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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | 白细胞介素-10在T_H1和T_H2反应相互调节中的作用显示文摘对于T 辅助细胞(T_H)亚群的识别进一步加深了对免疫效应功能调节的了解。T_H 亚群除控制体液免疫和延迟型超敏反应以外,还通过分泌抑制性细胞因子来相互调节。Tim Mosmann 和Kevin Moore 分析总结了这些现象,尤其是由T_H 2细胞分泌的能够抑制T_H 1细胞功能的白细胞介素-10的作用。 | Tim R Mosmann Kevin W Moore 边立军 | 1992 | 国外医学(免疫学分册)1992，15，1： | 5 |
| 3 | Layer-layout-based heuristics for loading homogeneous items into a single container显示文摘The container loading problem (CLP) is a well-known NP-hard problem. Due to the computation complexity, heuristics is an often-sought approach. This article proposes two heuristics to pack homogeneous rectangular boxes into a single container. Both algorithms adopt the concept of building layers on one face of the container, but the first heuristic determines the layer face once for all, while the second treats the remaining container space as a reduced-sized container after one layer is loaded and, hence, selects the layer face dynamically. To handle the layout design problem at a layer's level, a block-based 2D packing procedure is also developed. Numerical studies demonstrate the efficiency of the heuristics. | WANG Zhou-jing LI Kevin W | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，12： | 2 |
| 4 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 5 | Vectorcardiographic QRS area as a predictor of response to cardiac resynchronization therapy显示文摘Cardiac resynchronization therapy(CRT)is a good treatment for heart failure accompanied by ventricular conduction abnormalities.Current ECG criteria in international guidelines seem to be suboptimal to select heart failure patients for CRT.The criteria QRS duration and left bundle branch block(LBBB)QRS morphology insufficiently detect left ventricular activation delay,which is required for benefit from CRT.Additionally,there are various definitions for LBBB,in which each one has a different association with CRT benefit and is prone to subjective interpretation.Recent studies have shown that the objectively measured vectorcardiographic QRS area identifies left ventricular activation delay with higher accuracy than any of the current ECG criteria.Indeed,various studies have consistently shown that a high QRS area prior to CRT predicts both echocardiographic and clinical improvement after CRT.The beneficial relation of QRS area with CRT-outcome was largely independent from QRS morphology,QRS duration,and patient characteristics known to affect CRT-outcome including ischemic etiology and sex.On top of QRS area prior to CRT,the reduction in QRS area after CRT further improves benefit.QRS area is easily obtainable from a standard 12-lead ECG though it currently requires off-line analysis.Clinical applicability will be significantly improved when QRS area is automatically determined by ECG equipment. | Mohammed A Ghossein Antonius MW van Stipdonk Frits W Prinzen Kevin Vernooy | 2022 | Journal of Geriatric Cardiology2022，19，1： | 2 |
| 6 | A new perspective on recent global warming:A symmetric trends of daily maximum and minimum temperature显示文摘 | Thomas R Karl Richord W Knight Kevin P Callo | 1993 | Bulletin of the American Meteorological Society1993，74，6： | 2 |
| 7 | Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya显示文摘 | Wendy P O'Meara Phillip Bejon Tabitha W Mwangi Emelda A Okiro Norbert Peshu Robert W Snow Charles RJC Newton Kevin Marsh | 2008 | The Lancet2008，，9649： | 2 |
| 8 | Synapsing variable-length crossover:Meaningful crossover for variable-length genomes显示文摘 | Benjamin H Kevin W | 2007 | IEEE Trans on Evolutionary Computation2007，11，1： | 1 |
| 9 | Error-based pruning of decision trees grown on very large data sets can work显示文摘 | Lawrence O Hall Richard Collins Kevin W Bowyer | 2002 | International Conference on Tools for Artificial Intelligence2002，48，： | 1 |
| 10 | Temperature-insensitive near-infrared spectro scopic measurement of glucose in aqueous solutions显示文摘 | Hazen Kevin H Arnold Mark A Small Gary W | 1994 | Applied Spectroscopy1994，48，4： | 1 |
| 11 | The management of ascites in cirrhosis:report on the consensus conference of the international ascites club显示文摘 | Kevin PM Florence W Pere G | 2003 | Hepatology2003，38，1： | 1 |
| 12 | Helical conjugated polymers:Synthesis,stability,and chiroptical properties of poly(alkyl phenylpropiolate)s bearing stereogenic pendants显示文摘 | Jacky W Y Lam Dong Yuping Kevin K L Cheuk | 2004 | Macromolecules2004，37，18： | 1 |
| 13 | Visualizing knowledge domains 显示文摘 | Katy B Chaomei C Kevin W B | 2003 | Annual Review of Information Science & Technology2003，37，1： | 1 |
| 14 | Seismic refraction at Horse Mesa Dam: an application of the generalized reciprocal method 显示文摘 | Kevin T K Reger A N W R McLamore | 1986 | Geophysics1986，51，： | 1 |
| 15 | Vishny,Why Is Rent-Seeking So Costly to Growth?显示文摘 | Murphy Kevin M Andrei Shleifer and Robert W | 1983 | American Economic Review1983，，83： | 1 |
| 16 | Liquefaction of Autographa californica Nucleopolyhedrovirus-Infected Insects Is Dependent on the Integrity of Virus-Encoded Chitinase and Cathepsin Genes显示文摘 | Rachael E Hawtin Tamara Zarkowska Kevin Arnold Carole J Thomas Graham W Gooday Linda A King John A Kuzio Robert D Possee | 1997 | Virology1997，，： | 1 |
| 17 | Interaction between microbubbles and ultrasound: in vitro and vivo observations显示文摘 | Kevin W Danny M Skyba | 1997 | JACC1997，29，： | 1 |
| 18 | The fate of nitro- gen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Science2006，46，： | 1 |
| 19 | Conductive poly- mer composite materials and their utility in electromagneticshielding applications显示文摘 | Richard T F Vijay W Kevin E H | 2008 | Journal of Applied Polymer Sci- ence2008，107，4： | 1 |
| 20 | Monitoring changing position of coastlines using Thematic Mapper imagery:an example from the Nile Delta显示文摘 | Kevin W Hesham M | 1999 | Geomorphology1999，29，： | 1 |
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