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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | Tei指数评价Duchenne进行性肌营养不良症患者心功能显示文摘 | 吴进 Louis I Bezold Ricardo H Pignatelli Benjamin W Eidem | 2005 | 中华超声影像学杂志2005，14，5： | 2 |
| 4 | Synapsing variable-length crossover:Meaningful crossover for variable-length genomes显示文摘 | Benjamin H Kevin W | 2007 | IEEE Trans on Evolutionary Computation2007，11，1： | 1 |
| 5 | Analytical applications of acid potassium permanganate as a chemiluminescence reagent 显示文摘 | Benjamin J H Neil W | 2001 | Analytica Chimica Acta2001，445，1： | 1 |
| 6 | Expression of NOTCH-1 and Its Ligands, Delta-Like-1 and Jagged-1, Is Critical for Glioma Cell Survival and Proliferation显示文摘 | Benjamin W P Raqeeb M H Martha W N etal | 2005 | Cancer Res2005，65，6： | 1 |
| 7 | Alterations in intestinal permeability and blood flow in a new model of mesenteric ischemia显示文摘 | BENJAMIN I S ENGELBRECHT G H | 1992 | Circ Shock1992，36，： | 1 |
| 8 | Vancomycinresistant enterococci: 15 years andcounting 显示文摘 | Chavers L S S A Moser W H Benjamin | 2003 | J Hosp Infect2003，53，： | 1 |
| 9 | Using chlorine dioxide for trihalomethane control显示文摘 | BENJAMIN W L MARK H G | 1986 | Journal American Water Works Association1986，78，6： | 1 |
| 10 | Adaptive traffic signal control using approximate dynamic program- ming显示文摘 | Chen C Chi K W Benjamin G H | 2009 | Transportation Research Part C2009，17，5： | 1 |
| 11 | A Video-based Learning Ac- tivity is Effective for Preparing Physiotherapy Students for Practical Examinations 显示文摘 | BENJAMIN K W SEAN A H | 2013 | Physiotherapy2013，99，4： | 1 |
| 12 | Comparison of soluble manganese and acidic potassium permanganate chemiluminence detection using flow injection and sequential injection analysis for the determination of ascorbic acid in vitamin C tablets 显示文摘 | Nicole A Neil W B Benjamin J H | 2004 | Talanta2004，64，1： | 1 |
| 13 | Albino strain of Ophiostoma species for biological control of sapstain fungi显示文摘 | Benjamin W H Thwaites J M Farrell R L | 2003 | Holzforschung2003，57，： | 1 |
| 14 | lib Mesh:a C++Library for Parallel Adaptive Mesh Refinement/Coarsening Simulations显示文摘 | Benjamin S Kirk John W Peterson Roy H Stongner | 2006 | Enginnering with Computers2006，22，： | 1 |
| 15 | X-Ray Absorp-tion Fine Structure Characterization of the Local Structure ofFe in Fe-ZSM-5 显示文摘 | Sun H C Benjamin R W Jason A R | 2003 | J Phys Chem B2003，107，11： | 1 |
| 16 | Se- vere hemolytic disease of the newborn in a group B Afri- can-American infant delivered by a group 0 mother显示文摘 | Drabik-Clary K Reddy V V Benjamin W H ef al | 2006 | Ann Clin Lab Sci2006，36，2： | 1 |
| 17 | Primary production of grazed annual natural pasture and of grazed wheat in a semi-arid region of Israel显示文摘 | Benjamin R W Chen M Seligman N G Wallach D H adad M J A | 1978 | Agricultural Systems1978，，3： | 1 |
| 18 | Millibot trains for en-hanced mobility显示文摘 | Benjamin B H Michael J J Vande W C | 2002 | IEEE/ASME Transactions on Mechatronics2002，7，4： | 1 |
| 19 | Use of intravenous lidocaine to prevent reperfusion injury and subsequent multi- ple organ dysfunction syndrome显示文摘 | Benjamin H Cassutto Roger W Gfeller | 2003 | Journal of veterinary e- mergency and critical care2003，13，3： | 1 |
| 20 | A mechanistic analysis of the Rh-catalyzed intramolecular C-H amination reaction 显示文摘 | Kristin W F Christine G E Benjamin H B | 2009 | Tetrahedron2009，65，16： | 1 |
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