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| 1 | Tunable Q-factor wavelet transform denoising with neighboring coefficients and its application to rotating machinery fault diagnosis显示文摘Fault diagnosis of rotating machinery is of great importance to the high quality products and long-term safe operation.However,the useful weak features are usually corrupted by strong background noise,thus increasing the difficulty of the feature extraction.Thereby,a novel denoising method based on the tunable Q-factor wavelet transform(TQWT)using neighboring coefficients is proposed in this article.The emerging TQWT possesses excellent properties compared with the conventional constant-Q wavelet transforms,which can tune Q-factor according to the oscillatory behavior of the signal.Meanwhile,neighboring coefficients denoising is adopted to avoid the overkill of conventional term-by-term thresholding techniques.Because of having the combined advantages of the two methods,the presented denoising method is more practical and effective than other methods.The proposed method is applied to a simulated signal,a rolling element bearing with an outer race defect from antenna transmission chain and a gearbox fault detection case.The processing results demonstrate that the proposed method can successfully identify the fault features,showing that this method is more effective than the conventional wavelet thresholding denoising methods,term-by-term TQWT denoising schemes and spectral kurtosis. | HE WangPeng ZI YanYang CHEN BinQiang WANG Shuai HE ZhengJia | 2013 | Science China(Technological Sciences)2013，56，8： | 27 |
| 2 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 3 | Alternating shortcut nitrification-denitrification for nitrogen removal from soybean wastewater by SBR with real-time control显示文摘A novel treating technology for nitrogen removal from soybean wastewater was studied. The process for nitrogen removal was achieved by alternating aeration and mixing, combined with real\|time control strategies. Results showed that the COD and total nitrogen removal rates are more than 90% and 92% at COD and total nitrogen loads of 1\^0-1\^2 kg COD/(kgMLSS·d) and 0\^20-0\^27 kg TN/(kgMLSS·d), respectively. In addition, it could improve sludge settling property. SVI value is less than 70 g/ml during the whole cycles. The method not only may be adapted to treat soybean wastewater with high nitrogen, but also may be applied to treat other high nitrogen wastewater. | WANGShu-ying GAODa-wen PENGYong-zhen WANGPeng YANGQing | 2004 | Journal of Environmental Sciences2004，16，3： | 13 |
| 4 | Construction of a System for the Stable Expression of Foreign Genes in Dunaliella salina显示文摘A stable transformation system for the expression of foreign genes in the unicellular greenmarine alga (Dunaliella salina Teod.) was established. Using electroporation, the alga was transformed witha plasmid containing the hepatitis B surface antigen (HBsAg) gene and the chloramphenicol acetyltransferase(CAT) gene as a selectable gene. PCR and Southern blotting analysis indicated that the HBsAEgene wasintegrated into the D. salina genome. Northern dotting analysis showed that the HBsAg gene was expressedat the mRNA level. The stable expression of HBsAg protein in transformants was confirmed by HBsAgenzyme-linked immunosorbent assay (HBsAg EUSA) and Western blotting analysis. Also, PCR and Southernblotting analyses showed that the CA Tgene was integrated into the D, salina genome, and CAT EUSAindicated that CAT protein was stably expressed in the cells. The introduced HBsAg DNA and HBsAgprotein expression were stably maintained for at least 60 generations in media devoid of chloramphenicol.This is the first report of the stable expression of foreign genes in D. salina. | GENGDe-Gui HANYan WANGYi-Qin WANGPeng ZHANGLi-Ming LIWen-Bin SUNYong-Ru | 2004 | Acta Botanica Sinica2004，46，3： | 9 |
