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| 1 | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers显示文摘AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. | Doron Boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B Ho Yaron Niv | 2012 | World Journal of Gastroenterology2012，18，33： | 5 |
| 2 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 3 | Mucin gene expression in bile of patients with and without gallstone disease,collected by endoscopic retrograde cholangiography显示文摘AIM:To investigate the pattern of mucin expression and concentration in bile obtained during endoscopic retrograde cholangiography(ERC) in relation to gallstone disease.METHODS:Bile samples obtained at ERC from 29 consecutive patients,17 with and 12 without gallstone disease were evaluated for mucin content by gel filtration on a Sepharose CL-4B column.Dot blot analysis for bile mucin apoproteins was performed with antibodies to Mucin 1(MUC1) ,MUC2,MUC3,MUC5AC,MUC5B and MUC6.Staining intensity score(0-3) was used as a measure of antigen expression.RESULTS:MUC1,MUC2,MUC3,MUC5AC,MUC5B and MUC6 were demonstrated in 34.4%,34.4%,51.7%,51.7%,55.1% and 27.5% of bile samples,respectively.The staining intensity scores were 0.62 ± 0.94,0.58 ± 0.90,0.79 ± 0.97,1.06 ± 1.22,1.20 ± 1.26 and 0.41 ± 0.73,respectively.Mean mucin concentration measured in bile by the Sepharose CL-4B method was 22.8 ± 24.0 mg/mL(range 3.4-89.0 mg/mL) .Mean protein concentration was 8.1 ± 4.8 mg/mL(range 1.7-23.2 mg/mL) .CONCLUSION:High levels of MUC3,MUC5AC and MUC5B are expressed in bile aspirated during ERC examination.A specific pattern of mucin gene expression or change in mucin concentration was not found in gallstone disease. | Alexander Vilkin Alex Geller Zohar Levi Yaron Niv | 2009 | World Journal of Gastroenterology2009，15，19： | 4 |
| 4 | Presence of JC virus DNAin the tumor tissue and normal mucosa of patients with spo-radic colorectal cancer (CRC) or with positive family historyand Bethesda criteria 显示文摘 | Vilkin A Ronen Z Levi Z | 2012 | Dig Dis Sci2012，57，1： | 1 |
| 5 | Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation显示文摘 | VILKIN A NUDELMAN I MORGENSTEM S | 2007 | Dig Dis Sci2007，52，7： | 1 |
| 6 | MicrosateIlite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel显示文摘 | Vilkin A Niv Y Nagasaka T | 2009 | Cancer2009，115，4： | 1 |
| 7 | Improving the performance of SVMRFE to select genes in microarray显示文摘 | DING Yuan-yuan VILKINS D | 2006 | BMC Bioinformatics2006，7，2： | 1 |
| 8 | Endoscopy in Asymptomatic Minidose Aspirin Consumers显示文摘 | Yaron Niv MD Alex Battler MD Galia Abuksis RN MSc Eyal Gal MD Boris Sapoznikov MD Alex Vilkin MD | 2005 | Digestive Diseases and Sciences2005，，1： | 1 |
| 9 | Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic eolorectal cancers of different ethnic groups in Israel显示文摘 | Vilkin A Niv Y Nagasaka T | 2009 | Cancer2009，115，4： | 1 |
| 10 | Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation显示文摘 | Vilkin A Nudelman I Morgenstem S | 2007 | Dig Dis Sci2007，52，7： | 1 |
| 11 | Minidose aspirin and gastrointestinal bleed-A retrospective, case-control study in hospitalized patients 显示文摘 | Sapoznikov B Vilkin A | 2005 | Dig Dis Sci2005，50，9： | 1 |
| 12 | Minidose aspirin and gastrointestinal bleed-A retrospective, case-control study in hospitalized pa- tients显示文摘 | Sapoznikov B Vilkin A | 2005 | Dig Dis Sci2005，50，9： | 1 |
| 13 | Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation显示文摘 | Vilkin a Nudelman I Morgenstem S | 2007 | Dig Dis2007，52，7： | 1 |
| 14 | Taenia solium moleculax clonina and serologic evaluation of 14KD and 18KD related diagnostic antigens显示文摘 | Greene RM Hancock K Vilkins PP | 2000 | J Parasitol2000，86，5： | 1 |
| 15 | Perfomance characteristics and evaluation of an automated-developed and quantitative,immunochemical fecal occult blood screening tests显示文摘 | Vilkin A Rozen P Levi Z | | 0，，01： | 1 |
| 16 | Minidose aspirin and gastrointestinal bleeding-a retrospective,case-control study in hospitalized patients显示文摘 | Vilkin A Hershkovici M | 2005 | Dig Dis Sci2005，50，： | 1 |
| 17 | Gallbladder mucin plays a role in gallstone formation显示文摘 | Bar Dayan Y Vilkin A Niv Y | 2004 | Eur J Intern Med2004，15，7： | 1 |
| 18 | Microsatellite instability MLH1 promoter methylation and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel显示文摘 | Vilkin A Niv Y Nagasaka T | 2009 | Cancer2009，115，4： | 1 |
| 19 | Gallbladder mucin plays a role in gallstone formation显示文摘 | Bar Dayan Y Vilkin A Niv Y | 2004 | Eur J Intern Med2004，15，7： | 1 |
| 20 | Microsatellite instability, MLH1 promoter mcthylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel显示文摘 | Vilkin A Niv Y Nagasaka T | 2009 | Cancer2009，115，4： | 1 |
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