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| 1 | The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice显示文摘动脉粥样硬化(作为) 疾病被多重因素导致,包括基因、环境的元素。现在的学习的目的是在致病上调查高胆固醇,高蛋氨酸食谱,和 apolipoprotein E 缺乏(ApoE/) 的全面效果作为。ApoE/ 老鼠用高胆固醇和蛋氨酸饮食被喂 15 个星期导致 hyperlipidemia 和 hyperhomocysteinemia。genomic DNA (gDNA ) 和 B1 的 methylation 层次在大动脉的纸巾的重复元素被两 methylation 依赖的限制分析测量并且嵌套 methylation 特定的聚合酶链反应(PCR ) 。Methylation 顺序偏爱模式是由有限制 endonuclease 消化的 DNA 接受甲基的能力的 assayed。DNA methyltransferase-1 的 mRNA 表示, 3 (DNMT1, 3 ) 被即时 PCR 检测。S-adenosylmethionine (SAM ) 和 S-adenosylhomocysteine (SAH ) 的集中被高效的液体层析决定。结果显示出 gDNA 和 B1 的 hypomethylation 重复元素。DNMT1 的 mRNA 表示被减少。SAM, SAH,和 SAM/SAH 比率的层次被增加。动脉粥样硬化患者损害区域强烈与风险因素相关。DNA demethylation 的分发被喜欢而不是 non-CpG 岛,它可以在 DNA 正直和 genomic 不稳定性上建议 hypomethylation 的主要影响。总的来说,我们的数据不含糊地证明高胆固醇,高蛋氨酸食谱,和 ApoE/ 的全面角色不与一个单个风险因素的角色一致地一致。DNA methylation 模式在这是相当复杂的并且取决于基因背景和许多深奥风险因素。 | Yideng Jiang Huiping Zhang Tao Sun Ju Wang Weiwei Sun Huihui Gong Binbin Yang Yingkang Shi Jun Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 16 |
| 2 | Analysis of ecological quality in Lhasa Metropolitan Area during 1990-2017 based on remote sensing and Google Earth Engine platform显示文摘Based on a total of 519 images,the composite images with the lowest possible cloud cover were generated at pixel level with image synthesis method on Google Earth Engine(GEE)platform.The Remote Sensing Ecological Index(RSEI)was adopted,and calculated in an efficient way with the assistance of parallel cloud computing of the GEE platform.The RSEI was used in this paper to evaluate and monitor the eco-environmental quality of the Lhasa Metropolitan Area.Results show that:(1)The ecological quality is better in the west than in the east of Lhasa Metropolitan Area,with Lhasa as an approximate dividing point.The ecological quality improved and then deteriorated dramatically before 2000,with the mean RSEI value dropping from 0.51 to 0.46;the trend was followed by a gradual increase up until 2017,with the mean RSEI value increased from 0.46 to 0.55.(2)The RSEI is weakly and positively correlated with socioeconomic indicators.This indicates that the population growth and economic development did not negatively influence the ecological quality,but actually boosted it.(3)The GEE can serve as an efficient computing platform for the assessment and monitoring of eco-environmental quality in vast regions. | HUANG Huiping CHEN Wei ZHANG Yuan QIAO Lin DU Yunyan | 2021 | Journal of Geographical Sciences2021，31，2： | 9 |
| 3 | Human infection with a further evolved avian H9N2 influenza A virus in Sichuan, China显示文摘Dear Editor,Avian influenza A (H9N2) virus plays a crucial role in interspecies transmission between animals and humans due to its wide host range, adaptation in mammals and the diversified gene reassortments. Since 1990s, two lineages of H9N2 virus, A/Duck/HK/Y280/97 (Y280-like)and A/Quail/HK/G1/97 (G1) have established in domestic poultry in China and are now widespread in the | Jianan Xu Shuang Li Yong Yang Bing Liu Huiping Yang Tiansu Li Lin Zhang Wei Li Xiaohu Luo Liquan Zhang Ming Pan | 2018 | Science China(Life Sciences)2018，61，5： | 7 |
| 4 | Improvement of Ductility of Powder Metallurgy Titanium Alloys by Addition of Rare Earth Element显示文摘Ti-4.5AI-6.0Mo-1.5Fe, Ti-6AI-1Mo-1Fe 和 Ti-6AI-4V 合金被混合元素的粉末冶金学(下午) 准备微观结构和机械性质上的 Nd 的过程,和效果被扫描电子显微镜学(SEM ) 调查,传播电子显微镜学(TEM ) 和 X 光检查衍射(XRD ) 。因为液相的小数量发生在 sintering 期间, Nd 的增加由 1% 的最大的增长稍微增加了 sintered 钛合金的密度,这被发现。Nd 的增加在张力的力量的改进上显示出小效果,当延伸显著地被改进时。例如,没有 13percent 的 Nd 的增加, Ti-4.5AI-6.0Mo-1.5Fe 的延伸能在 1.2 wt % 的一个 Nd 内容从 1% 被增加。 | Yong LIU Lifang CHEN Weifeng WEI Huiping TANG Bin LIU Baiyun HUANG | 2006 | Journal of Materials Science & Technology2006，22，4： | 7 |