| 5 | Kinetics of aniline oxidation with chlorine dioxide显示文摘For the first time, kinetics of aniline oxidation with chlorine dioxide(ClO 2) were investigated systematically by detecting concentration of aniline with HPLC at regular intervals. Results showed that the reaction was first-order both in ClO 2 and in aniline, and the oxidation reaction could be described as second-order reaction. Stoichiometric factor η was experimentally determined to be 2 44. The second-order-reaction rate constant k was 0 11 L/(mol·s) under condition of pH 6 86 and water temperature(T w) 287K. Reaction activation energy was 72 31 kJ/mol, indicating that the reaction could take place under usual water treatment conditions. The reaction rate constants in acidic and alkali media were greater than that in neutral medium. Chlorite ion could slightly increase reaction rate in acidic medium. p-aminophenol and azobenzene were detected by GC-MS as intermediates. | FANZhi-yun HUANGJun-li WANGPeng SULi-qiang ZHENGYong-jie LIYing-jie | 2004 | Journal of Environmental Sciences2004，16，2： | 4 |
| 6 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 7 | Bridge Ontology: A Multi-Ontologies-Based Approach for Semantic Annotation显示文摘Representing the relationships between ontologies is the key problem of semantic annotations based on multi-ontologies. Traditional approaches only had the ability of denoting the simple concept subsumption relations between ontologies. Through analyzing and classifying the relationships between ontologies, the idea of bridge ontology was proposed, which had the powerful capability of expressing the complex relationships between concepts and relationships between relations in multi-ontologies. Meanwhile, a new approach employing bridge ontology was proposed to deal with the multi-ontologies-based semantic annotation problem. The bridge ontology is a peculiar ontology, which can be created and maintained conveniently, and is effective in the multi-ontologies-based semantic annotation. The approach using bridge ontology has the advantages of low-cost, scalable, robust in the web circumstance, and avoiding the unnecessary ontology extending and integration. | WANGPeng XUBao-wen LUjian-jiang LiYan-hui JIANGJian-hua | 2004 | Wuhan University Journal of Natural Sciences2004，9，5： | 2 |
| 8 | 显示文摘 | JIANGHong-Quan(姜洪泉) WANGPeng(王鹏) LUDan-Dan(卢丹丹) etal | | ChineseJInorgChem(WujiHuaxueXuebao)0，，： | 1 |
| 9 | 显示文摘 | YANGYu-Xiang(杨宇翔) WANGPeng(王鹏) WUJie-Da(吴介达) etal | | WujiHuaxueXueba0，，： | 1 |
| 10 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 11 | 显示文摘 | WANGPeng GUOQing-mei ZHAOQi-tao(王鹏 郭庆梅 赵启韬) | | 中国实验方剂学杂志0，，： | 1 |
| 12 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 13 | 显示文摘 | WANGPeng—Fei(王鹏飞) FANGQin(方勤) WUGuo—Zhi(吴国志) etat | 2013 | 无机化学学报2013，29，： | 1 |
| 14 | Automatic fault feature extraction of mechanical anomaly on induction motor bearing using ensemble super-wavelet transform 显示文摘 | HE Wangpeng ZI Yanyang CHEN Binqiang | 2015 | Mechanical Systems and Signal Processing2015，54，： | 1 |
| 15 | 显示文摘 | LIZheng(李正) ZHAOYue(赵越) WANGPeng(王鹏) etal | | WujiHuaxueXuebao0，，： | 1 |
| 16 | Application of catalytic wet oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | ZHU Wangpeng BIN Yuejing LI Zhonghe | 2002 | Water Research2002，36，8： | 1 |
| 17 | Application of catalytic wet oxidation for the treatment of H-acid manufacturing process wastewater显示文摘 | Zhu Wangpeng Bin Yuejing Li Zhonghe | 2002 | Wat Res2002，36，8： | 1 |
| 18 | 显示文摘 | ZHULi-jun WANGPeng SHIFeng-cheng etal(朱立军 王鹏 施丰成 等) | 2012 | 西南大学学报·自然科学版2012，34，3： | 1 |
| 19 | 显示文摘 | YANGYu-Xiang(杨宇翔) WANGPeng(王鹏) WUJie-Da(吴介达) etal | | ChinChemMag(HuaxueTongbao)0，，： | 1 |
| 20 | 显示文摘 | WANGPeng(王鹏) ZHUXiao-yan(朱晓燕) | | 计算机工程与应用0，，： | 1 |
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