the early stage of vehicle design due to lacking of forming tools and process parameters.An engineering approach is proposed to meet the requirement of accuracy as well as the time efficiency,where one-step simulation is conducted based on the geometry of the transformed part instead of the final part.The geometry of the transformed part is generated by simple die design engineering and proves to offer much more accuracy than the one-step simulation based on the final part geometry. | WANG WuRong GUO BiMeng WEI XiCheng WANG DaZhi DU HanBin | 2012 | Science China(Technological Sciences)2012，55，6： | 0 |
| 17 | Induction and Repair of DNA Double-strand Breaks in Human Hepatoma Cells显示文摘InductionandRepairofDNADouble-strandBreaksinHumanHepatomaCells￥ZhouGuangming;HeJing;LiWenjian;XieHongmei;ChenWeiqiang;LiQiang... | Zhou Guangming He Jing Li Wenjian Xie Hongmei Chen Weiqiang Li Qiang Dang Bingrong Han Guangwu Zhang Shumin Huang Tao Cai Xicheng Wei Zengquan and Gao Qingxiang(Lanzhou University) | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
| 18 | Internal Friction on the Bake-Hardening Behavior of 0.11C-1.67Mn-1.19Si TRIP Steel显示文摘The bake-hardening (BH) values and the 'internal friction-temperature' spectrums were studied for the baked 0.11C-1.67Mn-1.19Si TRIP (transformation induced plasticity) specimens with 0%, 2% and 6% prestrain. Results show that the experimental TRIP steel deserves good bake-hardening ability and Cottrell atmosphere is the reason for its bake hardening characteristic. It is also concluded that both the number and the saturation degree of Cottrell atmosphere might affect the BH value of TRIP steel. | Renyu Fu Yu Su Ping Ye Xicheng Wei Lin Li Jicheng Zhang | 2009 | Journal of Materials Science & Technology2009，25，1： | 0 |
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