| 5 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 6 | Study on Zn_2SiO_4 Formation Kinetics and Activity Stability of Desulfurization Sorbent显示文摘A new industrial S Zorb sorbent(Ni/Zn O-P) was prepared by using the spray drying technique. The other two traditional sorbents(Ni/Zn O-M and Ni/Zn O-H) were prepared in exactly the same way except the use of different silica-alumina binder matrices. The XRD, Rietveld quantitative phase analysis, BET, and laser particle size analysis were employed to characterize their physico-chemical properties. The deactivation mechanism and desulfurization kinetics of sorbent was investigated on a water vapor aging treatment device. It was shown that both the water vapor pressure and reaction temperature significantly could influence the formation rate of inactive Zn2 Si O4, which could decrease the sulfur storage capacity of sorbents. The Zn2 Si O4 content profiles could be fitted into the zero order equation, from which the apparent rate constant k and the activation energy E a were calculated. The matrix P greatly raised the E a of Zn2 Si O4 formation due to the less bridged hydroxyl silanol groups on its surface, which accounted for the high stability of Ni/Zn O-P. The desulfurization performance of the fresh and aged sorbents showed that the overall average sulfur conversion of Ni/Zn O-P(aged) was 92%, which was close to that of fresh sorbents(95%), and was higher than that of Ni/Zn O-M(aged)(86%) and Ni/Zn O-H(aged)(90%). Based on these findings, the application of Ni/Zn O-P can greatly improve the long-term running stability of the industrial unit. | Zou Kang Lin Wei Tian Huiping Xu Guangtong Wang Lei Xu Hua | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，1： | 4 |
| 7 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 8 | Experimental Investigation on Microstructure and Segregation of Ultrahigh Strength Al-Zn-Mg-Cu-Zr-Sc-Ni Alloy during Homogenization显示文摘Ultrahigh strength Al-12Zn-2.4Mg-1.1Cu-0.20Zr-0.30Sc-0.30Ni alloy billets were fabricated by spray deposition method(the Osprey process). The effect of homogenization treatment on the microstructures and tensile properties were investigated by OM, SEM and EDS. The results show that adding small amount of Sc and Zr can greatly refine the grain size of the billet, with the average grain size of 10 μm. Grain-boundary becomes coarser firstly and then thinner under different homogenizing condition and grain coarsening were observed. The solute elements content of Zn inside grains has a peak at 490 ℃ /2 h, and Cu element, which was solved into matrix, can enhance the matrix hardness obviously during homogenization. The suitable homogenizing treatment is 460~490 °C/2 h for the hot extrusion of the studied alloy; after the optimized solid solution and T6 aging, the highest ultimate tensile strength (UTS) is 858 MPa with a ductility of 4.8%. | Li Zhenliang Xie Jianxin Chen Wei Zhai Jing Ren Huiping Wang Yufeng | 2009 | 稀有金属材料与工程2009，38，A03： | 3 |
| 9 | Transcriptome analysis of purple pigment formation in Colocasia esculenta显示文摘Taro(Colocasia esculenta(L.)Schott)is an important crop in Africa,Southeast Asia,and subtropics and is used as a food and medicine.The purple color pigmentation is an appealing character in taro.We sampled taro corms of the cultivar‘Lipu Taro’at four developmental stages,including LPYS1(without purple pigment,50 days of development(DOD)),LPYS2(very few purple pigments,75 DOD),LPYS3(moderate purple pigments,115 DOD)and LPYS4(high purple pigments,205 DOD).The purpose of our study was to identify the key genes underpinning the purple