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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 3 | Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection?显示文摘 | Ioannis T. Konstantinidis Andrew L. Warshaw Jill N. Allen Lawrence S. Blaszkowsky Carlos Fernandez-del Castillo Vikram Deshpande Theodore S. Hong Eunice L. Kwak Gregory Y. Lauwers David P. Ryan Jennifer A. Wargo Keith D. Lillemoe Cristina R. Ferrone | 2013 | Annals of Surgery2013，，4： | 3 |
| 4 | International study group on rectal cancer regression grading: interobserver variability with commonly used regression grading systems显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang Vikram Deshpande David Driman Marisa Gomez Godman Greywoode Eleanor Jaynes C. Soon Lee Michael Locketz Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Ra | 2012 | Human Pathology2012，，11： | 2 |
| 5 | Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure显示文摘 | Cristina R. Ferrone Rafael Pieretti-Vanmarcke Jordan P. Bloom Hui Zheng Jackye Szymonifka Jennifer A. Wargo Sarah P. Thayer Gregory Y. Lauwers Vikram Deshpande Mari Mino-Kenudson Carlos Fernández-del Castillo Keith D. Lillemoe Andrew L. Warshaw | 2012 | Surgery2012，，： | 2 |
| 6 | Autoimmune Pancreatitis: A Systemic Immune Complex Mediated Disease显示文摘 | Vikram Deshpande Sonia Chicano Dmitry Finkelberg Martin K. Selig Mari Mino-Kenudson William R. Brugge Robert B. Colvin Gregory Y. Lauwers | 2006 | The American Journal of Surgical Pathology2006，，12： | 1 |
| 7 | Improved Contemporary Surgical Management of Insulinomas: A 25-year Experience at the Massachusetts General Hospital显示文摘 | Mehrdad Nikfarjam Andrew L. Warshaw Lloyd Axelrod Vikram Deshpande Sarah P. Thayer Cristina R. Ferrone Carlos Fernández-del Castillo | 2008 | Annals of Surgery2008，，1： | 1 |
| 8 | Recommendations for the nomenclature of IgG4‐related disease and its individual organ system manifestations显示文摘 | John H. Stone Arezou Khosroshahi Vikram Deshpande John K. C. Chan J. Godfrey Heathcote Rob Aalberse Atsushi Azumi Donald B. Bloch William R. Brugge Mollie N. Carruthers Wah Cheuk Lynn Cornell Carlos Fernandez‐Del Castillo Judith A. Ferry David Forcione Gü | 2012 | Arthritis & Rheumatism2012，，10： | 1 |
| 9 | Recommendations for the nomenclature of IgG4‐related disease and its individual organ system manifestations显示文摘 | John H. Stone Arezou Khosroshahi Vikram Deshpande John K. C. Chan J. Godfrey Heathcote Rob Aalberse Atsushi Azumi Donald B. Bloch William R. Brugge Mollie N. Carruthers Wah Cheuk Lynn Cornell Carlos Fernandez‐Del Castillo Judith A. Ferry David Forcione Gü | 2012 | Arthritis & Rheumatism2012，，10： | 1 |
| 10 | Recommendations for the nomenclature of IgG4‐related disease and its individual organ system manifestations显示文摘 | John H. Stone Arezou Khosroshahi Vikram Deshpande John K. C. Chan J. Godfrey Heathcote Rob Aalberse Atsushi Azumi Donald B. Bloch William R. Brugge Mollie N. Carruthers Wah Cheuk Lynn Cornell Carlos Fernandez‐Del Castillo Judith A. Ferry David Forcione Gü | 2012 | Arthritis & Rheumatism2012，，10： | 1 |
| 11 | IgG4+ to IgG+ Plasma Cells Ratio of Ampulla Can Help Differentiate Autoimmune Pancreatitis From Other “Mass Forming” Pancreatic Lesions显示文摘 | Alireza Sepehr Mari Mino-Kenudson Fumihiro Ogawa William R. Brugge Vikram Deshpande Gregory Y. Lauwers | 2008 | The American Journal of Surgical Pathology2008，，12： | 1 |
| 12 | Buried Dysplasia and Early Adenocarcinoma Arising in Barrett Esophagus After Porfimer-photodynamic Therapy显示文摘 | Mari Mino-Kenudson Shinichi Ban Masaya Ohana William Puricelli Vikram Deshpande Michio Shimizu Norman S. Nishioka Gregory Y. Lauwers | 2007 | The American Journal of Surgical Pathology2007，，3： | 1 |
| 13 | Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection?显示文摘 | Ioannis T. Konstantinidis Andrew L. Warshaw Jill N. Allen Lawrence S. Blaszkowsky Carlos Fernandez-del Castillo Vikram Deshpande Theodore S. Hong Eunice L. Kwak Gregory Y. Lauwers David P. Ryan Jennifer A. Wargo Keith D. Lillemoe Cristina R. Ferrone | 2013 | Annals of Surgery2013，，4： | 1 |
| 14 | Subclassification of Autoimmune Pancreatitis: A Histologic Classification With Clinical Significance显示文摘 | Vikram Deshpande Rajib Gupta Nisha Sainani Dushyant V. Sahani Renu Virk Cristina Ferrone Arezou Khosroshahi John H. Stone Gregory Y. Lauwers | 2011 | The American Journal of Surgical Pathology2011，，1： | 1 |
| 15 | Compressive behavior of age hardenable tetrahedral lattice truss structures made from aluminium显示文摘 | Gregory W Kooistra Vikram S Deshpande Haydn N.G Wadley | 2004 | Acta Materialia2004，，14： | 1 |
| 16 | IgG4-Related Systemic Disease as a Cause of “Idiopathic” Orbital Inflammation, Including Orbital Myositis, and Trigeminal Nerve Involvement显示文摘 | Zachary S. Wallace Arezou Khosroshahi Frederick A. Jakobiec Vikram Deshpande Mark P. Hatton Jill Ritter Judith A. Ferry John H. Stone | 2012 | Survey of Ophthalmology2012，，1： | 1 |
| 17 | Author Correction:Intragenic antagonistic roles of protein and circ RNA in tumorigenesis显示文摘We apologize for author name and affiliation errors that we just identified in our paper published in 2019 August issue.There were mistakes in the name of one author and the location of institutional affiliations for four authors.Specifically,author'D im itrios Spentzos'was previously listed as'Spentzos Dim itrios'resulting in a reversal of his first and last nam e. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Dimitrios Spentzos John G.Clohessy Mona Batish Pier Paolo Pandolfi | 2020 | Cell Research2020，30，2： | 0 |
| 18 | 无痛性黄疸伴系列器官功能障碍显示文摘2008年4月,一位68岁的男性因皮肤瘙痒和无痛性黄疸来就诊。2年前,患者被诊断患有主动脉瓣狭窄,因此接受了二叶式主动脉瓣以及扩张升主动脉的置换术。术前检查显示纵隔增宽、肺门淋巴结肿大。术中获取的淋巴结活检结果为淋巴滤泡增生。主动脉病理检查提示为慢性硬化性主动脉炎。1年之后,患者的双侧下颌下出现无痛性肿胀结节,被诊断为涎腺炎。此后,下颌下腺的肿胀几度起伏, | Arezou Khosroshahi James R Stone Daniel S Pratt Vikram Deshpande John H Stone 黎一兵(译) | 2009 | 世界临床医学2009，，12： | 0 |
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