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| 1 | Bone marrow derived stem cells for the treatment of end-stage liver disease显示文摘End-stage disease due to liver cirrhosis is an important cause of death worldwide. Cirrhosis results from progressive, extensive fibrosis and impaired hepatocyte regeneration. The only curative treatment is liver transplantation, but due to the several limitations of this procedure, the interest in alternative therapeutic strategies is increasing. In particular, the potential of bone marrow stem cell(BMSC) therapy in cirrhosis has been explored in different trials. In this article, we evaluate the results of 18 prospective clinical trials, and we provide a descriptive overview of recent advances in the research on hepatic regenerative medicine. The main message from the currently available data in the literature is that BMSC therapy is extremely promising in the context of liver cirrhosis. However, its application should be further explored in randomized, controlled trials with large cohorts and long follow-ups. | Cristina Margini Ranka Vukotic Lucia Brodosi Mauro Bernardi Pietro Andreone | 2014 | World Journal of Gastroenterology2014，20，27： | 18 |
| 2 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 5 |
| 3 | De novo autoimmune hepatitis in liver transplant: State-of-the-art review显示文摘In the two past decades, a number of communications, case-control studies, and retrospective reports have appeared in the literature with concerns about the development of a complex set of clinical, laboratory and histological characteristics of a liver graft dysfunction that is compatible with autoimmune hepatitis. The de novo prefix was added to distinguish this entity from a pre-transplant primary autoimmune hepatitis, but the globally accepted criteria for the diagnosis of autoimmune hepatitis have been adopted in the diagnostic algorithm. Indeed, de novo autoimmune hepatitis is characterized by the typical liver necroinflammation that is rich in plasma cells, the presence of interface hepatitis and the consequent laboratory findings of elevations in liver enzymes, increases in serum gamma globulin and the appearance of nonorgan specific auto-antibodies. Still, the overall features of de novo autoimmune hepatitis appear not to be attributable to a univocal patho-physiological pathway because they can develop in the patients who have undergone liver transplantation due to different etiologies. Specifically, in subjects with hepatitis C virus recurrence, an interferon-containing antiviral treatment has been indicated as a potential inception of immune system derangement. Herein, we attempt to review the currently available knowledge about de novo liver autoimmunity and its clinical management. | Ranka Vukotic Giovanni Vitale Antonia D'Errico-Grigioni Luigi Muratori Pietro Andreone | 2016 | World Journal of Gastroenterology2016，22，10： | 4 |
| 4 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 5 | Evaluation of rope shovel operators in surface coal mining using a Multi-Attribute Decision-Making model显示文摘Rope shovels are used to dig and load materials in surface mines. One of the main factors that influence the production rate and energy consumption of rope shovels is the performance of the operator. This paper presents a method for evaluating rope shovel operators using the Multi-Attribute Decision-Making(MADM) model. Data used in this research were collected from an operating surface coal mine in the southern United States. The MADM model consists of attributes, their weights of importance, and alternatives. Shovel operators are considered the alternatives. The energy consumption model was developed with multiple regression analysis, and its variables were included in the MADM model as attributes.Preferences with respect to min/max of the defined attributes were obtained with multi-objective optimization. Multi-objective optimization was conducted with the overall goal of minimizing energy consumption and maximizing production rate. Weights of importance of the attributes were determined by the Analytical Hierarchy Process(AHP). The overall evaluation of operators was performed by one of the MADM models, i.e., PROMETHEE II. The research results presented here may be used by mining professionals to help evaluate the performance of rope shovel operators in surface mining. | Vukotic Ivana Kecojevic Vladislav | 2014 | International Journal of Mining Science and Technology2014，24，2： | 2 |
| 6 | The role of partial cystectomy in treatment of muscle invasive bladder cancer显示文摘 | Vukotic V Lazic M Savic S | 2007 | Acta Chir Iugosl2007，54，4： | 1 |
| 7 | Pointwise multiplication operators between Bergman spaces on simply connected domains 显示文摘 | VUKOTIC D | 1999 | Indiana Univ Math J1999，48，3： | 1 |
| 8 | The role of partial cystectomy in treatment of muscle invasive bladder cancer显示文摘 | Vukotic V Lazic M Savic S | 2007 | Acta Chir Iugosl2007，54，4： | 1 |
| 9 | Letter: calcineurin inhibitor level reduction during treatment with sofosbuvir in liver transplanted patients显示文摘 | R. Vukotic M. C. Morelli A.D. Pinna M. Margotti F.G. Foschi E. Loggi M. Bernardi P. Andreone | 2014 | Aliment Pharmacol Ther2014，，4： | 1 |
| 10 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 1 |
| 11 | 等周不等式和Hardy,Littlewood的一个定理显示文摘也许每个数学家都曾遇到过经典的等周不等式:A(Ω)≤(4π)^-1 L(δΩ)^2.这里A(Ω)是平面Jordan区域Ω的面积,而L(δΩ)是其边界δΩ(一条可求长的简单闭曲线)的长度.仅当Ω是一个圆盘时等号才成立.这意味着,在所有具有给定长度L的简单闭曲线中,围绕最大面积L^2/(4π)的是半径为L/(2π)的一个圆周. | Dragan Vukotic 陆柱家(译) 姚景齐(校) | 2010 | 数学译林2010，，2： | 0 |
| 12 | Coffee, Traditional Chinese Medicine and cannabinoids as potential tools for prevention and treatment of hepatocellular carcinoma显示文摘In the last decade,the incidence of hepatocellular carcinoma(HCC)is growing in both Europe and United States.Conventional therapies such as liver resection,transplantation,ablation,chemoembolization and sorafenib are not enough to avoid a significant mortality.Many studies suggested the positive effect of caffeine for prevention of HCC.Nevertheless,the amount of therapeutic caffeine and the high-dose safety are unknown.Many authors proposed Traditional Chinese Medicine as preventive and/or curative approach.Although it reveals limits such as the uncertain safety profile and the lack of evidence about a unique product,it shows interesting results in terms of survival and quality of life if given in combination with standard loco-regional therapy.Among the future promises,cannabinoids show interesting background mechanisms of blocking cell proliferation and neoangiogenesis.It is conceivable that in the next years,some natural products may have a role in improving the standards of care of HCC. | Stefano Gitto Ranka Vukotic Pietro Andreone | 2016 | Hepatoma Research2016，2，1： | 0 |
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