pigmentation in taro based on RNA-sequencing.Through RNA-Seq,6453 differentially expressed transcripts(DETs)were identified between purple and non-purple pigmented samples.We identified 41 and 12 flavonoid and anthocyanin related DETs transcripts,respectively.These DETs were upregulated at LPYS2,LPYS3,and LPYS4 as compared to LPYS1,indicating their positive contribution to the color formation in taro.Moreover,we identified several DETs encoding for transcription factors,including MYB and bHLH,known to be major regulators of structural genes involved in the flavonoid-anthocyanin pathway.Finally,we reported several plant hormones(ethylene,auxin,gibberellin,jasmonic acid,and cytokinin)related DETs,which are predicted to play important roles in the corm coloration.Different regulation of transcripts representing the flavonoid-anthocyanin biosynthesis pathway,plant hormone transduction pathway,and transcription factors may have key roles in purple pigmentation in taro.Our findings will facilitate future research on improving the quality and appeal of taro. | FANGLIAN HE WEIQING DONG SHAOLONG WEI ZUYANG QIU JINGLI HUANG HUIPING JIANG SHIYU HUANG LILI LIU | 2021 | BIOCELL2021，45，3： | 2 |
| 10 | Effects of EDTA and Zn Stress on Physiological Characteristics of Medicago sativa L.显示文摘[Objectives]The paper was better understand the mechanisms of Zn plant uptake in the presence of EDTA and to evaluate the contributions of Zn-EDTA complexes to Zn uptake.[Methods]Three alfalfa cultivars were cultivated for 60 d before exposure to 0,250μg Zn and 250μg Zn+10μg EDTA per kg soil for 50 d.Zn concentrations in tissues were analyzed by flame atomic absorbance spectrometry.Subsequently,Zn amount per plant,translocation factor(TF)and bio-concentration factor(BCF)were calculated.Nonenzymatic compounds in tissues were analyzed spectrophotometrically.[Results]Application of Zn+EDTA expressively increased biomass of different tissues of three alfalfa cultivars.Among the three alfalfa cultivars,Medicago sativa ssp.displayed the highest Zn concentration in tissues,the largest Zn amount in aerial parts,and the highest BCF in aerial parts under Zn+EDTA exposure.Under Zn+EDTA stress,increases in free proline in roots,stem,and leaves of M.sativa ssp.were found.Inhibited O_(2)^(·-)production in stem and leaves,increases in soluble sugar,but decreases in soluble protein were observed in M.sativa ssp.[Conclusions]M.sativa ssp.is superior to other two cultivars for Zn phyto-remediation,and its well-coordinated physiological changes under Zn+EDTA exposure confer the great Zn tolerance of this cultivar. | Nan HOU Hui JING Shuhe WEI Huiping DAI Xiaona HOU | 2022 | Plant Diseases and Pests2022，13，3： | 2 |
| 11 | Gene variants in the folate-mediated one-carbon metabolism(FOCM)pathway as risk factors for conotruncal heart defects显示文摘 | ZHU Huiping YANG Wei LU Wei | 2012 | Am J Med Genet A2012，158，5： | 1 |
| 12 | Efficient Extraction and Isolation of Mangiferin from Mango Leaves by Ethyl Acetate Impurity Removal Method显示文摘[Objectives] To optimize the ethyl acetate impurity removal method for extracting and isolating mangiferin from mango leaves,and provide raw materials and technical support for development and use of mangiferin related products. [Methods]Five steps( material crushing→ ethyl acetate impurity removing → concentrated extract washing → extracting with methanol → crystallization and precipitation) were used.The single factor experiment and L9( 34) orthogonal experiment was carried out to optimize the process parameters including extraction time,ultrasonic power,extraction times,and extraction temperature.[Results] The optimum process of ethyl acetate impurity removal method for extracting and isolating mangiferin from mango leaves was as follows: the mango leaves were crushed and sieved; 3 m L/g of ethyl acetate was added,sealed and soaked for 4 h,ultrasonically shaken for 20 min( 50℃,350 W),filtered at room temperature,filtered with 100 mesh sieve,and extracted three times; added 100% methanol to the residue at 3 m L/g,extract by ultrasonic vibration for 20 min( 350 W,55℃)for four times,filtered with 100 mesh sieve when it was still hot; mixed the extract of each time,condensed by vacuum decompression to get the extract; added 100% methanol at 4 m L/g,mixed and washed for 5 min at room temperature,placed for 10 min,filtered with 100 mesh sieve,washed 3 times repeatedly,and dried the filter residue at 60℃ to obtain the crude mangiferin; added 100% methanol at 4 m L/g,mixed and washed at 50℃ for 5 min,placed at 6℃ for 8 h,dried the filter residue at 60℃,and repeatedly crystallized two times. According to the above process,crude and pure mangiferin products could be obtained,the purity of mangiferin of the crude product was higher than 64. 00%,the total recovery rate was 83. 90%,and the purity of mangiferin of the pure product was higher than 98. 00%,and the total recovery rate was about 66. 40%. [Conclusions] The optimized ethyl acetate impurity removal method is easy in operation,low in cost,and high in efficiency for extracting and isolating mangiferin,and can be applied for actual production of mangiferin. | Huiping WEI Yi ZHENG Hongbo HAN Yuanhong SHANG | 2018 | Asian Agricultural Research2018，10，6： | 1 |
| 13 | Aromatization and isomerization of methylcyclohexane over Ni catalysts supported on different supports显示文摘In this work, nickel metal supported on different supports(SiO_2, Al_2O_3, ZSM-5) were prepared by spraying nickel nitrate on the supports and calcined at 873 K. Then, they were characterized by XRD, XRF, N_2 adsorption–desorption, NH_3-TPD, MCH-TPD, H_2-TPR, and pyridine-FTIR,and tested as catalysts for the dehydrogenation aromatization and isomerization of methylcyclohexane(MCH) under the conditions of S-Zorb catalytic adsorption desulfurization(T ? 673 K, P ? 1.5 MPa, WHSV ? 5 h^(-1)). The H2-TPR results showed that the interaction of NiO with support decreased in the order of NiO/ZSM-5-Fe < NiO/ZSM-5 < NiO/Al_2O_3< NiO/SiO2. The decrease of the interaction appeared to facilitate the reduction of Ni and therefore to promote the dehydrogenation aromatization of MCH.It was found that a direct correlation existed between the gasoline components yields, cracking activity and the total number of different supports acid sites measured by NH_3-TPD tests. Higher total acidity of ZSM-5 resulted in gasoline loss because of higher cracking activity of MCH. The number of total acid sites of NiO/ZSM-5-Fe decreased and the medium strong Br€onsted acid sites necessary for MCH isomerization increased after the modification of ZSM-5 by iron metal. So, NiO/ZSM-5-Fe exhibited enhanced MCH conversion, aromatic and isomerization yields when compared to NiO/ZSM-5 and other Ni-based catalysts. This study shows that NiO/ZSM-5-Fe catalyst may be possible to be integrated into the S-Zorb system achieving the recovery of the octane number of gasoline. | Ye Song Wei Lin Xingcui Guo Linlin Dong Xindong Mu Huiping Tian Lei Wang | 2019 | Green Energy & Environment2019，4，1： | 1 |
| 14 | Assessment of Soil Heavy Metal Pollution with Principal Component Analysis and Geoaccumulation Index显示文摘 | WEI Zhiyuan WANG Dengfeng ZHOU Huiping QI Zhiping | 2011 | Procedia Environmental Sciences2011，，10： | 1 |
| 15 | Efficient Semi‑Transparent Wide‑Bandgap Perovskite Solar Cells Enabled by Pure‑Chloride 2D‑Perovskite Passivation显示文摘Wide-bandgap(WBG)perovskite solar cells suffer from severe non-radiative recombination and exhibit relatively large opencircuit voltage(V_(OC))deficits,limiting their photovoltaic performance.Here,we address these issues by in-situ forming a well-defined 2D perovskite(PMA)_(2)PbCl_(4)(phenmethylammonium is referred to as PMA)passivation layer on top of the WBG active layer.The 2D layer with highly pure dimensionality and halide components is realized by intentionally tailoring the side-chain substituent at the aryl ring of the post-treatment reagent.First-principle calculation and single-crystal X-ray diffraction results reveal that weak intermolecular interactions between bulky PMA cations and relatively low cation-halide hydrogen bonding strength are crucial in forming the well-defined 2D phase.The(PMA)_(2)PbCl_(4)forms improved type-I energy level alignment with the WBG perovskite,reducing the electron recombination at the perovskite/hole-transport-layer interface.Applying this strategy in fabricating semi-transparent WBG perovskite solar cells(indium tin oxide as the back electrode),the V_(OC)deficits can be reduced to 0.49 V,comparable with the reported state-of-the-art WBG perovskite solar cells using metal electrodes.Consequently,we obtain hysteresis-free 18.60%-efficient WBG perovskite solar cells with a high V_(OC)of 1.23 V. | Liu Yang Yongbin Jin Zheng Fang Jinyan Zhang Ziang Nan Lingfang Zheng Huihu Zhuang Qinghua Zeng Kaikai Liu Bingru Deng Huiping Feng Yujie Luo Chengbo Tian Changcai Cui Liqiang Xie Xipeng Xu Zhanhua Wei | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 16 | Prevalence of Glaucoma in a Rural Northern China Adult Population显示文摘 | Wulian Song Li Shan Fang Cheng Pan Fan Lijuan Zhang Wei Qu Qiuju Zhang Huiping Yuan | 2011 | Ophthalmology2011，，10： | 1 |
| 17 | Brain-derived neurotrophic factor and Bcl-2 expression in rat brain areas following chronic morphine treatment显示文摘The ventral tegmental area and the locus coeruleus are associated with psychological and physical dependence of opioid addiction. To date, very little is known about brain-derived neurotrophic factor (BDNF) and Bcl-2 gene and protein changes following morphine addiction. The present study utilized immunohistochemistry and in situ hybridization techniques, which revealed that there were increased BDNF levels, but decreased Bcl-2 levels in the prefrontal cortex, locus coeruleus, hippocampus, and the ventral tegmental area during morphine-dependence formation and abstinence. However, the levels of BDNF remained unchanged, and Bcl-2 expression was increased in the nucleus accumbens. These results showed that BDNF and Bcl-2 are involved in the development of morphine dependence, and precipitation of abstinence syndrome. | Huiping Yu Hua HU Huaqing Meng Wei Deng Yixiao Fu Qinghua Luo | 2011 | Neural Regeneration Research2011，6，7： | 1 |
| 18 | How to effectively detect and manage people living with HIV/AIDS in China: Establishment of a community-based model显示文摘 | Jing Xu Huiping Zhu Xiaohui Gao Wei Liu Yukai Du | 2012 | Journal of Huazhong University of Science and Technology2012，，5： | 1 |
| 19 | Prevalence of Glaucoma in a Rural Northern China Adult Population显示文摘 | Wulian Song Li Shan Fang Cheng Pan Fan Lijuan Zhang Wei Qu Qiuju Zhang Huiping Yuan | 2011 | Ophthalmology2011，，10： | 1 |
| 20 | Spectrum of clinical features and type Ⅳ collagen alpha-chain distribution in Chinese patients with Alport syndrome显示文摘 | Wei G Zhihong L Huiping C | 2006 | Nephrol Dial Transplant2006，21，11： | 1 |
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